Home Cart Sign in  
Chemical Structure| 260967-14-4 Chemical Structure| 260967-14-4

Structure of 260967-14-4

Chemical Structure| 260967-14-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 260967-14-4 ]

CAS No. :260967-14-4
Formula : C11H13NO2
M.W : 191.23
SMILES Code : O=C(OCC1=CC=CC=C1)N/C=C/C
MDL No. :MFCD30183516

Safety of [ 260967-14-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 260967-14-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 260967-14-4 ]

[ 260967-14-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6274-22-2 ]
  • [ 75-07-0 ]
  • [ 260967-14-4 ]
  • rac-benzyl ((2S,3S,4R)-2,3-dimethyl-6-(methylcarbamoyl)-1,2,3,4-tetrahydroquinolin-4-yl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a solution of acetaldehyde (0.292 mL, 5.23 mmol) in anhydrous DCM (10 mL) was added 4- amino-N-methylbenzamide (0.785 g, 5.23 mmol) and the reaction stirred at rt for I h. Diphenyl hydrogen phosphate (0.131 g, 0.523 mmol) in anhydrous DCM (5 mL) was added followed by (E)benzyl prop-1-en-1-ylcarbamate (for a preparation see Intermediate 1, 1 g, 5.23 mmol) in anhydrous DCM (5 mL). The mixture was then left to stir for 1 .5 h. The mixture was partitioned between 100 mLDCM and 25 mL sat. NaHCO3. The organic and aqueous layers were combined and evaporated to dryness under reduced pressure. The residue was treated with 30 mL MeOH and filtered. The filtrate was applied to a 100 g silica gel column which was then dried in a vacuum oven at 40 C. The dry column was then eluted with 0-8% MeOH in DCM to afford the crude desired product, as a white solid (1.15 g), which was used in the next step without further purification.LCMS (2 mm Formic): Rt = 0.92 mi [MH] = 368.
  • 2
  • [ 6274-22-2 ]
  • [ 123-38-6 ]
  • [ 260967-14-4 ]
  • rac-benzyl ((2S,3S,4R)-2-ethyl-3-methyl-6-(methylcarbamoyl)-1,2,3,4-tetrahydroquinolin-4-yl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
403 mg To a solution of propionaldehyde (0.105 mL, 1.464 mmol) in anhydrous DCM (10 mL), was added <strong>[6274-22-2]4-amino-N-methylbenzamide</strong> (220 mg, 1.464 mmol) and the reaction mixture stirred at rt for I h.Diphenyl hydrogen phosphate (36.6 mg, 0.146 mmol) in anhydrous DCM (5 mL) was then added followed by (E)-benzyl prop-1-en-1-ylcarbamate (for a preparation see Intermediate 1, 280mg, 1.464 mmol) in anhydrous DCM (5 mL). The reaction mixture was then left to stir for 2 h.The reaction mixture was diluted with DCM (10 mL) and washed with NaHCC3 (40 mL) and then water (40 mL)and the organic and aqueous layers separated. The organic layer was passed through a hydrophobic frit and then concentrated in vacuo to give a yellow oil which was purified by chromatography on silica gel (25 g column, eluting with 0-10% MeCH in DCM) to afford the desired product as a pale yellow solid (403 mg). LCMS (2 mm Formic): Rt = I .00mm, [MH] = 382.
 

Historical Records

Technical Information

Categories