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Chemical Structure| 243666-11-7 Chemical Structure| 243666-11-7

Structure of 243666-11-7

Chemical Structure| 243666-11-7

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Product Details of [ 243666-11-7 ]

CAS No. :243666-11-7
Formula : C10H7F3N2
M.W : 212.17
SMILES Code : NC1=CC=NC2=C1C=CC(=C2)C(F)(F)F
MDL No. :MFCD00269411
InChI Key :QZOOIAOULGJTJI-UHFFFAOYSA-N
Pubchem ID :2735960

Safety of [ 243666-11-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H319
Precautionary Statements:P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 243666-11-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 243666-11-7 ]

[ 243666-11-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 16883-16-2 ]
  • [ 243666-11-7 ]
  • 5-methyl-3-phenyl-N-(7-trifluoromethyl-4-quinolinyl)-4-isoxazolecarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; In dichloromethane; at 70℃; 5-METHYL-3-PHENYLISOXAZOLE-4-CARBONYL chloride (100 mg) and 4-amino-7- TRIFLUOROMETHYLQUINOLINE (250 mg) were dissolved in dichlorormethane (5 mL) and pyridine (0.3 mL). The reaction solution was heated at 70 C overnight and then diluted with ethyl acetate (60 mL). The organic solution was washed with water (60 mL), dried, evaporated and purified by flash column chromatography (EtOAc/hexanes = 1/6) to give 5-methyl-3-phenyl- N- (7-TRIFLUOROMETHYL-4-QUINOLINYL)-4-ISOXAZOLECARBOXAMIDE (100 mg) as a white solid. IH NMR (CD3) : 8 2.91 (s, 3H), 7.33-7. 69 (m, 9H), 8.39 (s, 1H, NH), 8.99 (d, J= 5. 1 Hz, 1H) ; 19F NMR (282 MHz, CDC13) : 8-63. 26; LCMS: ret. time: 34.04 min.; purity: 98.90% ; MS (M/E) : 398.77 (MH+).
 

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