[ CAS No. 2896-67-5 ] {[proInfo.proName]}

Name: 2896-67-5|2-Methoxy-6-methylphenol|97%
Brand: Ambeed
SKU: A388180
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2D 3D

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Quality Control of [ 2896-67-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 2896-67-5 ]

SDS Specification

Alternatived Products of [ 2896-67-5 ]

Product Details of [ 2896-67-5 ]

CAS No. :	2896-67-5	MDL No. :	MFCD00043771
Formula :	C₈H₁₀O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	WBHAUHHMPXBZCQ-UHFFFAOYSA-N
M.W :	138.16	Pubchem ID :	76173
Synonyms :

Calculated chemistry of [ 2896-67-5 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.25
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	39.92
TPSA :	29.46 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.62 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.96
Log Po/w (XLOGP3) :	2.14
Log Po/w (WLOGP) :	1.71
Log Po/w (MLOGP) :	1.48
Log Po/w (SILICOS-IT) :	1.8
Consensus Log Po/w :	1.82

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.42
Solubility :	0.522 mg/ml ; 0.00378 mol/l
Class :	Soluble
Log S (Ali) :	-2.39
Solubility :	0.562 mg/ml ; 0.00407 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.31
Solubility :	0.68 mg/ml ; 0.00492 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.0

Safety of [ 2896-67-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2896-67-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 2896-67-5 ]

[ 2896-67-5 ] Synthesis Path-Downstream 1~88

1
[ 40838-34-4 ]
[ 2896-67-5 ]
5-methoxy-2-(2-methoxy-6-methyl-phenoxymethyl)-pyran-4-one [ No CAS ]

Reference： [1]Patent: US2865930,1955,

2
[ 463-04-7 ]
[ 2896-67-5 ]
[ 857009-39-3 ]

Reference： [1]Journal of the Chemical Society,1955,p. 2619,2622

3
[ 67-66-3 ]
[ 2896-67-5 ]
[ 32263-14-2 ]

Reference： [1]Helvetica Chimica Acta,1930,vol. 13,p. 482,486

4
[ 2896-67-5 ]
[ 40940-01-0 ]

Reference： [1]Journal of the Chemical Society,1955,p. 2619,2622
[2]Journal of the Chemical Society,1955,p. 2619,2622

5
[ 2896-67-5 ]
[ 854214-79-2 ]

Reference： [1]Chemistry - A European Journal,2019,vol. 25,p. 2713 - 2716
[2]Journal of the Chemical Society,1955,p. 2619,2622

6
[ 2896-67-5 ]
2-benzoyloxy-3-methoxy-toluene [ No CAS ]

Reference： [1]Journal of the Chemical Society,1949,p. 3189,3193

7
[ 2896-67-5 ]
[ 40940-01-0 ]

Reference： [1]Chemische Berichte,1920,vol. 53,p. 1913
[2]Chemische Berichte,1920,vol. 53,p. 1913

8
[ 2896-67-5 ]
[ 488-17-5 ]

Yield	Reaction Conditions	Operation in experiment
91.3%	With hydrogen bromide; In water; at 85 - 90℃; for 6h;	Preparation of 3-methylcatechol from 2-methoxy-6-methylcatechol:[00104] To a 250 ml of flask <strong>[2896-67-5]2-methoxy-6-methylphenol</strong> (5.0 g, 36.2 mmol) is charged along with 40 ml of a 48% aqueous hydrobromic acid solution. The mixture is heated to 85- 90 C for 6 hours. After cooling to room temperature, the mixture was extracted with ethyl acetate. The ethyl acetate extract is washed with water and brine, and then dried over magnesium sulfate. After filtration, the filtrate is concentrated, and dried in vacuo to yield 4.1 g (91.3%) of the product as a yellowish liquid. NMR: 6.71 (s, 3H), 5.20 (br.s, 2H), 2.25 (s, 3H).

