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Chemical Structure| 25059-70-5 Chemical Structure| 25059-70-5

Structure of 25059-70-5

Chemical Structure| 25059-70-5

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Product Details of [ 25059-70-5 ]

CAS No. :25059-70-5
Formula : C4H10ClIS
M.W : 252.54
SMILES Code : C[S+](CCCl)C.[I-]
MDL No. :MFCD00012235

Safety of [ 25059-70-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 25059-70-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25059-70-5 ]

[ 25059-70-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25059-70-5 ]
  • [ 191805-29-5 ]
  • tert-butyl 4-oxo-8-azadispiro[2.1.55.23]dodecane-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
52.9% To a stirred solution of tert-butyl l-oxo-8-azaspiro[4.5]decane-8-carboxylate (600.00 mg, 2.368 mmol, 1.0 equiv) in t-BuOH (0.50 mL, 5.262 mmol, 109.87 equiv) was added t- BuOK (531.51 mg, 4.737 mmol, 2.0 equiv) at 25 C under nitrogen and the resulting mixture was stirred for 15 min at room temperature. To the mixture was added (2- chloroethyl)dimethyl-sulfanium iodide (598.10 mg, 2.368 mmol, 1.00 equiv) and the resulting mixture was stirred for additional 16 h at room temperature. After cooling to rt, the reaction mixture was quenched with water at 0 C and extracted with EtOAc. The combined organic layers were washed with brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by silica gel column chromatography, eluted with EtO Ac/PE (0-50%), to afford the title compound (350 mg, 52.9%).
 

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