Name: 29898-32-6|2,4-Dichloro-1-iodobenzene|98%
Brand: Ambeed
SKU: A245050
Price: 5.0 USD
Availability: InStock
Rating: 92 (27 reviews)

1
[ 29898-32-6 ]
[ 124-41-4 ]
[ 855403-42-8 ]

Reference： [1]Recueil des Travaux Chimiques des Pays-Bas,1932,vol. 51,p. 98,109

2
[ 18640-58-9 ]
[ 29898-32-6 ]
[ 39249-56-4 ]

Reference： [1]Patent: CH563331,1975,
Patent: DE2214561,
Chem.Abstr.,1973,vol. 78

3
[ 29898-32-6 ]
[ 25909-68-6 ]
2,4-dichlorobenzo<13C>nitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83.8%	With copper(l) iodide In various solvent(s) at 210℃; for 17h;

Reference： [1]Carr; Cable; Wells; Sutherland [Journal of labelled compounds and radiopharmaceuticals, 1994, vol. 34, # 9, p. 887 - 897]

4
[ 19230-28-5 ]
[ 29898-32-6 ]
[ 68194-04-7 ]

Reference： [1]Chemosphere,1995,vol. 31,p. 2687 - 2705

5
[ 6324-50-1 ]
[ 29898-32-6 ]
[ 39485-83-1 ]

Reference： [1]Chemosphere,1995,vol. 31,p. 2687 - 2705

6
[ 3032-81-3 ]
[ 29898-32-6 ]
[ 73575-52-7 ]

Reference： [1]Chemosphere,1995,vol. 31,p. 2687 - 2705

7
[ 29898-32-6 ]
[ 64634-61-3 ]
[ 65510-44-3 ]

Reference： [1]Chemosphere,1995,vol. 31,p. 2687 - 2705

8
[ 29898-32-6 ]
[ 38411-20-0 ]
[ 68194-05-8 ]

Reference： [1]Chemosphere,1995,vol. 31,p. 2687 - 2705
[2]Synthesis,2011,p. 1045 - 1054

9
[ 60-29-7 ]
[ 29898-32-6 ]
[ 7553-56-2 ]
magnesium [ No CAS ]
[ 1475-13-4 ]

Reference： [1]Journal of the Chemical Society,1927,p. 1165

10
[ 29898-32-6 ]
[ 27948-29-4 ]
[ 2128-90-7 ]
5-[1-(2,4-Dichloro-phenyl)-1-phenyl-meth-(E)-ylidene]-5H-furan-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 30% 2: 26%	With potassium carbonate In acetonitrile at 70℃; for 22.5h;

Reference： [1]Rossi, Renzo; Bellina, Fabio; Biagetti, Matteo; Catanese, Antonella; Mannina, Luisa [Tetrahedron Letters, 2000, vol. 41, # 27, p. 5281 - 5286]

11
[ 29898-32-6 ]
[ 173414-53-4 ]
4-(2,4-dichloro-phenyl)-3-propyl-isochromen-1-one [ No CAS ]
3-[1-(2,4-dichloro-phenyl)-butylidene]-3<i>H</i>-isobenzofuran-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 70% 2: 14%	With potassium carbonate In acetonitrile at 70℃; for 29.5h;

Reference： [1]Rossi, Renzo; Bellina, Fabio; Biagetti, Matteo; Catanese, Antonella; Mannina, Luisa [Tetrahedron Letters, 2000, vol. 41, # 27, p. 5281 - 5286]

12
[ 994-30-9 ]
[ 29898-32-6 ]
[ 802984-54-9 ]

Yield	Reaction Conditions	Operation in experiment
84%	Stage #1: 2,4-dichloro-1-iodo-benzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃; for 2h; Stage #2: triethylsilyl chloride In tetrahydrofuran; hexane
84%	With n-butyllithium In tetrahydrofuran; hexane at -75℃;

Reference： [1]Gorecka, Joanna; Heiss, Christophe; Scopelliti, Rosario; Schlosser, Manfred [Organic Letters, 2004, vol. 6, # 24, p. 4591 - 4593]
[2]Heiss, Christophe; Cottet, Fabrice; Schlosser, Manfred [European Journal of Organic Chemistry, 2005, # 24, p. 5236 - 5241]

13
[ 29898-32-6 ]
[ 107-18-6 ]
[ 98581-93-2 ]

Yield	Reaction Conditions	Operation in experiment
64%	With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate at 80℃; for 30h;
	With tetrabutyl-ammonium chloride; sodium hydrogencarbonate at 80℃; for 24.0833h;	37 Example 37: synthesis of 3-(2,4-dichlorophenyl)-propionaldehyde (51); To a flask containing demi- water degassed with N2 (bubbling through) for 30 minutes were added l,3-dichloro-4-iodobenzene (5 g, 18.3 mmol), allyl alcohol (3.76 mL, 3 eq), NaHCO3 (3.84 g, 2.5 eq), tetrabutylammonium chloride (509 mg, 0.1 eq) andPalladium(II) acetate (82 mg, 0.02 mmol) and the mixture was degassed for another 5 minutes. The resulting mixture was stirred vigorously at 8O0C under N2 for 24 h. The reaction mixture was then cooled to room temperature and ethyl acetate was added. The layers were separated and the organic layer was washed with brine and dried with Na2SO4. After concentration, the reaction mixture was purified by flash chromatography (ethyl acetate/heptane 5:95) yielding 1.23 g of the desired product 51.

