[ CAS No. 22282-75-3 ] {[proInfo.proName]}

Name: 22282-75-3|3-Fluoro-4-iodopyridine|97%
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Quality Control of [ 22282-75-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 22282-75-3 ]

Product Details of [ 22282-75-3 ]

CAS No. :	22282-75-3	MDL No. :	MFCD03092927
Formula :	C₅H₃FIN	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MSLUTDVOKZOXTA-UHFFFAOYSA-N
M.W :	222.99	Pubchem ID :	10998636
Synonyms :

Calculated chemistry of [ 22282-75-3 ]

Physicochemical Properties

Num. heavy atoms :	8
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	36.91
TPSA :	12.89 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.52 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.64
Log Po/w (XLOGP3) :	1.6
Log Po/w (WLOGP) :	2.25
Log Po/w (MLOGP) :	1.85
Log Po/w (SILICOS-IT) :	2.83
Consensus Log Po/w :	2.03

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.79
Solubility :	0.365 mg/ml ; 0.00164 mol/l
Class :	Soluble
Log S (Ali) :	-1.48
Solubility :	7.35 mg/ml ; 0.0329 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-3.26
Solubility :	0.122 mg/ml ; 0.000548 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.88

Safety of [ 22282-75-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 22282-75-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 22282-75-3 ]
Downstream synthetic route of [ 22282-75-3 ]

[ 22282-75-3 ] Synthesis Path-Upstream 1~7

1
[ 372-47-4 ]
[ 22282-75-3 ]

Reference： [1] Tetrahedron Letters, 2004, vol. 45, # 36, p. 6697 - 6701
[2] Tetrahedron Letters, 1980, vol. 21, # 43, p. 4137 - 4140
[3] Heterocycles, 1993, vol. 35, # 1, p. 151 - 169
[4] Tetrahedron, 1993, vol. 49, # 1, p. 49 - 64
[5] Heterocycles, 1996, vol. 43, # 8, p. 1641 - 1652
[6] Patent: US6440972, 2002, B1,

2
[ 372-47-4 ]
[ 22282-75-3 ]

Reference： [1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205

3
[ 372-47-4 ]
[ 22282-75-3 ]
[ 146141-04-0 ]

Reference： [1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205

4
[ 372-47-4 ]
[ 22282-75-3 ]
[ 146141-04-0 ]

Reference： [1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205

5
[ 22282-75-3 ]
[ 146141-04-0 ]

Reference： [1] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[2] Tetrahedron, 1993, vol. 49, # 1, p. 49 - 64

6
[ 372-47-4 ]
[ 22282-75-3 ]
[ 146141-04-0 ]

Reference： [1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205

7
[ 372-47-4 ]
[ 22282-75-3 ]
[ 146141-04-0 ]

Reference： [1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205

[ 22282-75-3 ] Synthesis Path-Downstream 1~73

1
[ 372-47-4 ]
[ 22282-75-3 ]

Yield	Reaction Conditions	Operation in experiment
	With iodine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; n-heptane; water;	The starting material was prepared as follows: A solution of 3-fluoropyridine (19.4 g) in dry tetrahydrofuran (20 ml) was added dropwise over 30 minutes, under an atmosphere of argon, to a stirred solution of 2M lithium diisopropylamide/tetrahydrofutran/heptane (100 ml) in dry tetrahydrofuran (700 ml) at -70° C. The mixture was stirred at -70° C. for 4 hours. A solution of iodine (50.7 g) in dry tetrahydrofuran (160 ml) was added dropwise to this stirred suspension at -70° C. over 45 minutes and stirring was continued for a further 45 minutes. A mixture of tetrahydrofuran (160 ml)/water (40 ml) was added to the resulting solution at -70° C. The solution was allowed to warm to 0° C. Water (200 ml) was added and diethyl ether (400 ml). The mixture was allowed to stand at ambient temperature for 16 hours. The ether layer was separated. The aqueous layer was extracted with ether (2100 ml). The ether layers were all combined, washed with aqueous sodium thiosulphate solution (2250 ml) and saturated brine (2*100 ml), dried (Na2O4) and evaporated to low bulk. The residue was dissolved in dry diethyl ether and the solution was cooled to -50° C. The solid, which had separated, was filtered off and washed with pentane at -50° C. to give 3-fluoro-4-iodopyridine (22.8 g) as a white solid: NMR (CDCl3): 7.75 (t, 1H), 8.05 (d, 1H), 8.3 5 (s, 1H); m/z 223 M.

