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Chemical Structure| 234108-42-0 Chemical Structure| 234108-42-0

Structure of 234108-42-0

Chemical Structure| 234108-42-0

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Product Details of [ 234108-42-0 ]

CAS No. :234108-42-0
Formula : C15H16N2O3
M.W : 272.30
SMILES Code : O=C(N1CC(N(CC#C)CC1)=O)OCC2=CC=CC=C2
MDL No. :MFCD12911962

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Application In Synthesis of [ 234108-42-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 234108-42-0 ]

[ 234108-42-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 211029-67-3 ]
  • [ 234108-42-0 ]
  • 4-[3-(4-<i>tert</i>-butoxycarbonylamino-pyridin-3-yl)-prop-2-ynyl]-3-oxo-piperazine-1-carboxylic acid benzyl ester [ No CAS ]
  • 2
  • [ 211029-67-3 ]
  • [ 234108-42-0 ]
  • [ 234108-43-1 ]
YieldReaction ConditionsOperation in experiment
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In DMF (N,N-dimethyl-formamide); at 50 - 100℃; for 2h; D. 2-(4-Benzyloxycarbonyl-2-oxopiperazin-1-ylmethyl)pyrrolo[3,2-c]pyridin-1-carboxylic acid tert-butyl ester. Pd(PPh3)2Cl2 (0.29 g, 0.41 mmol), CuI (0.05 g, 0.25 mmol) and triethylamine (4.6 ML, 3.29 mmol) is added to a solution of 3-oxo-4-prop-2-ynylpiperazine-1-carboxylic acid benzyl ester (2.24 g, 8.23 mmol) and (3-iodopyridin-4-yl)-carbamic acid tert-butyl ester (2.63 g, 8.23 mmol) in DMF (30 ML) at room temperature.The mixture is heated to 100 C. and stirred for 1.5 hours.The reaction mixture is then cooled to 50 C. and DBU (2.5 ML, 16.5 mmol) is added.After 30 minutes the solution is cooled to room temperature, diluted with ethyl acetate and washed with saturated ammonium chloride, water and brine.The organic layer is dried over MgSO4, filtered and concentrated in vacuo.The resulting solid is purified by column chromatography eluding with a gradient of 2% MeOH/CH2Cl2to 5% MeOH/CH2Cl2to give the product (2.93 g, 6.31 mmol) as a white solid. 1H NMR (CDCl3, 300 MHz) delta8.75 (s, 1H), 8.4 (d, 1H), 7.85 (d, 1H), 7.35 (m, 5H), 6.38 (s, 1H), 5.2 (s, 2H), 5.00 (s, 2H), 4.29 (s, 2H), 3.85 (m, 2H), 3.52 (m, 2H), 1.7 (s, 9H).Ion spray MS, [M+H]+=465.
 

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