[ CAS No. 27311-63-3 ] {[proInfo.proName]}

Name: 27311-63-3|Isoquinolin-1-ylmethanol|95%
Brand: Ambeed
SKU: A342824
Price: 39.0 USD
Availability: InStock
Rating: 93 (32 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 27311-63-3

Structure of 27311-63-3 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 27311-63-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 27311-63-3 ]

SDS Specification

Alternatived Products of [ 27311-63-3 ]

Product Details of [ 27311-63-3 ]

CAS No. :	27311-63-3	MDL No. :	MFCD03086097
Formula :	C₁₀H₉NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	HQABEHZXAJHCLV-UHFFFAOYSA-N
M.W :	159.18	Pubchem ID :	2776247
Synonyms :

Calculated chemistry of [ 27311-63-3 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.1
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	47.87
TPSA :	33.12 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.38 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.74
Log Po/w (XLOGP3) :	1.25
Log Po/w (WLOGP) :	1.58
Log Po/w (MLOGP) :	0.95
Log Po/w (SILICOS-IT) :	2.31
Consensus Log Po/w :	1.57

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.17
Solubility :	1.09 mg/ml ; 0.00684 mol/l
Class :	Soluble
Log S (Ali) :	-1.54
Solubility :	4.55 mg/ml ; 0.0286 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-3.52
Solubility :	0.0483 mg/ml ; 0.000303 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.22

Safety of [ 27311-63-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 27311-63-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 27311-63-3 ]
Downstream synthetic route of [ 27311-63-3 ]

[ 27311-63-3 ] Synthesis Path-Upstream 1~2

1
[ 27311-63-3 ]
[ 4494-18-2 ]

Reference： [1] Patent: EP1550657, 2005, A1, . Location in patent: Page/Page column 68

2
[ 27311-63-3 ]
[ 74417-44-0 ]

Reference： [1] Journal of the Chemical Society, 1951, p. 1145,1147

[ 27311-63-3 ] Synthesis Path-Downstream 1~33

1
[ 4494-18-2 ]
[ 27311-63-3 ]

Reference： [1]Journal of the Chemical Society,1951,p. 1145,1147

2
[ 27311-63-3 ]
[ 74417-44-0 ]

Reference： [1]Journal of the Chemical Society,1951,p. 1145,1147

3
[ 27311-63-3 ]
[ 156-57-0 ]
2-<(isoquinolin-1-ylmethyl)thio>ethylamine dihydrobromide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
44%	With hydrogen bromide for 18h; Heating;

Reference： [1]Young; Mitchell; Brown; Ganellin; Griffiths; Jones; Rana; Saunders; Smith; Sore; Wilks [Journal of Medicinal Chemistry, 1988, vol. 31, # 3, p. 656 - 671]

4
[ 27311-63-3 ]
[ 153758-56-6 ]

Yield	Reaction Conditions	Operation in experiment
71%	With hydrogen In acetic acid
	With platinum(IV) oxide hydrate; hydrogen In methanol at 20℃; for 16h; Autoclave;	1,2,3,4-tetrahydroisoquinolin-1-yl)methanol (Intermediate 44) A stirred solution of isoquinolin-1-ylmethanol (1.0 g, 6.28 mmol, 1.0 eq) in MeOH (100 mL) at room temperature in autoclave was treated with Pt02 monohydrate (0.129 g, 0.56 mmol, 0.09 eq). The resulting reaction mixture was stirred at room temperature for 16h under 60 psi pressure of H2 (gas). Reaction completion was monitored by TLC (DCM: MeOH; 9:1). The reaction mixture was filtered through celite bed and concentrated under reduced pressure yielding the title compound (0.85 g, 5.20 mmol. Yield: 85.0%,). (1922) [00516] LCMS (Method B): 1.46 min, MS: ES+ 164.16 (M+1). The crude material was used in next step without purification.
	With platinum(IV) oxide hydrate; hydrogen In methanol at 20℃; for 16h; Autoclave;	1,2,3,4-tetrahydroisoquinolin-1-yl)methanol (Intermediate 44) A stirred solution of isoquinolin-1-ylmethanol (1.0 g, 6.28 mmol, 1.0 eq) in MeOH (100 mL) at room temperature in autoclave was treated with Pt02 monohydrate (0.129 g, 0.56 mmol, 0.09 eq). The resulting reaction mixture was stirred at room temperature for 16h under 60 psi pressure of H2 (gas). Reaction completion was monitored by TLC (DCM: MeOH; 9:1). The reaction mixture was filtered through celite bed and concentrated under reduced pressure yielding the title compound (0.85 g, 5.20 mmol. Yield: 85.0%,). (1922) [00516] LCMS (Method B): 1.46 min, MS: ES+ 164.16 (M+1). The crude material was used in next step without purification.

