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Chemical Structure| 25007-54-9 Chemical Structure| 25007-54-9

Structure of 25007-54-9

Chemical Structure| 25007-54-9

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Product Details of [ 25007-54-9 ]

CAS No. :25007-54-9
Formula : C6H8O5
M.W : 160.12
SMILES Code : O=C(OC)C(CC(OC)=O)=O
MDL No. :MFCD11976874
InChI Key :ZOKLUHBZBGHBAB-UHFFFAOYSA-N
Pubchem ID :230407

Safety of [ 25007-54-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 25007-54-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25007-54-9 ]

[ 25007-54-9 ] Synthesis Path-Downstream   1~55

  • 3
  • [ 25007-54-9 ]
  • [ 5957-03-9 ]
  • 3,3'-dioxo-2,2'-biphenyl-4,4'-diyldihydrazono-di-succinic acid tetramethyl ester [ No CAS ]
  • 4
  • [ 25007-54-9 ]
  • [ 100-34-5 ]
  • oxo-phenylhydrazono-succinic acid dimethyl ester [ No CAS ]
  • 5
  • [ 25007-54-9 ]
  • [ 538-51-2 ]
  • [ 93729-64-7 ]
  • 6
  • (Z)-2-{2-[(Z)-(Z)-1,2-Bis-methoxycarbonyl-vinylimino]-3-ethoxycarbonyl-tetrahydro-furan-3-yl}-but-2-enedioic acid dimethyl ester [ No CAS ]
  • [ 25007-54-9 ]
  • 7
  • [ 58196-33-1 ]
  • [ 25007-54-9 ]
  • [ 138196-53-9 ]
  • 8
  • [ 19983-85-8 ]
  • [ 25007-54-9 ]
  • [ 102913-11-1 ]
  • 10
  • [ 25007-54-9 ]
  • [ 76953-33-8 ]
  • [ 90932-03-9 ]
  • 11
  • [ 25007-54-9 ]
  • [ 133082-57-2 ]
  • 12
  • [ 25007-54-9 ]
  • dimethyl oxaloacetate-d2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
36.6% With water-d2; In d(4)-methanol; at 20℃; for 168h; Example 194. Synthesis of 3-fluoro-2-(4-(3-(3-hydroxypyrrolidin-l-yl- 2,2,3,4,4,5,5-d7)-lH-pyrazol-l-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2- yl)benzonitrile, 1-194 Synthesis od compound 194.2. To a solution of 194.1 (1.7g, 10.6mmol, l.Oeq) in deuterated methanol (5.1ml) was added D20 (2.55mL). Reaction mixture was stirred at room temperature for 7 days. Upon completion of reaction, reaction mixture was concentrated under reduced pressure to obtain crude which was purified by column chromatography to provide 194.2. (0.630g, 36.6 %). NMR (CDCh, 400MHZ): 3.61 (s,3H), 3.66 (s,3H).
  • 13
  • [ 25007-54-9 ]
  • [ 108-98-5 ]
  • [ 84649-33-2 ]
  • 14
  • [ 91288-16-3 ]
  • [ 3646-68-2 ]
  • [ 25007-54-9 ]
  • [ 100-52-7 ]
  • 15
  • syn-benzaldehyde oxime [ No CAS ]
  • [ 762-42-5 ]
  • [ 25007-54-9 ]
  • [ 100-47-0 ]
  • 16
  • [ 762-42-5 ]
  • [ 25007-54-9 ]
YieldReaction ConditionsOperation in experiment
