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Chemical Structure| 213118-56-0 Chemical Structure| 213118-56-0

Structure of 213118-56-0

Chemical Structure| 213118-56-0

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Product Details of [ 213118-56-0 ]

CAS No. :213118-56-0
Formula : C12H18N2O3
M.W : 238.28
SMILES Code : COC1=CC=C(NC(=O)OC(C)(C)C)C(N)=C1
MDL No. :MFCD09701250

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Application In Synthesis of [ 213118-56-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 213118-56-0 ]

[ 213118-56-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 213118-56-0 ]
  • [ 2080-75-3 ]
YieldReaction ConditionsOperation in experiment
72% With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 5 h; Intermediate 37:[0168] Intermediate 36 (7.3 g, 30.6 mmol) was dissolved in DMF (70 mL). To this solution was added anhydrous K2C03 (4.7 g, 33.7 mmol) and the mixture was heated to reflux (130°C) for 5 h. The solvent was removed under pressure, the residue was poured into ice water, and the aq phase was extracted with EtOAc. The combined organic layers were dried over anhydrous Na2S04, concentrated under vacuum, and the resulting yellow solid was recrystallized from EtOH to give 5-methoxy-lH-benzo[^imidazol-2(3H)-one (intermediate 37) (3.6 g, 72percent) as a yellow solid, mp: 249-251°C.
References: [1] Patent: WO2012/3418, 2012, A2, . Location in patent: Page/Page column 71.
 

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