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Chemical Structure| 27350-01-2 Chemical Structure| 27350-01-2

Structure of 27350-01-2

Chemical Structure| 27350-01-2

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Product Details of [ 27350-01-2 ]

CAS No. :27350-01-2
Formula : C8H8N2O2S
M.W : 196.23
SMILES Code : O=S(C1=CC=CC=C1CC#N)(N)=O
MDL No. :MFCD18292000

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Application In Synthesis of [ 27350-01-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27350-01-2 ]

[ 27350-01-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 27350-01-2 ]
  • [ 87253-62-1 ]
  • [ 1602577-69-4 ]
YieldReaction ConditionsOperation in experiment
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20.0℃; for 4.0h;Inert atmosphere; General procedure: In 25ml RB flask to a solution of Compound 9 (200 mg) in dry DMF (5ml), EDCI (250 mg, 1.25eq) and DMAP (130 mg,1eq) were added followed by addition of Sulfonamide (1eq). RM was stirred at RT for 4hrs. Solvent from the reaction mixture was evaporated. To the residue water was added and acidified with 6N HCl, solid precipitated out. Solid was filtered and dried. Crude solid was purified by flash chromatography eluating with 4-8% MeOH/DCM as solvent system to give pure product.
 

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