Reference： [1]Tetrahedron Letters,2004,vol. 45,p. 6697 - 6701
[2]Tetrahedron Letters,1980,vol. 21,p. 4137 - 4140
[3]Heterocycles,1993,vol. 35,p. 151 - 169
[4]Tetrahedron,1993,vol. 49,p. 49 - 64
[5]Heterocycles,1996,vol. 43,p. 1641 - 1652
[6]Patent: US6440972,2002,B1

2
[ 124-38-9 ]
[ 22282-75-3 ]
3-Fluoro-2-iodo-4-pyridinecarboxylic acid [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838

3
[ 22282-75-3 ]
[ 146140-95-6 ]
[ 146141-07-3 ]

Reference： [1]Tetrahedron,1993,vol. 49,p. 49 - 64
[2]Tetrahedron Letters,1993,vol. 34,p. 7917 - 7918

4
[ 22282-75-3 ]
5-methoxy-2-(pivaloylamino)phenylboronic acid [ No CAS ]
[ 155727-47-2 ]

Reference： [1]Tetrahedron Letters,1994,vol. 35,p. 2003 - 2004
[2]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

5
[ 22282-75-3 ]
[ 146141-04-0 ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838
[2]Tetrahedron,1993,vol. 49,p. 49 - 64

6
[ 22282-75-3 ]
4-Deuterio-3-fluoro-2-iodopyridine [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838

7
[ 22282-75-3 ]
3-Fluoro-2,4-diiodopyridine [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838

8
[ 22282-75-3 ]
[ 100-52-7 ]
(3-Fluoro-2-iodo-4-pyridylphenyl)methanol [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838

9
[ 22282-75-3 ]
[ 120-14-9 ]
1-(3-Fluoro-2-iodo-4-pyridyl)-1-(3,4-dimethoxyphenyl)methanol [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838

10
[ 22282-75-3 ]
[ 74-88-4 ]
[ 153035-05-3 ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838

11
[ 22282-75-3 ]
6-methoxy-2-(pivaloylamino)phenylboronic acid [ No CAS ]
2,2-dimethyl-N-(3-methoxy-2-(3-fluoro-4-pyridyl)phenyl)propanamide [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

12
[ 22282-75-3 ]
3-methoxy-2-(pivaloylamino)phenylboronic acid [ No CAS ]
[ 170959-26-9 ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

13
[ 22282-75-3 ]
3,4-dichloro-2-(pivaloylamino)benzeneboronic acid [ No CAS ]
7,8-dichloro-β-carboline [ No CAS ]

Reference： [1]Synthetic Communications,1995,vol. 25,p. 2901 - 2908

14
[ 22282-75-3 ]
3,4-dichloro-2-(pivaloylamino)benzeneboronic acid [ No CAS ]
2,3-Dichloro-6-(3-fluoro-pyridin-4-yl)-phenylamine [ No CAS ]
N-[2,3-Dichloro-6-(3-fluoro-pyridin-4-yl)-phenyl]-2,2-dimethyl-propionamide [ No CAS ]

Reference： [1]Synthetic Communications,1995,vol. 25,p. 2901 - 2908

15
[ 22282-75-3 ]
3-carboxy-4-methoxy-2-(pivaloylamino)phenylboronic acid [ No CAS ]
6-methoxy-2-pivaloylamino-3-(3-fluoro-4-pyridyl)phenylcarboxylic acid [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

16
[ 504-61-0 ]
[ 22282-75-3 ]
3-(but-2-enyloxy)-4-iodopyridine [ No CAS ]

Reference： [1]Heterocycles,1996,vol. 43,p. 1641 - 1652

17
[ 22282-75-3 ]
[ 107-18-6 ]
3-allyloxy-4-iodopyridine [ No CAS ]

Reference： [1]Heterocycles,1996,vol. 43,p. 1641 - 1652

18
[ 22282-75-3 ]
[ 513-42-8 ]
3-iodo-2-(2-methyl-allyloxy)pyridine [ No CAS ]

Reference： [1]Heterocycles,1996,vol. 43,p. 1641 - 1652

19
[ 22282-75-3 ]
piperidin-4-yl-[4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-methanone [ No CAS ]
1-(4-trifluoromethylphenylsulphonyl)-4-[1-(3-fluoro-pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2001,vol. 11,p. 2213 - 2216

20
N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-methane-sulfonamide [ No CAS ]
[ 22282-75-3 ]
9-Methylsulfonyl-β-carboline [ No CAS ]

Reference： [1]Organic Letters,2007,vol. 9,p. 4893 - 4896

21
[ 22282-75-3 ]
[ 106531-57-1 ]

Reference： [1]Heterocycles,1996,vol. 43,p. 1641 - 1652

22
[ 22282-75-3 ]
3,3-Dimethyl-2,3-dihydro-furo[2,3-c]pyridine [ No CAS ]

Reference： [1]Heterocycles,1996,vol. 43,p. 1641 - 1652

23
[ 22282-75-3 ]
3-Ethyl-furo[2,3-c]pyridine [ No CAS ]

Reference： [1]Heterocycles,1996,vol. 43,p. 1641 - 1652

24
[ 22282-75-3 ]
bauerine B [ No CAS ]

Reference： [1]Synthetic Communications,1995,vol. 25,p. 2901 - 2908

25
[ 22282-75-3 ]
[ 99896-91-0 ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

26
[ 22282-75-3 ]
[ 58982-28-8 ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175
[2]Tetrahedron Letters,1994,vol. 35,p. 2003 - 2004

27
[ 22282-75-3 ]
8-hydroxy-β-carboline [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

28
[ 22282-75-3 ]
5-hydroxy-β-carboline [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

29
[ 22282-75-3 ]
8-hydroxy-1-vinyl-β-carboline [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

