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Chemical Structure| 24568-11-4 Chemical Structure| 24568-11-4

Structure of 24568-11-4

Chemical Structure| 24568-11-4

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Product Details of [ 24568-11-4 ]

CAS No. :24568-11-4
Formula : C8H5BrF3NO
M.W : 268.03
SMILES Code : O=C(NC1=CC=C(Br)C=C1)C(F)(F)F
MDL No. :MFCD00547382

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Application In Synthesis of [ 24568-11-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24568-11-4 ]

[ 24568-11-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24568-11-4 ]
  • [ 101166-65-8 ]
  • [ 338452-58-7 ]
YieldReaction ConditionsOperation in experiment
N-(4-Bromo-phenyl)-2,2,2-trifluoro-acetamide (1.12 g, 4.18 mmol) are [sic] initially introduced into 8.5 ml abs. dimethylformamide, and 1.2 g powdered molecular sieve 4 A are added. The mixture is stirred for 15 min, 612 mg (5.45 mmol) KOtBu are added and, after a further 5 min, 1.44 g (5.02 mmol) tert-butyl-(2-iodo-ethoxy)-dimethyl-silane are added. The mixture is allowed to react for 36 hours at 70° C. and is cooled. Filtration, extraction with ethyl acetate, washing with water, drying over MgSO4, evaporation under reduced pressure, followed by flash chromatography with SiO2 (n-hexane/ethyl acetate 9/1) gives 887 mg of the title compound as a colourless oil. [01096] MS (EI): 410.412 (M-CH3)+
 

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