Reference： [1]Gangjee, Aleem; Qiu, Yibin; Kisliuk, Roy L. [Journal of Heterocyclic Chemistry, 2004, vol. 41, # 6, p. 941 - 946]
[2]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2008/99021, 2008, A1 Location in patent: Page/Page column 50

14
[ 29898-32-6 ]
[ 7390-62-7 ]
8-((2,4-dichlorophenyl)thio)-9H-purin-6-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	With copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; sodium t-butanolate; In N,N-dimethyl-formamide; at 110℃; for 24.0h;Inert atmosphere; Sealed tube;	8-Mercaptoadenine (1, 1.23 g, 7 mmol), 1 -iodo-2,4-dichlorobenzene (3 g, 1 1 mmol), neocuprine hydrate (0.3 g, 1.4 mmol), Cul (0.28 g, 1.4 mmol), NaO/-Bu (1.4 g, 14 mmol) and DMF (20 mL) were charged in a nitrogen protected dry vessel. The reaction vessel was sealed and placed in an oil bath (1 10 C) and stirred for 24 hrs. The reaction mixture was then cooled to room temperature and DMF was removed in vacuo. The crude material was purified by silica gel flash chromatography (CH2Cl2:CH3OH:CH3COOH, 60: 1 :0.5 to 20: 1 :0.5) to afford the 2.0 g (87 %) of 18. MS (ESI): m/z 312.0 [M + H]+.

Reference： [1]Patent: WO2015/23976,2015,A2 .Location in patent: Paragraph 0322
[2]Journal of Medicinal Chemistry,2005,vol. 48,p. 2892 - 2905
[3]Journal of Medicinal Chemistry,2015,vol. 58,p. 3922 - 3943

15
[ 124-38-9 ]
[ 29898-32-6 ]
[ 50-84-0 ]

Yield	Reaction Conditions	Operation in experiment
74%	Stage #1: 2,4-dichloro-1-iodo-benzene With copper In tetrahydrofuran at 25℃; for 0.5h; Stage #2: carbon dioxide In tetrahydrofuran for 24h;

Reference： [1]Ebert, Greg W.; Juda, Wayne L.; Kosakowski, Robert H.; Ma, Bing; Dong, Liming; Cummings, Keith E.; Phelps, Mwita V. B.; Mostafa, Adel E.; Luo, Jianyuan [Journal of Organic Chemistry, 2005, vol. 70, # 11, p. 4314 - 4317]

16
[ 124-38-9 ]
[ 29898-32-6 ]
[ 74-88-4 ]
[ 35112-28-8 ]

Reference： [1]Journal of Organic Chemistry,2005,vol. 70,p. 4314 - 4317

17
[ 75-77-4 ]
[ 29898-32-6 ]
[ 876070-70-1 ]

Yield	Reaction Conditions	Operation in experiment
88%	With n-butyllithium In tetrahydrofuran; hexane at -75℃;

Reference： [1]Heiss, Christophe; Cottet, Fabrice; Schlosser, Manfred [European Journal of Organic Chemistry, 2005, # 24, p. 5236 - 5241]

18
[ 29898-32-6 ]
[ 63503-60-6 ]
[ 55712-37-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	Stage #1: 2,4-dichloro-1-iodo-benzene; 3-chlorophenylboronic acid With sodium carbonate In benzene at 25℃; for 12h; Stage #2: With dihydrogen peroxide In benzene at 25℃; for 0.75h;

Reference： [1]Heiss, Christophe; Cottet, Fabrice; Schlosser, Manfred [European Journal of Organic Chemistry, 2005, # 24, p. 5236 - 5241]

19
[ 29898-32-6 ]
[ 1679-18-1 ]
[ 7012-37-5 ]

Yield	Reaction Conditions	Operation in experiment
95%	Stage #1: 2,4-dichloro-1-iodo-benzene; 4-Chlorophenylboronic acid With sodium carbonate In benzene at 25℃; for 12h; Stage #2: With dihydrogen peroxide In benzene at 25℃; for 0.75h;
73%	With C₂₀H₂₉Cl₂N₅O₂Pd; potassium carbonate In ethanol at 80℃; for 2h;	Synthesis of PCB congeners 1 and 2 and chloromethoxybiphenyl 8 by the Suzuki reaction. General procedure: A 2×10-3 solution of complex 6 [27] in 8×10-7 mol of ethanol (0.4 mL) was added with stirring to a hot (80°) mixture of 5-10 mL of ethanol, 1.0-3.0 mmol of aryliodide, 1.1 equiv of arylboronic acid, and 1.5 equiv of K2CO3. The reaction mixture was heated on an oil bath at 80° for 2 h and then cooled to room temperature and diluted with 10 mL of water. The reaction product was extracted with a hexane-dichloromethane mixture (5 : 1, 3×20 mL), the organic layer was dried over anhydrous Na2SO4, the solvent was evaporated, and the residue was weighed and analyzed by 1H NMR and GLC. When necessary, the product was additionally purified by column chromatography (eluent hexane).
68%	With (R,R)-N,N'-bis[(2-trifluoromethylphenyl)methylene]-1,2-cyclohexanediamine PdCl₂ complex; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 24h; Aerobic conditions;

Reference： [1]Heiss, Christophe; Cottet, Fabrice; Schlosser, Manfred [European Journal of Organic Chemistry, 2005, # 24, p. 5236 - 5241]
[2]Khaibulova, T. Sh.; Boyarskaya; Polukeev; Boyarskii [Russian Journal of General Chemistry, 2016, vol. 86, # 10, p. 2318 - 2324][Zh. Obshch. Khim., 2016, vol. 86, # 10, p. 1670 - 1677,8]
[3]Location in patent: experimental part Kylmaelae, Tuula; Kuuloja, Noora; Xu, Youjun; Rissanen, Kari; Franzen, Robert [European Journal of Organic Chemistry, 2008, # 23, p. 4019 - 4024]

20
[ 75-77-4 ]
[ 29898-32-6 ]
[ 149021-04-5 ]

Yield	Reaction Conditions	Operation in experiment
93%	Stage #1: 2,4-dichloro-1-iodo-benzene With tert.-butyl lithium In tetrahydrofuran; pentane at -75℃; for 0.25h; Stage #2: chloro-trimethyl-silane In tetrahydrofuran; pentane

Reference： [1]Heiss, Christophe; Marzi, Elena; Mongin, Florence; Schlosser, Manfred [European Journal of Organic Chemistry, 2007, # 4, p. 669 - 675]

21
[ 29898-32-6 ]
[ 121412-28-0 ]

Yield	Reaction Conditions	Operation in experiment
	With n-butyllithium In tetrahydrofuran; diethyl ether at -78℃;	A solution of 6 was prepared by treating 1,3-dichloro-4-iodobenzene (3.5 g, 12.7 mmol) in EtO2:THF (35.0 mL:17.5 mL, 2:1) at -78° C. under N2 atmosphere with n-BuLi (5.6 mL, 14 mmol). To a solution of freshly prepared 6 was added 5 (2.9 g, 12.7 mmol) followed by BF3.Et2O (2.4 mL, 20 mmol). After stirring for 3 hours at -78° C., the temperature was brought to -40° C. and quenched the mixture with an ice-cold saturated aqueous NH4Cl solution. The organic layer was extracted with EtO2 and dried over MgSO4. The solvent was removed at reduced pressure and the residue was purified via silica gel column chromatograph (Ethylacetate:Hexane=5:95) to afford 7 (3.1 g, 69%).