30
[ 22282-75-3 ]
[ 170959-20-3 ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

31
[ 22282-75-3 ]
[ 170959-19-0 ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 1171 - 1175

32
[ 22282-75-3 ]
[ 67767-19-5 ]

Reference： [1]Tetrahedron Letters,1994,vol. 35,p. 2003 - 2004

33
[ 22282-75-3 ]
[ 155727-48-3 ]

Reference： [1]Tetrahedron Letters,1994,vol. 35,p. 2003 - 2004

34
[ 22282-75-3 ]
[ 245-08-9 ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838
[2]Tetrahedron,1993,vol. 49,p. 49 - 64

35
[ 22282-75-3 ]
[ 146141-10-8 ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 7832 - 7838
[2]Tetrahedron,1993,vol. 49,p. 49 - 64

36
[ 22282-75-3 ]
[ 155246-38-1 ]

Reference： [1]Tetrahedron Letters,1993,vol. 34,p. 7917 - 7918

37
[ 22282-75-3 ]
[ 155246-39-2 ]

Reference： [1]Tetrahedron Letters,1993,vol. 34,p. 7917 - 7918

38
[ 22282-75-3 ]
[ 157023-34-2 ]
4-[(3-fluoro-pyridin-4-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 56 4-[(3-Fluoro-pyridin-4-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester TFA salt A mixture of benzyl-4-(aminomethyl)piperidine-1-carboxylate (EXAMPLE 13, Step 1, 0.20 g, 0.81 mmol), 3-fluoro-4-iodo-pyridine (Tetrahedron, 49:49-64(1993) (0.18 g, 0.81 mmol) in IPA (0.1 mL) was heated at 100 C. in a sealed reaction tube for 100 h, then concentrated in vacuo. The residue was purified by reversed phase chromatography to give 4-[(3-fluoro-pyridin-4-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester as a TFA salt. M.S.(M+1):344.36.

Reference： [1]Patent: US2002/165241,2002,A1

39
[ 52409-22-0 ]
[ 22282-75-3 ]
[ 6163-58-2 ]
[ 203520-03-0 ]
[ 211820-04-1 ]

Yield	Reaction Conditions	Operation in experiment
	In 1,4-dioxane; dichloromethane;	To a suspension of <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (2.23 g), 1-(tert-butoxycarbonyl)-4-(piperidin-4-ylcarbonyl)piperazine (1.49 g) and sodium t-butoxide (1.06 g) in 1,4-dioxan (20 ml) was added tris(dibenzylidene acetone)dipalladium(0) (0.09 g) and tri-o-tolylphosphine (0.12 g) and the mixture heated at reflux for 3 hours. The mixture was diluted with diethyl ether and washed with saturated aqueous sodium chloride solution, dried (Na2SO4) and evaporated. The residue was purified by chromatography on alumina (N32-63) eluding with 0.4percent methanol in dichloromethane to give as a solid, 1-(tert-butoxycarbonyl)-4-[1-(3-fluoro-4-pyridyl)piperidin-4-ylcarbonyl]piperazine (0.70 g). 1H-NMR (CDCl3): 1.45 (s, 9H), 1.80 (m, 2H), 2.00 (m, 2H), 2.65 (m, 1H), 2.90 (m, 2H), 3.40 (m, 8H), 3.80 (m, 2H), 6.70 (dd, 1H), 8.10 (d, 1H) and 8.20 (d, 1H); m/z 393 (M+1).
	In 1,4-dioxane; dichloromethane;	To a suspension of <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (2.23 g), 1-(tert-butoxycarbonyl)-4-(piperidin-4-ylcarbonyl) piperazine (1.49 g) and sodium t-butoxide (1.06 g) in 1,4-dioxan (20 ml) was added tris(dibenzylidene acetone)dipalladium(0) (0.09 g) and tri-o-tolylphosphine (0.12 g) and the mixture heated at reflux for 3 hours. The mixture was diluted with diethyl ether and washed with saturated aqueous sodium chloride solution. dried (Na2SO4) and evaporated. The residue was purified by chromatography on alumina (N32-63) eluding with 0.4percent methanol in dichloromethane to give as a solid, 1-(tert-butoxycarbonyl)-4-[1-(3-fluoro-4-pyridyl)piperidin-4-ylcarbonyl]piperazine (0.70 g). 1H-NMR (CDCl3): 1.45 (s, 9H), 1.80 (m, 2H), 2.00 (m, 2H), 2.65 (m, 1H), 2.90 (m, 2H), 3.40 (m, 8H), 3.80 (m, 2H), 6.70 (dd, 1H), 8.10 (d, 1H) and 8.20 (d, 1H); m/z 393 (M+1).

