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Chemical Structure| 29682-15-3
Chemical Structure| 29682-15-3
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Product Details of [ 29682-15-3 ]

CAS No. :29682-15-3 MDL No. :MFCD04112493
Formula : C7H6BrNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :JEURNBCYNWNADN-UHFFFAOYSA-N
M.W :216.03 Pubchem ID :7016458
Synonyms :

Calculated chemistry of [ 29682-15-3 ]

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.14
Num. rotatable bonds : 2
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 43.22
TPSA : 39.19 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.07 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.92
Log Po/w (XLOGP3) : 2.18
Log Po/w (WLOGP) : 1.63
Log Po/w (MLOGP) : 1.09
Log Po/w (SILICOS-IT) : 1.87
Consensus Log Po/w : 1.74

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.82
Solubility : 0.324 mg/ml ; 0.0015 mol/l
Class : Soluble
Log S (Ali) : -2.64
Solubility : 0.499 mg/ml ; 0.00231 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.96
Solubility : 0.237 mg/ml ; 0.0011 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.64

Safety of [ 29682-15-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 29682-15-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 29682-15-3 ]
  • Downstream synthetic route of [ 29682-15-3 ]

[ 29682-15-3 ] Synthesis Path-Upstream   1~32

  • 1
  • [ 29682-15-3 ]
  • [ 30766-11-1 ]
YieldReaction ConditionsOperation in experiment
90% With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 15 h; General procedure: Ester (FAE, 4a-m, 2a or 2b) (500 mg scale, 1 equiv.) was dissolvedin 6 ml THF at 0 °C in a 25 ml round-bottom flask. ThenNaOH(aq) (5 equiv.) was added dropwise and stirred for 15 h atroom temperature. After starting materials were consumed (byTLC), water (20 ml) was added. The reaction mixture was washedwith ethyl acetate (2 x 20 ml). The aqueous solution was acidified(pH 2-3) with 1 M HCl(aq) causing precipitation of a solid, whichwas filtered and dried under vacuum. Recrystallization in ethanolafford clean compound.
Reference: [1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 1011 - 1020
  • 2
  • [ 29682-15-3 ]
  • [ 75754-04-0 ]
Reference: [1] Patent: JP2017/171619, 2017, A,
  • 3
  • [ 29682-15-3 ]
  • [ 98-80-6 ]
  • [ 75754-04-0 ]
Reference: [1] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4721 - 4734
  • 4
  • [ 29682-15-3 ]
  • [ 17880-57-8 ]
Reference: [1] Patent: WO2014/138484, 2014, A1,
[2] Patent: WO2016/22724, 2016, A1,
  • 5
  • [ 29682-15-3 ]
  • [ 17880-61-4 ]
Reference: [1] Journal of Organometallic Chemistry, 2011, vol. 696, # 25, p. 4039 - 4045
[2] Patent: WO2012/31298, 2012, A2,
[3] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 2, p. 94 - 102
  • 6
  • [ 29682-15-3 ]
  • [ 53234-55-2 ]
Reference: [1] Patent: WO2011/9897, 2011, A1,
[2] Patent: WO2011/9898, 2011, A1,
[3] Patent: US2012/190672, 2012, A1,
[4] Patent: WO2012/98213, 2012, A1,
  • 7
  • [ 624-28-2 ]
  • [ 67-56-1 ]
  • [ 201230-82-2 ]
  • [ 29682-15-3 ]
YieldReaction ConditionsOperation in experiment
58% With triethylamine In acetonitrile at 60℃; for 16 h; 2,5-Dibromopyridine (9.5 g, 40. 10MMOL), PDCL2 (PPH3) 2 (844 mg), triethylamine (8. 36 mL), methanol (38 mL), and acetonitrile (114 mL) were combined, heated under carbon monoxide atmosphere (75 psi) at 60oC for 16 hours and concentrated. The residue was purified by flash chromatography eluting with 25percent ethyl acetate in hexane. The title compound (5.02 g) was obtained at 58percent yield. MS (DCI/MH3) M/Z : 215.95 (M+H) +. LH NMR (500 MHz, DMSO- D6) 8 ppm 3.91 (s, 3 H) 8.00 (d, J=8.11 Hz, 1 H) 8. 27 (dd, J=8.42, 2.49 Hz, 1 H) 8.86 (d, J=1.56 Hz, 1 H)
Reference: [1] Synthetic Communications, 1997, vol. 27, # 3, p. 515 - 520
[2] Patent: WO2004/80973, 2004, A1, . Location in patent: Page 182-183
[3] Patent: US2003/236251, 2003, A1, . Location in patent: Page 29
[4] Dalton Transactions, 2011, vol. 40, # 29, p. 7534 - 7540
  • 8
  • [ 67-56-1 ]
  • [ 30766-11-1 ]
  • [ 29682-15-3 ]
YieldReaction ConditionsOperation in experiment
92% at 0 - 70℃; for 6 h; To a solution of 5-bromopicolinic acid (12.6, 6.0 g, 29.9 mmol) in methanol (60 mL), sulfuric acid (3.0 mL) was added at 0 °C and the reaction mixture was heated at 70 °C for 6 h. After completion, cooled the mixture to room temperature and methanol was removed under reduced pressure. To the mixture, water (50 mL) was added and pH was adjusted to 6 by a solution of sodium bicarbonate .The product was extracted with ethyl acetate (200 mL), the organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude product was purified by washings with diethyl ether and pentane to afford methyl 5-bromopicolinate (12.5) as white solid. Yield: 6.0 g, 92.0percent.
