Alternatived Products of [ 29064-82-2 ]
Product Details of [ 29064-82-2 ]
CAS No. : | 29064-82-2 |
MDL No. : | MFCD08275122 |
Formula : |
C7H3BrClNS
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | FXIKIVFBAQCMRY-UHFFFAOYSA-N |
M.W : |
248.53
|
Pubchem ID : | 18450773 |
Synonyms : |
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Application In Synthesis of [ 29064-82-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 29064-82-2 ]
- 1
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[ 29064-82-2 ]

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[ 17413-10-4 ]

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(3-Bromo-thieno[3,2-c]pyridin-4-yl)-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-amine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
77% |
With triethylamine; In 1-methyl-pyrrolidin-2-one; at 220℃; for 2h;Microwave; |
A stirred mixture of 3-bromo-4-chloro-thieno[3,2-c]pyridine (200 mg, 0.80 mmol), 2,3-dihydro-1,4-benzodioxin-6-yl-methylaminebenzylamine (266 mg, 1.61 mmol), and triethylamine (112 mul, 0.80 mmol) in NMP (2 ml) was heated in a Biotage microwave reactor for 2 h at 220 C. At which point the reaction was allowed to cool to room temperature and partitioned between EtOAc (10 ml) and distilled water (10 ml). The organic layer was separated and washed with additional portions of distilled water (2×10 ml), dried (MgSO4), filtered and the solvent removed in vacuo. The crude residue was then subjected to flash column chromatography (eluent petroleum spirit 40-60 C.:EtOAc, 3:1, Rf 0.6). This afforded the title compound as a yellow solid (233 mg, 77%). |