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Chemical Structure| 2268-17-9 Chemical Structure| 2268-17-9

Structure of 2268-17-9

Chemical Structure| 2268-17-9

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Product Details of [ 2268-17-9 ]

CAS No. :2268-17-9
Formula : C6H3F3O
M.W : 148.08
SMILES Code : OC1=C(F)C=C(F)C=C1F
MDL No. :MFCD00061216
InChI Key :QQFWMPUXPLBWTG-UHFFFAOYSA-N
Pubchem ID :519974

Safety of [ 2268-17-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 2268-17-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2268-17-9 ]

[ 2268-17-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 57641-66-4 ]
  • [ 2268-17-9 ]
  • [ 1392288-08-2 ]
  • 2
  • [ 182482-25-3 ]
  • [ 2268-17-9 ]
YieldReaction ConditionsOperation in experiment
72% With dihydrogen peroxide; In dichloromethane; water; at 20 - 25℃; for 20h;Inert atmosphere; (2)Under the protection of nitrogen, 150.0 g of the compound II product was added to the 3 L reaction flask.400.0 mL of water and 1.1 L of dichloromethane (DCM) were stirred and cooled to 20 C.To the reaction flask, 600.0 g of 30% hydrogen peroxide was slowly added dropwise, and the dropping temperature was less than 20 C.After the addition was completed, the reaction was incubated at 25 C for 20 hours, and after sampling and HPLC analysis,A crude 2,4,6-trifluorophenol product system;(3)The crude 2,4,6-trifluorophenol product system was allowed to stand for stratification, and the lower organic layer was separated.The upper aqueous phase was extracted once with 300 mL of dichloromethane (DCM) and discarded. Combine the organic phase,The organic layer was washed once with 1 L of a 12% sodium sulfite solution.The organic phase was washed once with 800 ml of half saturated saline.The organic phase was dried over anhydrous sodium sulfate. Filter by suction, rinse with dichloromethane (DCM).Concentrate under reduced pressure at 35 C in a water bath until no flow. Add 160.0 mL of n-heptane to the system.The mixture was further concentrated under reduced pressure at 35 C in a water bath to a residue of 250 g.The concentrated residue is heated to 45-55 C, and then slowly cooled to -5.0 C to stir and crystallize.The crystals were washed with n-heptane which had been pre-cooled to -5.0 C and dried to give 90.8 g of compound III.That is 2,4,6-trifluorophenol product. The yield was 72%.
 

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