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Chemical Structure| 28179-02-4 Chemical Structure| 28179-02-4

Structure of 28179-02-4

Chemical Structure| 28179-02-4

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Product Details of [ 28179-02-4 ]

CAS No. :28179-02-4
Formula : C11H12O2
M.W : 176.21
SMILES Code : CC(C1=C(O)C2=C(CCC2)C=C1)=O
MDL No. :MFCD24690967
InChI Key :WLOCMAAVURAHCA-UHFFFAOYSA-N
Pubchem ID :18694177

Safety of [ 28179-02-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 28179-02-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 28179-02-4 ]

[ 28179-02-4 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 28179-02-4 ]
  • [ 91910-67-7 ]
  • 2
  • [ 38997-98-7 ]
  • [ 28179-02-4 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride;aluminium trichloride; In water; b) Intermediate (1-a) (0.37 mol) was heated to 100 C. Aluminum chloride (200 g) was added and the reaction mixture was stirred for 1 hour at 120 C. The reaction mixture was cooled and ice was added, followed by a mixture of water and concentrated hydrochloric acid. This mixture was extracted with 1,1'-oxybisethane. The organic layer was separated, treated with activated charcoal, dried (MgSO4), filtered and the filtrate was evaporated. The residue was purified by distillation (oil pump; 110 C.), yielding 29 g of 1-(2,3-dihydro-4-hydroxy-1H-inden-5-yl)ethanone (interm. 2-a).
  • 3
  • [ 28179-02-4 ]
  • [ 77-78-1 ]
  • [ 38998-01-5 ]
  • 4
  • [ 28179-02-4 ]
  • [ 91254-81-8 ]
  • [ 76-05-1 ]
  • [ 109-77-3 ]
  • 2-amino-4-(1-amino-3-methyl-butyl)-6-(4-hydroxy-indan-5-yl)-nicotinonitrile; compound with trifluoro-acetic acid [ No CAS ]
  • 5
  • [ 1641-41-4 ]
  • [ 28179-02-4 ]
  • 6
  • [ 28179-02-4 ]
  • [ 38998-08-2 ]
  • 7
  • [ 28179-02-4 ]
  • [ 38998-11-7 ]
  • 8
  • [ 28179-02-4 ]
  • [ 38998-03-7 ]
  • 9
  • [ 28179-02-4 ]
  • [ 38998-10-6 ]
  • 10
  • [ 28179-02-4 ]
  • [ 95-92-1 ]
  • 4,7,8,9-tetrahydro-4-oxocyclopenta[h]-1-benzopyran-2-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; sodium methylate; acetic acid; In toluene; c) Sodium methylate (24 g) was stirred in methylbenzene (300 ml). A mixture of diethyl oxalate (0.16 mol) and intermediate (2-a) (0.16 mol) in methylbenzene (10 ml) was added dropwise. This mixture was stirred and refluxed for 2 hours. The resulting precipitate was filtered off and dried. The solid was stirred in a mixture of hydrochloric acid (10 ml) and acetic acid (500 ml). The reaction mixture was stirred and refluxed for 1 hour. The mixture was poured out into water. The resulting precipitate was filtered off and dried (vacuum), yielding 21 g of 4,7,8,9-tetrahydro-4-oxocyclopenta[h]-1-benzopyran-2-carboxylic acid (interm. 3-a).
 

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