Reference： [1]Crabb, Trevor A.; Patel, Asmita V. [Heterocycles, 1994, vol. 37, # 1, p. 431 - 440]
[2]Current Patent Assignee: NEOPHORE - WO2021/245405, 2021, A1 Location in patent: Paragraph 00515-00516
[3]Current Patent Assignee: NEOPHORE - WO2021/245405, 2021, A1 Location in patent: Paragraph 00515-00516

5
[ 50458-78-1 ]
[ 27311-63-3 ]

Yield	Reaction Conditions	Operation in experiment
75%	With lithium aluminium tetrahydride In tetrahydrofuran for 1.5h; Heating;

Reference： [1]Crabb, Trevor A.; Patel, Asmita V. [Heterocycles, 1994, vol. 37, # 1, p. 431 - 440]

6
[ 34456-69-4 ]
[ 27311-63-3 ]

Yield	Reaction Conditions	Operation in experiment
64%	With sulfuric acid for 3h; Heating;

Reference： [1]Abarca, Belen; Bellesteros, Rafael; Gomez-Aldaravi, Estrella; Jones, Gurnos [Journal of the Chemical Society. Perkin transactions I, 1985, p. 1897 - 1902]

7
Isoquinoline-1-carboxylic acid [(3S,6S,12R,15S,16R,19S,22S)-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacos-15-yl]-amide [ No CAS ]
[ 27311-63-3 ]
[ 143381-36-6 ]

Yield	Reaction Conditions	Operation in experiment
1: 30% 2: 33%	In sulfuric acid at 25℃; controlled potential electrochem. reduction, (-)Hg/Pt(+), -700 mV vs. s.c.e., 2.3 F;

Reference： [1]Largeron, M.; Vuilhorgne, M.; Potier, I. Le; Auzeil, N.; Bacque, E.; and al. [Tetrahedron, 1994, vol. 50, # l, p. 6307 - 6332]

8
[ 27311-63-3 ]
[ 124-63-0 ]
methanesulfonic acid isoquinolin-1-ylmethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	With triethylamine In dichloromethane at 5℃; for 1h;

Reference： [1]Oda, Kozo; Nishi, Takahide [Journal of Antibiotics, 1997, vol. 50, # 5, p. 446 - 448]

9
[ 27104-72-9 ]
[ 27311-63-3 ]

Yield	Reaction Conditions	Operation in experiment
54%	With sodium tetrahydroborate; In methanol; at 20℃; for 5.0h;	[00660] Step 2: isoquinolin-l-ylmethanol [00661] To a stirring solution of methyl isoquinoline- l-carboxylate (935 mg, 5.0 mmol) in MeOH (20 mL) was added NaBH4 (570 mg, 15.0 mmol) in portionwise at room temperature. After stirring continually at room temperature for 5 h, the reaction mixture was quenched with saturated aqueous NH4Cl, filtered and concentrated. The residue was purified by column chromatography on silica gel eluting with PE/EtOAc (4:1) to give isoquinolin-l-ylmethanol (430 mg, 54%) as yellow oil. ES-MS (m/z): [M+l]+ = 160.1.