Reference： [1]Patent: US6440972,2002,B1
[2]Patent: US6440972,2002,B1

40
[ 203520-35-8 ]
[ 22282-75-3 ]
[ 6163-58-2 ]
[ 211820-06-3 ]

Yield	Reaction Conditions	Operation in experiment
	tris-(dibenzylideneacetone)dipalladium(0); In 1,4-dioxane; methanol; dichloromethane;	Tris(dibenzylideneacetone)dipalladium(0) (0.184 g) and tri-o-tolylphosphine (0.244 g) were added to a suspension of <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (4.46 g), 1-[1-(t-butoxycarbonyl)piperazin-4-ylcarbonyl]piperazine (3.0 g) and sodium t-butoxide (2.12 g) in dry 1,4-dioxane (40 ml) under an atmosphere of argon. The mixture was heated at 100° C. for 18 hours. The mixture was cooled, diluted with diethyl ether (200 ml) and washed with saturated brine (40 ml). The aqueous layer was back-extracted with diethyl ether (2100 ml). The ether layers were all combined, washed with saturated brine (2100 ml), dried (Na2SO4) and evaporated. The residual oil was purified by chromatography on alumina (N32-63) using 0.1-0.4percent methanol in dichloromethane as eluent to give 1-(t-butoxycarbonyl)-4-[1-(3-fluoro-4-pyridyl)piperazin-4-ylcarbonyl]piperazine (1.7 g) as an orange solid: NMR (CDCl3): 1.47 (s, 9H), 3.25 (m, 8H), 3.45 (m, 8H), 6.75 (dd, 1H), 8.20 (dd, 2H); m/z 394 (M+1).

Reference： [1]Patent: US6440972,2002,B1

41
[ 22282-75-3 ]
[ 95-92-1 ]
[ 388612-88-2 ]

Yield	Reaction Conditions	Operation in experiment
		1 Ethyl (3-fluoro-2-iodopyridin-4-yl)oxoacetate n-Butyllithium (1.59M in hexane) (1.75 ml, 2.78 mmol) was added to a solution of diisopropylamine (390 mul, 2.78 mmol) in tetrahydrofuran (10 ml) at -78 C., and the mixture was warmed up to 0 C., then stirred for 30 minutes. The mixture was again cooled down to -78 C. A solution of <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (500 mg, 2.24 mmol) synthesised by the method of P. Rocca et. al. (Tetrahedron 49,49-64(1993)) in tetrahydrofuran (4 ml) was added to said mixture, and the resulting mixture was stirred for 1.5 hours. The reaction mixture was dropwise added to a solution of diethyl oxalate (900 mul, 6.63 mmol) in tetrahydrofuran (10 ml) at -78 C. under stirring. The mixture was warmed up to room temperature and stirred for 20 minutes. Aqueous ammonium chloride was added to the reaction mixture, and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate, 3:2) to give the title compound (659 mg).

Reference： [1]Patent: US2003/203907,2003,A1 .Location in patent: Page/Page column 54

42
[ 807618-13-9 ]
[ 22282-75-3 ]
[ 1104082-65-6 ]

Yield	Reaction Conditions	Operation in experiment
	(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In ISOPROPYLAMIDE; at 80℃;	Synthesis of Example 10: Intermediate 10a): [Show Image] A flame dried Schlenk flask was charged with <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (1.00 g), [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane (110 mg), copper(I) iodide (51 mg), and dry N,N-dimethylacetamide (6 ml). The resulting mixture was degassed with alternating vacuum/argon purges. Then 1-tert-butoxycarbonylpiperidin-4-yl)(iodo)zinc (6.28 mmol, prepared as described above) was added. The mixture was degassed once again and then heated to 80 °C overnight. The mainpart of N,N-dimethylacetamide was then evaporated and the remainder was taken up in a mixture of EtOAc and water (each with 100 ml). The mixture was then filtered through Celite and transferred into a separatory funnel. The phases were separated and the water layer was extracted with EtOAc (3 x 30 ml). The combined organic layer was washed with water and brine (each with 75 ml), dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by column chromatography to furnish the desired compound in form of a brownish solid.

Reference： [1]Patent: EP2019100,2009,A1 .Location in patent: Page/Page column 37

43
[ 10075-50-0 ]
[ 22282-75-3 ]
[ 1255145-25-5 ]

Yield	Reaction Conditions	Operation in experiment
46%	With copper(l) iodide; potassium carbonate; lithium chloride; In N,N-dimethyl-formamide; at 120℃; for 64h;Inert atmosphere;	Description 205-bromo-1-(3-fluoro-pyridin-4-yl)-1H-indole (D20)5-bromo-1H-indole [CA.S. 10075-50-0] (2 g, 10.202 mmol) was dissolved in DMF (16 ml). A nitrogen stream was bubbled through the mixture and then were added 3-Fluoro- 4-iodopyridine [CA.S. 22282-75-3] (2.502 g, 11.222 mmol), lithium chloride (0.432 g, 10.202 mmol), copper(I) iodide (0.0195 g, 0.102 mmol) and K2CO3 (4.23 g, 30.605 mmol). The reaction mixture was heated at 120 0C for 2 days. After cooling to room temperature, the reaction mixture was refilled with lithium chloride (0.100 g) and (copper(I) iodide (0.010) stirred at 1200C for 16 h. After cooling to room temperature, the reaction mixture was washed with NH3 (aqueous sat. solution) and extracted with DCM. The organic layer was separated, washed with water, dried (Na2SO4), and the solvent was evaporated in vacuo. The residue was purified by column chromatography (silica gel; eluent: Heptane/EtOAc up to 15percent as eluent). The desired fractions were collected and the solvent was evaporated in vacuo to yield intermediate compound D20 (1.37 g, 46 percent).

