[ CAS No. 29274-23-5 ] {[proInfo.proName]}

Name: 29274-23-5|Pyrazolo[1,5-a]pyrimidin-7(4H)-one|98%
Brand: Ambeed
SKU: A619566
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Quality Control of [ 29274-23-5 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 29274-23-5 ]

Product Details of [ 29274-23-5 ]

CAS No. :	29274-23-5	MDL No. :	MFCD09746272
Formula :	C₆H₅N₃O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BUEFDJQUUGMUJO-UHFFFAOYSA-N
M.W :	135.12	Pubchem ID :	335418
Synonyms :

Calculated chemistry of [ 29274-23-5 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	9
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	35.81
TPSA :	50.16 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.9 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.77
Log Po/w (XLOGP3) :	0.31
Log Po/w (WLOGP) :	0.02
Log Po/w (MLOGP) :	0.44
Log Po/w (SILICOS-IT) :	0.66
Consensus Log Po/w :	0.44

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.54
Solubility :	3.91 mg/ml ; 0.0289 mol/l
Class :	Very soluble
Log S (Ali) :	-0.93
Solubility :	16.0 mg/ml ; 0.119 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.59
Solubility :	3.49 mg/ml ; 0.0258 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.73

Safety of [ 29274-23-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 29274-23-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 29274-23-5 ]
Downstream synthetic route of [ 29274-23-5 ]

[ 29274-23-5 ] Synthesis Path-Upstream 1~2

1
[ 29274-23-5 ]
[ 58347-49-2 ]

Yield	Reaction Conditions	Operation in experiment
71%	at 90℃;	PREPARATION 32 7-Chloropyrazolo[1,5-a]pyrimidine Pyrazolo[1,5-a]pyrimidin-7(4H)-one (0.50g, 3.70 mmols), phosphorus oxychloride (0.88 mL, 9.62 mmols) and diisopropylethylamine (DIEA, 0.13 mL, 0.74 mmols) were mixed and stirred at 90ºC overnight. It was poured onto water/ice, extracted with dichloromethane and washed with brine. It was dried, filtered and concentrated in vacuo. It was purified by chromatography (Silica gel, Hexane/Ethyl acetate 9:1) to afford the expected compound (83 mg, 71percent). LRMS (m/z): 154 (M+1)⁺ 1H NMR (400 MHz, DMSO-d₆) d ppm 6.93 (d, 1 H) 7.43 (d, 1 H) 8.37 (d, 1 H) 8.52 (d, 1 H)
71%	at 90℃;	Pyrazolo[1 ,5-a]pyrimidin-7(4/-/)-one (0.50g, 3.70 mmols), phosphorus oxychloride (0.88 mL, 9.62 mmols) and diisopropylethylamine (DIEA, 0.13 mL, 0.74 mmols) were mixed and stirred at 90°C overnight. It was poured onto water/ice, extracted with dichloromethane and washed with brine. It was dried, filtered and concentrated in vacuum. It was purified by chromatography (Silica gel, Hexane/Ethyl acetate 9:1 ) to afford the expected compound (83 mg, 71 percent).LRMS (m/z): 154 (M+1 )⁺ ¹H NMR (400 MHz, DMSO-d₆) δ ppm 6.93 (d, 1 H) 7.43 (d, 1 H) 8.37 (d, 1 H) 8.52 (d, 1 H)
71%	at 90℃;	PREPARATION 897-Chloropyrazolo[1 ,5-a]pyrimidinePyrazolo[1 ,5-a]pyrimidin-7(4H)-one (0.50g, 3.70 mmols), phosphorus oxychloride (0.88ml, 9.62 mmols) and diisopropylethylamine (DIEA, 0.13ml, 0.74 mmols) were mixed and stirred at 90°C overnight. It was poured onto water/ice, extracted with dichloromethane and washed with brine. It was dried, filtered and concentrated in vacuum. It was purified by chromatography (Silica gel, Hexane/Ethyl acetate 9:1 ) to afford the expected compound (83mg, 71 percent).LRMS (m/z): 154 (M+1 )⁺ ¹ H N MR (400 MHz, DMSO-d₆) d ppm 6.93 (d, 1 H) 7.43 (d, 1 H) 8.37 (d , 1 H) 8.52 (d, 1 H)