1.2 ml of dimethyl butynylacetate was dissolved in 20 ml of dichloromethane and the reaction flask was placed in an ice-water bath and 0.6 ml of methylhydrazine into the reaction flask, Stir for 15 minutes. Slowly drop 20ml of 10N sulfuric acid solution, add and then react for 15 minutes. At this time the solution was yellow. Dispensing, And the organic phase was washed with saturated aqueous ammonium sulfate solution, And then washed three times. The organic phase is dried and concentratedShrink after the bright yellow solution, dried to give colorless crystals, that is, the intermediate oxaloacetate dimethyl ester.
  • 17
  • [ 762-42-5 ]
  • [ 25007-54-9 ]
  • [ 78704-24-2 ]
  • [ 151797-12-5 ]
  • 18
  • [ 25007-54-9 ]
  • [ 60-34-4 ]
  • [ 70608-97-8 ]
  • 20
  • [ 25007-54-9 ]
  • [ 41804-94-8 ]
  • (E)-2-[(Cyano-phenyl-methyl)-amino]-but-2-enedioic acid dimethyl ester [ No CAS ]
  • 21
  • [ 762-42-5 ]
  • [ 75-65-0 ]
  • [ 25007-54-9 ]
  • (Z)-2-tert-Butoxy-but-2-enedioic acid dimethyl ester [ No CAS ]
  • 22
  • [ 762-42-5 ]
  • [ 25007-54-9 ]
  • (Z)-2-tert-Butoxy-but-2-enedioic acid dimethyl ester [ No CAS ]
  • 23
  • [ 25007-54-9 ]
  • [ 617-55-0 ]
  • [ 70681-41-3 ]
  • 24
  • [ 25007-54-9 ]
  • [ 70681-41-3 ]
  • 25
  • [ 25007-54-9 ]
  • benzaldehyde phenylimine [ No CAS ]
  • 2-benzylidene-3-phenylimino-succinic acid dimethyl ester [ No CAS ]
  • 26
  • [ 120-72-9 ]
  • [ 25007-54-9 ]
  • [ 37914-31-1 ]
  • 27
  • [ 25007-54-9 ]
  • [ 99-07-0 ]
  • 7-dimethylamino-2-oxo-2<i>H</i>-chromene-4-carboxylic acid methyl ester [ No CAS ]
  • 28
  • [ 25007-54-9 ]
  • [ 74-88-4 ]
  • [ 100249-39-6 ]
  • 29
  • [ 25007-54-9 ]
  • [ 122-51-0 ]
  • 2-ethoxymethylene-3-oxosuccinic acid dimethyl ester [ No CAS ]
  • 30
  • [ 25007-54-9 ]
  • methyl 2-sulfamoylacetate [ No CAS ]
  • dimethyl 2-{[(methoxycarbonyl)methyl]sulfonyl}amino}but-2-enedioate [ No CAS ]
  • 31
  • [ 25007-54-9 ]
  • [ 534-85-0 ]
  • [ 22004-71-3 ]
  • 32
  • [ 25007-54-9 ]
  • [ 512779-63-4 ]
  • [5-phenylsulfanyl-1-(toluene-4-sulfonyl)-1<i>H</i>-indol-4-yl]-acetic acid methyl ester [ No CAS ]
  • 33
  • methyl-4-bromo-2-butenoate [ No CAS ]
  • [ 25007-54-9 ]
  • methyl (3SR,4RS)-3-hydroxy-3,4-di-(methoxycarbonyl)-5-hexenoate [ No CAS ]
  • methyl (3RS,4RS)-3-hydroxy-3,4-di-(methoxycarbonyl)-5-hexenoate [ No CAS ]
  • 34
  • [ 25007-54-9 ]
  • methyl 4-methyl-4H-1,2-dithiolo[4,3-c]isothiazole-3-carboxylate 5,5-dioxide [ No CAS ]
  • 35
  • [ 25007-54-9 ]
  • [ 863641-13-8 ]
  • 36
  • [ 25007-54-9 ]
  • [ 863641-03-6 ]
  • 37
  • [ 25007-54-9 ]
  • methyl 4-methyl-6-nitro-4H-1,2-dithiolo[4,3-c]isothiazole-3-carboxylate 5,5-dioxide [ No CAS ]
  • 38
  • [ 25007-54-9 ]
  • [ 863641-19-4 ]
  • 39
  • [ 25007-54-9 ]
  • methyl 6-bromo-4,5-dihydro-1,4-dimethyl-5-oxo-1H-pyrrolo[3,2-c]isothiazole-3-carboxylate 2,2-dioxide [ No CAS ]
  • 40
  • [ 25007-54-9 ]
  • [ 863641-15-0 ]
  • 41
  • [ 25007-54-9 ]