Reference： [1]Patent: WO2010/130422,2010,A1 .Location in patent: Page/Page column 60

44
C₁₁H₁₁FN₂ [ No CAS ]
[ 22282-75-3 ]
3-fluoro-4-(3-fluoro-3-(pyridin-2-ylethynyl)pyrrolidin-1-yl)pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
27.2%	With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0); In N,N-dimethyl-formamide; at 120℃; for 1h;Inert atmosphere;	To a solution of 1 (15mg, 0.079mmol), 2 (35mg, 0.158mmol) and Cs2CO3 (128mg, 0.395mmol) in DMF (lmL) were added 2 mg of Pd(dba)2 and 2 mg of Xantphos. The suspension was degassed under vacuum and purged with N2 several times. The mixture was stirred at 120 °C for 1h. LCMS showed the SM was consumed completely. Then the reaction mixture was diluted with EA (10mL) and washed with brine (2mL) twice. The organic solution was dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure and purified by p-TLC to give the desired compound Compound 217 (6mg, yield: 27.2percent). LCMS: m/z, 286.1 (M+H)+; 1HNMR (CDCl3, 400MHz): delta 8.62(d, J=4.8, 1H), 8.17(d, J=5.6, 1H), 8.08(d, J=5.2, 1H), 7.69~7.74(m, 1H), 7.52(d, J=8.0, 1H), 7.31~7.33(m, 1H), 6.47(dd, J1=5.6,J2=8.0, 1H), 4.03~4.15(m, 2H), 3.71~3.78(m, 2H), 2.58~2.74(m, 1H), 2.40~2.46(m, 1H).

Reference： [1]Patent: WO2014/124560,2014,A1 .Location in patent: Page/Page column 94; 95

45
[ 1160004-88-5 ]
[ 22282-75-3 ]
(3S,4S)-tert-butyl 3-azido-4-((3-(3-fluoropyridin-4-yl)prop-2-yn-1-yl)oxy)pyrrolidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15%		A mixture of Cul (20 mg, 0.10 mmol), Pd(PPh3)4(24 mg, 0.021 mmol) and 3-fluoro- 4-iodopyridine (469 mg, 2.10 mmol) in Et3N (28 ml) under nitrogen was stirred at r.t. for 60 min. Then, a solution of (3S,4S)-tert-butyl-3-azido-4-(prop-2- ynyloxy)pyrrolidine-1 -carboxylate (560 mg, 2.10 mmol) in Et3N (17 ml) was added and the mixture was heated at 60 °C overnight. After cooling to r.t., water was added and the mixture was extracted with EtOAc. The organic phase was washed with brine, dried over Na2S04, filtered and concentrated. Purification by flash chromatography, silica gel, gradient hexane to ethyl acetate, afforded the desired product (398 mg, 52percent) and the corresponding cyclic intermediate of general formula (V) (1 18 mg, 15percent yield).1H-NMR (400MHz, CDCI3): mixture of two rotamers, delta ppm: 8.50 (s, 1 H), 8.39 (d, J = 5 Hz, 1 H), 7.33 (t, J = 5 Hz, 1 H), 4.50 (m, 2H), 4.15 (m, 1 H), 4.10 (m, 1 H), 3.65 (m, 2H), 3.47 (m, 2H), 1.46 (s, 9H).

Reference： [1]Patent: WO2014/170494,2014,A1 .Location in patent: Page/Page column 34; 35

46
[ 1160004-88-5 ]
[ 22282-75-3 ]
(3S,4S)-tert-butyl 3-azido-4-((3-(3-fluoropyridin-4-yl)prop-2-yn-1-yl)oxy)pyrrolidine-1-carboxylate [ No CAS ]
C₁₇H₂₀FN₅O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15%; 15%		b) Synthesis of (3S,4S)-tert-butyl-3-azido-4-((3-(3-fluoropyridin-4-yl)prop-2-yn-1-yl)oxy)pyrrolidine-1-carboxylate A mixture of Cul (20 mg, 0.10 mmol), Pd(PPh3)4 (24 mg, 0.021 mmol) and <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (469 mg, 2.10 mmol) in Et3N (28 ml) under nitrogen was stirred at r.t. for 60 min. Then, a solution of (3S,4S)-tert-butyl-3-azido-4-(prop-2-ynyloxy)pyrrolidine-1-carboxylate (560 mg, 2.10 mmol) in Et3N (17 ml) was added and the mixture was heated at 60 ºC overnight. After cooling to r.t., water was added and the mixture was extracted with EtOAc. The organic phase was washed with brine, dried over Na2SO4, filtered and concentrated. Purification by flash chromatography, silica gel, gradient hexane to ethyl acetate, afforded the desired product (398 mg, 52percent) and the corresponding cyclic intermediate of general formula (V) (118 mg, 15percent yield). 1H-NMR (400MHz, CDCl3): mixture of two rotamers, delta ppm: 8.50 (s, 1 H), 8.39 (d, J = 5 Hz, 1 H), 7.33 (t, J = 5 Hz, 1 H), 4.50 (m, 2H), 4.15 (m, 1 H), 4.10 (m, 1 H), 3.65 (m, 2H), 3.47 (m, 2H), 1.46 (s, 9H).