65%	at 90℃; for 2.5 h;	7-Hydroxypyrazolo[1 ,5-a]pyrimidine (60 g, 444 mmol), phosphorus oxychloride (108 mL, 1.15 mol) and dimethylaniline (10.8 mL, 89 mmol) were added to a 250 mL round- bottomed flask and the contents heated to 90 ⁰C. After 2.5 h, the reaction mixture was allowed to cool and was concentrated. The black residue was poured into a beaker containing crushed ice (600 mL) and the resulting solution kept cold using an ice bath. The aqueous solution was extracted with CH₂CI₂ (3 ^χ 150 mL) and the combined organic phase was washed with brine (100 mL). The organic phase was dried and concentrated to yield the desired crude product, 7-chloropyrazolo[1 ,5-a]pyrimidine, (44.2 g, 65percent) as a red solid. As the crude product was sufficiently pure to use in the subsequent step, a small sample was purified by column chromatography (33-66percent EtOAc/hexane) to yield an analytical sample as a white solid. HPLC 95percent; ¹H NMR (250 MHz, CDCI₃) δ 8.41 (d, J = 4.5 Hz, 1 H), 8.25 (d, J = 2.3 Hz, 1 H)₁ 6.99 (d, J ~ 4.5 Hz, 1 H), 6.84 (d, J = 2.3 Hz, 1 H); ¹³C NMR (62.9 MHz, CDCI₃) δ 150.0, 148.2, 145.4, 139.0, 108.0, 98.7; MS (APCI) 154 [M+Hf.
47%	for 72 h;	The compound prepared in preparative example 1 (2.4 g, 17.4 mmol) was stirred in POCl₃(54 mL) and N,N-dimethylaniline (6.7 mL) 3 days. The reaction mixture was concentrated, dissolved in saturated NaHCO₃(2000 mL) and extracted with CH₂Cl₂, dried over Na₂SO₄, filtered and concentrated. The crude product was purified by flash chromatography using a 2.5percent MeOH in CH₂Cl₂solution as eluent (1.3 g, 47percent yield): M+H=154.

Reference： [1] Patent: EP2518071, 2012, A1, . Location in patent: Page/Page column 38
[2] Patent: WO2012/146667, 2012, A1, . Location in patent: Page/Page column 90
[3] Patent: WO2012/146666, 2012, A1, . Location in patent: Page/Page column 160
[4] Patent: WO2007/17678, 2007, A1, . Location in patent: Page/Page column 44
[5] Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613
[6] Patent: US2007/82901, 2007, A1, . Location in patent: Page/Page column 21
[7] ChemMedChem, 2014, vol. 9, # 11, p. 2516 - 2527

2
[ 29274-23-5 ]
[ 877173-84-7 ]

Reference： [1] ChemMedChem, 2014, vol. 9, # 11, p. 2516 - 2527

[ 29274-23-5 ] Synthesis Path-Downstream 1~21

1
[ 874-14-6 ]
[ 1820-80-0 ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
72%		A mixture of <strong>[874-14-6]1,3-dimethyluracil</strong> (4.7 g, 1.4 eq.) and 3-aminopyrazole (2.0 g, 24.1 mmol) was heated to reflux in 1M NaOEt in EtOH (31 mL) for one hour. The resulting solution was cooled to 0° C. The resulting precipitate was dissolved in water and neutralized with acetic acid and cooled to 0° C. The precipitate was collected and dried under reduced pressure to yield a cream-colored solid (2.4 g, 72percent yield): M+H=136.