Reference： [1]Current Patent Assignee: MERCK & CO INC - US2007/254952, 2007, A1 Location in patent: Page/Page column 35-36

22
[ 29898-32-6 ]
(3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one [ No CAS ]
C₃₂H₃₀Cl₂O₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,4-dichloro-1-iodo-benzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one In tetrahydrofuran; hexane at -78℃; Further stages.;

Reference： [1]Silverman, Adam P.; Kool, Eric T. [Journal of the American Chemical Society, 2007, vol. 129, # 35, p. 10626 - 10627]

23
[ 29898-32-6 ]
[ 3972-56-3 ]

Reference： [1]European Journal of Organic Chemistry,2005,p. 5236 - 5241

24
methyl (4'-methoxy-3'-(2-propynyloxy)biphenyl-3-yl)-acetate [ No CAS ]
[ 29898-32-6 ]
methyl {3'-[3-(2,4-dichlorophenyl)-2-propynyloxy]-4'-methoxybiphenyl-3-yl}acetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃; for 72h;	374.b {3'-[3-(2,4-Dichloro-phenyl)-2-propynyloxy]-4'-methoxybiphenyl-3-yl}acetic acid [328.2] 9 mg of methyl (4'-methoxy-3'-(2-propynyloxy) biphenyl-3-yl)acetate was dissolved in 0.1 ml of N,N-dimethylformamide, 30 mg of 2,4-dichloroiodobenzene, 2 mg of copper iodide, 2 mg of tetrakistriphenyl phosphine palladium and 0.05 ml of triethylamine were added thereto, and the mixture was stirred at room temperature for 3 days. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was concentrated to give methyl {3'-[3-(2,4-dichlorophenyl)-2-propynyloxy]-4'-methoxybiphenyl-3-yl}acetate. This product was dissolved in 0.5 ml of ethanol, then 0.1 ml of 5N sodium hydroxide was added thereto, and the mixture was left overnight at room temperature. The reaction mixture was neutralized with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was concentrated, and the residue was purified by reverse-phase high performance liquid chromatography to give 4.24 mg of the title compound. MS m/e(ESI) 463(MNa+)

Reference： [1]Current Patent Assignee: EISAI CO LTD - EP1394147, 2004, A1 Location in patent: Page 190

25
[ 29898-32-6 ]
[ 927-74-2 ]
3,5-DIAMINO-6- 3-(2,4-DICHLOROPHENYL)PROPYL)-1,2,4-TRIAZINE [ No CAS ]
4-(2,4-dichlorophenyl)-3-butyn-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In triethylamine; acetonitrile	4.A Step A Step A Synthesis of 4-(2,4-dichlorophenyl)-3-butyn-1-ol Under a nitrogen atmosphere 97.2 g (0.356 mole) of 2,4-dichloroiodobenzene, 3.21 g (0.0046 mole) of bis(triphenylphosphine)palladium(II) chloride, and 0.8 g (0.0042 mole) of copper(I) iodide were suspended in 50 mL of triethylamine and 100 mL of acetonitrile. This mixture was cooled in an ice/water bath to 0°-5° C., and 24.6 g (0.356 mole) of 3-butyn-1-ol dispersed in 25 mL of acetonitrile was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature at which it was stirred for approximately 16 hours. The solvent was evaporated from the reaction mixture under reduced pressure, leaving a brown oil as the residue. This oil was passed through a column of silica gel, eluding first with hexane and then with methylene chloride. Product-containing factions were combined, and the solvent was evaporated under reduced pressure, leaving 4-(2,4-dichlorophenyl)-3-butyn-1-ol as the residue. The NMR spectrum was consistent with the proposed structure.

Reference： [1]Current Patent Assignee: FMC CORP - US5502054, 1996, A

26
(5R)-2-(trans-4-hydroxycyclohexyl)-2,7-diaza-spiro[4.5]decan-1-one [ No CAS ]
[ 29898-32-6 ]
(5R)-7-(2-chloro-4-methylphenyl)-2-(trans-4-hydroxycyclohexyl)-2,7-diaza-spiro[4.5]decan-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; (1S,2S)-trans-1,2-Cyclohexanediol; potassium carbonate In <i>tert</i>-butyl alcohol at 100℃; for 18h;	188 Example 188 (5R)-7-(2-ChIoro-4-methylphenyl)-2-(trans-4-hydroxycyclohexyl)-2,7-diazaspiro[4.5]decan-l- one H A mixture of (5R)-2-(trans-4-hydroxycyclohexyl)-2,7-diazaspiro[4.5]decan-l-one (20 mg,0.00007 mol, this compound was prepared by using procedures analogous to those described in example 1, steps 1-5), 2,4-dichloroiodobenzene (22.7 mg, 0.0000831 mol), potassium carbonate (20.1 mg, 0.000145 mol), copper(I) iodide (0.6 mg, 0.000003 mol), and (lS,2S)-cyclohexane-l,2-diol (16.1 mg, 0.000138 mol) in tert-butyl alcohol (1.0 mL, 0.010 mol) was heated at 100 0C for 18 h. The crude product was purified by prep-HPLC to afford the desired product. LC-MS: 377.1 (M+H)+.