  • [ 863641-02-5 ]
  • 42
  • [ 25007-54-9 ]
  • [ 863641-04-7 ]
  • 43
  • [ 25007-54-9 ]
  • [ 863641-11-6 ]
  • 44
  • [ 25007-54-9 ]
  • [ 863641-07-0 ]
  • 45
  • [ 25007-54-9 ]
  • [ 863641-17-2 ]
  • 46
  • [ 25007-54-9 ]
  • methyl (3Z)-3-[bromo(methoxycarbonyl)methylene]-2,3-dihydro-4-hydroxyisothiazole-5-carboxylate 1,1-dioxide [ No CAS ]
  • 47
  • [ 25007-54-9 ]
  • [ 863641-06-9 ]
  • 48
  • [ 25007-54-9 ]
  • methyl 6-[(tert-butoxy)carbonyl]amino}-4-methyl-4H-1,2-dithiolo[4,3-c]isothiazole-3-carboxylate 5,5-dioxide [ No CAS ]
  • 49
  • [ 25007-54-9 ]
  • methyl 6-(benzylcarbamoyl)-4-methyl-4H-1,2-dithiolo[4,3-c]isothiazole-3-carboxylate 5,5-dioxide [ No CAS ]
  • 50
  • [ 25007-54-9 ]
  • [ 189389-80-8 ]
  • 52
  • [ 25007-54-9 ]
  • [ 224171-41-9 ]
  • 53
  • [ 25007-54-9 ]
  • [ 59133-23-2 ]
  • 54
  • [ 25007-54-9 ]
  • [ 102913-12-2 ]
  • 55
  • [ 4923-01-7 ]
  • [ 25007-54-9 ]
  • [ 115761-40-5 ]
YieldReaction ConditionsOperation in experiment
In methanol; acetic acid; The (6R,7R)-7-(2-amino-4-thiazoleglyoxylamido)-3-[[[5-(hydroxycarbamoyl)-2-methyl-s-triazolo[1,5-a]pyrimidin-7-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid used as the starting material can be prepared as follows: 3-Amino-5-methyl-1H-s-triazole (112 mg) and 320 mg of dimethyl 2-oxo-succinate are dissolved in 5 ml of glacial acetic acid. After boiling under reflux for 22 hours the solvent is distilled off in a vacuum. The residue is suspended in warm methanol. After cooling the product is filtered off and washed several times with methanol. After drying in a high vacuum there are obtained 73 mg of methyl 7-hydroxy-2-methyl-s-triazolo[1,5-a]pyrimidine-5-carboxylate as a beige powder, m.p.>220 C. 1 H NMR (DMSOd6): signals at, inter alia, δ2.44 (s, 3H), 3.88 (s, 3H), 6.54 (s, 1H).
In methanol; acetic acid; The (6R,7R)-7-(2-amino-4-thiazoleglyoxylamido)-3-[[[5-(hydroxycarbamoyl)-2-methyl-s-triazolo[1,5-a]pyrimidin-7-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid used as the starting compound can be prepared as follows: 3-Amino-5-methyl-1H-s-triazole (112 mg) and 320 mg of dimethyl 2-oxo-succinate are dissolved in 5 ml of glacial acetic acid. After boiling under reflux for 22 hours the solvent is distilled off in a vacuum. The residue is suspended in warm methanol. After cooling the product is filtered off and washed several times with methanol. After drying in a high vacuum there are obtained 73 mg of methyl 7-hydroxy-2-methyl-s-triazolo[1,5-a]pyrimidine-5-carboxylate as a beige powder, m.p.>220 C. 1 H NMR (DMSO-d6): signals at, inter alia, δ2.44 (s, 3H), 3.88 (s, 3H), 6.54 (s, 1H).
 

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