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Chemical Structure| 215190-21-9 Chemical Structure| 215190-21-9

Structure of 215190-21-9

Chemical Structure| 215190-21-9

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Product Details of [ 215190-21-9 ]

CAS No. :215190-21-9
Formula : C26H23NO4
M.W : 413.47
SMILES Code : O=C([C@H]1N(C(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)[C@@H](C5=CC=CC=C5)CC1)O
MDL No. :MFCD00673788
InChI Key :JEEBFSSXASHKSF-RPWUZVMVSA-N
Pubchem ID :2756140

Safety of [ 215190-21-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 215190-21-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 215190-21-9 ]

[ 215190-21-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 215190-21-9 ]
  • [ 23357-46-2 ]
  • 2-phenyl-5-(1,2,3,4-tetrahydro-naphthalen-1-ylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
> 95% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; at 20℃; for 5h; A solution of (2S,5R)-5-phenyl-pyrrolidine-l,2-dicarboxylic acid l-(9H-fluoren- 9-ylmethyl) ester (1001 mg, 2.42 mmol) and (R)- 1,2,3, 4-tetrahydro-naphthalen-l- ylamine (520 mg, 3.50 mmol) in tetrahydrofuran (TΗF) (40 mL) was added l-ethyl-3-(3- dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (950 mg, 4.95 mmol) and 1- hydroxybenzotriazole monohydrate (ΗOBt) (450 mg, 3.33 mmol), followed by iV-methyl- 2-pyrrolidinone (0.75 mL) and 4-methyl morpholine (0.75 mL). This mixture was stirred at room temperature for 5 hours. The reaction mixture was treated with water (20 mL), then partitioned between ethyl acetate/water. The organic phase was washed with IN HCl (2 x 25 mL), saturated sodium bicarbonate solution (50 mL) and brine solution (50 mL), dried over Na2SO4 and evaporated to dryness. The residue was purified by medium pressure column chromatography on silica gel eluting with ethyl acetate/hexane (0-100%) to give the title compound (1310 mg, >95%) as a glassine solid. TLC (25% ethyl acetate/hexane) R/= 0.12; MS (ES) for C36H34N2O3 (MW=542.67): positive 543 (M+H).
 

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