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Chemical Structure| 28587-05-5 Chemical Structure| 28587-05-5

Structure of 28587-05-5

Chemical Structure| 28587-05-5

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Product Details of [ 28587-05-5 ]

CAS No. :28587-05-5
Formula : C11H12ClNO
M.W : 209.67
SMILES Code : O=C(C1=CC=C(Cl)C=C1)/C=C/N(C)C
MDL No. :MFCD00172116

Safety of [ 28587-05-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 28587-05-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 28587-05-5 ]

[ 28587-05-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 580-15-4 ]
  • [ 28587-05-5 ]
  • 1-(4-chlorophenyl)-3-(quinolin-6-ylamino)prop-2-en-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% With potassium hydrogensulfate; In ethanol; water; at 20℃; for 0.166667h;Sonication; General procedure: To a mixture of 3-aminoquinoline (1 mmol) and enaminones4a (1 mmol) in 6 cm3of EtOH: H2O(1:1) taken in a roundbottomflask was added KHSO4(2 mmol) and the resultingmixture was irradiated in an ultrasound cleaner for 10 minat room temperature when a solid product precipitated out.The progress and completion of the reaction was monitoredby TLC. The precipitate was collected by filtration withrepeated washing with water to ensure complete removal ofthe acid and then dried to give a practically pure 5a in 89%yield. Further purification of 5a was carried out by silicagel column chromatography using 50% EtOAc-hexane.The rest of the enaminones 5b-5e, 6a-6e, and 7a-7e wereequally easily prepared in 10-12 min in 79-94% overallyields. The structures of these enaminones were unambiguouslyassigned with the help of analytical and spectral datapresented hereunder.
 

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Technical Information

• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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