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Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	25753-16-6
Formula :	C₁₆H₈F₆O₃
M.W :	362.22
SMILES Code :	O=C(OC(C1=CC=C(C(F)(F)F)C=C1)=O)C2=CC=C(C(F)(F)F)C=C2
English Name :	4-(Trifluoromethyl)benzoic anhydride
MDL No. :	MFCD00671577
InChI Key :	FNAWJOBKLWLHTA-UHFFFAOYSA-N
Pubchem ID :	2760733

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Yield	Reaction Conditions	Operation in experiment
	With tin(II) trifluoromethanesulfonate; trimethylsilyl acetate In dichloromethane Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
	With tin(II) trifluoromethanesulfonate; trimethylsilyl acetate In dichloromethane for 6h; Ambient temperature; Yield given. Yields of byproduct given;

Yield	Reaction Conditions	Operation in experiment
11%	With sodium acetate; zinc at 170℃; for 23h;	13 Example 13 Example 13 2-((2E,6E, 1 OE, 14E, 18E,22E)-3 ,7, 11,15,19,23 ,27-Heptamethyloctacosa- 2,6,10,14,18,22,26-heptaen-l-yl)-3-methylnaphthalene-l,4-dione (0.524 g, 0.807 mmol), 4-(trifluoromethyl)benzoic anhydride (0.757 g, 2.09 mmol), NaOAc (87.3 mg, 1.06 mmol) and Zn powder (0.156 g, 2.38 mmol) were added together and heated to 170 °C. After 23 h at 170 °C the reaction mixture was cooled down to r.t. and diluted with THF (40 mL). Et2NH (20 mL) was added and the reaction mixture was stirred for another hour after which heptane (50 mL) was added. The resulting mixture was filtrated and the solvent of the filtrate was removed under reduced pressure. The crude product was purified by HPLC to obtain 83.7 mg (11%) of 2- ((2E,6E, 10E, 14E, 18E,22E)-3 ,7, 11 , 15 , 19,23 ,27-heptamethyloctacosa- 2,6,10,14,18,22,26-heptaen-l-yl)-3-methylnaphthalene-l,4-diyl bis(4- (trifluoromethyl)benzoate). 1H NMR (400 MHz, CDC13) δ 8.45 (t, J= 8.6, 4 H), 7.88 - 7.81 (m, 4 H), 7.76 - 7.65 (m, 2 H), 7.45 - 7.40 (m, 2 H), 5.17 - 4.98 (m, 7 H), 3.59 - 3.34 (m, 2 H), 2.31 (s, 3 H), 2.15 - 1.83 (m, 24 H), 1.65 (s, 3 H), 1.62 - 1.46 (m, 18 H), 1.24 (s, 3 H). MS: m/z [M + Na calcd for 1017.52; found: 1017.3
11%	Stage #1: menaquinone-7; 4-(trifluoromethyl)benzoic anhydride With sodium acetate; zinc at 170℃; for 23h; Stage #2: With diethylamine In tetrahydrofuran at 20℃; for 1h;	13 Example 13 Example 13 0190] 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione (0.524 g, 0.807 mmol), 4-(trifluoromethyl)benzoic anhydride (0.757 g, 2.09 mmol), NaOAc (87.3 mg, 1.06 mmol) and Zn powder (0.156 g, 2.38 mmol) were added together and heated to 170° C. After 23 h at 170° C. the reaction mixture was cooled down to r.t. and diluted with THF (40 mL). Et2NH (20 mL) was added and the reaction mixture was stirred for another hour after which heptane (50 mL) was added. The resulting mixture was filtrated and the solvent of the filtrate was removed under reduced pressure. The crude product was purified by HPLC to obtain 83.7 mg (11%) of 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl bis(4-(trifluoromethyl)benzoate). [0191] 1H NMR (400 MHz, CDCl3) δ 8.45 (t, J=8.6, 4H), 7.88-7.81 (m, 4H), 7.76-7.65 (m, 2H), 7.45-7.40 (m, 2H), 5.17-4.98 (m, 7H), 3.59-3.34 (m, 2H), 2.31 (s, 3H), 2.15-1.83 (m, 24H), 1.65 (s, 3H), 1.62-1.46 (m, 18H), 1.24 (s, 3H). [0192] MS: m/z [M+Na]+ calcd for C62H72F6O4: 1017.52; found: 1017.3

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CAS No.: 25753-16-6

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CAS No.: 25753-16-6

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Yield	Reaction Conditions	Operation in experiment
89%	With bis-triphenylphosphine-palladium(II) chloride; quartz; potassium carbonate at 110℃; for 8h; Inert atmosphere;	14 Synthesis of 4-methoxy-4'-trifluoromethylbenzophenone In a 25 ml two-necked flask, p-trifluoromethylbenzoic anhydride (0.1 mmol), 4-methoxyphenylboric acid (0.11 mmol), bis(triphenylphosphine)palladium dichloride (1% mol), powdered potassium carbonate (0.165 mmol), quartz sand (2.5 g), and a magnet were added. After mixing evenly under a nitrogen atmosphere, the system was placed at 110° C. for 8 hours without stirring. After the reaction was completed, it was cooled to room temperature. Ethyl acetate (10 ml) was added to the reaction system, and it was stirred for another 15 minutes. The organic phase was filtered to obtain the organic phase, and the solvent was removed. The target product 4-methoxy-4′-trifluoromethylbenzophenone was obtained by recrystallization with ethyl acetate and n-hexane in a yield of 89%.
89%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate at 110℃; for 8h; Inert atmosphere;

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