86.9%
Stage #1: at 20℃; for 3 h; Reflux
(a) Preparation of methyl 5-bromopicolinate 2:To a 100 mL round bottle flask with 5-bromopicolinic acid (7.0 g, 35 mmol) in methanol (80 mL) was added dropwise thionyl chloride (3.0 mL) at ambient temperature. After addition the reaction mixture was heated to reflux for 3 h. Methanol was removed and ethyl acetate (100 mL) was added to the residue and was adjusted pH to 7.0 by addition of sodium bicarbonate solution. The organic phase was separated and dried over sodium sulfate. The organic solvent was removed and methyl 5-bromopicolinate 2 was obtained as white solid which was used for the next step of the reaction without further purification. Yield: 6.57 g, 86.9percent
80% With thionyl chloride In dichloromethane at 0 - 50℃; for 12 h; Example 89 - Preparation of Intermediate 25 [ 00379 ] The synthesis of Intermediate 25 followed General Procedure 1 following. Intermediate 25 [ 00380 ] To a cooled solution (0°C) of 5-bromopyridine-2-carboxylic acid (50.0 g, 0.247 mol, 1.0 eq) in anhydrous methanol (400 mL) was added thionyl chloride (107.0 mL, 2.47 mol, 10.0 eq) dropwise. The reaction mixture was slowly brought to ambient temperature and then heated at 50°C for 12 hours. The reaction was monitored by TLC and LC-MS. After completion, the reaction mixture was concentrated under reduced pressure to obtain a white solid residue, which was slowly quenched with saturated sodium bicarbonate. The white solid was filtered to give desired product methyl-5-bromopyridine-2-carboxylate (43.0 g, yield-80percent) m/z 216.14; 1H NMR (400 MHz, DMSO) δ 8.86 (d, J = 1.9 Hz, 1H), 8.28 (dd, J = 8.4, 2.4 Hz, 1H), 8.00 (d, J = 8.4 Hz, 1H), 3.89 (s, 3H) ppm.
79% at 20℃; for 12 h; Reflux 5-bromo-2-pyridinecarboxylic acid (1.65 g, 8.19 mmol) was dissolved in a methanol solution (30 ml) at room temperature, concentrated sulfuric acid (2.5 ml) was added dropwise, heated, condensed and refluxed for 12 hours, The reaction solution was slowly added dropwise to a saturated sodium bicarbonate solution (200 ml), extracted with ethyl acetate (100 ml * 3) and washed with a saturated sodium chloride solution (100 ml * 2). The organic phase was dried over anhydrous magnesium sulfate Filtered and concentrated under reduced pressure to give methyl 5-bromo-2-pyridinecarboxylate (white solid, 1.39 g), yield: 79percent
76% at 60℃; for 18 h; Example 53; 3-(3,4-Dichloro-phenoxy)-6-(4-isopropyl-piperazine-1-carbonyl)-pyridine-2-carbonitrile trifluoroacetic acid salt Step A; 5-Bromo-pyridine-2-carboxylic acid methyl ester. A mixture of 5-bromo-2-pyridine carboxylic acid (26.2 g, 0.124 mol) and conc. H2SO4 (12.5 mL) in MeOH (250 mL) was heated to 60° C. and diluted with additional MeOH (250 mL). After 18 h at 60° C., the mixture was cooled to rt, diluted with DCM, and washed with a solution consisting of 21 g KOH in 200 mL water, sat. K2CO3, and water. The organic layer was dried and concentrated to give the title compound (21.4 g, 76percent) as a white solid. This material was used in the next step without further purification.

