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[ CAS No. 26638-43-7 ]

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Chemical Structure| 26638-43-7
Chemical Structure| 26638-43-7
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Product Details of [ 26638-43-7 ]

CAS No. :26638-43-7 MDL No. :MFCD00009797
Formula : C8H7ClO4S Boiling Point : 344.8°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :234.66 g/mol Pubchem ID :117830
Synonyms :

Safety of [ 26638-43-7 ]

Signal Word:Danger Class:8
Precautionary Statements:P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310 UN#:3261
Hazard Statements:H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 26638-43-7 ]

  • Upstream synthesis route of [ 26638-43-7 ]
  • Downstream synthetic route of [ 26638-43-7 ]

[ 26638-43-7 ] Synthesis Path-Upstream   1~11

  • 1
  • [ 134-20-3 ]
  • [ 26638-43-7 ]
YieldReaction ConditionsOperation in experiment
94%
Stage #1: With hydrogenchloride; sodium nitrite In water at 80℃; for 0.0277778 h; Large scale
Stage #2: With sodium hydrogensulfite In dichloromethane; water at 100℃; for 0.025 h; Large scale
The first tubular reactor was 20 m long and 15 mm in diameter; the second tubular reactor length was40m, diameter of 10mm, copper ball packing diameter of 3mm. 1587 g of methyl anthranilate,(Containing 1916 g of hydrogen chloride) of 35 wtpercent hydrochloric acid, 6720 g of 30 wtpercent sodium nitrite solution(Containing 2016 g of sodium nitrite), 6825 g of saturated sodium bisulfite solution (containing sulfurous acidSodium hydride 2730 g), and the mass of methylene chloride was 7936 g.The first tubular reactor was weighed using a heat exchanger maintained at a temperature of 80 ° C20percent by weight of hydrochloric acid, and 40percent by weight of sodium nitrite solution, respectively,A storage tank 1, a second storage tank and a third storage tank, each of the three materials is passed through a first metering pump,The second metering pump and the third metering pump are simultaneously conveyed to the first mixer, and the flow rate is controlled so that the three metering pumps1: 5: 3 flow rate, the three strands of material mixed by the first mixer into the first tube reactionAnd the diazotization reaction was carried out at 80 ° C for a residence time of 100 s, and stored in a fourth storage tankSaturated sodium bisulfite solution and dichloromethane stored in the fifth tank, respectivelyThe fourth metering pump and the fifth metering pump and the diazotization reaction flowing out of the first tubular reactorLiquid and simultaneously fed to a second mixer to control the flow rate so that methyl anthranilate and saturatedThe molar flow ratio of sodium bisulfite was 1: 2.5, methyl anthranilate and methylene chlorideMass flow ratio of 1: 5; mixed by the second mixer after the second mixed solution into the pre-securityTemperature of 100 ° C, and a residence time in the tube of 90 s;Two minutes after the exit of the two-tube reactor, the reaction solution was collected and collected for 2 minutesAnd the amount of the o-aminobenzoic acid methyl ester was 624 g), and the reaction solution was allowed to stand in a receiving tankThe layers were separated, the organic layer was removed, the methylene chloride was removed and dried to give 2- (chlorosulfonyl)Yl) benzoic acid methyl ester (910 g) in a yield of 94percent
Reference: [1] Organic Process Research and Development, 2016, vol. 20, # 12, p. 2116 - 2123
[2] Patent: CN105732441, 2016, A, . Location in patent: Paragraph 0041; 0042
[3] Patent: CN105949091, 2016, A, . Location in patent: Paragraph 0030
  • 2
  • [ 7446-09-5 ]
  • [ 134-20-3 ]
  • [ 26638-43-7 ]
Reference: [1] Patent: US4602938, 1986, A,
[2] Patent: US4647665, 1987, A,
[3] Patent: US4725303, 1988, A,
[4] Patent: US4725305, 1988, A,
[5] Patent: US4797484, 1989, A,
[6] Patent: US4840661, 1989, A,
[7] Patent: US4880932, 1989, A,
  • 3
  • [ 342-54-1 ]
  • [ 26638-43-7 ]
Reference: [1] ChemSusChem, 2017, vol. 10, # 1, p. 151 - 155
  • 4
  • [ 57897-77-5 ]
  • [ 26638-43-7 ]
Reference: [1] Journal of the American Chemical Society, 2006, vol. 128, # 35, p. 11693 - 11712
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 20, p. 5078 - 5082[3] Angew. Chem., 2014, vol. 126, # 20, p. 5178 - 5182,5
  • 5
  • [ 127-65-1 ]
  • [ 4892-02-8 ]
  • [ 26638-43-7 ]
Reference: [1] Journal of Organic Chemistry, 2016, vol. 81, # 7, p. 3051 - 3057
  • 6
  • [ 146335-12-8 ]
  • [ 26638-43-7 ]
Reference: [1] Synthesis, 1992, # 12, p. 1203 - 1204
[2] Synthesis, 1992, # 12, p. 1203 - 1204
  • 7
  • [ 81-08-3 ]
  • [ 26638-43-7 ]
Reference: [1] Journal of the American Chemical Society, 2006, vol. 128, # 35, p. 11693 - 11712
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 20, p. 5078 - 5082[3] Angew. Chem., 2014, vol. 126, # 20, p. 5178 - 5182,5
  • 8
  • [ 5459-63-2 ]
  • [ 26638-43-7 ]
Reference: [1] Patent: US2667503, 1951, ,
[2] Patent: US2667503, 1951, ,
  • 9
  • [ 119300-80-0 ]
  • [ 26638-43-7 ]
Reference: [1] Patent: DE124407, , ,
  • 10
  • [ 85-44-9 ]
  • [ 26638-43-7 ]
Reference: [1] Patent: CN105949091, 2016, A,
  • 11
  • [ 67-56-1 ]
  • [ 34684-21-4 ]
  • [ 26638-43-7 ]
Reference: [1] American Chemical Journal, 1906, vol. 35, p. 502
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