Reference： [1]Patent: US2007/82901,2007,A1 .Location in patent: Page/Page column 21
[2]Journal of Heterocyclic Chemistry,1986,vol. 23,p. 349 - 352

2
[ 75-03-6 ]
[ 29274-23-5 ]
[ 55197-18-7 ]

Yield	Reaction Conditions	Operation in experiment
46%	With potassium carbonate In N,N-dimethyl-formamide for 20h; Ambient temperature;

Reference： [1]Senga; Novinson; Wilson; Robins [Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613]

3
sodium 3-ethoxy-3-oxoprop-1-en-1-olate [ No CAS ]
[ 1225387-53-0 ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
31%	In ethanol for 5h; Heating;

Reference： [1]Senga; Novinson; Wilson; Robins [Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613]

4
[ 29274-23-5 ]
[ 74-88-4 ]
[ 77494-09-8 ]

Yield	Reaction Conditions	Operation in experiment
89%	Stage #1: 4,7-dihydropyrazolo<1,5-a>pyrimidin-7-one With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 0.5h; Further stages.;
50%	With potassium carbonate In N,N-dimethyl-formamide for 20h; Ambient temperature;
20%	With potassium carbonate In N,N-dimethyl-formamide for 5h; Heating;

Reference： [1]Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C. [Journal of Organic Chemistry, 2007, vol. 72, # 3, p. 1043 - 1046]
[2]Senga; Novinson; Wilson; Robins [Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613]
[3]Auzzi, Gabriella; Bruni, Fabrizio; Cecchi, Lucia; Costanzo, Annarella; Vettori, Lorenzo Pecori; et al. [Journal of Medicinal Chemistry, 1983, vol. 26, # 12, p. 1706 - 1709]

5
[ 29274-23-5 ]
[ 58347-49-2 ]

Yield	Reaction Conditions	Operation in experiment
71%	With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 90℃;	PREPARATION 32 7-Chloropyrazolo[1,5-a]pyrimidine Pyrazolo[1,5-a]pyrimidin-7(4H)-one (0.50g, 3.70 mmols), phosphorus oxychloride (0.88 mL, 9.62 mmols) and diisopropylethylamine (DIEA, 0.13 mL, 0.74 mmols) were mixed and stirred at 90ºC overnight. It was poured onto water/ice, extracted with dichloromethane and washed with brine. It was dried, filtered and concentrated in vacuo. It was purified by chromatography (Silica gel, Hexane/Ethyl acetate 9:1) to afford the expected compound (83 mg, 71%). LRMS (m/z): 154 (M+1)+ 1H NMR (400 MHz, DMSO-d6) d ppm 6.93 (d, 1 H) 7.43 (d, 1 H) 8.37 (d, 1 H) 8.52 (d, 1 H)
71%	With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 90℃;	Pyrazolo[1 ,5-a]pyrimidin-7(4/-/)-one (0.50g, 3.70 mmols), phosphorus oxychloride (0.88 mL, 9.62 mmols) and diisopropylethylamine (DIEA, 0.13 mL, 0.74 mmols) were mixed and stirred at 90C overnight. It was poured onto water/ice, extracted with dichloromethane and washed with brine. It was dried, filtered and concentrated in vacuum. It was purified by chromatography (Silica gel, Hexane/Ethyl acetate 9:1 ) to afford the expected compound (83 mg, 71 %).LRMS (m/z): 154 (M+1 )+ 1H NMR (400 MHz, DMSO-d6) delta ppm 6.93 (d, 1 H) 7.43 (d, 1 H) 8.37 (d, 1 H) 8.52 (d, 1 H)
71%	With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 90℃;	PREPARATION 897-Chloropyrazolo[1 ,5-a]pyrimidinePyrazolo[1 ,5-a]pyrimidin-7(4H)-one (0.50g, 3.70 mmols), phosphorus oxychloride (0.88ml, 9.62 mmols) and diisopropylethylamine (DIEA, 0.13ml, 0.74 mmols) were mixed and stirred at 90C overnight. It was poured onto water/ice, extracted with dichloromethane and washed with brine. It was dried, filtered and concentrated in vacuum. It was purified by chromatography (Silica gel, Hexane/Ethyl acetate 9:1 ) to afford the expected compound (83mg, 71 %).LRMS (m/z): 154 (M+1 )+ 1 H N MR (400 MHz, DMSO-d6) d ppm 6.93 (d, 1 H) 7.43 (d, 1 H) 8.37 (d , 1 H) 8.52 (d, 1 H)

