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Chemical Structure| 26420-79-1 Chemical Structure| 26420-79-1

Structure of 26420-79-1

Chemical Structure| 26420-79-1

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Product Details of [ 26420-79-1 ]

CAS No. :26420-79-1
Formula : C10H13ClO
M.W : 184.66
SMILES Code : ClCCCOCC1=CC=CC=C1
MDL No. :MFCD00028196

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Application In Synthesis of [ 26420-79-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 26420-79-1 ]

[ 26420-79-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 26420-79-1 ]
  • [ 1027-35-6 ]
  • 1-benzyl-4-(3-benzyloxy-propyl)-3-pyrrolidone [ No CAS ]
  • 2
  • [ 26420-79-1 ]
  • [ 1027-35-6 ]
  • [ 1430075-15-2 ]
YieldReaction ConditionsOperation in experiment
64.4% With tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; In 1,2-dimethoxyethane; for 4h;Reflux; Inert atmosphere; <strong>[1027-35-6]1-benzyl-4-ethoxycarbonyl-3-pyrrolidone</strong> (10.0g, 40.4mmol), 3-chloropropylbenzylether (11.0g, 60.6mmol), potassium iodide (3.3g, 20.2mmol), tetrabutylammonium bromide (1.3g, 4.04mmol) and DBU (12.0g, 80.8mmol) are added to 150ml ethylene glycol dimethyl ether and then subjected to reflux reaction for 4 hours under the protection of nitrogen. 150ml water is added at the end of reaction, extraction is carried out by ethyl acetate (100ml*3 times), organic phase is combined, washed once by saturated saline water and dried by anhydrous sodium sulfate, and the solvent is dried by concentration under reduced pressure to obtain oily product, which is then purified by column chromatography to obtain oily product (7-1) (10.3g, 26.0mmol, yield: 64.4percent). H NMR (500 MHz, CDCl3) delta7.33-7.27 (m, 10H), 4.47 (s, 2H), 4.17(q, 2H), 3.67(t 2H), 3.46-3.43(m,3H), 3.19(d, J =17.1Hz,1H), 2.94(d, J = 17.1Hz,1H), 2.72(d,1H), 2.04-1.98(m,1H), 1.85-1.82(m,1H), 1.72-1.71 (m,1H), 1.56-1.53(m,1H), 1.24(t,3H).
 

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