Reference： [1]Current Patent Assignee: INCYTE CORP - WO2006/53024, 2006, A2 Location in patent: Page/Page column 122

27
[ 29898-32-6 ]
[ 105459-84-5 ]
[ 92736-81-7 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; magnesium; trifluoroacetic anhydride; In water;	PREPARATION A 2',4'-Dichloro-2,2,2-trifluoroacetophenone STR27 A solution of 2,4-dichlorophenylmagnesium iodide, prepared from 2,4-dichloroiodobenzene (27.3 g, 0.1 mole) and magnesium (3.3 g, 0.138 mole), in ether (150 ml) was added dropwise to a solution of trifluoroacetic anhydride (24 g, 0.114 mole) in ether (20 ml) at -78 C. Stirring was continued at -78 C. for 10 minutes and the mixture was then allowed to warm to room temperature over 4 hours, stirred for a further 18 hours at this temperature and then heated under reflux for 3 hours. The mixture was then cooled and treated with concentrated hydrochloric acid (25 ml) in iced water (125 ml). The ether layer was separated and the aqueous layer was washed a further four times with ether (200 ml in total). The combined ether extracts were washed successively with aqueous sodium bisulphite, aqueous sodium bicarbonate and water, dried over magnesium sulphate and distilled to give as a pale yellow liquid which solidified on cooling, the title compound, 14.2 g (58%), b.p. 46 C. (0.2 mm Hg), m.p. 38 C. m/e 242.

Reference： [1]Patent: US4616027,1986,A

28
[ 74-96-4 ]
[ 29898-32-6 ]
[ 95-92-1 ]
[ 34966-51-3 ]

Yield	Reaction Conditions	Operation in experiment
80%	With ammonium chloride; sodium hydrogensulfite; magnesium In diethyl ether	2 Synthesis of (2,4-dichloro-phenyl)-oxo-acetic acid ethyl ester EXAMPLE 2 Synthesis of (2,4-dichloro-phenyl)-oxo-acetic acid ethyl ester A suspension of magnesium (6.7 g; 0.275 moles) in ethyl ether (125 ml) under stirring and nitrogen flow was added with ethyl bromide (180 mg). A solution of 1,3-dichloro-4-iodobenzene (50 g; 0.183 moles) and ethyl bromide (180 mg) in ethyl ether (100 ml) was dropped in about 1 hour keeping the temperature at 15-20° C. The suspension was stirred for further 2 hours. After decanting the magnesium in excess, the solution was dropped in about 1 hour in a solution of diethyloxalate (29.32 g; 0.2 moles) in ethyl ether (125 ml) cooled to -70° C. At the end of the addition it was stirred at -70° C. for 1 hour, then the temperature was left to rise to 10° C. and the stirring was kept on for another hour. The suspension was added with a saturated solution of NH4Cl (125 ml), the phases were separated and the aqueous one extracted with ethyl acetate (50 ml). The organic phases were washed with a solution of sodium bisulfite and treated with discolouring charcoal. After filtration, the organic solution was distilled under vacuum to give a crude which was purified by chromatography (SiO2; hexane/ethyl ether 9/1) to give 36.2 g of (2,4-dichloro-phenyl)-oxo-acetic acid ethyl ester (yield 80%) as a colourless oil. 1H-NMR (200 MHz, CDCl3, δ=ppm, J=Hz): 1.37 (t, 3H, J=7.2); 4.39 (q, 2H, J=7.2); 7.37 (dd, 1H); 7.45 (d, 1H, J=2.0); 7.70 (d, 1H, J=8.4).

Reference： [1]Current Patent Assignee: GEFIM S.P.A. - US6211387, 2001, B1

29
[ 74-96-4 ]
palladium triphenylphosphine dichloride [ No CAS ]
[ 38318-63-7 ]
[ 29898-32-6 ]
[ 226922-40-3 ]

Yield	Reaction Conditions	Operation in experiment
63%	With magnesium In diethyl ether; N,N-dimethyl-formamide	1.b Synthesis of (E)-2-(2,4-dichlorophenyl)-butendioic acid diethyl ester b) with catalyst prepared in situ from preformed PdCl2(PPh3)2 A suspension of magnesium (0.73 g, 0.03 moles) in ethyl ether (20 ml) under nitrogen flow was added with ethyl bromide (50 mg). The solution was stirred for 15 minutes then added with a solution of 1,3-dichloro-4-iodobenzene (5.45 g, 0.02 moles) in ethyl ether (10 ml) in 1 hour keeping the temperature at 18-22° C. At the end of the addition the suspension was kept under stirring for 90 minutes at 18-22° C., then decanted and the surnatant added in 10 minutes to a suspension of dry zinc chloride (5.4 g, 0.04 moles) in ethyl ether (8 ml). At the end of the addition the stirring was kept on at 20° C. for further 90 minutes, then cooled to 0° C. DMF (10 ml) and palladium dichloride triphenylphosphine (351 mg, 0.0005 moles), then a solution of diethyl iodo-fumarate (4.18 g, 0.014 moles) in DMF (4 ml) were added. The mixture was kept under stirring for 15 hours at 25° C. and after a work-up similar to the one of point a) 2.1 g of (E)-2-(2,4-dichlorophenyl)-butendioic acid diethyl ester were yielded (yield: 63% calculated with respect to the iodo-furmarate). 1H-NMR (200 MHz, CDCl3, δ=ppm, J=Hz): 1.10 (t, 3H, J=7.1); 1.25 (t, 3H, J=7.1); 4.05 (q, 2H, J=7.1); 4.24 (q, 2H, J=7.1); 7.09 (s, 1H); 7.07-7.42 (m, 3H).