Reference: [1] Patent: WO2018/126072, 2018, A1, . Location in patent: Paragraph 0246; 0247
[2] Patent: WO2012/76898, 2012, A1, . Location in patent: Page/Page column 64-65
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 22, p. 4780 - 4784
[4] Patent: WO2016/44662, 2016, A1, . Location in patent: Paragraph 00379-00380
[5] Patent: CN103360407, 2016, B, . Location in patent: Paragraph 0135-0137
[6] Patent: US2007/281923, 2007, A1, . Location in patent: Page/Page column 23
[7] ChemMedChem, 2017, vol. 12, # 24, p. 2044 - 2053
[8] Patent: WO2009/55828, 2009, A1, . Location in patent: Page/Page column 282
[9] Patent: WO2009/156966, 2009, A1, . Location in patent: Page/Page column 38
[10] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 3012 - 3023
[11] Patent: WO2015/48503, 2015, A2, . Location in patent: Paragraph 0129
[12] Patent: US2015/252057, 2015, A1, . Location in patent: Paragraph 0937; 0938; 0939
  • 9
  • [ 30766-11-1 ]
  • [ 18107-18-1 ]
  • [ 29682-15-3 ]
YieldReaction ConditionsOperation in experiment
87% at 20℃; for 1 h; Inert atmosphere Example 29(i) (TMS)CHN2, MeOH, benzene, 0°C to room temperature, 1 h, 87percent. (ii) (trimethylsily)acetylene, PdCI2(PPh3)2, Cul, DIEA, THF, 70°C, 14h, 95percent. (iii) K2CO3, MeOH, room temperature, 40 min, 84percent. (iv) 4-ethylnylaniline, Cu(OAc)2, pyridine, MeOH, room temperature, 20 h. (v) 3N NaOH, MeOH, reflux, 40 min, 31 percent (from 142). (vi) EDC. HCI, HOBt, DIEA, DMF, 13, 0°C, 1 h, then room temperature, 36h, 74percent. (vii) hydroxylamine hydrochloride, 25percent NaOMe/MeOH, THF, 0°C, 2h, then room temperature, 16h, 40percent.5-Bromopyridine-2-carboxylic acid (140): To an ice-cold solution of 139 (3.00 g, 15.0 mmol) dissolved in anhydrous MeOH (20 mL) and benzene (20 mL) is added dropwise (TMS)CHN2 (2.5 ml, 5.0 mmol, 2.0 equiv), then is allowed to warm to ambient temperature with stirring is continued under argon for 1 h. The reaction is monitored byLC/MS and TLC. The resulting solution is condensed to dryness with a rotavapor, and the residue is purified by CombiFlash (eluting with 0-10percent EtOAc in hexane) to give 140 as with solid (2.79 g, 87 percent yield). 1 H NMR (300 MHz, CDCI3) 53.93 (s, 3H), 7.56 (d, J=9.3 Hz, 1 H), 8.10 (d, J=10.5 Hz, 1 H), 8.93 (s, 1 H); 13C NMR (300 MHz, CDCIs) 552.88, 125.52, 128.28, 139.40, 147.03, 151 .62, 165.23; MS (ESI, positive): m/z 490 [M+H+].