Reference： [1]Patent: WO2012/135189,2012,A2 .Location in patent: Page/Page column 17
[2]Journal of applied chemistry of the USSR,1985,vol. 58,p. 2520 - 2521
[3]Chemische Berichte,1916,vol. 49,p. 1490

9
2-(2-methoxy-6-methyl-phenoxy)-5-nitro-benzophenone [ No CAS ]
[ 2896-67-5 ]

Reference： [1]Journal of the Chemical Society,1953,p. 265,268

10
[ 148-53-8 ]
[ 2896-67-5 ]

Yield	Reaction Conditions	Operation in experiment
95%	With hydrogen;5%-palladium/activated carbon; In acetic acid; ethyl acetate; at 20℃; for 84h;	A 3-liter three-necked flask equipped with a thermometer and a mechanical stirrer was charged with 300 g (1.97 moles) of o-vaniline, 100 g of palladium-carbon supporting 5% by weight of palladium, 2 liters of ethyl acetate and 500 ml of acetic acid. The contents were stirred under a hydrogen atmosphere and at room temperature, for 84 hours. The reaction mixture thus obtained was filtered and the filtrate was condensed. To the condensate, 2 liters of ethyl acetate was added again, and the mixture was washed with 1 liter of water three times. The obtained organic layer was condensed and cooled, to yield 259 g of colorless crystal of 2-hydroxy-3-methoxytoluene having the following properties. The yield was 95% based on the o-vaniline.1H-NMR (270 MHz, deuterated benzene, TMS, ppm) delta : 2.28 (s, 3H. Ar-CH3), 3.19 (s. 3H, Ar-O-CH3), 5.78(s. 1H, Ar-OH), 6.38 (d, 1H), 6.63-6.80 (m. 2H).
	With hydrogen;5%-palladium/activated carbon; In methanol; at 20℃; for 72h;Inert atmosphere;	EXAMPLES[0099] Preparation of 2-methoxy-6-methylphenol from hydrogenation of o-vanillin [00100] This reaction is performed inside a drybox for safety precautions because hydrogen gas is used. During the procedure, the drybox is purged periodically with nitrogen to ensure no build up of hydrogen gas. An adaptor with a balloon on one end is attached to a 250 mL flask with a side arm and a magnetic stir bar. One gram of Pd on carbon (5% Pd) is charged slowly into the flask. Then, 7.6 g of o-vanillin and 100 ml of methanol are added. Through the side-arm, hydrogen gas is introduced into the flask system until the balloon is inflated to a volume of about 250 ml. The reaction is allowed to stir at room temperature for 3 days. Hydrogen gas is added when the balloon deflates due to the reaction and diffusion. GC samples are taken to monitor the reaction. When reaction is complete, as evidenced by the appearance of the intermediate first and then by the appearance of the product, the gas inside the balloon and flask is released slowly. The reaction is stirred openly inside the dry box for another 10 minutes to ensure complete dissipation of hydrogen inside the flask into the dry box. The dry box is also purged several times with nitrogen. The flask is taken out of the drybox. The reaction mixture is filtered to separate off the catalyst. The solvent is removed to yield the crude product. The GC and NMR data are compared with the authentic sample to be 2-methoxy-6-methylphenol. Yield is 7.3 g or 95%