Reference： [1]Current Patent Assignee: GEFIM S.P.A. - US6211387, 2001, B1

30
[ 74-96-4 ]
Pd(OAc)2+PPh₃ [ No CAS ]
[ 38318-63-7 ]
[ 29898-32-6 ]
[ 226922-40-3 ]

Yield	Reaction Conditions	Operation in experiment
70%	With magnesium; triphenylphosphine In hydrogenchloride; diethyl ether; N,N-dimethyl-formamide	1.a Synthesis of (E)-2-(2,4-dichlorophenyl)-butendioic acid diethyl ester a) with catalyst prepared in situ from Pd(OAc)2+PPh3 A suspension of magnesium (1.82 g; 0.075 moles) kept under stirring at 25° C. in ethyl ether (20 ml) was added with ethyl bromide (50 mg). After 15 minutes 1,3-dichloro-4-iodobenzene (13.65 g; 0.05 moles) in ethyl ether (20 ml) was added in about 1 hour at the temperature of 18-22° C., and at the end of the addition the stirring was kept on at 20° C. for further 90 minutes. The metallic magnesium was decanted and the surnatant solution was added in 10 minutes to a suspension of dry zinc chloride (13.6 g; 0.1 mole) in ethyl ether (20 ml). The suspension was stirred at room temperature for 90 minutes, then cooled to 0° C., added with dry DMF (40 ml) then with palladium acetate (168 mg; 0.75 mmoles) and triphenylphosphine (395 mg; 1.5 mmoles) and at last a solution of diethyl iodo-fumarate (10.45 g; 0.035 moles), prepared according to J. Am. Chem. Soc. 1972, 94 (12), 4363-4, in DMF (10 ml) was dropped in about 30 minutes. The mixture was stirred at room temperature overnight, then cooled to 0° C. added with IN HCl (80 ml) and twice extracted with hexane (80 ml) The organic phases were anhydrified over Na2SO4 and evaporated to dryness. The residue (13 g) was purified by flash chromatography (SiO2; hexane/ethyl ether 95/5) to give 7.82 g of pure (E)-2-(2,4-dichlorophenyl)-butendioic acid diethyl ester (yield: 70% calculated with respect to the diethyl iodo-fumarate).

Reference： [1]Current Patent Assignee: GEFIM S.P.A. - US6211387, 2001, B1

31
[ 29898-32-6 ]
[ 169526-37-8 ]
C₂₃H₃₈Cl₂O₄Si₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,4-dichloro-1-iodo-benzene; (6aR,9aS)-2,2,4,4-tetraisopropyltetrahydro-8H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-one With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: With triethylsilane; boron trifluoride diethyl etherate In tetrahydrofuran at -78℃;	5 The following synthetic scheme has been used to generate a radiolabeled analog of the dichloro nucleoside. By using different isotopes of iodine, including 123I, 124I, 125I, 128I and 131I, the molecule is varied for PET imaging analogs or radiotherapeutic analogs. In an alternative synthesis, an 11C-labeled methyl group is introduced in the final step of synthesis.

Reference： [1]Current Patent Assignee: STANFORD UNIVERSITY - US2007/65360, 2007, A1 Location in patent: Page/Page column 21-22

32
[ 873-73-4 ]
[ 29898-32-6 ]
[ 944819-21-0 ]

Yield	Reaction Conditions	Operation in experiment
87%	With diisopropylamine In dichloromethane at 20℃; for 16h;	81.1 Preparation of Compounds 157 and 158; Step 1; Scheme 81:; A mixture of 1-chloro-4-ethynyl-benzene (2.71 g, 0.020 mol), 2,4-dichloro-1-iodo-benzene (3.23 mL, 0.024 mol), PdCl2(PPh3)2 (0.10 g, 1.4 mmol), CuI (1.44 g, 7.6 mmol), and diisopropylamine (7 mL) in DCM (i.e., dichloromethane) (100 mL) was stirred at room temperature for 16 h. The mixture was filtered through CELITE. The filtrate was concentrated in vacuo. The residue was chromatographed (SiO2, hexane) to afford 2,4-dichloro-1-(4-chloro-phenylethynyl)-benzene as a white solid (3.23 g, 87%).

Reference： [1]Current Patent Assignee: MERCK & CO INC - US2007/197628, 2007, A1 Location in patent: Page/Page column 156

33
[ 29898-32-6 ]
[ 10039-57-3 ]
C₂₀H₁₅Cl₂NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56%	With formic acid; triphenyl-arsane; triethylamine In N,N-dimethyl-formamide at 65℃;

Reference： [1]Göksu, Gökce; Gül, Melek; Öcal, Nüket; Kaufmann, Dieter E. [Tetrahedron Letters, 2008, vol. 49, # 17, p. 2685 - 2688]

34
[ 3054-95-3 ]
[ 29898-32-6 ]
[ 70017-27-5 ]

Yield	Reaction Conditions	Operation in experiment
87%	With potassium chloride; tetrabutylammonium acetate; potassium carbonate at 20℃;

Reference： [1]Tran, Joe A.; Tucci, Fabio C.; Arellano, Melissa; Jiang, Wanlong; Chen, Caroline W.; Marinkovic, Dragan; Fleck, Beth A.; Wen, Jenny; Foster, Alan C.; Chen, Chen [Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 1931 - 1938]

35
[ 4068-68-2 ]
[ 29898-32-6 ]
[ 1066-54-2 ]
[ 1048992-94-4 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,4-dichloro-1-iodo-benzene; trimethylsilylacetylene With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Stage #2: methyl 5-chloro-2-hydroxy-3-iodobenzoate With tetrabutyl ammonium fluoride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 2h;	25 Description 25 (D25)Methyl S-chloro-ς-f∑λ-dichlorophenvD-i-benzofuran-Z-carboxylateSolution of 2,4-dichloroiodobenzene (0.500 g, 1.85 mmol) in dry DMF (7.5 ml) was stirred at room temperature under an atmosphere of argon. (Ph3P)2PdCI2 (0.133 g, 0.19 mmol), Et3N (0.514 ml, 3.7 mmol), CuI (0.036 g, 0.19 mmol) and trimethylsilylacetylene (0.287 ml, 2.04 mmol) were added. The mixture was stirred for 40 minutes. After this time, TBAF(2.04 ml, 2.04 mmol, 1 M in THF) and methyl 5-chloro-2-hydroxy-3-iodobenzoate (0.861 g, 2.77 mmol) and the mixture stirred for a further 2 hours at room temperature. After this time, the mixture was diluted with EtOAc and the organics washed with water. The combined organics were dired over MgSO4, filtered and concentrated under reduced pressure to give a brown oil. The residue was chromatographed [Siθ2, Hexane/EtOAc, 0- 10%) to give the title compound (0.523 g). LC/MS Rt = 4.34 min [M+H]+ 353, 357