Reference： [1]Organic Letters,2005,vol. 7,p. 3609 - 3612
[2]Patent: WO2020/14332,2020,A1 .Location in patent: Paragraph 00660-00661
[3]Journal of Antibiotics,1997,vol. 50,p. 446 - 448

Yield	Reaction Conditions	Operation in experiment
	1-(Benzoyloxy-methyl)-isochinolin-hydrochlorid, wss.-ethanol. KOH;
	1-Methylisochinolin-N-oxid. 1) sd. Ac2O, 2) sd. wss. HCl;
	Isochinolin-1-carbonsaeureethylester (XXXVI), NaBH4; neben Tetrahydro-verb. (XXXVIII);

	Isochinolin-1-carbonsaeureethylester (XXXVI), NaBH4; neben Tetrahydro-Verb. (XXXVIII);
	Isochinolin-1-carbonsaeure-ethylester (XXXVI), NaBH4 ( neben Tetrahydro-Verb. (XXXVIII) );
		19.f EXAMPLE 19 (f) 1-(hydroxymethyl) isoquinoline with cysteamine hydrobromide in hydrobromic acid gives the corresponding 2-aminoethylthiomethyl derivatives which may be substituted for 2-(5-methyl-4-imidazolylmethylthio)-ethylamine in the procedure of Example 1 (iv) to give:

11
[ 119-65-3 ]
[ 107-21-1 ]
[ 27311-63-3 ]

Yield	Reaction Conditions	Operation in experiment
58%	With ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid Heating;

Reference： [1]Minisci, Francesco; Porta, Ombretta; Recupero, Francesco; Punta, Carlo; Gambarotti, Cristian; Pruna, Barbara; Pierini, Monica; Fontana, Francesca [Synlett, 2004, # 5, p. 874 - 876]

12
[ 27311-63-3 ]
[ 108-24-7 ]
[ 27039-28-7 ]

Yield	Reaction Conditions	Operation in experiment
86%	With pyridine; dmap In tetrahydrofuran at 20℃; for 17h;

Reference： [1]Weitgenant, Jeremy A.; Mortison, Jonathan D.; Helquist, Paul [Organic Letters, 2005, vol. 7, # 17, p. 3609 - 3612]

13
[ 27311-63-3 ]
1-(2-hydroxybutyl)-isoquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 86 percent / pyridine; DMAP / tetrahydrofuran / 17 h / 20 °C 2: 70 percent / samarium(II) iodide / tetrahydrofuran / 20 °C

Reference： [1]Weitgenant, Jeremy A.; Mortison, Jonathan D.; Helquist, Paul [Organic Letters, 2005, vol. 7, # 17, p. 3609 - 3612]

14
[ 27311-63-3 ]
1-(2-ethyl-2-hydroxybutyl)-isoquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 86 percent / pyridine; DMAP / tetrahydrofuran / 17 h / 20 °C 2: 77 percent / samarium(II) iodide / tetrahydrofuran / 20 °C

Reference： [1]Weitgenant, Jeremy A.; Mortison, Jonathan D.; Helquist, Paul [Organic Letters, 2005, vol. 7, # 17, p. 3609 - 3612]

15
[ 27311-63-3 ]
[ 66948-16-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 86 percent / pyridine; DMAP / tetrahydrofuran / 17 h / 20 °C 2: 25 percent / samarium(II) iodide / tetrahydrofuran / 20 °C

Reference： [1]Weitgenant, Jeremy A.; Mortison, Jonathan D.; Helquist, Paul [Organic Letters, 2005, vol. 7, # 17, p. 3609 - 3612]

16
[ 486-73-7 ]
[ 27311-63-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 91 percent / H₂SO₄ / 17 h / Heating 2: 85 percent / NaBH₄; LiCl / tetrahydrofuran; ethanol / 17 h / 20 °C
	Multi-step reaction with 2 steps 1: sulfuric acid / methanol / 16 h / 60 °C 2: sodium tetrahydroborate / methanol / 5 h / 20 °C
	Multi-step reaction with 2 steps 1: sulfuric acid / 5 h / 65 °C 2: sodium tetrahydroborate; ethanol; lithium chloride / tetrahydrofuran / 24 h / 20 °C

