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CAS No. : | 27912-85-2 | MDL No. : | MFCD09951713 |
Formula : | C10H12O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | OZGUGVRKYBSDBN-UHFFFAOYSA-N |
M.W : | 180.20 | Pubchem ID : | 15608813 |
Synonyms : |
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.3 |
Num. rotatable bonds : | 5 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 48.69 |
TPSA : | 46.53 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.48 cm/s |
Log Po/w (iLOGP) : | 1.77 |
Log Po/w (XLOGP3) : | 1.29 |
Log Po/w (WLOGP) : | 1.53 |
Log Po/w (MLOGP) : | 1.41 |
Log Po/w (SILICOS-IT) : | 1.77 |
Consensus Log Po/w : | 1.55 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -1.78 |
Solubility : | 2.98 mg/ml ; 0.0165 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.87 |
Solubility : | 2.45 mg/ml ; 0.0136 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -2.72 |
Solubility : | 0.34 mg/ml ; 0.00189 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.66 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With oxalyl dichloride; In dichloromethane; at 20℃; for 3h;Inert atmosphere; Cooling with ice; | step one:Under nitrogen protection, 180 g of <strong>[27912-85-2]3-(benzyloxy)propionic acid</strong> was added to the reaction flask.1 L of dichloromethane, 95 g of oxalyl chloride was added dropwise under ice bath, and the reaction was carried out for 3 hours at room temperature.After completion of the reaction, the solvent was distilled under reduced pressure to give 180 g of Intermediate 1.Yield: 90%. |
With thionyl chloride; In N,N-dimethyl-formamide; | 1-(2-Benzyloxyethyl)-3-(2-chloroethyl)-2-imidazolidinon, 22a To <strong>[27912-85-2]3-benzyloxypropionic acid</strong> (129.6 g) in ether (310 ml) and N,N-dimethylformamide (4 ml) was added thionyl chloride (155 ml). The solution was refluxed for 2 hours, and solvents and excess thionyl chloride were removed by evaporation in vacuo. Yield 132 g of 3-Benzyloxypropionic acid chloride as an oil. | |
With thionyl chloride; In N-methyl-acetamide; | (b) Preparation of 3-benzyloxypropionyl chloride (VIII R1 =H, X=Cl) Thionyl chloride (60 ml) is added dropwise into a 500 ml four-necked flask fitted with a mechanical stirrer, a thermometer, a condenser and a dropping funnel, charged with <strong>[27912-85-2]3-benzyloxypropionic acid</strong> (100 g). Dimethylformamide (two drops) is then added while the temperature is kept at about 20 C. by means of a warm water bath. After stirring at room temperature for 2 hours the excess of thionyl chloride is removed by vacuum distillation and the residue is taken up twice with methylene chloride (two 100 ml portions). By evaporating the methylene chloride under reduced pressure 3-benzyloxypropionyl chloride (108.8 g) is obtained. |
With oxalyl dichloride; N,N-dimethyl-formamide; In hexane; at 0℃; for 1h; | Cool a solution of <strong>[27912-85-2]3-benzyloxy-propionic acid</strong> (1.66 g, 9.19 mmol) in hexanes (40 mL) to 0C and add oxalyl chloride (3.50 g, 27.6 mmol) dropwise. After the addition is completed, add DMF (2 drops) and stir the resulting mixture for 1 hour. Remove the solvent under reduced pressure and dissolve the crude acid chloride in dry THF (20 mL). In a separate flask, dissolve 2-AMINO-4- (3-TRIFLUOROMETHYL-PYRIDIN-2-YL)-BENZAMIDE (2.35 g, 8. 