Reference： [1]Patent: EP2792679,2014,A1 .Location in patent: Page/Page column 0092-0093

47
[ 22282-75-3 ]
[ 1692-15-5 ]
[ 1131-30-2 ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 2852 - 2855

48
[ 22282-75-3 ]
[ 1692-15-5 ]
3-fluoro-1,1'-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H,1'H-4,4'-bipyridinylidene [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 2852 - 2855

49
3-amino-5-chloropyrazine-2-thiol [ No CAS ]
[ 22282-75-3 ]
6-chloro-3-((3-fluoropyridin-4-yl)thio)pyrazin-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25 mg	With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105℃; for 10h;	00287] A mixture of 3-amino-5-chloropyrazine-2-thiol (50 mg, 0.181 mmol), 3-fluoro- 4-iodopyridine (121 mg, 0.544 mmol), Xantphos (10.5 mg, 0.018 mmol), Pd2(dba)3 (8.3 mg, 0.009 mmol), and DIPEA (95 muEpsilon, 0.544 mmol) in dioxane (degassed, 1.8 mL) was stirred for 10 h at 105 °C. After cooling to RT, the reaction was filtered through a pad of Celite followed by EtO Ac (25 mL) wash. The combined filtrates were concentrated under reduced pressure and the resulting residue was purified by silica chromatography (0 to 40percent gradient of EtO Ac/heptane (containing 2percent of Et3N)) to give 6-chloro-3-((3-fluoropyridin-4-yl)thio)pyrazin-2-amine (25 mg, 0.097 mmol). MS m/z 257.0 (M+H)+.

Reference： [1]Patent: WO2015/107494,2015,A1 .Location in patent: Paragraph 00287

50
[ 372-47-4 ]
[ 22282-75-3 ]
[ 146141-04-0 ]
3-Fluoro-2,4-diiodopyridine [ No CAS ]

Reference： [1]Tetrahedron,2016,vol. 72,p. 2196 - 2205

51
[ 372-47-4 ]
[ 22282-75-3 ]
3-Fluoro-2,4-diiodopyridine [ No CAS ]

Reference： [1]Tetrahedron,2016,vol. 72,p. 2196 - 2205

52
[ 372-47-4 ]
[ 22282-75-3 ]
[ 146141-04-0 ]

Reference： [1]Tetrahedron,2016,vol. 72,p. 2196 - 2205

53
3-amino-5-chloropyrazine-2-thiol trifluoroacetate [ No CAS ]
[ 22282-75-3 ]
6-chloro-3-((3-fluoropyridin-4-yl)thio)pyrazin-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25 mg	With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105℃; for 10h;	A mixture of 3-amino-5-chloropyrazine-2-thiol (50mg, 0.181 mmol), <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (121 mg, 0.544 mmol), Xantphos (10.5 mg, 0.018 mmol), Pd2(dba)3 (8.3 mg, 0.009 mmol), and DIPEA (95 IL, 0.544 mmol) in dioxane (degassed, 1.8 mE) was stirred for 10 hat 105° C. Afier cooling to RT, the reaction was filtered through a pad of Celite followed by EtOAc (25 mE) wash. The combined filtrates were concentrated under reduced pressure and the resulting residue was purified by silica chromatography (0 to 40percent gradient of EtOAc/heptane (containing 2percent of Et3N)) to give 6-chloro-3-((3-fluoropyridin-4-yl)thio)pyrazin-2- amine (25 mg, 0.097 mmol). MS mlz 257.0 (M+H).

Reference： [1]Patent: US2017/1975,2017,A1 .Location in patent: Paragraph 0320; 0321

54
[ 64185-12-2 ]
[ 22282-75-3 ]
3-fluoro-4-(3,3,3-trifluoroprop-1-yn-1-yl)pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
31%	With tetrakis(triphenylphosphine) palladium(0); sodium; In toluene; at 130℃; for 5h;	Preparation 1A 3-fluoro-4-(3,3,3-trifluoroprop-1-yn-1-yl)pyridine A mixture of <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (1 g, 4.48 mmol), 1-tributylstannyl-3,3,3-trifluoro-1-propyne (2.3 g, 5.38 mmol, 90percent) and Pd(PPh3)4 (259 mg, 0.045 mmol) in toluene (15 mL) was heated for 5 hr at 130° C. under Na in a microwave oven. The mixture was concentrated and purified by flash column chromatography on silica gel (EtOAc/Hex=0percent-20percent) to afford the title compound (260 mg, 31percent). [M+H] calculated for C8H3F4N: 190; found: 190.