Reference： [1]Weitgenant, Jeremy A.; Mortison, Jonathan D.; Helquist, Paul [Organic Letters, 2005, vol. 7, # 17, p. 3609 - 3612]
[2]Current Patent Assignee: NEXYS THERAPEUTICS - WO2020/14332, 2020, A1
[3]Current Patent Assignee: NEOPHORE - WO2021/245405, 2021, A1

17
[ 27311-63-3 ]
[ 1027940-24-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 87 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C 2: 100 percent / dimethylformamide / 0.5 h / 5 °C

Reference： [1]Oda, Kozo; Nishi, Takahide [Journal of Antibiotics, 1997, vol. 50, # 5, p. 446 - 448]

18
[ 27311-63-3 ]
[ 192769-81-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 87 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C 2: 100 percent / dimethylformamide / 0.5 h / 5 °C 3: 81 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C

Reference： [1]Oda, Kozo; Nishi, Takahide [Journal of Antibiotics, 1997, vol. 50, # 5, p. 446 - 448]

19
[ 27311-63-3 ]
[ 192769-82-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 87 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C 2: 100 percent / dimethylformamide / 0.5 h / 5 °C 3: 81 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C 4: 62 percent / 1,1,1,3,3,3-hexamethyldisilazane; n-BuLi; Et₃N / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / -78 - 21 °C

Reference： [1]Oda, Kozo; Nishi, Takahide [Journal of Antibiotics, 1997, vol. 50, # 5, p. 446 - 448]

20
[ 27311-63-3 ]
(3S,4S)-3-[(1R)-(1-tert-butyldimetylsilyloxy)ethyl]-4-[(1r)-1-((1-isoquinolylmethyl)thiocarbonyl)ethyl]-2-azetidinone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 87 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C 2: 100 percent / dimethylformamide / 0.5 h / 5 °C 3: 81 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C 4: 62 percent / 1,1,1,3,3,3-hexamethyldisilazane; n-BuLi; Et₃N / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / -78 - 21 °C 5: 98 percent / ZnCl₂ / CH₂Cl₂ / 12 h / 0 - 21 °C / under N₂

Reference： [1]Oda, Kozo; Nishi, Takahide [Journal of Antibiotics, 1997, vol. 50, # 5, p. 446 - 448]

21
[ 27311-63-3 ]
1,5,6,10b-tetrahydro-3H-oxazolo<4,3-a>isoquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 71 percent / H₂ / PtO₂ / acetic acid / 760 Torr 2: 55 percent / ethanol; H₂O / 3 h

Reference： [1]Crabb, Trevor A.; Patel, Asmita V. [Heterocycles, 1994, vol. 37, # 1, p. 431 - 440]

22
[ 27311-63-3 ]
[ 4494-18-2 ]

Yield	Reaction Conditions	Operation in experiment
	With manganese(IV) oxide; In chloroform; at 20℃; for 0.5h;	Isoquinolin-1-yl-methanol (123.7 mg) was dissolved in chloroform (6.2 ml) and then added with manganese dioxide (chemically processed product) (1.24 g), followed by stirring at room temperature for 30 minutes. The reaction solution was filtrated through Celite and the solvent was then distilled off. The residue was dried under vacuum, thereby obtaining the subject compound (103.9 mg) as a brown solid. 1H-NMR(500MHz,CDCl3):delta=7.72-7.80(2H,m),7.88-7.96(2H,m),8.77(1H,d,J=5.4Hz),9.30-9.36(1H,m),10.3(1H,s).

