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Chemical Structure| 26482-53-1 Chemical Structure| 26482-53-1

Structure of 26482-53-1

Chemical Structure| 26482-53-1

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Product Details of [ 26482-53-1 ]

CAS No. :26482-53-1
Formula : C12H21N
M.W : 179.30
SMILES Code : NCCC12CC3CC(C2)CC(C3)C1
MDL No. :MFCD00233043

Safety of [ 26482-53-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 26482-53-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 26482-53-1 ]

[ 26482-53-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1480-65-5 ]
  • [ 26482-53-1 ]
  • N-[2-(1-adamantyl)ethyl]-5-chloropyridin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
24% With potassium carbonate; In N,N-dimethyl-formamide; at 140℃; for 24h;Inert atmosphere; General procedure: An argon filled one-neck flask equipped with a magnetic stir bar and reflux condenser was charged with 2-fluoropyridine 1a (146 mg, 1.5 mmol), finely powdered potassium carbonate (276 mg, 2 mmol), DMF (1 mL), and the corresponding amine (0.5 mmol). The reaction mixture was stirred at 140 °C for 24 h. In the case of diamine 2p (0.5 mmol), 291 mg (3 mmol) of compound 1a and 552 mg (4 mmol) of K2CO3 were used. 2-Fluoro-5-halopyridines 1b-d were used in the amount of 0.5 mmol. After completion of the reaction, the mixture was diluted with dichloromethane (5 mL), the precipitate was filtered off and washed with dichloromethane (5 mL). The organic layers were combined and concentrated in vacuo. The obtained residues were analyzed by NMR spectroscopy. If required, the products were isolated by column chromatography using gradient elution as follows: petroleum ether-CH2Cl2 (4 : 1 1 : 4),CH2Cl2, CH2Cl2-MeOH (500 : 1 3 : 1). Spectral data for compounds 3d,e,q have been published in work,18 for compounds 3a-c,g,i,m,n, in work.23
 

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