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Chemical Structure| 265644-03-9 Chemical Structure| 265644-03-9

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Chemical Structure| 265644-03-9

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Product Details of [ 265644-03-9 ]

CAS No. :265644-03-9
Formula : C7H6F2N2O
M.W : 172.13
SMILES Code : NNC(=O)C1=C(F)C=CC(F)=C1
MDL No. :MFCD02183537

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 265644-03-9 ]

[ 265644-03-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2991-28-8 ]
  • [ 265644-03-9 ]
YieldReaction ConditionsOperation in experiment
56% To a solution of 2,5- difluorobenzoic acid (5.0 g, 31.6 mmol) in CH2Cl2 (60 mL) was added SOCl2 (23 mL) slowly at rt. The mixture was refiuxed for 3h, allowed to cool and concentrated in vacuo. The residue was treated with toluene and concentrated in vacuo. A solution of the crude acid chloride in CH2Cl2 (100 mL) was treated with anhydrous hydrazine (5.0 g) and heated at reflux for 4h. Once at rt, the reaction was washed with brine, dried over Na2SO4, filtered and evaporated. The resulting solid was recrystallized from MeOH (20 mL). The colorless crystals were collected by filtration and dried to give 1.99 g (56percent yield) of the hydrazide. 1H NMR (DMSO-dbeta) delta 4.52 (2H, s), 7.29- 7.33 (3H, m), 9.53 (IH, s). MS m/e 173 (M + if); Calculated MW: 172 for C7H6F2N2O.
 

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