Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	214472-37-4
Formula :	C₁₆H₂₂N₂O₇
M.W :	354.36
SMILES Code :	O=C(OC)C1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O
English Name :	Methyl 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzoate
MDL No. :	MFCD26743437

GHS Pictogram:
Signal Word:
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UN#:
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Yield	Reaction Conditions	Operation in experiment
87.5%	With potassium carbonate; In acetonitrile; for 2.5h;Reflux;	To a slurry of compound 2 (10.0 g, 0.044 mol) and anhydrous potassium carbonate (18.2 g, 0.1317 mol) in acetonitrile (100 ml), <strong>[57616-74-7]4-<strong>[57616-74-7](3-chloropropyl)morpholine hydrochloride</strong></strong> (10 g, 0.05 mol) was added and refluxed for 2.5 h. The solvent was distilled under reduced pressure to give residue which was diluted with water(60 ml) and extracted with ethyl acetate (100 ml) after completion of reaction. The organic layer was distilled under vacuum and dried to obtain 13.65 g (87.50%) of the compound 3; m. p. 231-233 C. 1HNMR (DMSO-d6, 400 MHz): delta 7.62 (s, 1H), 7.31 (s, 1H), 7.07 (s, 1H),3.90 (s, 3H), 3.79 (s, 3H), 4.18 (t, 2H), 4.17 (s, 2H), 4.16 (s, 3H), 2.37 (d,1H), 1.91 (d, 2H). IR (numax, cm-1): 3134, 1695, 1601.
	With potassium carbonate; In acetonitrile; for 2.5h;Reflux;	Example 6; Preparation of 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitro benzoic acid methyl ester; To a mixture of 5-hydroxy-4-methoxy-2-nitrobenzoic acid methyl ester (10 g) and anhydrous potassium carbonate (18.2 g) in acetonitrile (100 ml), <strong>[57616-74-7]4-(3-chloropropyl)-morpholine hydrochloride</strong> (10 g) was added and refluxed for 2.5 hours. After completion of reaction, the solvent was distilled under reduced pressure to give residue which was diluted with water and extracted with ethyl acetate. The organic layer was distilled under vacuum and dried to obtain 14 g of the title compound.

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CAS No.: 214472-37-4

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CAS No.: 214472-37-4

Alternative Products

Product Details of [ 214472-37-4 ]

Safety of [ 214472-37-4 ]

Application In Synthesis of [ 214472-37-4 ]

[ 214472-37-4 ] Synthesis Path-Downstream 1~2

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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
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H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
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Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
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