Reference： [1]Journal of the American Chemical Society,1995,vol. 117,p. 12691 - 12699
[2]Organic Letters,2015,vol. 17,p. 2030 - 2033
[3]Zeitschrift fur Naturforschung, B: Chemical Sciences,1993,vol. 48,p. 387 - 393
[4]Journal of Organic Chemistry,1986,vol. 51,p. 4347 - 4353
[5]Journal of Organic Chemistry,2002,vol. 67,p. 6493 - 6502
[6]Patent: EP1489087,2004,A1 .Location in patent: Page 11
[7]Journal of applied chemistry of the USSR,1985,vol. 58,p. 2520 - 2521
[8]Chemical Research in Toxicology,1997,vol. 10,p. 335 - 343
[9]European Journal of Organic Chemistry,2014,vol. 2014,p. 2565 - 2575
[10]Chemische Berichte,1939,vol. 72,p. 367,370
Nippon Kagaku Kaishi,1939,vol. 60,p. 276
[11]Patent: US2366611,1943,
[12]Patent: US2366611,1943,
[13]Helvetica Chimica Acta,1930,vol. 13,p. 482,486
[14]Monatshefte fur Chemie,1954,vol. 85,p. 802,805
[15]Chemische Berichte,1916,vol. 49,p. 1490
[16]Justus Liebigs Annalen der Chemie,1970,vol. 740,p. 18 - 30
[17]Acta Chemica Scandinavica,1989,vol. 43,p. 44 - 50
[18]Gazzetta Chimica Italiana,1982,vol. 112,p. 513 - 518
[19]Journal of Natural Products,2001,vol. 64,p. 2 - 5
[20]Angewandte Chemie - International Edition,2007,vol. 46,p. 4077 - 4080
[21]Patent: WO2012/135189,2012,A2 .Location in patent: Page/Page column 16-17
[22]ACS Catalysis,2015,vol. 5,p. 6964 - 6972
[23]Organic Letters,2019,vol. 21,p. 8761 - 8764
[24]ChemSusChem,2020

11
[ 2896-67-5 ]
[ 121-33-5 ]
2,2',2''-trimethoxy-6,6'-dimethyl-4,4',4''-methanetriyl-tri-phenol [ No CAS ]

Reference： [1]Patent: DE686987,1937,
DRP/DRBP Org.Chem.,

12
[ 2896-67-5 ]
[ 106-95-6 ]
[ 186743-33-9 ]

Reference： [1]Chemical Research in Toxicology,1997,vol. 10,p. 335 - 343
[2]Chemische Berichte,1939,vol. 72,p. 367,370
Nippon Kagaku Kaishi,1939,vol. 60,p. 276

13
[ 2896-67-5 ]
[ 74-88-4 ]
[ 4463-33-6 ]

Reference： [1]Chemische Berichte,1916,vol. 49,p. 1490

14
[ 2896-67-5 ]
[ 26674-18-0 ]
[ 71233-03-9 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1979,p. 879 - 884

15
[ 2896-67-5 ]
[ 67-68-5 ]
[ 18738-47-1 ]

Reference： [1]Monatshefte fur Chemie,1968,vol. 99,p. 1034 - 1044

16
[ 110-89-4 ]
[ 50-00-0 ]
[ 2896-67-5 ]
[ 66495-65-6 ]

Reference： [1]Arzneimittel-Forschung/Drug Research,1988,vol. 38,p. 501 - 507

17
[ 4383-05-5 ]
[ 2896-67-5 ]

Reference： [1]Journal of Medicinal Chemistry,1986,vol. 29,p. 2315 - 2325

18
[ 4463-33-6 ]
[ 2896-67-5 ]

Reference： [1]Synthetic Communications,1996,vol. 26,p. 49 - 62
[2]Australian Journal of Chemistry,1985,vol. 38,p. 777 - 792
[3]Journal of the Chemical Society. Chemical communications,1984,p. 227 - 229

19
[ 2896-67-5 ]
[ 611-68-7 ]

Reference： [1]Journal of Organic Chemistry,1989,vol. 54,p. 5712 - 5727
[2]Journal of Organic Chemistry,1986,vol. 51,p. 4347 - 4353
[3]Zeitschrift fur Naturforschung, B: Chemical Sciences,1993,vol. 48,p. 387 - 393
[4]Journal of the American Chemical Society,1995,vol. 117,p. 12691 - 12699
[5]Journal of Organic Chemistry,1994,vol. 59,p. 6567 - 6587
[6]Journal of Natural Products,2001,vol. 64,p. 2 - 5
[7]Journal of Organic Chemistry,1988,vol. 53,p. 4263 - 4273
[8]Chemische Berichte,1916,vol. 49,p. 1490
[9]Chemische Berichte,1916,vol. 49,p. 1490
[10]Chemische Berichte,1916,vol. 49,p. 1490
[11]Organic and Biomolecular Chemistry,2011,vol. 9,p. 70 - 73
[12]Organic Letters,2019,vol. 21,p. 8761 - 8764