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2008/98978, 2008, A2 Location in patent: Page/Page column 41-42

36
[ 29898-32-6 ]
[ 137076-22-3 ]
[ 645378-86-5 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,4-dichloro-1-iodo-benzene With iodine; magnesium In diethyl ether for 0.5h; Heating / reflux; Stage #2: tert butyl 4-formylpiperidine-1-carboxylate In diethyl ether at 0 - 23℃; for 0.5h;	39 Intermediate 39; [1.] 1-dimethylethyl [4-F (2. 4-DICHLOROPHENVL) (HVDROXY) METHVLL-1-PIPERIDINECARBOXVLATE] A solution of 2, 4-dichloroiodobenzene (2.23 mL) in anhydrous Et20 (8 mL) was dropped into a suspension of magnesium turning (0.395 [G)] and few crystals of iodine in anhydrous [ET20] (8 [ML)] under a Nitrogen atmosphere. The mixture was refluxed for 30 minutes, then it was allowed to cool to r. t. then cooled to [0°C] and a mixture of intermediate 3 (1.3 [G)] in anhydrous Et20 (8 mL) was added dropwise. At the end of the addition the mixture was allowed to warm to r. t. and stirred at [23°C] for 30 minutes. The mixture was quenched with ammonium chloride saturated solution, stirred for 10 minutes then extracted with DCM (3 x 50 mL). The combined organic extracts were concentrated in vacuo. The residue was purified by flash chromatography (CH/AcOEt from 95: 5 to 8: 2) to give the title compound (0.9 [G)] as a white foam. T. [I.] c.: CH/AcOEt 75: 25, Rf=0.35 MS (ES/+): m/z=360 [M+H] +.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2004/5255, 2004, A1 Location in patent: Page 35

37
[ 1093209-76-7 ]
[ 29898-32-6 ]
[ 1093209-89-2 ]

Yield	Reaction Conditions	Operation in experiment
67%	Stage #1: 2,4-dichloro-1-iodo-benzene With triethylamine In tetrahydrofuran for 0.25h; Stage #2: 4-(3-ethynyl-benzyl)-piperazine-1-carboxylic acid benzo[d]isoxazol-3-ylamide In tetrahydrofuran at 20℃; for 3h;	81 To a solution of Pd(PPh3)2CI2 (7.2 mg) in THF/Et3N (1 ml_ each) was added 1 ,3-dichloro-4-iodobenzene (60.3 mg). The solution was degassed for 15 min, then copper(l) iodide (4.3 mg) and 4-(3-ethynyl-benzyl)-piperazine-1- carboxylic acid benzo[d]isoxazol-3-ylamide (75.6 mg) were added. The reaction mixture was stirred at rt for 3 h, then poured into water, and extracted with EtOAc (3x). The organic layers were combined, washed with NH4OH, dried (Na2SO4), and concentrated. The crude residue was purified (FCC) to give the title compound (70.8 mg, 67%). MS: 505.1. 1H NMR (d4-MeOH): 7.87-7.83 (m, 1 H), 7.61-7.56 (m, 4H), 7.55-7.52 (m, 1 H), 7.51-7.47 (m, 1 H), 7.46-7.36 (m, 3H), 7.34-7.29 (m, 1 H), 3.69-3.60 (m, 6H), 2.61-2.53 (m, 4H).

Reference： [1]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2008/153752, 2008, A2 Location in patent: Page/Page column 63

38
[ 1104393-95-4 ]
[ 29898-32-6 ]
[ 1104394-01-5 ]

Yield	Reaction Conditions	Operation in experiment
76%	With norborn-2-ene; trifuran-2-yl-phosphane; caesium carbonate; palladium dichloride In acetonitrile at 100℃; for 24h; sealed vial;

Reference： [1]Jafarpour, Farnaz; Ashtiani, Parvaneh T. [Journal of Organic Chemistry, 2009, vol. 74, # 3, p. 1364 - 1366]

39
[ 1173983-76-0 ]
[ 29898-32-6 ]
[ 1173978-53-4 ]

Yield	Reaction Conditions	Operation in experiment
45%	With [2,2]bipyridinyl; caesium carbonate In N,N-dimethyl-formamide at 150℃; for 12h;	96 10-Chloro-1-(2,4-dichlorophenyl)-7-nitro-2,3,4,5-tetrahydro-1H-[1,3]diazepino[1,2-a]benzimidazole Example 96 10-Chloro-1-(2,4-dichlorophenyl)-7-nitro-2,3,4,5-tetrahydro-1H-[1,3]diazepino[1,2-a]benzimidazole A mixture of 10-chloro-7-nitro-2,3,4,5-tetrahydro-1H-[1,3]diazepino[1,2-a]benzimidazole (Reference Example 106; 1.74 g, 6.50 mmol), 2,4-dichloro-1-iodobenzene (8.87 g, 32.5 mmol), copper(I) iodide (1.24 g, 6.50 mmol), 2,2'-bipyridyl (2.02 g, 13.0 mmol) and cesium carbonate (4.24 g, 13.0 mmol) in N,N-dimethylformamide (100 mL) was stirred at 150° C. for 12 hr. The mixture was diluted with ethyl acetate, washed with water, dried over anhydrous sodium 1010 sulfate and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluding with a 10-25% ethyl acetate/n-hexane gradient mixture. The filtrate was concentrated in vacuo to give the title compound (1.20 g, 2.91 mmol, 45%) as a light yellow amorphous. 1H-NMR(CDCl3, 300 MHz) δ: 2.15-2.36 (4H, m), 3.70-3.86 (2H, m), 4.22-4.40 (2H, m), 7.14 (1H, d, J=9.0 Hz), 7.34 (1H, dd, J=2.4, 8.4 Hz), 7.47 (1H, d, J=8.4 Hz), 7.53 (1H, d, J=2.4 Hz), 7.61 (1H, d, J=9.0 Hz). MS Calcd.: 410; Found: 411 (M+H)

