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Chemical Structure| 2614-88-2 Chemical Structure| 2614-88-2

Structure of 2614-88-2

Chemical Structure| 2614-88-2

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Product Details of [ 2614-88-2 ]

CAS No. :2614-88-2
Formula : C6H7ClO
M.W : 130.57
SMILES Code : C/C=C/C=C/C(Cl)=O
MDL No. :MFCD00045227

Safety of [ 2614-88-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 2614-88-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2614-88-2 ]

[ 2614-88-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 14019-62-6 ]
  • [ 2614-88-2 ]
  • C11H17NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 58% With triethylamine; In chloroform; at -10 - 20℃; for 6h; In a 100 ml three-necked flask, the synthesized <strong>[14019-62-6]glycine isopropyl ester hydrochloride</strong> was added, followed by the addition of 10 ml of chloroform and 2 ml of triethylamine. After cooling in an ice-salt bath, the chloroform diluted chloroformylationized sorbic acid solution was added dropwise, and the temperature was controlled to -10 ~ 0 C in the dripping process. The reaction was then continued under stirring for 2h, and the reaction was warmed naturally to react at room temperature for 4h. A cloudy yellow liquid was obtained. The excess chloroform and other low boiling substances were removed under reduced pressure. Ethyl acetate and distilled water was added for extraction. The ethyl acetate extract was then added with the same amount of 0.5mol / L sodium hydroxide solution to wash 3 times. The ethyl acetate was then removed from the ethyl acetate extract under reduced pressure to get a yellow solid. The resulting yellow solid was chromatographed on a silica gel column and eluted with a 2: 1 by volume mixture of petroleum ether and ethyl acetate as the mobile phase. The eluent of the same fraction was collected and the solvent removed under reduced pressure to give a lighter yellow solid. The yield was about 58%.
  • 2
  • [ 14019-62-6 ]
  • [ 2614-88-2 ]
  • isopropyl N-[1-oxo-2,4-hexadien-1-yl]glycinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In chloroform; at 0 - 60℃; for 7h; General procedure: A solution of L-ethyl glycinate hydrochloride and sorbic chloride in chloroform (15ml) was added to triethylamine (2ml, 0.014mol) with stirring at 0C for 3h and then at 60C for 4h. The reaction mixture was poured into water (25ml), extracted with ethyl acetate (3×25ml), washed with NaOH solution (0.5mol/l, 2×25ml) and then dried over anhydrous MgSO4. After removal of the solvent under reduced pressure, the residual paste was purified by column chromatography (silica gel, petroleum ether/ethyl acetate, 2:1) to give Etheyl N-[1-oxo-2, 4-hexadien-1-yl] glycinate (a1). Other compounds (a2-a7 and b1-b7) were synthesized using procedures similar to that described above for compound a1.
  • 3
  • [ 27757-86-4 ]
  • [ 2614-88-2 ]
  • (2E,4E)-N-(thiophen-3-ylmethyl)hexa-2,4-dienamide [ No CAS ]
 

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