[ CAS No. 261763-29-5 ] {[proInfo.proName]}

Name: 261763-29-5|2,3-Difluoro-4-methoxyphenol|98%
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COA NMR CNMR HPLC LC-MS

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Product Details of [ 261763-29-5 ]

CAS No. :	261763-29-5	MDL No. :	MFCD01631505
Formula :	C₇H₆F₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CKKAZWYLHGNVDZ-UHFFFAOYSA-N
M.W :	160.12	Pubchem ID :	2774120
Synonyms :

Safety of [ 261763-29-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P322-P330-P332+P313-P337+P313-P340-P362-P363-P403-P403+P233-P405-P501	UN#:	N/A
Hazard Statements:	H302-H312-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 261763-29-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 261763-29-5 ]

[ 261763-29-5 ] Synthesis Path-Downstream 1~14

Yield	Reaction Conditions	Operation in experiment
		A compound according to claim 2, wherein said substituted 2,3-difluorophenol is: ... 4-octyl-2,3-difluorophenol, 4-nonyl-2,3-difluorophenol, 4-decyl -2,3-difluorophenol, 4-heptyl-2,3-difluorophenol, 4-methoxy-2,3-difluorophenol, 4-propoxy -2,3-difluorophenol, 4-butoxy-2,3difluorophenol, 4-pentoxy-2,3-difluorophenol, ...

2
[ 261763-29-5 ]
[ 1365243-95-3 ]
[ 1554458-53-5 ]

Yield	Reaction Conditions	Operation in experiment
65%		A solution of 31 .9 g (199 mmol) 2,3-dif luoro-4-methoxyphenol in 450 mL of dimethylsulfoxide was treated with 7.96 g (199 mmol) of sodium hydride and stirred at room temperature for 1 hour. Then 16 g (33.2 mmol) of 4-{6-bromo- 8-[(3,3,3-trifluoropropyl)amino]imidazo[1 ,2-b]pyridazin-3-yl}-N-cyclopropyl-2- methylbenzamide, which was prepared according to intermediate example 31a, was added and the mixture was heated overnight at 130C. After cooling, 300 mL ethyl acetate were added and the organic phase is washed with water. After evaporation of the organic phase, the residue was triturated with 200 mL EtOH to give 12.05 g (65%) of the title compound. 1 H-NMR (DMS0-d6): delta= 0.47-0.53 (2H), 0.62-0.70 (2H), 2.11 (3H), 2.72 (2H), 2.80 (1 H), 3.64 (2H), 3.92 (3H), 6.22 (1 H), 7.12 (1 H), 7.18 (1 H), 7.27 (1 H), 7.63 (1 H), 7.72 (1 H), 7.75-7.81 (1 H), 7.97 (1 H), 8.24 (1 H) ppm.
65%		A solution of 31.9 g (199 mmol) 2,3-difluoro-4-methoxyphenol in 450 mL of dimethylsulfoxide was treated with 7.96 g (199 mmol) of sodium hydride and stirred at room temperature for 1 hour. Then 16 g (33.2 mmol) of 4-{6-bromo-8- [(3,3,3-trifluoropropyl)amino]imidazo[1 ,2-b]pyridazin-3-yl}-N-cyclopropyl-2- methylbenzamide, which was prepared according to intermediate example 2a, was added and the mixture was heated overnight at 130C. After cooling, 300 mL ethyl acetate were added and the organic phase is washed with water. After evaporation of the organic phase, the residue was triturated with 200 mL EtOH to give 12.05 g (65%) of the title compound. 1 H-NMR (DMSO-d6): delta= 0.47-0.53 (2H), 0.62-0.70 (2H), 2.11 (3H), 2.72 (2H), 2.80 (1 H), 3.64 (2H), 3.92 (3H), 6.22 (1 H), 7.12 (1 H), 7.18 (1 H), 7.27 (1 H), 7.63 (1 H), 7.72 (1 H), 7.75-7.81 (1 H), 7.97 (1 H), 8.24 (1 H) ppm.
65%		Compound A27 N^yclopropy l-4-{6-(2, 3 iif luoro-4-methoxyphenoxy )-8-[ (3, 3, 3- trifluoro ropyl)amino]imidazo[1 ,2-b]pyridazin-3-yl}-2-methylbenzami A solution of 31.9 g (199 mmol) 2,3-difluoro-4-methoxyphenol in 450 mL of dimethylsulfoxide was treated with 7.96 g (199 mmol) of sodium hydride and stirred at room temperature for 1 hour. Then 16 g (33.2 mmol) of 4-{6-bromo- 8-[(3,3,3-trifluoropropyl)amino]imidazo[1 ,2-b]pyridazin-3-yl}-N-cyclopropyl-2- methylbenzamide, which was prepared according to intermediate example 27a, was added and the mixture was heated overnight at 130C. After cooling, 300 mL ethyl acetate were added and the organic phase is washed with water. After evaporation of the organic phase, the residue was triturated with 200 mL ethanol to give 12.05 g (65%) of the title compound. 1 H-NMR (DMSO-d6): delta= 0.47-0.53 (2H), 0.62-0.70 (2H), 2.11 (3H), 2.72 (2H), 2.80 (1 H), 3.64 (2H), 3.92 (3H), 6.22 (1 H), 7.12 (1 H), 7.18 (1 H), 7.27 (1 H), 7.63 (1 H), 7.72 (1 H), 7.75-7.81 (1 H), 7.97 (1 H), 8.24 (1 H) ppm.