65%	With trichlorophosphate;N,N-dimethyl-aniline; at 90℃; for 2.5h;	7-Hydroxypyrazolo[1 ,5-a]pyrimidine (60 g, 444 mmol), phosphorus oxychloride (108 mL, 1.15 mol) and dimethylaniline (10.8 mL, 89 mmol) were added to a 250 mL round- bottomed flask and the contents heated to 90 0C. After 2.5 h, the reaction mixture was allowed to cool and was concentrated. The black residue was poured into a beaker containing crushed ice (600 mL) and the resulting solution kept cold using an ice bath. The aqueous solution was extracted with CH2CI2 (3 chi 150 mL) and the combined organic phase was washed with brine (100 mL). The organic phase was dried and concentrated to yield the desired crude product, 7-chloropyrazolo[1 ,5-a]pyrimidine, (44.2 g, 65%) as a red solid. As the crude product was sufficiently pure to use in the subsequent step, a small sample was purified by column chromatography (33-66% EtOAc/hexane) to yield an analytical sample as a white solid. HPLC 95%; 1H NMR (250 MHz, CDCI3) delta 8.41 (d, J = 4.5 Hz, 1 H), 8.25 (d, J = 2.3 Hz, 1 H)1 6.99 (d, J ~ 4.5 Hz, 1 H), 6.84 (d, J = 2.3 Hz, 1 H); 13C NMR (62.9 MHz, CDCI3) delta 150.0, 148.2, 145.4, 139.0, 108.0, 98.7; MS (APCI) 154 [M+Hf.
47%	With N,N-dimethyl-aniline; trichlorophosphate; for 72h;	The compound prepared in preparative example 1 (2.4 g, 17.4 mmol) was stirred in POCl3 (54 mL) and N,N-dimethylaniline (6.7 mL) 3 days. The reaction mixture was concentrated, dissolved in saturated NaHCO3 (2000 mL) and extracted with CH2Cl2, dried over Na2SO4, filtered and concentrated. The crude product was purified by flash chromatography using a 2.5% MeOH in CH2Cl2 solution as eluent (1.3 g, 47% yield): M+H=154.

Reference： [1]Patent: EP2518071,2012,A1 .Location in patent: Page/Page column 38
[2]Patent: WO2012/146667,2012,A1 .Location in patent: Page/Page column 90
[3]Patent: WO2012/146666,2012,A1 .Location in patent: Page/Page column 160
[4]Patent: WO2007/17678,2007,A1 .Location in patent: Page/Page column 44
[5]Journal of Medicinal Chemistry,1981,vol. 24,p. 610 - 613
[6]Patent: US2007/82901,2007,A1 .Location in patent: Page/Page column 21
[7]ChemMedChem,2014,vol. 9,p. 2516 - 2527

6
5-(N-pyrazol-3-ylaminomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione [ No CAS ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
48%	at 600℃;

Reference： [1]Clarke, David; Mares, Richard W.; McNab, Hamish [Journal of the Chemical Society. Perkin transactions I, 1997, # 12, p. 1799 - 1804]

Yield	Reaction Conditions	Operation in experiment
	Saeure 14;
	Saeure 13;
	1) Na-Methylat,abs. Diethylether, Ameisensaeure-ethylester, Ethylacetat ,5grad, 2) 3-Amino-pyrazol, abs. EtOH;

8
[ 1820-80-0 ]
[ 1117-37-9 ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
60%	In ethanol for 6h; Heating;

Reference： [1]Al-Saleh, Balkis; Makhseed, Saad; Hassaneen, Huwaida M. E.; Elnagdi, Mohamed Hilmy [Synthesis, 2006, # 1, p. 59 - 62]

9
[ 141-78-6 ]
[ 1225387-53-0 ]
[ 109-94-4 ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
60%	Stage #1: ethyl acetate; formic acid ethyl ester With sodium In ethanol; toluene at 20℃; for 16h; Stage #2: 3⁽⁵⁾-aminopyrazole In ethanol; toluene at 80℃; for 4h; Further stages.;

10
[ 197367-75-2 ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
98%	With diphenyl ether-biphenyl eutectic at 250℃; for 2h;
	In diphenylether; biphenyl at 260℃; for 2h;

Reference： [1]Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C. [Journal of Organic Chemistry, 2007, vol. 72, # 3, p. 1043 - 1046]
[2]Gehringer, Matthias; Forster, Michael; Pfaffenrot, Ellen; Bauer, Silke M.; Laufer, Stefan A. [ChemMedChem, 2014, vol. 9, # 11, p. 2516 - 2527]

