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Chemical Structure| 279261-80-2 Chemical Structure| 279261-80-2

Structure of 279261-80-2

Chemical Structure| 279261-80-2

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Product Details of [ 279261-80-2 ]

CAS No. :279261-80-2
Formula : C8H8BrClO
M.W : 235.51
SMILES Code : CCOC1=CC=C(Br)C=C1Cl
MDL No. :MFCD09835099
Boiling Point : No data available
InChI Key :JMGHGJRBIZDABO-UHFFFAOYSA-N
Pubchem ID :21938513

Safety of [ 279261-80-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 279261-80-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 279261-80-2 ]

[ 279261-80-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 279261-80-2 ]
  • [ 749929-97-3 ]
  • [ 945619-14-7 ]
  • 2
  • [ 279261-80-2 ]
  • [ 121-43-7 ]
  • 3-chloro-4-ethoxyphenyl borate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With n-butyllithium; sulfuric acid; In diethyl ether; hexane; To a solution of <strong>[279261-80-2]4-bromo-2-chloro-1-ethoxybenzene</strong> (12.0 g) in diethylether (100 ml) was added dropwise at -78 C. a solution of 1.6M n-butyllithium in hexane (35 ml), and the mixture was stirred for 1 hour. To the mixture was added dropwise a solution of trimethyl borate (17 ml) in diethylether (20 ml), and the mixture was allowed to warm to room temperature and then stirred at room temperature for 2 hours. To the mixture was added dropwise 10% sulfuric acid (100 ml), and the mixture was stirred for 1 hour and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried with magnesium sulfate. The solvent was evaporated under reduced pressure to give colorless crystals, which were collected by filtration and washed with hexane to give colorless crystals of 3-chloro-4-ethoxyphenyl borate (4.44 g). 1H-NMR (200 MHz, CDCl3) δ 1.53 (3H, t, J=7.0 Hz), 4.21 (2H, q, J=7.0 Hz), 7.02 (1H, d, J=8.2 Hz), 8.05 (1H, dd, J=8.2, 1.8 Hz), 8.14 (1H, d, J=1.8 Hz).
  • 3
  • [ 3964-56-5 ]
  • [ 75-03-6 ]
  • [ 279261-80-2 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In water; N,N-dimethyl-formamide; Reference Example 64 To a mixture of 4-bromo-2-chlorophenol (10.81 g) and potassium carbonate (8.65 g) in DMF (10 ml) was added at room temperature ethyl iodide (4.17 ml), and the mixture was stirred for 68 hours. To the mixture was added water, and the mixture was extracted with hexane. The organic layer was washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give pale yellow oil of 4-bromo-2-chloro-1-ethoxybenzene (12.28 g).
 

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