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[ CAS No. 286836-25-7 ] {[proInfo.proName]}

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Chemical Structure| 286836-25-7
Chemical Structure| 286836-25-7
Structure of 286836-25-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 286836-25-7 ]

CAS No. :286836-25-7 MDL No. :MFCD18451086
Formula : C9H5BrO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 241.04 Pubchem ID :-
Synonyms :

Safety of [ 286836-25-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 UN#:N/A
Hazard Statements:H302-H312-H332 Packing Group:N/A
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Application In Synthesis of [ 286836-25-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 286836-25-7 ]

[ 286836-25-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 286836-25-7 ]
  • [ 199609-62-6 ]
  • 7-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)benzofuran-5-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% With bis-triphenylphosphine-palladium(II) chloride; potassium hydrogencarbonate; In 1,4-dioxane; water; at 100℃; for 3h;Inert atmosphere; General procedure: To a degassed solution of ethyl 2-(2-((7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)benzofuran-5-yl)methoxy)phenyl)acetate (le) (2 g, 4.58 mmol) in dioxane (24 mL) was added 4-bromothiophene-2-carbaldehyde (0.876 g, 5.01 mmol), bis(triphenylphosphine)Palladium(II)chloride [Pd(PPh3)2Cl2] (0.527 g, 0.751 mmol), a solution of K2CO3 (2.076 g, 15.02 mmol) in water (8 mL) and heated at 90 C for 3 h on oil bath under a nitrogen atmosphere. The reaction mixture was cooled to room temperature diluted with EtOAc (100 mL) and water (15 mL). The organic layer was separated, and aqueous layer was extracted with ethyl acetate (100 mL). The combined organic layers were dried, filtered and evaporated to dryness. The residue obtained was purified by flash column chromatography [silica gel 12 g, eluting with DMA-80 in DCM from 0-50%] to give ethyl 2- (2-((7-(5-formylthiophen-3-yl)benzofuran-5-yl)methoxy)phenyl)acetate (If) (2.022 g, 100 % yield) as a yellow syrup. NMR (300 MHz, DMSO-7e) 5 10.11 - 10.02 (m, 1H), 8.70 (s, 2H), 7.83 (d, 7 = 1.6 Hz, 1H), 7.72 (d, 7 = 1.6 Hz, 1H), 7.30 - 7.25 (m, 1H), 7.25 - 7.21 (m, 2H), 7.14 - 7.09 (m, 1H), 7.08 (d, 7 = 2.2 Hz, 1H), 6.92 (td, 7 = 7.4, 1.1 Hz, 1H), 5.24 (s, (0171) 2H), 3.98 - 3.92 (m, 2H), 3.65 (s, 2H), 1.00 (t, 7= 7.1 Hz, 3H).
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