37 mmol) in dry THF (40 mL) and pyridine (0.727 g, 9.19 mmol) and cool to 0C. Add the solution containing the crude acid chloride dropwise to the second solution. Allow the mixture to warm to room temperature and stir for 1 hour. Add a solution of 10% NaOH (aq) (20 mL) to the mixture and stir the solution for 1 hour. Concentrate the mixture (-20 mL), dilute with water (20 mL), and acidify with conc. HCI. Extract the resulting solution with ETOAC (3 x 50 mL). Wash the combined organic extracts with brine and dry over NA2S04. Remove the solvent under reduced pressure to yield the title compound as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Sodium metal (249mg, 10. [8MMOL)] was added to benzyl alcohol (30g, [278MMOL)] at room temperature under nitrogen and the reaction was stirred for 30 minutes. Methyl acrylate (25. 9ml, 259mmol) was then added dropwise and the reaction was stirred at room temperature for 18h. After quenching with saturated aqueous ammonium chloride solution [(200ML)] the mixture was extracted with ethyl acetate [(2X300M1)] and the combined organic extracts were washed with brine [(100MOI),] dried over magnesium sulphate and concentrated under reduced pressure. The residual oil was dissolved in ethanol [(300MOI)] and 1M aqueous sodium hydroxide solution [(300ML)] was added dropwise. After 3 hours the ethanol was removed under reduced pressure and the aqueous residue was washed with [DICHLOROMETHANE] [(200ML).] The aqueous phase was then acidified with 2N aqueous hydrochloric acid (150ml), extracted with [DICHLOROMETHANE] [(2X250ML)] and the combined organic extracts were dried over magnesium sulphate and concentrated under reduced pressure. The residual oil was dissolved in 10% aqueous potassium carbonate [SOLUTION (300ML),] washed with diethylether [(300ML)] and the aqueous phase was acidified to pH1 using concentrated hydrochloric acid. The mixture was then extracted with [DICHLOROMETHANE] [(2X300M1)] and the combined organic extracts were dried over magnesium sulphate and concentrated under reduced pressure to provide the title compound (44.4g) as a colourless oil. | ||
With sodium hydroxide; water; In ethanol; for 3h; | Sodium metal (249 mg, 10.8 mmol) was added to benzyl alcohol (30 g, 278 mmol) at room temperature under nitrogen and the reaction was stirred for 30 minutes. Methyl acrylate (25.9 ml, 259 mmol) was then added dropwise and the reaction was stirred at room temperature for 18 h. After quenching with saturated aqueous ammonium chloride solution (200 ml) the mixture was extracted with ethyl acetate (2×300 ml) and the combined organic extracts were washed with brine (100 ml), dried over magnesium sulphate and concentrated under reduced pressure. The residual oil was dissolved in ethanol (300 ml) and 1 M aqueous sodium hydroxide solution (300 ml) was added dropwise. After 3 hours the ethanol was removed under reduced pressure and the aqueous residue was washed with dichloromethane (200 ml). The aqueous phase was then acidified with 2N aqueous hydrochloric acid (150 ml), extracted with dichloromethane (2×250 ml) and the combined organic extracts were dried over magnesium sulphate and concentrated under reduced pressure. The residual oil was dissolved in 10% aqueous potassium carbonate solution (300 ml), washed with diethylether (300 ml) and the aqueous phase was acidified to pH1 using concentrated hydrochloric acid. The mixture was then extracted with dichloromethane (2×300 ml) and the combined organic extracts were dried over magnesium sulphate and concentrated under reduced pressure to provide the title compound (44.4 g) as a colourless oil. 1H NMR (300 MHz, CDCl3): delta=2.67 (t, 2H), 3.89 (t, 2H), 4.58 (s, 2H), 7.18 (m, 5H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 1,1'-carbonyldiimidazole; In DMF (N,N-dimethyl-formamide); at 20℃; for 19h; | A suspension of magnesium turnings (1.74g, 71. 