Reference： [1]Patent: US2017/298044,2017,A1 .Location in patent: Paragraph 0146; 0147; 0175; 0176

55
[ 22282-75-3 ]
3-fluoro-4-{1-[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl}pyridine [ No CAS ]
3-fluoro-4-{1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-1H-1,2,3-triazol-5-yl}pyridine [ No CAS ]

Reference： [1]Patent: US2017/298044,2017,A1

56
[ 22282-75-3 ]
3-fluoro-4-[5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]pyridine [ No CAS ]

Reference： [1]Patent: US2017/298044,2017,A1

57
[ 22282-75-3 ]
N-(5-chloro-2-fluorophenyl)-4-[5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]pyridin-3-amine [ No CAS ]

Reference： [1]Patent: US2017/298044,2017,A1

58
N-(1-methylpiperidin-4-yl)-N-(1H-pyrazol-3-yl)thiophene-2-carboxamide [ No CAS ]
[ 22282-75-3 ]
N-[1-(3-fluoropyridin-4-yl)-1H-pyrazol-3-yl]-N-(1-methylpiperidin-4-yl)thiophene-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; trans-1,2-Diaminocyclohexane; caesium carbonate; In acetonitrile; for 6h;Reflux;	General procedure: Arylation conditions A: N,N,N',N'-Tetramethylethane-1,2-diamine (21 muL, 0.14 mmol) was added to a suspension of N-(1-methylpiperidin-4-yl)-N-(1H-pyrazol-3- yl)thiophene-2-carboxamide (Intermediate C1, 100 mg, 0.34 mmol), 2-iodopyridine (44 muL, 0.41 mmol) and Cs2CO3 (235 mg, 0.72 mmol) in MeCN (8 mL). The reaction mixture was deoxygenated, CuI (13 mg, 0.07 mmol) was added and it was heated under reflux for 6 h. It was cooled down to room temperature, poured into NaHCO3 (saturated aqueous solution, 10 mL) and extracted with CH2Cl2. The combined organic layers were dried over Na2SO4 (anhydrous), filtered and concentrated. The crude residue was purified by flash chromatography on SiO2 (CH2Cl2/MeOH/NH4OH 97:3:1), to afford 118 mg of title compound (beige solid, 93percent yield). HPLC-MS (Method G): Ret, 14.94 min; ESI+-MS m/z, 368 (M+1). Arylation conditions B: (±)-trans-1,2-diaminocyclohexane was used instead of N,N,N',N'-tetramethylethane-1,2-diamine

Reference： [1]Patent: WO2017/178510,2017,A1 .Location in patent: Page/Page column 265; 266

59
C₁₈H₁₅N₃O₂ [ No CAS ]
[ 22282-75-3 ]
5-(3-fluoropyridin-4-yl)-4-methyl-N,6-diphenylpyrimidin-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	With triphenylphosphine; silver carbonate; palladium dichloride; In N,N-dimethyl acetamide; at 155 - 160℃; for 16h;Inert atmosphere; Molecular sieve;	General procedure: A ame-dried tube lled with argon was charge with 2-aminopyrimidine-5-carboxylic acid 2 (0.13 mmol), PdCl2 (5 molpercent), PPh3 (10 mol percent), Ag2CO3 (0.39 mmol), ArI (0.26 mmol) and 4 Amolecular sieves (100 mg) in DMA (2 mL). The resulting mixturewas stirred at 155e160C for 16 h. After cooling to room temper-ature, the mixture was ltered through Celite pad and washed withEtOAc (25 mL). The ltrate was washed with water (5 mL x 2) andbrine (5 mL), dried over anhydrous MgSO4, ltered, and concen-trated under reduced pressure. The crude product was puried bysilica gel column chromatography (n-hexane/EtOAc 10:1 v/v) toafford the corresponding product.

Reference： [1]Tetrahedron,2018,vol. 74,p. 3843 - 3851

60
[ 4187-86-4 ]
[ 22282-75-3 ]
1-(thiopheno[2,3-c]pyridin-2-yl)propan-1-one [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2018,vol. 83,p. 8768 - 8774

61
[ 4187-86-4 ]
[ 22282-75-3 ]
1-(3-fluoro-4-pyridyl)pent-1-yn-3-ol [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2018,vol. 83,p. 8768 - 8774

62
[ 7383-19-9 ]
[ 22282-75-3 ]
1-(thiopheno[2,3-c]pyridin-2-yl)pentan-1-one [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2018,vol. 83,p. 8768 - 8774

63
[ 7383-19-9 ]
[ 22282-75-3 ]
1-(3-fluoro-4-pyridyl)hept-1-yn-3-ol [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2018,vol. 83,p. 8768 - 8774