Reference： [1]Patent: EP1550657,2005,A1 .Location in patent: Page/Page column 68

23
[ 27311-63-3 ]
[ 27311-65-5 ]

Yield	Reaction Conditions	Operation in experiment
90%		Preparation of 1-chloromethyl-isoquinoline 1g; An excess of thionyl chloride (1.8 mL; 25 mmol) was dropwise added to a stirred ice-cold solution of 1-hydroxymethyl-isoquinoline 1f (2.0 g; 12.6 mmol) in CHCl3 during 30 min. The reaction medium was poured into an ice (100 g)-water (50 mL)-NH4OH (10 mL) mixture and then stirred during 20 min. The organic layer was collected, dried over anhydrous MgSO4 and evaporated under reduced pressure. The resulting oil was purified by flash chromatography (Me2CO) to afford a white solid (2 g); yield, 90%1H-NMR (CDCl3) δ 5.18 (s, 2H), 7.68-7.76 (m, 3H), 7.88 (d, 1H, J=8.1 Hz), 8.27 (d, 1H, J=7.8 Hz), 8.49 (d, 1H, J=5.7 Hz)

Reference： [1]Patent: US2009/93517,2009,A1 .Location in patent: Page/Page column 7-8

24
[ 27311-63-3 ]
[ 27311-65-5 ]
[ 950853-47-1 ]

Yield	Reaction Conditions	Operation in experiment
68%	With sodium hydride; In N,N-dimethyl-formamide; at 20℃; for 2h;	Preparation of 1,1'-bis(1-isoquinolyl)-dimethylether 2v; A solution of 1-hydroxymethyl-isoquinoline 1f (0.62 g; 3.9 mmol) and <strong>[27311-65-5]1-chloromethyl-isoquinoline</strong> 1 g (0.7 g; 3.9 mmol) in DMF (15 mL) was added dropwise to a stirred suspension of sodium hydride (0.16 g; 3.9 mmol) in DMF (15 mL) at room temperature. The reaction medium was stirred for 2 h and poured into water (200 mL). The aqueous solution was extracted with CHCl2 (3×50 ml). The organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure to afford oil. This oil was purified by flash chromatography (Me2CO) to afford a cream solid (0.8 g); yield 68%1H-NMR (CDCl3) δ 5.40 (s, 4H), 7.58 (t, 2H, J=7.6 Hz), 7.68 (d, 2H, J=5.8 Hz), 7.72 (t, 2H, J=7.6 Hz), 7.85 (d, 2H, J=8.2 Hz), 8.33 (d, 2H, J=8.4 Hz), 8.50 (d, 2H, J=5.8 Hz)

Reference： [1]Patent: US2009/93517,2009,A1 .Location in patent: Page/Page column 10

25
[ 50-00-0 ]
2-benzoyl-1-cyano-1,2-dihydroisoquinoline [ No CAS ]
[ 27311-63-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	Stage #1: formaldehyd; 2-benzoyl-1-cyano-1,2-dihydroisoquinoline With sodium hydride In N,N-dimethyl-formamide at -10℃; for 1h; Stage #2: With sodium hydroxide; ethanol; water for 0.25h; Heating / reflux;	Preparation of 1-hydroxymethyl-isoquinoline 1f; A solution of 2-benzoyl-1-cyano-1,2-dihydroisoquinoline la (5.0 g; 19.2 mmol) in DMF (15 mL) was dropwise added to a stirred suspension of sodium hydride (0.46 g; 19.2 mmol) and paraformaldehyde (0.62 g; 19.2 mmol) in DMF (15 mL) at -10° C. The content was stirred for 1 h and poured into ice-cold water (200 mL). The aqueous solution was extracted with CH2Cl2 (3×50 ml). The organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure to afford oil. This oil was dissolved in EtOH and refluxed with aqueous NaOH (2 g in 2 mL H2O) during 15 min. After removal of EtOH, the crude residue was dissolved in water (150 mL). The aqueous solution was extracted with CH2Cl2 (3×30 mL). The organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure to afford a cream solid which recrystallized from Et2O/n-hexane; yield, 88%1H-NMR (DMSO) δ 5.50 (s, 2H), 7.98 (t, 1H, J=7.6 Hz), 8.18 (t, 1H, J=7.6 Hz), 8.33 (d, 1H, J=8.2 Hz), 8.37 (d, 1H, J=6.5 Hz), 8.48 (d, 1H, J=6.5 Hz), 8.53 (d, 1H, J=8.5 Hz)

