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Chemical Structure| 2856-54-4 Chemical Structure| 2856-54-4

Structure of 2856-54-4

Chemical Structure| 2856-54-4

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Product Details of [ 2856-54-4 ]

CAS No. :2856-54-4
Formula : C9H6Cl2N2O
M.W : 229.06
SMILES Code : O=C1NC(CCl)=NC2=C1C=C(Cl)C=C2
MDL No. :MFCD07339537

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Application In Synthesis of [ 2856-54-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2856-54-4 ]

[ 2856-54-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2343-22-8 ]
  • [ 2856-54-4 ]
  • 6-chloro-2-[(5-fluoroindolin-1-yl)methyl]-3H-quinazolin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
50.3% With triethylamine; In ethanol; at 80℃; for 22h; A suspension of 6-chloro-2-(chloromethyl)quinazolin-4(3H)-one (50 mg, 0.218 mmol) and triethylamine (0.091 ml, 0.655 mmol) in EtOH (2 mL) was treated with 5-f uoroindoline (35.9mg, 0.262 mmol) and the resulting suspension was stirred at 80 C for 22 h. The reaction mixture was concentrated onto silica and the cmde product was purified by chromatography on silica gel (12 g cartridge, 0-100% EtOAc(+0.5% Et3N)/isohexane) to afford 6-chloro-2-((5-fluoroindolin-l- yl)methyl)quinazolin-4(3H)-one (36.6 mg, 50.3 %) as a flocculent white solid. 1H NMR (500 MHz, DMSO-d6) d 12.46 (br s, 1H), 8.04 (d, 1H), 7.83 (dd, 1H), 7.66 (d, 1H), 6.94 (dd, 1H), 6.80 (ddd, 1H), 6.55 (dd, 1H), 4.17 (s, 2H), 3.50 (app. t, 2H), 2.93 (app. t, 2H). MS (ES+): 330/332 (M+H)+.
 

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