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Chemical Structure| 27798-43-2 Chemical Structure| 27798-43-2

Structure of 27798-43-2

Chemical Structure| 27798-43-2

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Product Details of [ 27798-43-2 ]

CAS No. :27798-43-2
Formula : C14H11ClO
M.W : 230.69
SMILES Code : ClC1=CC(CC(C2=CC=CC=C2)=O)=CC=C1
MDL No. :MFCD02260685

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Application In Synthesis of [ 27798-43-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27798-43-2 ]

[ 27798-43-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178686-24-3 ]
  • [ 27798-43-2 ]
  • [ 57-13-6 ]
  • [ 1283117-25-8 ]
YieldReaction ConditionsOperation in experiment
22.3% With hydrogenchloride; In ethanol; water; for 72.0h;Reflux; 00166] To a mixture of 2-(3-chlorophenyl)-l-phenylethanone (200 mg, 0.88 mmol),<strong>[178686-24-3]3-ethoxy-4-hydroxy-5-nitrobenzaldehyde</strong> (220 mg, 1.04 mmol), and urea (159 mg, 2.65 mmol) in anhydrous EtOH (20 mL) was added concentrated HC1 solution (0.1 mL), and the reaction mixture was refluxed for three days. When TLC (EtOAc:MeOH=10: l) showed that about 50% of starting materials were consumed, the reaction mixture was concentrated and purified by column chromatography (EtOAc:MeOH=40: l) and preparative HPLC to afford Compound 21 as a yellow solid (90 mg, yield 22.3%). 1H NMR (DMSO- 6 400 MHz): delta 10.30 (s, 1H), 8.81 (s, 1H), 7.60 (s, 1H), 7.45 (s, 1H), 7.25 (d, J = 4.0 Hz, 3H), 7.15-7.25 (m, 3H), 7.03 (d, J = 4.8 Hz, 2H), 6.71-6.81 (m, 2H), 5.25 (s, 1H), 4.00-4.10 (m, 2H), 1.33 (t, J = 6.8 Hz, 3H); MS (ESI): mJz 466.0 [M+l]+.
 

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