Home Cart Sign in  
Chemical Structure| 286836-25-7 Chemical Structure| 286836-25-7

Structure of 286836-25-7

Chemical Structure| 286836-25-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 286836-25-7 ]

CAS No. :286836-25-7
Formula : C9H5BrO3
M.W : 241.04
SMILES Code : O=C(C1=CC(Br)=C(OC=C2)C2=C1)O
MDL No. :MFCD18451086

Safety of [ 286836-25-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 286836-25-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 286836-25-7 ]

[ 286836-25-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 286836-25-7 ]
  • [ 199609-62-6 ]
  • 7-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)benzofuran-5-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% With bis-triphenylphosphine-palladium(II) chloride; potassium hydrogencarbonate; In 1,4-dioxane; water; at 100℃; for 3h;Inert atmosphere; General procedure: To a degassed solution of ethyl 2-(2-((7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)benzofuran-5-yl)methoxy)phenyl)acetate (le) (2 g, 4.58 mmol) in dioxane (24 mL) was added 4-bromothiophene-2-carbaldehyde (0.876 g, 5.01 mmol), bis(triphenylphosphine)Palladium(II)chloride [Pd(PPh3)2Cl2] (0.527 g, 0.751 mmol), a solution of K2CO3 (2.076 g, 15.02 mmol) in water (8 mL) and heated at 90 C for 3 h on oil bath under a nitrogen atmosphere. The reaction mixture was cooled to room temperature diluted with EtOAc (100 mL) and water (15 mL). The organic layer was separated, and aqueous layer was extracted with ethyl acetate (100 mL). The combined organic layers were dried, filtered and evaporated to dryness. The residue obtained was purified by flash column chromatography [silica gel 12 g, eluting with DMA-80 in DCM from 0-50%] to give ethyl 2- (2-((7-(5-formylthiophen-3-yl)benzofuran-5-yl)methoxy)phenyl)acetate (If) (2.022 g, 100 % yield) as a yellow syrup. NMR (300 MHz, DMSO-7e) 5 10.11 - 10.02 (m, 1H), 8.70 (s, 2H), 7.83 (d, 7 = 1.6 Hz, 1H), 7.72 (d, 7 = 1.6 Hz, 1H), 7.30 - 7.25 (m, 1H), 7.25 - 7.21 (m, 2H), 7.14 - 7.09 (m, 1H), 7.08 (d, 7 = 2.2 Hz, 1H), 6.92 (td, 7 = 7.4, 1.1 Hz, 1H), 5.24 (s, (0171) 2H), 3.98 - 3.92 (m, 2H), 3.65 (s, 2H), 1.00 (t, 7= 7.1 Hz, 3H).
 

Historical Records

Technical Information

Categories