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Chemical Structure| 2394-87-8 Chemical Structure| 2394-87-8

Structure of 2394-87-8

Chemical Structure| 2394-87-8

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Product Details of [ 2394-87-8 ]

CAS No. :2394-87-8
Formula : C10H5Cl2F3N4
M.W : 309.08
SMILES Code : FC(C1=CC(NC2=NC(Cl)=NC(Cl)=N2)=CC=C1)(F)F
MDL No. :MFCD00115402

Safety of [ 2394-87-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 2394-87-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2394-87-8 ]

[ 2394-87-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1597-32-6 ]
  • [ 2394-87-8 ]
  • C15H9ClF4N6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% 4,6-Dichloro-N-(3-(trifluoromethyl)phenyl)-[1,3,5]triazine-2-amine (400mg, 1.3mmol)Dissolve in 10mL tetrahydrofuran,Add DIPEA (170mg, 1.3mmol),Stir for 2min,Slowly add <strong>[1597-32-6]2-amino-6-fluoropyridine</strong> (150mg, 1.3 mmol) dropwiseIn tetrahydrofuran (4mL),React overnight at room temperature, add 100mL water to dilute after concentration,Extract with ethyl acetate (50 mL×3), dry with anhydrous magnesium sulfate,Purified by column chromatography to obtain 320mg of the target product,The yield was 65%.
  • 2
  • [ 33322-60-0 ]
  • [ 2394-87-8 ]
  • 3-((4-((2-hydroxy-2-methylpropyl)amino)-6-((3-(trifluoromethyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)-N,N-dimethylbenzamide [ No CAS ]
  • 3
  • [ 33322-60-0 ]
  • [ 2394-87-8 ]
  • 3-((4-chloro-6-((3-(trifluoromethyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)-N,N-dimethylbenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% 4,6-Dichloro-N-(3-(trifluoromethyl)phenyl)-[1,3,5]triazine-2-amine (500mg, 1.6mmol)Dissolve in 10mL tetrahydrofuran,Add DIPEA (210mg, 1.6mmol),Stir for 2min,Slowly add <strong>[33322-60-0]3-amino-N,N-dimethylbenzamide</strong> (270mg, 1.6mmol) dropwiseIn tetrahydrofuran (4mL),React at room temperature for 6h,After concentration, add 100mL water to dilute,Extract with ethyl acetate (50mL×3), dry with anhydrous magnesium sulfate,Purified by column chromatography to obtain 530 mg of the target product,The yield was 75%.
 

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