Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 214472-37-4 | MDL No. : | |
Formula : | C16H22N2O7 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 354.36 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87.5% | With potassium carbonate; In acetonitrile; for 2.5h;Reflux; | To a slurry of compound 2 (10.0 g, 0.044 mol) and anhydrous potassium carbonate (18.2 g, 0.1317 mol) in acetonitrile (100 ml), <strong>[57616-74-7]4-<strong>[57616-74-7](3-chloropropyl)morpholine hydrochloride</strong></strong> (10 g, 0.05 mol) was added and refluxed for 2.5 h. The solvent was distilled under reduced pressure to give residue which was diluted with water(60 ml) and extracted with ethyl acetate (100 ml) after completion of reaction. The organic layer was distilled under vacuum and dried to obtain 13.65 g (87.50%) of the compound 3; m. p. 231-233 C. 1HNMR (DMSO-d6, 400 MHz): delta 7.62 (s, 1H), 7.31 (s, 1H), 7.07 (s, 1H),3.90 (s, 3H), 3.79 (s, 3H), 4.18 (t, 2H), 4.17 (s, 2H), 4.16 (s, 3H), 2.37 (d,1H), 1.91 (d, 2H). IR (numax, cm-1): 3134, 1695, 1601. |
With potassium carbonate; In acetonitrile; for 2.5h;Reflux; | Example 6; Preparation of 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitro benzoic acid methyl ester; To a mixture of 5-hydroxy-4-methoxy-2-nitrobenzoic acid methyl ester (10 g) and anhydrous potassium carbonate (18.2 g) in acetonitrile (100 ml), <strong>[57616-74-7]4-(3-chloropropyl)-morpholine hydrochloride</strong> (10 g) was added and refluxed for 2.5 hours. After completion of reaction, the solvent was distilled under reduced pressure to give residue which was diluted with water and extracted with ethyl acetate. The organic layer was distilled under vacuum and dried to obtain 14 g of the title compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96.18% | With potassium carbonate In N,N-dimethyl-formamide at 50 - 100℃; for 1h; | I.2 (2) Preparation of Methyl 2-nitro-4-methoxy-5-(3-morpholinopropoxy)benzoate 4 Methyl 2-nitro-5-hydroxy-4-methoxyethoxybenzoate 21 (1 g, 0.0044 mol) is dissolved in dimethylformamide (10 ml), and 3-morpholinopropoxy chloride (0.83 g, 5.269 mmol) is added. K2CO3 (1.21 g, 8.768 mmol) is added to react at 50-100° C. for 1 hour. And then, after water (20 ml) is added, the reaction mixture is extracted by ethyl acetate (20 ml) for three times, and extracts of ethyl acetate layer are combined, to be dried by MgSO4, filtered and concentrated to obtain yellowish solid compound 4 (1.5 g, 96.18%). 1H-NMR (CDCl3) spectrum: 2.02 (t, 2H, J=6.8 Hz), 2.42 (brs, 4H), 2.51 (m, 2H), 3.68 (m, 4H), 3.87 (s, 3H), 3.92 (s, 3H), 4.16 (t, 2H, J=6.8 Hz), 7.07 (s, 1H), 7.42 (s, 1H). |