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Chemical Structure| 22091-39-0 Chemical Structure| 22091-39-0

Structure of 22091-39-0

Chemical Structure| 22091-39-0

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Product Details of [ 22091-39-0 ]

CAS No. :22091-39-0
Formula : C10H7ClFNO
M.W : 211.62
SMILES Code : FC1=CC=C(C2=NC(CCl)=CO2)C=C1
MDL No. :MFCD08276487

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Application In Synthesis of [ 22091-39-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22091-39-0 ]

[ 22091-39-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25519-82-8 ]
  • [ 22091-39-0 ]
  • 1-((2-((4-fluorophenyl)oxazol-4-yl)methyl)piperidin-4-yl)(4-methoxyphenyl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In water; acetonitrile; for 4h;Reflux; General procedure: To a solution of (2-(4-fluorophenyl)oxazol-4-yl)methanol 6a (1.13 g, 6 mmol) in 30 mL DCM was added SOCl2 (0.58 mL, 8 mmol). The solution was refluxed for 2 h and then poured into 30 mL of ice cold water. The organic layer was concentrated in vacuo to afford crude 7a as a yellow oil without a further purification. To a solution of 7a and 11a (1.70 g, 6 mmol) in 12 mL of 1 mol/L NaOHaq and 15 mL of CH3CN was refluxed for 4 h. Then the solution concentrated in vacuo. The residue extracted with CH2Cl2 (20 mL × 2) and washed with brine, dried over anhydrous sodium sulfate. The solution filtered to remove the precipitate and concentrated in vacuo. The crude product was purified by silica gel chromatography using 40:1 DCM/MeOH as the eluent to afford 1a (1.74 g, 69% yield) as a pale yellow solid.
 

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