20
[ 5034-74-2 ]
[ 2896-67-5 ]
[ 86232-54-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1983,vol. 19,p. 458 - 463
Zhurnal Organicheskoi Khimii,1983,vol. 19,p. 522 - 528

21
[ 2896-67-5 ]
[ 108-24-7 ]
[ 60632-42-0 ]

Reference： [1]Gazzetta Chimica Italiana,1982,vol. 112,p. 513 - 518

22
[ 50-00-0 ]
[ 2896-67-5 ]
[ 124-40-3 ]
[ 104113-84-0 ]

Reference： [1]Journal of Organic Chemistry,1988,vol. 53,p. 4263 - 4273
[2]Journal of Medicinal Chemistry,1986,vol. 29,p. 2315 - 2325

23
[ 488-17-5 ]
[ 74-88-4 ]
[ 18102-31-3 ]
[ 2896-67-5 ]

Reference： [1]Acta Chemica Scandinavica,1989,vol. 43,p. 44 - 50

24
[ 2896-67-5 ]
[ 98-09-9 ]
2-methoxy-6-methyl-1-phenyl benzenesulfonate [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,1995,vol. 30,p. 179 - 190

25
[ 67-56-1 ]
[ 2896-67-5 ]
(+/-)-(1R,2R,7R,8S)-5,8-dimethyl-3,3,10,10-tetramethoxytricyclo[6.2.2.0^2,7]dodeca-5,11-diene-4,9-dione [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2006,vol. 4,p. 2267 - 2277
[2]RSC Advances,2015,vol. 5,p. 8050 - 8055
[3]Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,1975,vol. 29,p. 948 - 952
[4]RSC Advances,2013,vol. 3,p. 1165 - 1178
[5]European Journal of Organic Chemistry,2014,vol. 2014,p. 2565 - 2575

26
[ 50-00-0 ]
[ 2896-67-5 ]
[ 37987-18-1 ]

Reference： [1]Monatshefte fur Chemie,1972,vol. 103,p. 1178 - 1193
[2]Archiv der Pharmazie,1963,vol. 296,p. 650 - 660

27
[ 50-00-0 ]
[ 2896-67-5 ]
[ 93728-07-5 ]

Reference： [1]Archiv der Pharmazie,1963,vol. 296,p. 650 - 660

28
[ 1731-79-9 ]
[ 2896-67-5 ]
[ 30151-75-8 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1970,vol. 740,p. 18 - 30

29
[ 100-97-0 ]
[ 2896-67-5 ]
[ 32263-14-2 ]

Reference： [1]Monatshefte fur Chemie,1975,vol. 106,p. 1191 - 1201

30
[ 85-44-9 ]
[ 2896-67-5 ]
[ 602-63-1 ]

Reference： [1]Synthetic Communications,1996,vol. 26,p. 49 - 62

31
[ 4463-33-6 ]
[ 18102-31-3 ]
[ 2896-67-5 ]

Reference： [1]Journal of Organic Chemistry,1997,vol. 62,p. 4097 - 4104
[2]Synlett,2004,p. 1104 - 1106
[3]European Journal of Organic Chemistry,2006,p. 752 - 758

32
[ 2896-67-5 ]
[ 86232-54-4 ]