Reference： [1]Current Patent Assignee: UNIVERSITY OF LIEGE - US2009/93517, 2009, A1 Location in patent: Page/Page column 7

26
[ 75-30-9 ]
[ 27311-63-3 ]
[ 1457730-48-1 ]

Yield	Reaction Conditions	Operation in experiment
55%	With silver(l) oxide In 1,4-dioxane at 20℃; for 24h;	General Procedure: Isopropyl Picolinate (2)[5] General procedure: Freshly prepared Ag2O (2.20 mmol) was added at room temperature to a solution of pyridin-2-ylmethanol (1.00 mmol) and 2-iodopropane (2.20 mmol) in 1,4-dioxane (10 mL) and stirred for 24 h. The reaction mixture was filtered through a Celite bed and washed with ethyl acetate. Filtrate was concentrated under vacuum.The resulting material was purified by flash chromatography on a Biotage instrumentusing 4-g flash cartridge and eluted with 12-15% ethyl acetate in hexane to give isopropyl picolinate (2) (65% yield).

Reference： [1]Patil, Vikas S.; Reddy, M. Rajendar; Pal, Shyam Sundar; Sharma, Somesh; Reddy, L. Krishnakanth [Synthetic Communications, 2014, vol. 44, # 14, p. 2121 - 2127]

27
[ 27311-63-3 ]
[ 1721-93-3 ]

Yield	Reaction Conditions	Operation in experiment
60%	With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; tributylammonium formate; toluene-4-sulfonic acid In dimethyl sulfoxide at 23℃; UV-irradiation;

Reference： [1]Jin, Jian; MacMillan, David W. C. [Nature, 2015, vol. 525, # 7567, p. 87 - 90]

28
[ 100-42-5 ]
[ 27311-63-3 ]
C₁₈H₁₅N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; toluene-4-sulfonic acid In dimethyl sulfoxide at 23℃; UV-irradiation;

Reference： [1]Jin, Jian; MacMillan, David W. C. [Nature, 2015, vol. 525, # 7567, p. 87 - 90]

29
[ 14371-10-9 ]
[ 27311-63-3 ]
C₁₉H₁₇NO₂ [ No CAS ]
C₁₉H₁₇NO₂ [ No CAS ]
C₁₉H₁₇NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 96 % ee 2: 89 % ee	Stage #1: 1-Hydroxymethyl-isoquinoline With trifluorormethanesulfonic acid In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: With (S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)pyrrolidine In N,N-dimethyl-formamide at 10℃; for 0.0833333h; Stage #3: (E)-3-phenylpropenal In N,N-dimethyl-formamide at 10℃; for 96h; Overall yield = 84 %; stereoselective reaction;

Reference： [1]Tong, Mengchao; Wang, Sinan; Zhuang, Jinchen; Qin, Cong; Li, Hao; Wang, Wei [Organic Letters, 2018, vol. 20, # 4, p. 1195 - 1199]

30
[ 27311-63-3 ]
4-bromocinnamaldeyde [ No CAS ]
C₁₉H₁₆BrNO₂ [ No CAS ]
C₁₉H₁₆BrNO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 97 % ee 2: 98 % ee	Stage #1: 1-Hydroxymethyl-isoquinoline With trifluorormethanesulfonic acid In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: With (S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)pyrrolidine In N,N-dimethyl-formamide at 10℃; for 0.0833333h; Stage #3: 4-bromocinnamaldeyde In N,N-dimethyl-formamide at 10℃; for 96h; Overall yield = 87 %; stereoselective reaction;

Reference： [1]Tong, Mengchao; Wang, Sinan; Zhuang, Jinchen; Qin, Cong; Li, Hao; Wang, Wei [Organic Letters, 2018, vol. 20, # 4, p. 1195 - 1199]

