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Chemical Structure| 2244-59-9 Chemical Structure| 2244-59-9

Structure of 2244-59-9

Chemical Structure| 2244-59-9

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Product Details of [ 2244-59-9 ]

CAS No. :2244-59-9
Formula : C13H10ClNO
M.W : 231.68
SMILES Code : ClC1=CC=C2OC3=CC=CC=C3CNC2=C1

Safety of [ 2244-59-9 ]

Application In Synthesis of [ 2244-59-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2244-59-9 ]

[ 2244-59-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 78502-71-3 ]
  • [ 2244-59-9 ]
  • [ 149518-61-6 ]
  • 2
  • [ 168173-56-6 ]
  • ammonium chloride [ No CAS ]
  • [ 2244-59-9 ]
  • 10-[(2-bromo-5-pyridinyl)methyl]-8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With n-butyllithium; In tetrahydrofuran; hexane; ethyl acetate; To a stirred solution of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine (2 g) in THF (25 mL) at -78 C. was added 1.6 M hexane solution of n-butyl lithium (5.4 mL). After 25 minutes, <strong>[168173-56-6]3-chloromethyl-6-bromopyridine</strong> (1.79 g) in THF (5 mL) was added. After 30 minutes, the temperature was raised to -23 C. After 30 minutes, an excess saturated solution of NH4 Cl was added and the mixture was extracted with ether. The organic extract was dried over MgSO4 and concentrated. The residue was chromatographed over silica gel using 10% ethyl acetate in hexane as eluant. Appropriate fractions were pooled to give the title compound (2.8 g) as a thick gum.
 

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