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Chemical Structure| 262852-11-9 Chemical Structure| 262852-11-9

Structure of 262852-11-9

Chemical Structure| 262852-11-9

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Product Details of [ 262852-11-9 ]

CAS No. :262852-11-9
Formula : C6H9ClF3N
M.W : 187.59
SMILES Code : NC1(C2)CC2(C(F)(F)F)C1.[H]Cl
MDL No. :MFCD22056474
InChI Key :SZJRBVKLWBBKBK-UHFFFAOYSA-N
Pubchem ID :73994784

Safety of [ 262852-11-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 262852-11-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 262852-11-9 ]

[ 262852-11-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13211-32-0 ]
  • [ 262852-11-9 ]
  • 2-(tert-butoxy)-N-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20℃; [0245] A solution of 3-(trifluoromethyl)bicyclo[l. l. l]pentan-l-amine hydrochloride (12.0g, 64.0mmol) in DMF (128mL) at 0°C was treated with 2-tertiary- butoxyaceticacid (8.23mL, 64.0mmol) and N,N-diisopropylethylamine (22.3mL, 128mmol). HATU (26.8g, 70.4mmol) was added and the resulting solution was stirred at rt overnight. The mixture was concentrated to approximately 1/3 of the original volume, diluted with H20 (200mL) and extracted with EtOAc (3xl50mL). The combined organics were washed with 10percent citric acid (lOOmL), water ( lOOmL) then brine (lOOmL). The organic layer was dried (Na2S04) and concentrated to afford the crude product which was further purified by flash chromatography (Si02, Hexanes/EtOAc) to provide 14.0g (82percent) of 2-(tert-butoxy)-N-(3- (trifluoromethyl)bicyclo[l. l. l]pentan-l-yl)acetamide 7-1 as a white solid. LC/MS (APCI) mlz 210.1 [Ci2Hi8F3N02 -C4H8+H]+.
 

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