Yield	Reaction Conditions	Operation in experiment
66%	With N-Bromosuccinimide; acetic acid; In dichloromethane; at 20℃; for 21.5h;	10a) 4-bromo-2-methoxy-6-methyl-phenol A solution of 56.2 g (0.32 mol) N-bromosuccinimide in 1700 mL AcOH was added dropwise within 5.5 h to a solution of 42.3 g (0.31 mol) 2-methoxy-6-methyl-phenol in 450 mL AcOH and the mixture was stirred for 16 h at RT. The reaction mixture was concentrated by evaporation i. vac. and the residue was taken up in DCM. The organic phase was washed with 5% NaHCO3 and saturated NaCl solution, dried on Na2SO4 and concentrated by evaporation i. vac. The red oil was used in the next reaction step without any further purification. Yield: 65.9 g (66% of theory) Rf=0.32 (silica gel, hexane/EtOAc 4:1) Retention time (HPLC-MS): 11.1 min (method D)
66%		Within 5.5 h a solution of 56.2 g (0.32 mol) N-bromosuccinimide in 1700 mL AcOH was added dropwise to a solution of 42.3 g (0.31 mol) 2-methoxy-6-methyl-phenol in 450 mL AcOH and the mixture was stirred for 16 h at RT. The reaction mixture was concentrated by evaporation i. vac. and the residue was taken up in DCM. The organic phase was washed with 5% NaHCO3 and saturated NaCl solution, dried on Na2SO4 and concentrated by evaporation i. vac. The red oil was used in the next reaction step without further purification.Yield: 65.9 g (66% of theory)Rf=0.32 (silica gel, hexane/EtOAc 4:1)Retention time (HPLC-MS): 11.1 min (Method D)

Reference： [1]Organic Letters,2015,vol. 17,p. 2030 - 2033
[2]Synlett,1997,p. 1351 - 1352
[3]Journal of Organic Chemistry,2002,vol. 67,p. 6493 - 6502
[4]Patent: US2007/72847,2007,A1 .Location in patent: Page/Page column 100
[5]Patent: US2008/280887,2008,A1 .Location in patent: Page/Page column 61
[6]Patent: WO2006/100009,2006,A1 .Location in patent: Page/Page column 117-118

33
[ 25414-22-6 ]
[ 67-56-1 ]
[ 2896-67-5 ]
(1R,2R,6R,7S)-4,4,9,9-Tetramethoxy-7-methyl-3-oxa-tricyclo[5.2.2.0^2,6]undec-10-en-8-one [ No CAS ]

Reference： [1]Chemical Communications,1999,p. 713 - 714

34
[ 4383-05-5 ]
[ 824-42-0 ]
[ 2896-67-5 ]
[ 95-48-7 ]

Reference： [1]Journal of Organic Chemistry,2000,vol. 65,p. 1376 - 1389

35
[ 104199-12-4 ]
[ 824-42-0 ]
[ 2896-67-5 ]
[ 95-48-7 ]

Reference： [1]Journal of Organic Chemistry,2000,vol. 65,p. 1376 - 1389

37
[ 67-66-3 ]
[ 2896-67-5 ]
aqueous NaOH [ No CAS ]
[ 32263-14-2 ]

Reference： [1]Helvetica Chimica Acta,1930,vol. 13,p. 482,486

39
[ 64-17-5 ]
[ 2896-67-5 ]
[ 7722-84-1 ]
[ 854214-79-2 ]

Reference： [1]Journal of the Chemical Society,1955,p. 2619,2622

40
[ 2896-67-5 ]
8-benzyloxy-3,7-dimethoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline [ No CAS ]
4-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-2-methoxy-6-methyl-phenol [ No CAS ]

Reference： [1]Synlett,2000,p. 801 - 804

41
[ 67-56-1 ]
[ 2896-67-5 ]
[ 67903-06-4 ]

Yield	Reaction Conditions	Operation in experiment
	With [bis(acetoxy)iodo]benzene; In dichloromethane; at -40℃; for 0.166667h;Inert atmosphere;	General procedure: To a solution of the masked o-benzoquinones, which was in situ prepared by the teatment of guaiacols 5 (0.80 mmol) withDIB (399 mg, 1.24 mmol) for 10 min at -40 C in the mixed solvent of MeOH (3.0 mL) and DCM (3.0 mL), was addeddropwise a solution of hydroxamic acid (1a: 54.9 mg, 1b: 66.9 mg, 1c: 53.3 mg; 0.40 mmol) in the mixed solvent of MeOH(0.5 mL) and DCM (2.0 mL) at the same temperature over 3 h. After being stirred at the same temperature for 0.5 h, thereaction mixture was allowed to warm to room temperature, and then concentrated in vacuo to dryness. The residue waspurified by medium pressure liquid chromatography (MPLC, hexane/EtOAc 1:4, flow rate 20 mL/min) to give 6aa-6ag and6ba, or by PTLC (hexane/EtOAc 1:1) to give 5ca.

