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Chemical Structure| 244081-70-7 Chemical Structure| 244081-70-7

Structure of 244081-70-7

Chemical Structure| 244081-70-7

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Product Details of [ 244081-70-7 ]

CAS No. :244081-70-7
Formula : C12H7ClFN3
M.W : 247.66
SMILES Code : FC1=CC=C(C2=CN3N=C(Cl)C=CC3=N2)C=C1
MDL No. :MFCD00828906

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Application In Synthesis of [ 244081-70-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 244081-70-7 ]

[ 244081-70-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 625-51-4 ]
  • [ 244081-70-7 ]
  • [ 951310-44-4 ]
YieldReaction ConditionsOperation in experiment
50% With sulfuric acid; acetic acid; for 6h;Heating / reflux; Example I: General method for the preparation of acetamides (VIII) [Show Image] To a solution of (VI) (1 eq) in acetic acid was added a solution of (VII) (1 eq) in acetic acid. To this mixture was added dropwise a solution of 2.5 eq of H2SO4. The mixture was stirred at reflux for 6 h. The solvent was removed in vacuo and the residue was extracted with dichloromethane / NaOH 1 N and with dichloromethane / water. The organic layer was dried over Na2SO4 and filtered off, and the solvent was removed in vacuo, thus affording the acetamide (VIII). [Show Image] 1H NMR (400 MHz, DMSO-d6): delta 7.99-6.98 (m, 6H, Ar), 4.45 (s, 2H, CH2), 2.09 (s, 3H, CH3). MS (ES) m/z = 319 (MH+) HPLC = 85% Yield = 50%
 

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