31
[ 27311-63-3 ]
[ 1504-75-2 ]
C₂₀H₁₉NO₂ [ No CAS ]
C₂₀H₁₉NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 98 % ee 2: 98 % ee	Stage #1: 1-Hydroxymethyl-isoquinoline With trifluorormethanesulfonic acid In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: With (S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)pyrrolidine In N,N-dimethyl-formamide at 10℃; for 0.0833333h; Stage #3: 3-(4-methylphenyl)acrylaldehyde In N,N-dimethyl-formamide at 10℃; for 96h; Overall yield = 93 %; stereoselective reaction;

Reference： [1]Tong, Mengchao; Wang, Sinan; Zhuang, Jinchen; Qin, Cong; Li, Hao; Wang, Wei [Organic Letters, 2018, vol. 20, # 4, p. 1195 - 1199]

32
[ 119-65-3 ]
[ 67-56-1 ]
[ 27311-63-3 ]

Yield	Reaction Conditions	Operation in experiment
30%	Stage #1: isoquinoline With trifluoroacetic acid In 1,2-dichloro-ethane at 27℃; for 0.25h; Sealed tube; Stage #2: methanol In 1,2-dichloro-ethane at 27℃; for 24h; Sealed tube; Irradiation;
25%	With oxygen; trifluoroacetic acid at 35℃; for 14h; Irradiation;

Reference： [1]Bhakat, Manotosh; Biswas, Promita; Dey, Jayanta; Guin, Joyram [Organic Letters, 2021, vol. 23, # 17, p. 6886 - 6890]
[2]Vijeta, Arjun; Reisner, Erwin [Chemical Communications, 2019, vol. 55, # 93, p. 14007 - 14010]

33
[ 109-99-9 ]
[ 119-65-3 ]
[ 27311-63-3 ]
1-(tetrahydrofuran-2'-yl)isoquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 42% 2: 15%	With ethylene glycol; bis-[(trifluoroacetoxy)iodo]benzene In dimethyl sulfoxide; 1,2-dichloro-ethane at 20℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;

Reference： [1]Li, Xiang; Liu, Chaoyang; Guo, Shixun; Wang, Wei; Zhang, Yongqiang [European Journal of Organic Chemistry, 2021, vol. 2021, # 3, p. 411 - 421]

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 27311-63-3 ]

Alcohols

[ 1823904-12-6 ]

(1-Methylisoquinolin-3-yl)methanol

Similarity: 0.97

[ 76884-34-9 ]

Isoquinolin-3-ylmethanol

Similarity: 0.97

[ 1369191-08-1 ]

(7-Methylisoquinolin-1-yl)methanol

Similarity: 0.95

[ 171880-37-8 ]

(5-Methylisoquinolin-1-yl)methanol

Similarity: 0.95

[ 1780-17-2 ]

2-Quinolinylmethanol

Similarity: 0.90

Related Parent Nucleus of
[ 27311-63-3 ]

Isoquinolines

[ 1823904-12-6 ]

(1-Methylisoquinolin-3-yl)methanol

Similarity: 0.97

[ 76884-34-9 ]

Isoquinolin-3-ylmethanol

Similarity: 0.97

[ 1369191-08-1 ]

(7-Methylisoquinolin-1-yl)methanol

Similarity: 0.95

[ 171880-37-8 ]

(5-Methylisoquinolin-1-yl)methanol

Similarity: 0.95

[ 1318897-45-8 ]

(7-Bromoisoquinolin-3-yl)methanol

Similarity: 0.83

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 27311-63-3 ] {[proInfo.proName]}

Quality Control of [ 27311-63-3 ]

Related Doc. of [ 27311-63-3 ]

Product Details of [ 27311-63-3 ]

Calculated chemistry of [ 27311-63-3 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 27311-63-3 ]

Application In Synthesis of [ 27311-63-3 ]

[ 27311-63-3 ] Synthesis Path-Upstream 1~2

[ 27311-63-3 ] Synthesis Path-Downstream 1~33

Related Functional Groups of [ 27311-63-3 ]

Alcohols

Related Parent Nucleus of [ 27311-63-3 ]

Isoquinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 27311-63-3 ]

Related Parent Nucleus of
[ 27311-63-3 ]