Reference： [1]Chemical Communications,2001,p. 1624 - 1625
[2]Journal of Organic Chemistry,2015,vol. 80,p. 10979 - 10991
[3]Beilstein Journal of Organic Chemistry,2018,vol. 14,p. 531 - 536
[4]Journal of the Chinese Chemical Society,2020,vol. 67,p. 383 - 398

42
[ 504-61-0 ]
[ 3240-34-4 ]
[ 2896-67-5 ]
[ 611-68-7 ]
4-hydroxy-3-methoxy-5-methylphenyl acetate [ No CAS ]
(+/-)-(1R,3R,6R,7R,10R)-3-methoxy-1,10-dimethyl-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-2-one [ No CAS ]
(+/-)-(1R,3R,6R,7S,10R)-3-methoxy-1,10-dimethyl-2-oxo-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-8-yl acetate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2002,vol. 67,p. 8157 - 8165

43
[ 627-27-0 ]
[ 3240-34-4 ]
[ 2896-67-5 ]
[ 611-68-7 ]
4-hydroxy-3-methoxy-5-methylphenyl acetate [ No CAS ]
(+/-)-(1S,3R,7S,8R)-3-methoxy-1-methyl-4-oxatricyclo[5.3.1.0^3,8]undec-9-en-2-one [ No CAS ]
(+/-)-(1S,3R,7S,8S)-3-methoxy-1-methyl-2-oxo-4-oxatricyclo[5.3.1.0^3,8]undec-9-en-9-yl acetate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2002,vol. 67,p. 8157 - 8165

44
[ 67-56-1 ]
[ 2896-67-5 ]
[ 78-94-4 ]
(+/-)-(1R,2R,7R,8S)-5,8-dimethyl-3,3,10,10-tetramethoxytricyclo[6.2.2.0^2,7]dodeca-5,11-diene-4,9-dione [ No CAS ]
(+/-)-(1S,4S,7S)-7-acetyl-3,3-dimethoxy-1-methylbicyclo[2.2.2]oct-5-en-2-one [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2002,vol. 67,p. 6493 - 6502

45
[ 3240-34-4 ]
[ 2896-67-5 ]
[ 107-18-6 ]
[ 611-68-7 ]
4-hydroxy-3-methoxy-5-methylphenyl acetate [ No CAS ]
(+/-)-(1S,3R,6R,7R)-3-methoxy-1-methyl-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-2-one [ No CAS ]
(+/-)-(1S,3R,6R,7S)-3-methoxy-1-methyl-2-oxo-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-8-yl acetate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2002,vol. 67,p. 8157 - 8165

46
[ 67-56-1 ]
[ 2896-67-5 ]
[ 292638-85-8 ]
(+/-)-(1R,2R,7R,8S)-5,8-dimethyl-3,3,10,10-tetramethoxytricyclo[6.2.2.0^2,7]dodeca-5,11-diene-4,9-dione [ No CAS ]
(+/-)-methyl (1S,2S,4S)-8,8-dimethoxy-1-methyl-7-oxobicyclo[2.2.2]oct-5-ene-2-carboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2002,vol. 67,p. 6493 - 6502

47
[ 67-56-1 ]
[ 2896-67-5 ]
[ 80-62-6 ]
(+/-)-(1R,2R,7R,8S)-5,8-dimethyl-3,3,10,10-tetramethoxytricyclo[6.2.2.0^2,7]dodeca-5,11-diene-4,9-dione [ No CAS ]
(+/-)-methyl (1S,2S,4S)-8,8-dimethoxy-1,2-dimethyl-7-oxobicyclo[2.2.2]oct-5-ene-2-carboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2002,vol. 67,p. 6493 - 6502

