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[ CAS No. 23932-84-5 ]

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2D
Chemical Structure| 23932-84-5
Chemical Structure| 23932-84-5
Structure of 23932-84-5 *Storage: {[proInfo.prStorage]}

Quality Control of [ 23932-84-5 ]

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Related Doc. of [ 23932-84-5 ]

SDS

Product Details of [ 23932-84-5 ]

CAS No. :23932-84-5MDL No. :MFCD11053086
Formula : C8H5FO2 Boiling Point : 306.6±42.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :152.12Pubchem ID :11171082
Synonyms :

Computed Properties of [ 23932-84-5 ]

TPSA : 26.3 H-Bond Acceptor Count : 3
XLogP3 : - H-Bond Donor Count : 0
SP3 : 0.13 Rotatable Bond Count : 0

Safety of [ 23932-84-5 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 23932-84-5 ]

  • Upstream synthesis route of [ 23932-84-5 ]
  • Downstream synthetic route of [ 23932-84-5 ]

[ 23932-84-5 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 138786-65-9 ]
  • [ 23932-84-5 ]
YieldReaction ConditionsOperation in experiment
92% With calcium carbonate In 1,4-dioxane; water for 2.50 h; Reflux Example 15; 4-(3-(6-Fluoro-1-oxoisoindolin-2-yl)-2-methylphenyl)-7-(2-methoxyethoxy)-9H- pyrido[3,4-b]indole- 1-carboxamide; 1. 6-Fluoroisobenzofuran- 1 (3H)-one; A mixture of methyl 2-(bromomethyl)-5-fluorobenzoate (0.750 g, 3.04 mmol) and calcium carbonate (1.823 g, 18.21 mmol) in 1,4-dioxane (30 mL) and water (30.0 mL) was heated at reflux for 2.5 hr. The insoluble material was removed by filtration. The filtrate was concentrated under vacuum and then extracted with CH2CI2 (4 x 30 mL). The combined extract was dried over anhydrous MgSC . Removal of solvent under vacuum provided the desired product (0.423 g, 2.78 mmol, 92percent yield) as a white solid.
Reference: [1] Patent: WO2011/159857, 2011, A1. Location in patent: Page/Page column 90-91
  • 2
  • [ 124-38-9 ]
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Reference: [1] Green Chemistry, 2017, vol. 19, # 11, p. 2501 - 2505
  • 3
  • [ 57319-65-0 ]
  • [ 23932-84-5 ]
Reference: [1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 5, p. 1941 - 1946
  • 4
  • [ 57584-70-0 ]
  • [ 23932-84-5 ]
Reference: [1] Journal of the American Chemical Society, 2014, vol. 136, # 23, p. 8350 - 8360
  • 5
  • [ 229027-89-8 ]
  • [ 23932-84-5 ]
Reference: [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 9, p. 3997 - 4015
  • 6
  • [ 59142-68-6 ]
  • [ 23932-84-5 ]
Reference: [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 9, p. 3997 - 4015
  • 7
  • [ 459-56-3 ]
  • [ 23932-84-5 ]
Reference: [1] Green Chemistry, 2017, vol. 19, # 11, p. 2501 - 2505
  • 8
  • [ 62558-08-1 ]
  • [ 23932-84-5 ]
  • [ 700-85-6 ]
Reference: [1] ChemCatChem, 2014, vol. 6, # 1, p. 109 - 112
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