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Chemical Structure| 24484-55-7 Chemical Structure| 24484-55-7

Structure of 24484-55-7

Chemical Structure| 24484-55-7

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Product Details of [ 24484-55-7 ]

CAS No. :24484-55-7
Formula : C9H10BrF
M.W : 217.08
SMILES Code : FC1=CC=C(CCCBr)C=C1
MDL No. :MFCD09744418
InChI Key :SCVWLBZEYMAAHN-UHFFFAOYSA-N
Pubchem ID :14737133

Safety of [ 24484-55-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 24484-55-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24484-55-7 ]

[ 24484-55-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24484-55-7 ]
  • [ 6638-05-7 ]
  • [ 1138338-45-0 ]
YieldReaction ConditionsOperation in experiment
91% 3,5-Dimethoxy-4-hydroxy-toluene (1.0 g, 5.95 mmol) and 1-(3-bromopropyl)-4- fluorobenzene (1.5 g, 6.15 mmol) were reacted as described under General Procedure A and the crude product was purified by flash chromatography (silica- gel, hexane/Et2O 19:1) to afford the title compound (1.64 g, 91percent) as a colourless oil. 1H NMR (300 MHz, CDCI3) delta 7.31-7.19 (m, 6H), 4.06 (t, J = 6.4 Hz, 2H), 3.95 (s, 3H), 3.90 (S, 3H), 2.81 (t, J = 7.7 Hz, 2H), 2.46 (s, 3H), 2.10-2.05 (m, 2H). ; General Procedure A: Alkylation of 1,3-dimethoxyphenolsNaH (60percent dispersion in oil, 1.2 eq.) was added to a stirred solution of 3,5- dimethoxy-4-hydroxytoluene (1.0 eq.) in dry DMF (1.0 M) at room temperature.After the reaction mixture was stirred for 0.25 h, a solution of the bromoalkane(1.03 eq.) in dry DMF (5.0 M) was added, followed by stirring at room temperature overnight. The mixture was quenched with NH4CI(aq) (sat.), extracted with EtOAc and washed with water. The organic layer was separated and dried over MgSO4 and concentrated under vacuum. The crude product was purified by flash chromatography.
 

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