6mmol) in methanol [(85MI)] was heated at reflux under nitrogen for 1.5 hours, cooled to room temperature and the [P-KETO] acid from Preparation 4 (16.6g, [143MMOL)] was added. The reaction was stirred for 1.5 hours and the solvent was removed under reduced pressure to give the magnesium salt of the acid as a white solid. Meanwhile, the acid from Preparation 5 (12.9g, 71. [6MMOL)] was dissolved in [N,] [N'-DIMETHYLFORMAMIDE] (150ml) and [CARBONYLDIIMIDAZOLE] (12.8g, 78. [8MMOL)] was added portionwise under nitrogen at room temperature. This was stirred for 1 hour and then the magnesium salt from above was added as a solution in N, [N'-DIMETHYLFORMAMIDE] [(50ML).] Evolution of gas was noted, and the reaction was allowed to stir at room temperature for 18 hours. The mixture was concentrated under reduced pressure and the residual orange oil was dissolved in [DICHLOROMETHANE (300ML),] washed with 0.5M aqueous hydrochloric acid [(250ML)] containing methanol [(1 OML)] and the aqueous phase was separated and extracted with dichloromethane [(2X300ML).] The combined organic extracts were washed with brine (300ml) containing methanol (20ml), dried over magnesium sulphate, filtered and concentrated under reduced pressure. The residual orange oil was purified by flash chromatography on silica gel eluting with cyclohexane : ethyl acetate (80: 20, by volume) to provide the title compound (12. 0g) as an orange oil. | |
A suspension of magnesium turnings (1.74 g, 71.6 mmol) in methanol (85 ml) was heated at reflux under nitrogen for 1.5 hours, cooled to room temperature and the beta-keto acid from Preparation 4 (16.6 g, 143 mmol) was added. The reaction was stirred for 1.5 hours and the solvent was removed under reduced pressure to give the magnesium salt of the acid as a white solid. Meanwhile, the acid from Preparation 5 (12.9 g, 71.6 mmol) was dissolved in N,N'-dimethylformamide (150 ml) and carbonyldiimidazole (12.8 g, 78.8 mmol) was added portionwise under nitrogen at room temperature. This was stirred for 1 hour and then the magnesium salt from above was added as a solution in N,N'-dimethylformamide (50 ml). Evolution of gas was noted, and the reaction was allowed to stir at room temperature for 18 hours. The mixture was concentrated under reduced pressure and the residual orange oil was dissolved in dichloromethane (300 ml), washed with 0.5M aqueous hydrochloric acid (250 ml) containing methanol (10 ml) and the aqueous phase was separated and extracted with dichloromethane (2×300 ml). The combined organic extracts were washed with brine (300 ml) containing methanol (20 ml), dried over magnesium sulphate, filtered and concentrated under reduced pressure. The residual orange oil was purified by flash chromatography on silica gel eluting with cyclohexane:ethyl acetate (80:20, by volume) to provide the title compound (12.0 g) as an orange oil. 1H NMR (400 MHz, CDCl3): delta=1.17 (t, 3H), 2.33 (q, 2H), 2.58 (t, 2H), 3.76 (t, 2H), 4.53 (s, 2H), 5.57 (s, 1H), 7.13 (m, 5H). LRMS (electrospray): m/z [MNa+] 257. Microanalysis: Found C, 71.77; H, 7.74. C14H18O3 requires C, 71.76; H, 7.69%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Add sodium hydride (2.22 g, 60% dispersion in mineral oil, 55.4 mmol) in small portions to a cold (0C) solution of benzyl alcohol (4.0 g, 37 mmol) in toluene (100 mL). Add ethyl 3-bromopropionate (8.0 g, 44 mmol) dropwise to the mixture, allow the resulting solution to warm to room temperature and stir for 1 hour. Quench the reaction with the addition of water until all bubbling ceases. Dilute the mixture with ethyl acetate (100 mL) and extract with water (100 mL) and brine (100 mL). Dry the organic extract over NA2S04 and