64
[ 1820-80-0 ]
[ 22282-75-3 ]
1-(3-fluoropyridin-4-yl)-1H-pyrazol-3-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	With caesium carbonate; copper(I) bromide; In 1-methyl-pyrrolidin-2-one; at 120℃; for 18h;Inert atmosphere; Sealed tube;	[289] 1H-pyrazol-3-amine (500 mg, 6.02 mmol), <strong>[22282-75-3]3-fluoro-4-iodo-pyridine</strong> (1.5 g, 6.73 mmol), copper (I) bromide (100 mg, 0.70 mmol), and cesium carbonate (3.0 g, 9.21 mmol) were combined and suspended in NMP (7.0 mL). The resultant mixture was heated in a sealed vessel at 120°C under an atmosphere of nitrogen for 18 h. The reaction mixture was partitioned into 1:1 ethyl acetate/water. The layers were separated, and the aqueous further extracted with ethyl acetate (2 x 20 mL). The combined organics were dried (Na2SO4), filtered, and concentrated. The crude residue was purified by reverse phase chromatography (ISCO C18 Aq 150g column; linear gradient of 10- 50percent acetonitrile in water with TFA modifier). Pure fractions were washed with saturated sodium bicarbonate and extracted with dichloromethane. The combined organic extracts were dried (Na2SO4), filtered, and concentrated to provide a yellow solid. The solid was further purified by trituration with warm ethyl acetate/heptane to provide 1-(3-fluoropyridin-4-yl)-1H-pyrazol-3-amine (431 mg; 48percent yield) as a yellow powder. 1H NMR (300 MHz, DMSO-d6) delta 8.70 (d, J = 5.1Hz, 1H), 8.42 (d, J = 5.6 Hz, 1H), 8.07 (t, J = 2.5 Hz, 1H), 7.82 (dd, J = 7.5, 5.6 Hz, 1H), 6.00 (d, J = 2.8 Hz, 1H), 5.44 (s, 2H) ppm. ESI-MS m/z calc. 178.07, found 179.00 (M+1).

Reference： [1]Patent: WO2018/107056,2018,A1 .Location in patent: Paragraph 289

65
[ 22282-75-3 ]
N-(1-(3-fluoropyridin-4-yl)-1H-pyrazol-3-yl)-1-phenylcyclopropane-1-carboxamide [ No CAS ]

Reference： [1]Patent: WO2018/107056,2018,A1

66
[ 110-85-0 ]
[ 22282-75-3 ]
1-(3-fluoropyridin-4-yl)piperazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 80℃; for 16h;	To a stirred solution of 3-fluoro-4- iodopyridine (2, 2 g, 4.48 mmol, 1 eq) in NMP (20 mL), DIPEA (0.694 g, 5.38 mmol, 1.2 eq) and piperazine (1, 0.484 g, 6.72 mmol, 1.5 eq) were added at RT. The resulting mixture was stirred at 80°C for 16h. After the completion, the reaction mixture was concentrated under reduced pressure. The residue was taken in water and lyophilized. The gummy solid obtained was triturated with diethyl ether and n-pentane to afford l-(3-fluoropyridin-4- yl)piperazine, 3 (0.750 g, 92percent>) as light yellow colour solid. LCMS (ESI positive ion) m z: calculated: 181.21; Observed; 182.2 (M+1).

Reference： [1]Patent: WO2018/178338,2018,A1 .Location in patent: Page/Page column 89

67
[ 22282-75-3 ]
5-amino-3-(2-(4-(3-fluoropyridin-4-yl)piperazin-1-yl)ethyl)-8-(furan-2-yl)thiazolo[5,4-e][1,2,4]triazolo[1,5-c]pyrimidin-2(3H)-one [ No CAS ]

Reference： [1]Patent: WO2018/178338,2018,A1

68
[ 22282-75-3 ]
[ 1066-54-2 ]
3-fluoro-4-((trimethylsilyl)ethynyl)pyridine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 9756 - 9783

69
[ 22282-75-3 ]
C₂₀H₁₄F₄N₆O₂ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 9756 - 9783

70
[ 22282-75-3 ]
C₁₈H₉F₇N₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 9756 - 9783

71
[ 22282-75-3 ]
4-ethynyl-3-fluoropyridine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 9756 - 9783

72
[ 104987-11-3 ]
[ 22282-75-3 ]
C₄₉H₇₁FN₂O₁₂ [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2019,vol. 10,p. 1279 - 1283

73
[ 67-56-1 ]
[ 22282-75-3 ]
[ 1331850-50-0 ]

Yield	Reaction Conditions	Operation in experiment
54 %Spectr.	With 18-crown-6 ether; potassium <i>tert</i>-butylate In tetrahydrofuran at 25℃; for 20h; Inert atmosphere; regioselective reaction;

Reference： [1]Puleo, Thomas R.; Klaus, Danielle R.; Bandar, Jeffrey S. [Journal of the American Chemical Society, 2021, vol. 143, # 32, p. 12480 - 12486]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
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P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
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P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
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P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
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P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
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P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
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P353	Rinse skin with water/shower.
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P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
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P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
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P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 22282-75-3 ] {[proInfo.proName]}

Quality Control of [ 22282-75-3 ]

Related Doc. of [ 22282-75-3 ]

Product Details of [ 22282-75-3 ]

Calculated chemistry of [ 22282-75-3 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 22282-75-3 ]

Application In Synthesis of [ 22282-75-3 ]

[ 22282-75-3 ] Synthesis Path-Upstream 1~7

[ 22282-75-3 ] Synthesis Path-Downstream 1~73

Related Functional Groups of [ 22282-75-3 ]

Fluorinated Building Blocks

Related Parent Nucleus of [ 22282-75-3 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 22282-75-3 ]

Related Parent Nucleus of
[ 22282-75-3 ]