Reference: [1] Patent: WO2012/31298, 2012, A2, . Location in patent: Page/Page column 123-124
[2] Patent: WO2014/138484, 2014, A1, . Location in patent: Page/Page column 187; 188
[3] Patent: WO2016/22724, 2016, A1, . Location in patent: Page/Page column 330
[4] Green Chemistry, 2018, vol. 20, # 17, p. 3931 - 3943
  • 10
  • [ 624-28-2 ]
  • [ 107-31-3 ]
  • [ 29682-15-3 ]
YieldReaction ConditionsOperation in experiment
55%
Stage #1: With trimethylsilylmethyllithium In toluene at -78 - 0℃; for 0.5 h;
Stage #2: for 3 h;
Stage #3: With iodine; potassium carbonate In toluene at 20℃; for 18 h;
General procedure: N,N-Dimethylaminoethanol (0.85 ml, 8.5 mmol, 1 equiv.) and(trimethylsilyl)methyllithium 1 M (25.3 ml, 25.3 mmol, 3 equiv.)was added dropwise to 25 ml of dry toluene at 0 °C and the solutionwas stirred for 30 min to form TMSCH2Li-LiDMAE (in situ). Then, Asolution of 2,5-dibromopyridine 1 (2 g, 8.5 mmol, 1 equiv.) in 9 mlof dry toluene was added dropwise. The reaction mixture wasstirred for 30 min, cooled to 78 °C and added methyl formate(5.2 ml, 85 mmol, 10 equiv.) or ethyl formate (6.9 ml, 85 mmol,10 equiv.) in 10 ml of toluene. The reaction mixture stirred for 3 h,and I2 (6.4 g, 25.5 mmol, 3 equiv.), K2CO3 (5.8 g, 42.5 mmol, 5 equiv.)and 20 ml methanol or ethanol were added. The mixture wasstirred at room temperature for 18 h and added 10 ml of a sat.aqueous Na2SO3 solution.Water (10 ml)was added and the mixtureextracted with dichloromethane (3x40 ml), washed with water(1 x 25 ml) and brine (1 x 25 ml). The residue was purified bysilica-gel flash column chromatography (eluent: heptane/diethylether 2: 1) to obtain 2a-b.4.2.2.1. Methyl 5-bromopicolinate (2a). From 1 (2 g) gave 2a(997 mg, 55percent); white solid; >99percent purity; mp 103-104 °C (reported98.0-102.0 °C [30a]); 1H NMR (600 MHz, CDCl3)δ 8.77 (dd, J = 2.2,0.71 Hz, 1H, H2), 8.01 (dd, J = 8.3, 0.8 Hz, 1H, H5), 7.98 (dd, J = 2.3,2.2 Hz, 1H, H6), 3.99 (s, 1H, CH3);13C NMR (100 MHz, CDCl3):δ 165.0(C]O, C-7), 151.0(C-2), 146.3(C-4), 139.7(C-6), 126.3(C-5),125.1(C-1); HRMS (ESI) m/z [M+H]+ calcd for C7H7BrNO2 +215.9660,found 215.9659. Data was in accordance with those reported [30a].
Reference: [1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 1011 - 1020
  • 11
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  • [ 201230-82-2 ]
  • [ 223463-13-6 ]
  • [ 29682-15-3 ]
Reference: [1] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 605 - 608
  • 12
  • [ 30766-11-1 ]
  • [ 75-77-4 ]
  • [ 29682-15-3 ]
YieldReaction ConditionsOperation in experiment
0.21 g at 20℃; To a solution of 5-bromo picolinic acid (0.20 g, 0.99 mmol) in MeOH (5 mL) was added TMSCl (0.50 mL, 3.96 mmol). The reaction mixture was left to stir at room temperature overnight. Water (20 mL) was added to quench the reaction and extracted three times with DCM (50 mL). Organic layer was combined, dried over Na2SO4 and concentrated in vacuo to give compound 4 as a white solid (0.21 g, 94percent) 1H NMR (400 MHz, CDCl3) δ 8.81 (s, 1H), 8.03 – 7.97 (m, 2H), 3.96 (s, 3H).
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 4, p. 744 - 749
  • 13
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Reference: [1] Tetrahedron, 2005, vol. 61, # 45, p. 10748 - 10756
[2] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 605 - 608
  • 14
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Reference: [1] Tetrahedron, 2005, vol. 61, # 45, p. 10748 - 10756
  • 15
  • [ 31181-90-5 ]
  • [ 29682-15-3 ]
Reference: [1] Green Chemistry, 2018, vol. 20, # 17, p. 3931 - 3943
  • 16
  • [ 30766-11-1 ]
  • [ 29682-15-3 ]
Reference: [1] Tetrahedron, 2005, vol. 61, # 45, p. 10748 - 10756
  • 17
  • [ 186581-53-3 ]
  • [ 30766-11-1 ]
  • [ 29682-15-3 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 4, p. 1407 - 1412
  • 18
  • [ 29682-15-3 ]
  • [ 88139-91-7 ]
YieldReaction ConditionsOperation in experiment
94.8% With sodium tetrahydroborate In methanol at 20℃; for 12 h; Cooling with ice 5-bromo-2-pyridinecarboxylic acid, methyl ester (648mg, 3mmol) was dissolved in a solution of methanol (10ml) was slowly added sodium borohydride (340mg, 9mmol) in an ice bath after complete addition the ice bath was removed, warmed to at room temperature, the reaction was stirred for 12 hours; then 1N HCl was added to adjust PH 1, again was added saturated sodium bicarbonate solution to adjust PH 8, and then extracted with ethyl acetate, the organic phase was dried over anhydrous magnesium sulfate and filtered , concentrated under reduced pressure to give 5-bromo-2-pyridinemethanol (535 mg of the, white solid), yield: 94.8percent.