Reference： [1]Patent: WO2014/20041,2014,A1 .Location in patent: Page/Page column 138-139
[2]Patent: WO2014/131739,2014,A2 .Location in patent: Page/Page column 42-43
[3]Patent: WO2014/198776,2014,A1 .Location in patent: Page/Page column 80; 81

3
[ 67-56-1 ]
[ 261763-29-5 ]
[ 1600530-19-5 ]

Yield	Reaction Conditions	Operation in experiment
85%	Stage #1: methanol; 2,3-difluoro-4-methoxy-phenol at 0℃; for 0.166667h; Stage #2: With [bis(acetoxy)iodo]benzene for 1h;

Reference： [1]Yin, Zhiwei; Zhang, Jinzhu; Wu, Jing; Green, Riana; Li, Sihan; Zheng, Shengping [Organic and Biomolecular Chemistry, 2014, vol. 12, # 18, p. 2854 - 2858]

4
[ 261763-29-5 ]
[ 1600530-34-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: 0.17 h / 0 °C 1.2: 1 h 2.1: N,N'-Dimethylhydrazine dihydrochloride / acetonitrile / 0.5 h / Reflux

Reference： [1]Yin, Zhiwei; Zhang, Jinzhu; Wu, Jing; Green, Riana; Li, Sihan; Zheng, Shengping [Organic and Biomolecular Chemistry, 2014, vol. 12, # 18, p. 2854 - 2858]

5
[ 134364-69-5 ]
[ 261763-29-5 ]

Reference： [1]Patent: CN110922306,2020,A

6
(2,3-difluoro-4-methoxyphenyl)boronic acid [ No CAS ]
[ 261763-29-5 ]

Yield	Reaction Conditions	Operation in experiment
90.1%	Stage #1: (2,3-difluoro-4-methoxyphenyl)boronic acid With dihydrogen peroxide at 20 - 25℃; for 2h; Stage #2: With hydrogenchloride In water	1.2 second step:In the previous water phase system, start stirring to control the temperature at 20-25 and add 38.0% hydrogen peroxide 68.0g (0.6mol) dropwiseAfter the dropwise addition, the temperature was kept for 2.0 hours.Sample delivery liquid detection2,3-difluoro-4-methoxybenzeneboronic acidLess than 0.2%. After the reaction,36.5% hydrochloric acid to adjust pH = 6-7, suction filtration to obtain crude product,The crude product was distilled to obtain 2,3-difluoro-4-methoxyphenol 57.3g (0.36mol), the yield was 90.1%,The purity is 99.97%.The maximum impurity in gas phase detection is 35ppm.

Reference： [1]Current Patent Assignee: CHINA SYNCHEM TECH - CN110922306, 2020, A Location in patent: Paragraph 0026; 0029

7
[ 261763-29-5 ]
2-chloro-9-(tetrahydro-2H-pyran-2-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-9H-purin-6-amine [ No CAS ]
2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-9H-purin-6-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78 mg	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tert-butyl XPhos In toluene at 120℃; for 12h; Inert atmosphere;	2.1 Step 1: 2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-N-((tetrahydro-2H-pyran -4-yl)methyl)-9H-purin-6-amine (Compound 19-1) Compound 1-3 (70.2mg, 0.2mmol), 2,3-difluoro-4-methoxyphenol (40mg, 0.24mmol), Pd2(dba)3 (18.3mg, 0.02mmol), di-tBuxphos( 17mg, 0.04mmol) and Cs2CO3 (130.3mg, 0.4mmol) were added to toluene (5mL), protected by nitrogen, and reacted at 120°C for 12 hours. Cool to room temperature, add water, extract with ethyl acetate, combine the organic phases it was dried over anhydrous sodium sulfate, and the concentrated residue was purified by column chromatography to obtain 78 mg of the title compound.