11
[ 29274-18-8 ]
[ 29274-23-5 ]

Reference： [1]Journal of Organic Chemistry,2007,vol. 72,p. 1043 - 1046
[2]ChemMedChem,2014,vol. 9,p. 2516 - 2527

12
[ 29274-23-5 ]
[ 77493-96-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 60 percent / N,N-dimethylaniline, POCl₃ / 3 h / Heating 2: 56 percent / thiourea / ethanol / 5 h / Heating

Reference： [1]Senga; Novinson; Wilson; Robins [Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613]

13
[ 29274-23-5 ]
[ 77494-12-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 50 percent / K₂CO₃ / dimethylformamide / 20 h / Ambient temperature 2: 46 percent / P₂S₅ / pyridine / 5 h / Heating

Reference： [1]Senga; Novinson; Wilson; Robins [Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613]

14
[ 29274-23-5 ]
[ 77494-13-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 46 percent / K₂CO₃ / dimethylformamide / 20 h / Ambient temperature 2: 33 percent / P₂S₅ / pyridine / 5 h / Heating

Reference： [1]Senga; Novinson; Wilson; Robins [Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613]

15
[ 1225387-53-0 ]
[ 109-94-4 ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
77%	Stage #1: ethyl acetate; formic acid ethyl ester With sodium In toluene at 20 - 40℃; for 16h; Stage #2: 3⁽⁵⁾-aminopyrazole In ethanol; toluene for 4h; Heating / reflux; Stage #3: With hydrogenchloride In water	Sodium (30 wt. % dispersion in toluene, Acros 24326) (250 mL, 2.9 mol), toluene (1 L) and ethyl acetate (290 mL, 3 mol) were added to a 5 L three necked, round-bottomed flask. Ethyl formate (30 mL, 0.37 mmol) was added to the reaction mixture and the contents heated to 35-40 0C using a hot air gun. After initiation (2-16 h), ethyl formate (206 mL, 2.55 mol) was added dropwise to the suspension, taking care to ensure that the reaction temperature did not rise above 35 0C. After stirring for 16 h at room temperature, a solution of 3-aminopyrazole (122 g, 1.47 mol) in ethanol (1 L) was added to the brown mixture and was refluxed for 4 h. The viscous, yellow suspension was allowed to cool and was concentrated in vacuo, the residue was dissolved in hot water (500 mL) and the contents acidified by the addition of cone. HCI (140 mL). The precipitate was collected by filtration and dried to yield the desired product, 7-hydroxypyrazolo[1,5-a]pyrimidine, as a white solid (152 g, 77 %). 1H NMR (250 MHz, DMSO) δ 12.37 (brs, 1H), 7.86 (d, J = 7.3 Hz, 1H), 7.85 (d, J = 2.0 Hz, 1H), 6.16 (d, J = 2.0 Hz, 1 H), 5.66 (d, J = 7.3 Hz, 1 H); 13C NMR (62.9 MHz, DMSO) δ 156.6, 142.6, 141.7, 139.4, 95.2, 88.9; MS (APCI) 136 [M+H]+.

Reference： [1]Current Patent Assignee: EIRX THERAPEUTICS PLC - WO2007/17678, 2007, A1 Location in patent: Page/Page column 43

16
[ 29274-23-5 ]
[ 1404086-53-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 90 °C 2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 7 h / 120 °C

Reference： [1]Current Patent Assignee: ALMIRALL SA - WO2012/146667, 2012, A1 Current Patent Assignee: ALMIRALL SA - EP2518071, 2012, A1

17
dimethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3,6-dicarboxylate [ No CAS ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: water; lithium hydroxide monohydrate / methanol / 1.5 h / Reflux 1.2: pH Ca_. 3 2.1: neat (no solvent) / 4 h / 250 °C

Reference： [1]Drev, Miha; Grošelj, Uroš; Mevec, Špela; Pušavec, Eva; Štrekelj, Janja; Golobič, Amalija; Dahmann, Georg; Stanovnik, Branko; Svete, Jurij [Tetrahedron, 2014, vol. 70, # 44, p. 8267 - 8279]