90%
Stage #1: at 0 - 20℃;
Stage #2: With hydrogenchloride In water
Stage #3: With potassium carbonate In water
Intermediate 5,4 (5 -Bromopyridin-2-y] (methanol Methyl 5-bromopyridine-2-carboxylate (2.00 g, 9.27 mmol) was dissolved in ethanol (20.0 mL). Sodium borohydride (1 .05 g, 27.8 mmol) was added at 0°C, and the mixture was stirred at room temperature for 18 h. The mixture was then concentrated under reduced pressure, quenched with 1 N hydrochloric acid, neutralized with solid potassium carbonate and extracted with dichloro- methane. The organic layer was dried over magnesium sulfate and evaporated to give 1.57 g (90percent of th.) of the title compound. LC-MS (method 6): Rt = 0.56 min; MS (ESIpos): m/z (percent) = 188.0 (100) [M+H]+.
Reference: [1] Patent: CN103360407, 2016, B, . Location in patent: Paragraph 0135; 0138; 0139
[2] Patent: WO2013/4551, 2013, A1, . Location in patent: Page/Page column 35
[3] Chemistry - A European Journal, 2011, vol. 17, # 38, p. 10670 - 10681
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  • [ 29682-15-3 ]
  • [ 77199-09-8 ]
Reference: [1] Organic Letters, 2009, vol. 11, # 16, p. 3690 - 3693
  • 20
  • [ 75-16-1 ]
  • [ 29682-15-3 ]
  • [ 290307-40-3 ]
YieldReaction ConditionsOperation in experiment
81% at 0 - 20℃; for 1 h; General procedure: To a solution of methyl 5-bromopicolinate (2.16 g, 10 mmol) in THF (50 mL) at 0 °C was added a solution of 10 mL of 3.0 M methyl magnesium bromide in diethyl ether (30 mmol) dropwise over 0.5 h. The reaction mixture was stirred at rt for 1 h, quenched with saturated NH4C1 (1 mL) and partitioned between saturated NaHC03 (10 mL) and EtOAc (2* 15 mL). The combined organic layers were dried over Na2S04 and concentrated. The residue was purified by gradient elution on silica gel (0 to 20percent EtOAc in petroleum) to afford the title compound as a yellow oil (1.75 g, 81percent). LRMS m/z (M+H) 218.1 found, 218.1 required.
68% at 0 - 20℃; Inert atmosphere [00494] Intermediate 45a: 2-(5-bromo-2-pyridyl)propan-2-oI[00495] To a solution of methyl 5-bromopyridine-2-carboxylate (2.lg, 9.72mmol) in dry THF(48mL) at 0 °C, under nitrogen, was slowly added bromo(methyl)magnesium 2.7M in Et20 (10.8mL,29.l6mmol). The resulting solution was allowed to warm to room temperature and stirred overnight. The reaction was then quenched by the dropwise addition of sat. aq. NH4CI (2mL) then diluted with sat. aq. NaHCO3 (3OmL). The aqueous layer was extracted with EtOAc (2 x 3OmL). The combined organic extracts were washed with brine (3OmL), dried over Na2504 and concentrated in vacuo.The crude material was purified by flash column chromatography using an eluent of 0-100percent EtOAcin heptane to give 2-(5-bromo-2-pyridyl)propan-2-ol (1 .43g, 6.64mmol, 68percent yield) as a yellow oil.1H NMR (CDCI3, 400MHz) O/ppm: 7.89 (1H, m), 7.83 (1H, dd, J= 8.4Hz, 2.4Hz), 7.33 (1H, dd, J=8.4Hz, 0.8Hz), 4.41 (1 H, br 5), 1 .55 (6H, 5).MS Method 2: RT: 1.31 mi m/z 217.8 [M+H]
Reference: [1] Patent: WO2014/81619, 2014, A1, . Location in patent: Page/Page column 38
[2] Patent: WO2016/51193, 2016, A1, . Location in patent: Paragraph 00493; 00494; 00495
[3] Patent: WO2013/40863, 2013, A1, . Location in patent: Page/Page column 89-90
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  • [ 107504-07-4 ]
Reference: [1] Journal of the American Chemical Society, 2014, vol. 136, # 10, p. 3792 - 3795
  • 22
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  • [ 168823-76-5 ]
Reference: [1] Chemistry - A European Journal, 2011, vol. 17, # 38, p. 10670 - 10681
  • 23
  • [ 29682-15-3 ]
  • [ 137178-88-2 ]
Reference: [1] Patent: WO2004/814, 2003, A1, . Location in patent: Page 69
  • 24
  • [ 29682-15-3 ]
  • [ 75-65-0 ]
  • [ 845306-08-3 ]