Reference： [1]Current Patent Assignee: SICHUAN KELUN PHARMACEUTICAL COMPANY LIMITED - CN111377925, 2020, A Location in patent: Paragraph 0182-0186

8
[ 261763-29-5 ]
2-chloro-N-methyl-9-(tetrahydro-2H-pyran-2-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-9H-purin-6-amine [ No CAS ]
2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-N-(methyl((tetrahydro-2H-pyran-4-yl)methyl))-9H-purin-6-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81 mg	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tert-butyl XPhos In toluene at 120℃; for 12h; Inert atmosphere;	4.2 Step 2: 2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-N-(methyl((tetrahydro-2H -Pyran-4-yl)methyl))-9H-purin-6-amine (compound 16-2) Compound 16-1 (73.2mg, 0.2mmol), 2,3-difluoro-4-methoxyphenol (40mg, 0.24mmol), Pd2(dba)3 (18.3mg, 0.02mmol), di-tBuxphos( 17mg, 0.04mmol) and Cs2CO3 (130.3mg, 0.4mmol) were added to toluene (5mL), protected by nitrogen, and reacted at 120°C for 12 hours. Cooled to room temperature, added water, extracted with ethyl acetate, combined the organic phases, dried over anhydrous sodium sulfate, and the concentrated residue was purified by column chromatography to obtain 81 mg of the title compound.

Reference： [1]Current Patent Assignee: SICHUAN KELUN PHARMACEUTICAL COMPANY LIMITED - CN111377925, 2020, A Location in patent: Paragraph 0208-0210; 0213-0215

9
[ 261763-29-5 ]
2-chloro-9-(tetrahydro-2H-pyran-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-9H-purin-6-amine [ No CAS ]
2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-9H-purin-6-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73 mg	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tert-butyl XPhos In toluene at 120℃; for 12h; Inert atmosphere;	5.2 Step 2: 2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-N-(tetrahydro-2H-pyran- 4-yl)-9H-purin-6-amine (Compound 25-2) Compound 25-1 (67.4mg, 0.2mmol), 2,3-difluoro-4-methoxyphenol (40mg, 0.24mmol), Pd2(dba)3 (18.3mg, 0.02mmol), di-tBuxphos (17mg, 0.04mmol), Cs2CO3 (130.3mg, 0.4mmol) was added to toluene (5mL), protected by nitrogen, and reacted at 120 °C for 12 hours. Cooled to room temperature, added water, extracted with ethyl acetate, combined the organic phases, dried over anhydrous sodium sulfate, and the concentrated residue was purified by column chromatography to obtain 73 mg of the title compound.

Reference： [1]Current Patent Assignee: SICHUAN KELUN PHARMACEUTICAL COMPANY LIMITED - CN111377925, 2020, A Location in patent: Paragraph 0222-0224; 0228-0229

10
[ 261763-29-5 ]
2-chloro-N-propyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine [ No CAS ]
N-propyl-2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-6-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80 mg	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tert-butyl XPhos In toluene at 120℃; for 12h; Inert atmosphere;	6.2 Step 2: N-propyl-2-(2,3-difluoro-4-methoxyphenoxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-6- Amine (Compound 26-2) Compound 1-3 (60mg, 0.2mmol), 2,3-difluoro-4-methoxyphenol (40mg, 0.24mmol), Pd2(dba)3 (18.3mg, 0.02mmol), di-tBuxphos (17mg , 0.04mmol), Cs2CO3 (130.3mg, 0.4mmol) were added to toluene (5mL), protected by nitrogen, and reacted at 120 °C for 12 hours. Cool to room temperature, add water, extract with ethyl acetate, combine the organic phases, dry with anhydrous sodium sulfate, and purify the concentrated residue by column chromatography to obtain 80 mg of the title compound.