48
[ 3240-34-4 ]
[ 2896-67-5 ]
[ 4407-36-7 ]
[ 611-68-7 ]
4-hydroxy-3-methoxy-5-methylphenyl acetate [ No CAS ]
(+/-)-(1R,3R,6S,7R,10S)-3-methoxy-1-methyl-10-phenyl-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-2-one [ No CAS ]
(+/-)-(1R,3R,6R,7S,10R)-3-methoxy-1-methyl-2-oxo-10-phenyl-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-8-yl acetate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2002,vol. 67,p. 8157 - 8165

49
[ 4949-20-6 ]
[ 2896-67-5 ]
(2aRS,5aRS,8aRS,8bSR)-8a-methoxy-7-methyl-2a,5,5a,8,8a,8b-hexahydro-2H-benzo[cd]isobenzofuran-8-one [ No CAS ]
(1RS,3RS,6RS,7SR,10RS)-3-methoxy-1-methyl-10-vinyl-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-2-one [ No CAS ]
[ 28814-66-6 ]

Reference： [1]Journal of Organic Chemistry,2005,vol. 70,p. 9156 - 9167

50
[ 17102-64-6 ]
[ 2896-67-5 ]
(1RS,3RS,6RS,7SR,10RS)-3-methoxy-1-methyl-10-[(E)-1-propenyl]-4-oxatricyclo[4.3.1.0^3,7]dec-8-en-2-one [ No CAS ]
(2aRS,5SR,5aRS,8aRS,8bSR)-8a-methoxy-5,7-dimethyl-2a,5,5a,8,8a,8b-hexahydro-2H-benzo[cd]isobenzofuran-8-one [ No CAS ]
(1RS,3RS,6RS,7RS,10RS)-3-methoxy-1-methyl-10-[(E)-1-propenyl]-4-oxatricyclo[4.3.1.0^3,7]decane-2,8-dione [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2005,vol. 70,p. 9156 - 9167

51
[ 2896-67-5 ]
[ 124-63-0 ]
2-methoxy-6-methylphenyl methanesulfonate [ No CAS ]

Reference： [1]European Journal of Organic Chemistry,2006,p. 752 - 758

52
[ 914454-81-2 ]
[ 2896-67-5 ]

Reference： [1]European Journal of Medicinal Chemistry,2006,vol. 41,p. 1025 - 1040

53
[ 2896-67-5 ]
[ 106-93-4 ]
[ 914454-87-8 ]

Reference： [1]European Journal of Medicinal Chemistry,2006,vol. 41,p. 1025 - 1040

54
[ 123-73-9 ]
[(CO)5Cr=C(OMe)CH₃] [ No CAS ]
[ 2896-67-5 ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 17162 - 17163

55
[ 2896-67-5 ]
[ 1011264-21-3 ]

Yield	Reaction Conditions	Operation in experiment
		4,N-Dihydroxy-3-methoxy-5-methyl-benzamidineThe title compound is prepared from commercially available 2-methoxy-6-methyl-phenol in analogy to literature procedures (e.g B. Roth et al. J. Med. Chem. 31 (1988) 122-129; and literature cited for 3-ethyl-4,N-dihydroxy-5-methyl-benzamidine); LC-MS: tR = 0.50 min; [M+1]+ = 197.23.

Reference： [1]Patent: WO2008/29371,2008,A1 .Location in patent: Page/Page column 54

56
[ 2896-67-5 ]
[ 18162-48-6 ]
C₁₄H₂₄O₂Si [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2007,vol. 46,p. 4077 - 4080

57
[ 2896-67-5 ]
[ 914454-99-2 ]

Reference： [1]European Journal of Medicinal Chemistry,2006,vol. 41,p. 1025 - 1040

58
[ 2896-67-5 ]
[ 914454-92-5 ]

Reference： [1]European Journal of Medicinal Chemistry,2006,vol. 41,p. 1025 - 1040

59
[ 2896-67-5 ]
(S)-2-[((2-(2-methyl-6-methoxyphenoxy)ethyl)amino)methyl]-1,4-benzodioxane [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,2006,vol. 41,p. 1025 - 1040