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US2009/186879, 2009, A1 Location in patent: Page/Page column 127

40
[ 29898-32-6 ]
[ 143097-29-4 ]
[ 1173978-56-7 ]

Yield	Reaction Conditions	Operation in experiment
5%	With [2,2]bipyridinyl; caesium carbonate In N,N-dimethyl-formamide at 150℃; for 12h;	99 9-Chloro-1-(2,4-dichlorophenyl)-6-nitro-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole Example 99 9-Chloro-1-(2,4-dichlorophenyl)-6-nitro-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole A mixture of 9-chloro-6-nitro-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole (Reference Example 108; 10.0 g, 39.6 mmol), 2,4-dichloro-1-iodobenzene (54.0 g, 197.9 mmol), copper(I) iodide (7.57 g, 39.6 mmol), 2,2'-bipyridyl (12.3 g, 79.2 mmol) and cesium carbonate (25.8 g, 79.2 mmol) in N,N-dimethylformamide (600 mL) was stirred at 150° C. for 12 hr. The mixture was diluted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluding with a 10-25% ethyl acetate/n-hexane gradient mixture. The filtrate was concentrated in vacuo to give the title compound (750 mg, 1.88 mmol, 5%) as a light yellow amorphous. 1H-NMR(CDCl3, 300 MHz) δ:2.30-2.42 (2H, m), 3.70-3.85 (2H, m), 4.36 (2H, t, J=6.0 Hz), 7.14 (1H, d, J=9.0 Hz), 7.34 (1H, dd, J=2.4, 8.4 Hz), 7.47 (1H, d, J=8.4 Hz), 7.53 (1H, d, J=2.4 Hz), 7.61 (1H, d, J=9.0 Hz) MS Calcd.: 396; Found: 397 (M+H)
5%	With [2,2]bipyridinyl; copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 150℃; for 12h;	27 5.1.27 9-Chloro-1-(2,4-dichlorophenyl)-6-nitro-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole (27) A mixture of 43 26 (10.0g, 39.6mmol), 156 2,4-dichloro-1-iodobenzene (54.0g, 197.9mmol), 157 copper(I)iodide (7.57g, 39.6mmol), 158 2,2′-bipyridyl (12.3g, 79.2mmol) and 159 Cs2CO3 (25.8g, 79.2mmol) in 118 DMF (600mL) was stirred at 150°C for 12h. The mixture was diluted with EtOAc, washed with water, dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with a 10-25% EtOAc/n-hexane gradient mixture to give 44 27 as a light yellow amorphous (750mg, 1.88mmol, 5%). 1H NMR (CDCl3, 300MHz) δ 2.30-2.42 (2H, m), 3.70-3.85 (2H, m), 4.36 (2H, t, J=6.0Hz), 7.14 (1H, d, J=9.0Hz), 7.34 (1H, dd, J=2.4, 8.4Hz), 7.47 (1H, d, J=8.4Hz), 7.53 (1H, d, J=2.4Hz), 7.61 (1H, d, J=9.0Hz).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US2009/186879, 2009, A1 Location in patent: Page/Page column 128
[2]Kojima, Takuto; Mochizuki, Michiyo; Takai, Takafumi; Hoashi, Yasutaka; Morimoto, Sachie; Seto, Masaki; Nakamura, Minoru; Kobayashi, Katsumi; Sako, Yuu; Tanaka, Maiko; Kanzaki, Naoyuki; Kosugi, Yohei; Yano, Takahiko; Aso, Kazuyoshi [Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2229 - 2250]

41
[ 29898-32-6 ]
[ 107-18-6 ]
3-(2,4-dichlorophenyl)acrylaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With tetrabutyl-ammonium chloride; oxygen; palladium diacetate; sodium hydrogencarbonate In dimethyl sulfoxide; N,N-dimethyl-formamide at 60℃; for 12.5h;

Reference： [1]Liu, Jie; Zhu, Jin; Jiang, Hualiang; Wang, Wei; Li, Jian [Chemical Communications, 2010, vol. 46, # 3, p. 415 - 417]

42
[ 29898-32-6 ]
[ 766-97-2 ]
[ 1024655-01-3 ]

Yield	Reaction Conditions	Operation in experiment
99%	With tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; triethylamine; triphenylphosphine In water; acetonitrile at 20℃; for 3h; Inert atmosphere;

Reference： [1]Location in patent: experimental part Oliva, Cristina G.; Jagerovic, Nadine; Goya, Pilar; Alkorta, Ibon; Elguero, Jose; Cuberes, Rosa; Dordal, Alberto [ARKIVOC, 2010, vol. 2010, # 2, p. 127 - 147]

43
[ 58960-11-5 ]
[ 29898-32-6 ]
[ 1202503-61-4 ]

Yield	Reaction Conditions	Operation in experiment
33%	Stage #1: 6-methoxy-3,4-dihydro-2H-benzo[b][1,4]oxazine; 2,4-dichloro-1-iodo-benzene In toluene at 20℃; for 0.25h; Inert atmosphere; Stage #2: With caesium carbonate at 20 - 110℃; for 16h; Inert atmosphere;	62 4-(2,4-dichlorophenyl)-6-methoxy-3,4-dihydro-2H-1,4-benzoxazine Reference Example 62 4-(2,4-dichlorophenyl)-6-methoxy-3,4-dihydro-2H-1,4-benzoxazine To a solution of 6-methoxy-3,4-dihydro-2H-1,4-benzoxazine (6.0 g, 36.4 mmol) in toluene were added 2,4-dichloro-1-iodobenzene (12.0 g, 43.6 mmol), tris(dibenzylideneacetone)dipalladium (330 mg, 0.36 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (624 mg, 1.08 mmol) at room temperature, and the mixture was stirred under an argon stream for 15 min. To the reaction mixture was added cesium carbonate (18 g, 55.6 mmol) at room temperature, and the mixture was heated under an argon stream at 110°C for 16 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate 1:9) to give the title compound (3.76 g, yield 33%). Oil. 1H-NMR (CDCl3) δ: 3.50-3.70 (5H, m), 4.27 (2H, brs), 5.88 (1H, d, J = 2.7 Hz), 6.27 (1H, dd, J = 9.0, 2.7 Hz), 6.79 (1H, d, J = 9.0 Hz), 7.10 - 7.33 (2H, m), 7. 50 (1H, t, J = 1.5 Hz).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP2298731, 2011, A1 Location in patent: Page/Page column 62

