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Chemical Structure| 219492-28-1 Chemical Structure| 219492-28-1

Structure of 219492-28-1

Chemical Structure| 219492-28-1

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Product Details of [ 219492-28-1 ]

CAS No. :219492-28-1
Formula : C17H20N2O
M.W : 268.35
SMILES Code : O=C(NC1=CC=CC=C1N)C2=CC=C(C(C)(C)C)C=C2
MDL No. :MFCD02585708

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Application In Synthesis of [ 219492-28-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 219492-28-1 ]

[ 219492-28-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 704-91-6 ]
  • [ 219492-28-1 ]
  • [ 219507-07-0 ]
YieldReaction ConditionsOperation in experiment
330 mg (26%) With 1,2-dichloro-ethane; In methanol; ethyl acetate; N,N-dimethyl-formamide; C N2-(4-t-Butylbenzoyl)-N1-(6-indazolylcarbonyl)-1,2-benzenediamine To a stirring solution of N2-(4-t-butylbenzoyl)-1,2-benzenediamine (830 mg, 3.1 mmol) and <strong>[704-91-6]6-indazolecarboxylic acid</strong> (European Pat. Appln. Pub. No. 242 167 A2, p 43) (500 mg, 3.1 mmol) in DMF (5 mL) was added EDC (1.19 g, 6.2 mmol). After 12 h, the solvent was removed in vacuo and the residue was dissolved in ethyl acetate and washed twice with water and twice with brine. The organic phase was dried with MgSO4, filtered and concentrated in vacuo, then chromatographed over silica gel, eluding with a solvent gradient of dichloromethane through 5percent methanol/dichloromethane. The product containing fractions were combined and concentrated in vacuo to give 330 mg (26percent) of an off-white solid. 1H NMR FD-MS, m/e 412 (M+) Anal. for C24H24N4O2: Calc: C, 72.80; H, 5.87; N, 13.58. Found: C, 72.15; H, 5.80; N, 13.19.
 

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