60
[ 2896-67-5 ]
(R)-2-[((2-(2-methyl-6-methoxyphenoxy)ethyl)amino)methyl]-1,4-benzodioxane hydrochloride [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,2006,vol. 41,p. 1025 - 1040

61
[ 150710-99-9 ]
[ 2896-67-5 ]

Reference： [1]European Journal of Medicinal Chemistry,2006,vol. 41,p. 1025 - 1040

62
[ 2896-67-5 ]
[ 186743-24-8 ]

Reference： [1]Chemical Research in Toxicology,1997,vol. 10,p. 335 - 343
[2]Chemische Berichte,1939,vol. 72,p. 367,370
Nippon Kagaku Kaishi,1939,vol. 60,p. 276

63
[ 2896-67-5 ]
6-methylisoeugenol [ No CAS ]

Reference： [1]Chemical Research in Toxicology,1997,vol. 10,p. 335 - 343

64
[ 2896-67-5 ]
(1R,2R,6R,7S)-9,9-Dimethoxy-7-methyl-3-oxa-tricyclo[5.2.2.0^2,6]undec-10-ene-4,8-dione [ No CAS ]

Reference： [1]Chemical Communications,1999,p. 713 - 714

65
[ 2896-67-5 ]
[ 302321-77-3 ]

Reference： [1]Synlett,1997,p. 1351 - 1352
[2]Organic Letters,2015,vol. 17,p. 2030 - 2033

66
[ 2896-67-5 ]
(+/-)-methyl (1S,2S,4S)-8,8-dimethoxy-1-methyl-7-oxobicyclo[2.2.2]oct-5-ene-2-carboxylate [ No CAS ]

Reference： [1]Synlett,1997,p. 1351 - 1352

67
[ 2896-67-5 ]
(+/-)-methyl (1S,2S,4S)-8,8-dimethoxy-1,2-dimethyl-7-oxobicyclo[2.2.2]oct-5-ene-2-carboxylate [ No CAS ]

Reference： [1]Synlett,1997,p. 1351 - 1352

68
[ 2896-67-5 ]
(+/-)-methyl (1S,2S,4R)-5-bromo-8,8-dimethoxy-1-methyl-7-oxobicyclo[2.2.2]oct-5-ene-2-carboxylate [ No CAS ]

Reference： [1]Synlett,1997,p. 1351 - 1352

69
[ 2896-67-5 ]
(+/-)-methyl (1S,2S,4R)-5-bromo-8,8-dimethoxy-1,2-dimethyl-7-oxobicyclo[2.2.2]oct-5-ene-2-carboxylate [ No CAS ]

Reference： [1]Synlett,1997,p. 1351 - 1352

70
[ 2896-67-5 ]
laccase [ No CAS ]
[ 28814-66-6 ]

Reference： [1]Journal of the American Chemical Society,1995,vol. 117,p. 12691 - 12699

71
[ 2896-67-5 ]
laccase [ No CAS ]
[ 38790-14-6 ]

Reference： [1]Journal of the American Chemical Society,1995,vol. 117,p. 12691 - 12699

72
[ 2896-67-5 ]
laccase [ No CAS ]
[ 767-81-7 ]

Reference： [1]Journal of the American Chemical Society,1995,vol. 117,p. 12691 - 12699

73
[ 2896-67-5 ]
laccase [ No CAS ]
[ 477-86-1 ]

Reference： [1]Synthetic Communications,1996,vol. 26,p. 49 - 62

74
[ 2896-67-5 ]
laccase [ No CAS ]
[ 73484-74-9 ]

Reference： [1]Synthetic Communications,1996,vol. 26,p. 49 - 62

75
[ 2896-67-5 ]
laccase [ No CAS ]
[ 73484-75-0 ]

Reference： [1]Synthetic Communications,1996,vol. 26,p. 49 - 62

76
[ 2896-67-5 ]
laccase [ No CAS ]
[ 126402-13-9 ]