Reference： [1]Current Patent Assignee: SICHUAN KELUN PHARMACEUTICAL COMPANY LIMITED - CN111377925, 2020, A Location in patent: Paragraph 0236-0238; 0242-0243

11
[ 261763-29-5 ]
((R)-6-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl 4-methylbenzenesulfonate [ No CAS ]
((1R,3S)-1-amino-3-((R)-6-((2,3-difluoro-4-methoxyphenoxy)methyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium <i>tert</i>-butylate / tetrahydrofuran / 16 h / 0 - 70 °C / Inert atmosphere 2: alkali metal hydroxide / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

Reference： [1]Xiao, Zili; Yang, Michael G.; Dhar, T. G. Murali; Xiao, Hai-Yun; Gilmore, John L.; Marcoux, David; Mcintyre, Kim W.; Taylor, Tracy L.; Shi, Hong; Levesque, Paul C.; Marino, Anthony M.; Cornelius, Georgia; Mathur, Arvind; Shen, Ding Ren; Cvijic, Mary Ellen; Lehman-Mckeeman, Lois D.; Sun, Huadong; Xie, Jenny H.; Carter, Percy H.; Dyckman, Alaric J. [ACS Medicinal Chemistry Letters, 2020, vol. 11, # 9, p. 1766 - 1772]

12
[ 261763-29-5 ]
((R)-6-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl 4-methylbenzenesulfonate [ No CAS ]
C₂₅H₂₇F₂NO₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium <i>tert</i>-butylate In tetrahydrofuran at 0 - 70℃; for 16h; Inert atmosphere;

13
[ 261763-29-5 ]
methyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)-4-methylbenzenesulfonate [ No CAS ]
2,3-difluoro-1-methoxy-4-((4-(-methyl-3-pentenyl)-3-cyclohexenyl)methoxy)benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
5 g	Stage #1: 2,3-difluoro-4-methoxy-phenol With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 0.5h; Inert atmosphere; Stage #2: methyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)-4-methylbenzenesulfonate In N,N-dimethyl-formamide at 100℃; for 0.5h; Inert atmosphere;	1.3 Step 3. Preparation of 2,3-difluoro-1-methoxy-4-((4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methoxy)benzene A 250ml three-necked flask, equipped with a thermometer, mechanically stirred, and vented with nitrogen, add 16g of 2,3-difluoro-4-methoxyphenol to the system, 27.6g potassium carbonate, 50ml DMF, adjust the pH to 9 - 11, heat to about 65 °C, after about 0.5h, Add a mixture of 34.85g of the sulfonate obtained in step 2 and 70ml DMF in batches, and react at 100°C for 0.5h. The reaction was stopped, the temperature was lowered, ethyl acetate and water were added to the system for layered extraction, and the organic phases were combined. Wash with water until it is neutral, dry with anhydrous magnesium sulfate, filter and concentrate to remove the solvent to obtain 23 g of oil. Dilute the n-hexane through the separation column, collect the product, and then dry it through methanol recrystallization to obtain 5g of liquid with a content of 99.85% or more 2,3-difluoro-1-methoxy-4-((4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methoxy)benzene.

Reference： [1]Current Patent Assignee: JINGMEISHENG PHOTOELECTRIC MAT NANJING - CN112707798, 2021, A Location in patent: Paragraph 0046-0047; 0052-0054

14
[ 536-57-2 ]
[ 261763-29-5 ]
2,3-difluoro-5-tosylbenzene-1,4-diol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42%	With lithium perchlorate In acetonitrile at 20℃; for 6h; Electrochemical reaction; Inert atmosphere;

Reference： [1]Sun, Xue; Zhang, Fanjun; Yan, Kelu; Feng, Wenfeng; Sun, Xuejun; Yang, Jianjing; Wen, Jiangwei [Advanced Synthesis and Catalysis, 2021, vol. 363, # 14, p. 3485 - 3490]

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 261763-29-5 ] {[proInfo.proName]}

Quality Control of [ 261763-29-5 ]

Related Doc. of [ 261763-29-5 ]

Product Details of [ 261763-29-5 ]

Safety of [ 261763-29-5 ]

Application In Synthesis of [ 261763-29-5 ]

[ 261763-29-5 ] Synthesis Path-Downstream 1~14

Related Functional Groups of [ 261763-29-5 ]

Fluorinated Building Blocks

Aryls

Ethers

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 261763-29-5 ]