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Chemical Structure| 221198-11-4 Chemical Structure| 221198-11-4

Structure of 221198-11-4

Chemical Structure| 221198-11-4

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Product Details of [ 221198-11-4 ]

CAS No. :221198-11-4
Formula : C6H13NO2
M.W : 131.17
SMILES Code : COCCOC1CNC1
MDL No. :MFCD13559915

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Application In Synthesis of [ 221198-11-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 221198-11-4 ]

[ 221198-11-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24242-20-4 ]
  • [ 221198-11-4 ]
  • [ 1403248-78-1 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; Standard Method C; HATU Coupling[0201] To a solution of the carboxylic acid (1.0 eq), the amine (1.0-1.5 eq), DIPEA (1.0-1.5 eq) in DMF was added HATU (1.0-1.5 eq). The reaction mixture was stirred at rt for 8 - 16 h. The solvent was evaporated and the residue purified by RP-MPLC (Ci8, MeOH/H20, 0-100percent w/ 0.1percent TFA) to provide the desired compounds. The desired fractions were collected and the solvent evaporated under reduced pressure. Alternatively, the resulting solid was recrystallized from EtOAc/Hexanes to afford the desired compound.
 

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