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Chemical Structure| 2236-11-5 Chemical Structure| 2236-11-5

Structure of 2236-11-5

Chemical Structure| 2236-11-5

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Product Details of [ 2236-11-5 ]

CAS No. :2236-11-5
Formula : C8H14O3
M.W : 158.20
SMILES Code : COC(=O)C1CCCCC1O
MDL No. :MFCD00001459

Safety of [ 2236-11-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H318-H335
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 2236-11-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2236-11-5 ]

[ 2236-11-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2236-11-5 ]
  • [ 2840-29-1 ]
  • [ 1446262-49-2 ]
YieldReaction ConditionsOperation in experiment
2.2 g methyl 2-hydroxycyclohexane-1-carboxylate(1.70 g, 10 mmol),3-Amino-4-bromobenzoic acid (2.16 g, 10 mmol),A mixture of polyphosphoric acid (15 g) and dioxane (12 mL) was heated to 130 and stirred for 5 hours. Cool to room temperature, dilute the mixture with water,Sodium acetate trihydrate (27 g) was slowly added to a pH of about 3.Precipitation filtration, filter cake drying. The dried cake was suspended in methanol (80 mL)Dichloromethane (16 mL) was added dropwise with cooling at 0-15 C,The mixture was heated to reflux for 5 hours. Cool to room temperature,The solvent was removed by rotary evaporation, water (100 mL) was added and extracted three times with ethyl acetate (100 mL). The organic phases were combined and concentrated to give the crude product.The crude product was purified by silica gel column (eluent:Dichloromethane and methanol) to give methyl 4-bromo-9-oxo-5,6,7,8,9,10-hexahydroacridine-1-carboxylate (2.20 g).
 

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