Reference: [1] Organic Letters, 2008, vol. 10, # 13, p. 2909 - 2912
  • 25
  • [ 13737-04-7 ]
  • [ 29682-15-3 ]
  • [ 845827-15-8 ]
YieldReaction ConditionsOperation in experiment
48% With tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; silver(l) oxide In tetrahydrofuran at 90℃; for 18 h; This compound is synthesized as described by adaptation of the following reference: Tye et al., Tet. Lett., 2008, 49, 3939. To a stirred suspension of methyl-5-bromo-2- pyridine carboxylate (0.25 g, 1.16 mmol) and 2-(trimethylsilyl)pyridine (0.48 mL), 3.48 mmol) in anhydrous N,N-dimethyl formamide (7.5 mL) is added silver (I) oxide (0.27 g, 1.16 mmol), allyl palladium chloride dimer (21 mg, 5 molpercent) and tetrabutyl ammonium fluoride (IM in THF, 0.116 mL). The reaction is heated at 90 0C for 18 h. The reaction mixture is filtered and washed with EtOAc. The filtrate is concentrated under reduced pressure. Purification by column chromatography (silica, eluent DCM, 0- 2percent MeOH) gives 0.12g (48percent) of methyl 2,3'-bipyridine-6'-carboxylate. m/z = 215 [M++H].
Reference: [1] Patent: WO2010/80357, 2010, A1, . Location in patent: Page/Page column 53
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  • [ 936342-91-5 ]
Reference: [1] Patent: CN103360407, 2016, B,
  • 27
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  • [ 73183-34-3 ]
  • [ 957065-99-5 ]
Reference: [1] Patent: WO2009/156966, 2009, A1, . Location in patent: Page/Page column 38-39
[2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 1011 - 1020
  • 28
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  • [ 1158763-55-3 ]
Reference: [1] Patent: WO2012/3189, 2012, A1,
  • 29
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  • [ 1201326-81-9 ]
Reference: [1] Patent: WO2012/76898, 2012, A1,
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 3012 - 3023
  • 30
  • [ 29682-15-3 ]
  • [ 1380672-71-8 ]
Reference: [1] Patent: WO2012/76898, 2012, A1,
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 3012 - 3023
  • 31
  • [ 29682-15-3 ]
  • [ 1380672-07-0 ]
Reference: [1] Patent: WO2012/76898, 2012, A1,
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 3012 - 3023
  • 32
  • [ 29682-15-3 ]
  • [ 1214353-79-3 ]
YieldReaction ConditionsOperation in experiment
59%
Stage #1: With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 60℃; for 20 h;
Stage #2: at 0 - 95℃; for 2 h;
A mixture of 5-bromo-pyridine-2-carboxylic acid methyl ester (CAN 29682-15-3, 50 g, 0.23 mol) and m-CPBA (CAN 937-14-4, 80 g, 0.46 mol) in 400 mL dry methylene chloride was heated to 60° C. for 20 h. After that, the mixture was quenched with saturated sodium sulfite solution and extracted with ethyl acetate (2.x.200 mL). The organic layer was washed with brine (2.x.200 mL) and evaporated to dryness. The residue was purified by column chromatography (silica gel, 300 g, eluting with 15percent ethyl acetate in petroleum ether) to obtain a brown oil. The brown oil, 5-bromo-2-(methoxycarbonyl)pyridine 1-oxide (30 g, 0.13 mol) was added into phosphoryl trichloride (CAN 10025-87-3, 80 mL) at 0° C. over 1 h, then the mixture was heated to 95° C. for 1 h. After that the mixture was evaporated to dryness, the residue was dissolved in water (50 mL), extracted with ethyl acetate (3.x.50 mL) and the organic layer was evaporated to dryness to obtain the product as a white solid (19 g, 59percent); MS (EI): m/e=249.9 [M+H]+.
Reference: [1] Patent: US2012/316147, 2012, A1, . Location in patent: Page/Page column 32
[2] Patent: WO2012/168350, 2012, A1,
[3] Patent: WO2014/86806, 2014, A1,
[4] Patent: WO2014/86705, 2014, A1,
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 10, p. 4266 - 4277
[6] Patent: WO2016/44662, 2016, A1,
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