remove the solvent under reduced pressure to yield the crude ester as a clear oil. Dissolve the oil in methanol (20 mL) and 6 N NAOH (20 mL), stir for 1 hour, concentrate the mixture (-20 mL) and dilute with water (20 mL). Extract the aqueous mixture once with CHZCLZ (40 mL). Acidify the aqueous phase with conc. HCI, extract with EtOAc (3 x 50 mL), and dry the combined EtOAc extracts over NA2SO4. Remove the solvent under reduced pressure to yield the title compound as a clear oil that solidifies upon standing |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Meanwhile, the acid from Preparation 57 (12.9 g, 71.6 mmol) was dissolved in dimethylformamide (150 ml) and carbonyldiimidazole (12.8 g, 78.8 mmol) was added portionwise under nitrogen at room temperature. This was stirred for 1 hour and the magnesium salt from above was added as a solution in dimethylformamide (50 ml). Evolution of gas was noted, and the reaction was allowed to stir at room temperature for 18 hours. The mixture was concentrated under reduced pressure and the residual orange oil was dissolved in dichloromethane (300 ml), washed with 0.5M aqueous hydrochloric acid (250 ml) containing methanol (10 ml) and the aqueous phase was separated and extracted with dichloromethane (2*300 ml). The combined organic extracts were washed with brine (300 ml) containing methanol (20 ml), dried over magnesium sulphate and concentrated under reduced pressure. The residual orange oil was purified by flash chromatography on silica gel eluding with cyclohexane:ethyl acetate (80:20, by volume) to provide the title compound (12.0 g) as an orange oil. 1H NMR (400 MHz, CDCl3): delta=1.17 (t, 3H), 2.33 (q, 2H), 2.58 (t, 2H), 3.76 (t, 2H), 4.53 (s, 2H), 5.57 (s, 1H), 7.13 (m, 5H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In tetrahydrofuran; N-methyl-acetamide; ethyl acetate; benzene; | (2) Oxalyl chloride (880 mg) was added to a solution of <strong>[27912-85-2]3-benzyloxypropionic acid</strong> (1.04 g) in benzen (10 ml). Subsequently, dimethylformamide (100 mg) was added. After the resultant mixture was stirred for 30 minutes at room temperature, benzen was distilled off. Azeotropic distillation was performed twice through use of benzen (10 ml), and the resultant residue was dissolved in tetrahydrofuran (10 ml). To the solution were added 3-methyl-3-oxetanyl-methyl alcohol (620 mg) and then triethylamine (620 mg). The mixture was stirred for 5 hours at room temperature. Ethyl acetate was added to the reaction mixture, followed by washing with sat. aq. K2 CO3, water, 1N-HCl, water, and saturated brine and then drying over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate-hexane 2:1), to give 1.01 g of 3-methyl-3-oxetanylmethyl 3-benzyloxypropionate as a pale yellow oil. 1 H-NMR(CDCl3, ppm, TMS): 1.32(3H, s), 2.67(2H, t, J=6.4 Hz), 3.77(2H, t, J=6.4 Hz), 4.20(2H, s), 4.36(2H, d, J=6.1 Hz), 4.51(2H, t, J=6.1 Hz), 4.53(2H, s), 7.24-7.39(5H, m); IR(CDCl3)cm-1: 3012, 2968, 2878, 1736, 1455, 1379, 1365, 1249, 1183, 1103, 1072, 981, 834 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethyl acetate; acetone; | (1) To 3-benzyloxy-1-propanol (1.66 g) dissolved in acetone (10 ml) was added 2N Jones reagent (10 ml) while cooling on ice, and the mixture was stirred for 4 hours at room temperature. Ethyl acetate was added, and the resultant mixture was washed with water. The organic layer was extracted with a sat. aq. K2 CO3, and the aqueous layer was washed with ethyl acetate. The washed material was acidified with dilute HCl, again extracted with ethyl acetate, then washed with saturated brine. Drying over anhydrous magnesium sulfate and concentrating under reduced pressure yielded 1.27 g of 3-benzyloxypropionic acid as a colorless crystals. 