18
7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3,6-dicarboxylic acid [ No CAS ]
[ 29274-23-5 ]

Yield	Reaction Conditions	Operation in experiment
51%	In neat (no solvent) at 250℃; for 4h;	4.6. Thermal decarboxylation of the dicarboxylic acid 8a. Synthesis of 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine (9) Compound 8a (167 mg, 0.75 mmol) was heated at 250 °C for 4 h to give a 1:2 mixture of 8a and 9. Subsequent crystallization of this mixture from aqueous EtOH gave the title compound 9 (52 mg, 51%) as a white solid; mp 333-338 °C, lit.10a mp 335-338 °C, lit.16 mp 338-340 °C; δH (500 MHz, DMSO-d6) 5.69 (1H, d, J=7.0 Hz, 6-H), 6.18 (1H, d, J=2.0 Hz, 3-H), 7.81-7.93 (2H, m, 2-H, 5-H), 12.36 (1H, br s, 4-H); HRMS (ESI): MH+, found 136.0503. C6H6N3O requires 136.0511.

19
[ 29274-23-5 ]
[ 877173-84-7 ]

Reference： [1]ChemMedChem,2014,vol. 9,p. 2516 - 2527

20
[ 29274-23-5 ]
methyl (3R,4R)-4-methyl-3-[methyl({pyrazolo[1,5-a]pyrimidin-7-yl})amino]piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: <i>N</i>,<i>N</i>-dimethyl-aniline; trichlorophosphate / 3 h / 105 °C / Inert atmosphere; Schlenk technique 2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere; Sealed tube

Reference： [1]Gehringer, Matthias; Forster, Michael; Pfaffenrot, Ellen; Bauer, Silke M.; Laufer, Stefan A. [ChemMedChem, 2014, vol. 9, # 11, p. 2516 - 2527]

21
[ 29274-23-5 ]
3-[(3R,4R)-3-({3-bromopyrazolo[1,5-a]pyrimidin-7-yl}(methyl)amino)-4-methylpiperidin-1-yl]-3-oxopropanenitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: <i>N</i>,<i>N</i>-dimethyl-aniline; trichlorophosphate / 3 h / 105 °C / Inert atmosphere; Schlenk technique 2: N-Bromosuccinimide / dichloromethane; acetonitrile / 2 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; N,N-dimethyl-formamide / 24 h / 105 °C / Inert atmosphere; Sealed tube

Reference： [1]Gehringer, Matthias; Forster, Michael; Pfaffenrot, Ellen; Bauer, Silke M.; Laufer, Stefan A. [ChemMedChem, 2014, vol. 9, # 11, p. 2516 - 2527]

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4-Ethylpyrazolo[1,5-a]pyrimidin-7(4H)-one

Similarity: 0.89

Related Parent Nucleus of
[ 29274-23-5 ]

Other Aromatic Heterocycles

[ 77494-09-8 ]

4-Methylpyrazolo[1,5-a]pyrimidin-7(4H)-one

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5-Aminopyrazolo[1,5-a]pyrimidin-7(4H)-one

Similarity: 0.92

[ 463327-79-9 ]

6-Aminopyrazolo[1,5-a]pyrimidin-7(4H)-one

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[ 29274-35-9 ]

5-Methylpyrazolo[1,5-a]pyrimidin-7(4H)-one

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[ 55197-18-7 ]

4-Ethylpyrazolo[1,5-a]pyrimidin-7(4H)-one

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 29274-23-5 ] {[proInfo.proName]}

Quality Control of [ 29274-23-5 ]

Related Doc. of [ 29274-23-5 ]

Product Details of [ 29274-23-5 ]

Calculated chemistry of [ 29274-23-5 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 29274-23-5 ]

Application In Synthesis of [ 29274-23-5 ]

[ 29274-23-5 ] Synthesis Path-Upstream 1~2

[ 29274-23-5 ] Synthesis Path-Downstream 1~21

Related Functional Groups of [ 29274-23-5 ]

Amides

Related Parent Nucleus of [ 29274-23-5 ]

Other Aromatic Heterocycles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 29274-23-5 ]

Related Parent Nucleus of
[ 29274-23-5 ]