1 H-NMR(CDCl3, ppm, TMS): 2.67(2H, t, J=6.4 Hz), 3.75(2H, t, J=6.4 Hz), 4.55(2H, s), 7.25-7.38(5H, m) IR(KBr)cm-1: 3430, 3032, 2927, 1716, 1455, 1366, 1235, 1201, 1104, 1072, 739, 698 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1) 10.36. 10-[5-[2-(benzyloxy)ethyl]-1,2,4-oxadiazol-3yl]-3-chloro-9H-imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine, m.p. 143-145 C., from 3-chloro-9H-imidazo[1,5-a]-[1,2,4]triazolo[1,5-d][1,4]benzodiazepine-10-carboxamidoxime and 3-(benzyloxy) propionic acid; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium aluminium deuteride; In tetrahydrofuran; at 0 - 20℃; | Step 1: To a mixture of L1AID4 (850mg, 20.2mmol) in THF (25mL) at 0 C under vigorous stirring is added 3-(benzyloxy) propanoic acid (3.2 g, 17.7 mmol) in batches. The mixture temperature is kept under 5 C during addition process. The mixture is then stirred at room temperature overnight and cooled to 0 C. Water (0.85mL) and NaOH (15%, 0.85mL) are slowly added to quench the reaction. The solvents are removed and the residue is diluted with dichloromethane (lOOmL) and dried over MgSCU. MgSCU is filtered and the filtrate is evaporated to dryness. The product 3-(benzyloxy)-l,l-dideuteriopropan-l-ol is obtained as a pale solid (2.86 g, yield 96%). This product is used directly in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With sulfuric acid;Inert atmosphere; Reflux; | To a solution of 17(500 mg, 2.77 mmol) in ethanol was added conc. H2SO4(cat.) and the solution heated at reflux overnight. The solution was allowed tocool and was evaporated in vaccuo. The yellow residue was dissolved in EtOAcand washed with sat. aq. NaHCO3 and brine, dried (Na2SO4),filtered and concentrated to provide the title compound as a yellow oil (330mg, 1.59 mmol, 57%).1H NMR: (400 MHz; CDCl3): 1.28 (3H,t, J = 7.2 Hz, OCH2CH3), 2.64 (2H, t, J = 6.3 Hz, BnOCH2), 3.78 (2H, t, J= 6.3 Hz, CH2COOEt), 4.18(2H, q, J = 7.2 Hz, OCH2CH3), 4.56 (2H,s, CH2Ph), 7.28-7.35 (5H,m, ArCH).13CNMR: (100 MHz; CDCl3): 14.20 (CH3), 35.22 (CH2), 60.52 (CH2),65.66 (CH2), 73.10 (CH2Ph),127.64, 127.66, 128.37, 138.10, (ArCH), 171.60 (C(O)). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | Isopropyl 3-hydroxypropanoate (E-3a) To a solution of <strong>[27912-85-2]3-benzyloxypropanoic acid</strong> (27.7 mmol) in propan-2-ol (40 mL) under nitrogen at 0 C. was added dropwise thionyl chloride (30.5 mmol). The reaction mixture was allowed to reach room temperature over 30 minutes and stirred at room temperature overnight. The mixture was diluted with CH2Cl2 and washed with a saturated solution of NaHCO3 and brine. The organic layer was dried on Na2SO4, filtered and concentrated under reduced pressure. The crude was diluted with isopropanol (80 mL) and Pd(OH)2 (20%, 1 g) in isopropanol was added. The system (reaction in a stainless steel reactor) was purged with nitrogen, vacuum and H2 and the reaction mixture was stirred under H2 atmosphere (3 bars) overnight at room temperature. The reaction mixture was filtered through autocup and the precipitate was washed with isopropanol. The filtrates were concentrated under reduced pressure and dried under vacuum pump to give the expected compound in 78% yield. 1H NMR (CDCl3, 400 MHz) delta (ppm) 1.26 (d, J=6.31 Hz, 6H), 2.19 (brs, 1H), 2.54 (t, J=5.56 Hz, 2H), 3.86 (t, J=5.56 Hz, 2H), 5.06 (heptuplet, J=6.25 Hz, 1H). |
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P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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