44
[ 17422-43-4 ]
[ 29898-32-6 ]
[ 1202503-72-7 ]

Yield	Reaction Conditions	Operation in experiment
50%	With sodium t-butanolate In toluene at 100℃; for 13h; Inert atmosphere;	66 1-(2,4-dichlorophenyl)-8-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepine Reference Example 66 1-(2,4-dichlorophenyl)-8-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepine To a solution of 8-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepine (1.17 g, 6.60 mmol) obtained in Reference Example 65, 1,3-dichloro-4-iodobenzene (996 μL, 6.60 mmol) and sodium t-butoxide (1.59 g, 16.5 mmol) in toluene (80 mL) were added tris(dibenzylideneacetone)dipalladium(0) (604 mg, 0.66 mmol) and 2'-(dicyclohexylphosphino)-N,N-dimethylbiphenyl-2-amine (519 mg, 1.32 mmol), and the mixture was stirred with heating under a nitrogen atmosphere at 100°C for 13 hr. Ethyl acetate was added to the reaction mixture, and the mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (1.07 g, yield 50%) as an oil. 1H-NMR (CDCl3) δ: 1.64 - 1.74 (2H, m), 1.74 - 1.89 (2H, m), 2.85 - 2.93 (2H, m), 3.52 - 3.59 (2H, m), 3.63 (3H, s), 6.00 (1H, d, J = 2.7 Hz), 6.47 (1H, dd, J = 8.3, 2.7 Hz), 7.07 (1H, d, J = 8.3 Hz), 7.22 (2H, d, J = 3.0 Hz), 7.33 (1H, d, J = 1.9 Hz).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP2298731, 2011, A1 Location in patent: Page/Page column 63

45
[ 1202502-28-0 ]
[ 29898-32-6 ]
[ 1202502-30-4 ]

Yield	Reaction Conditions	Operation in experiment
74%	With caesium carbonate In toluene at 100℃; for 40h; Inert atmosphere;	3 methyl 3-[1-(2,4-dichlorophenyl)-2,3-dihydro-1H-indol-6-yl]benzoate Reference Example 3 methyl 3-[1-(2,4-dichlorophenyl)-2,3-dihydro-1H-indol-6-yl]benzoate To a solution of methyl 3-(2,3-dihydro-1H-indol-6-yl)benzoate (300 mg, 1.18 mmol) obtained in Reference Example 2, 1,3-dichloro-4-iodobenzene (193 μL, 1.42 mmol) and cesium carbonate (577 mg, 1.77 mmol) in toluene (3 mL) were added tris(dibenzylideneacetone)dipalladium(0) (25.6 mg, 0.028 mmol) and 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (16.7 mg, 0.035 mmol), and the mixture was stirred with heating under a nitrogen atmosphere at 100°C for 40 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (350 mg, yield 74%) as an oil. 1H-NMR (CDCl3) δ : 3.22 (2H, t, J = 8.3 Hz), 3.86 - 4.02 (5H, m), 6.62 (1H, d, J = 1.3 Hz), 7.01 (1H, dd, J = 7.5, 1.5 Hz), 7.21 - 7.29 (2H, m), 7.37 - 7.47 (2H, m), 7.50 (1H, d, J = 2.4 Hz), 7.64 - 7.72 (1H, m), 7.91 - 7.99 (1H, m), 8.17 (1H, t, J = 1.6 Hz).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP2298731, 2011, A1 Location in patent: Page/Page column 49

46
[ 1202502-35-9 ]
[ 29898-32-6 ]
[ 1202502-75-7 ]

Yield	Reaction Conditions	Operation in experiment
60%	With copper; potassium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 20h; Inert atmosphere;	25 ethyl 3-[1-(2,4-dichlorophenyl)-1H-indol-6-yl]benzoate Reference Example 25 ethyl 3-[1-(2,4-dichlorophenyl)-1H-indol-6-yl]benzoate A suspension of ethyl 3-(1H-indol-6-yl)benzoate (1.00 g, 3.77 mmol) obtained in Reference Example 5, 1,3-dichloro-4-iodobenzene (1.02 mL, 7.54 mmol), copper powder (240 mg, 3.77 mmol) and potassium carbonate (1.04 g, 7.54 mmol) in NMP (8 mL) was stirred with heating under a nitrogen atmosphere at 150°C for 20 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (930 mg, yield 60%) as an oil. 1H-NMR (CDCl3) δ : 1.40 (3H, t, J = 7.1 Hz), 4.40 (2H, q, J = 7.0 Hz), 6.73 (1H, dd, J = 3.3, 0.8 Hz), 7.24 (1H, d, J = 3.4 Hz), 7.29 - 7.32 (1H, m), 7.40 - 7.43 (2H, m), 7.44 - 7.51 (2H, m), 7.64 (1H, dd, J = 1.8, 0.8 Hz), 7.73 - 7.81 (2H, m), 7.93 - 8.01 (1H, m), 8.27(1H, t, J = 1.6 Hz).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP2298731, 2011, A1 Location in patent: Page/Page column 54

47
[ 1202502-95-1 ]
[ 29898-32-6 ]
[ 1202503-03-4 ]

Yield	Reaction Conditions	Operation in experiment
19%	With potassium phosphate In 1,4-dioxane at 120℃; for 1h;	38 ethyl 3-[1-(2,4-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]benzoate Reference Example 38 ethyl 3-[1-(2,4-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]benzoate A mixture of ethyl 3-(1H-pyrrolo[2,3-b]pyridin-6-yl)benzoate (200 mg, 0.751 mmol) obtained in Reference Example 34, 1,3-dichloro-4-iodobenzene (153 μl, 1.12 mmol), potassium phosphate (351 mg, 1.65 mmol), copper iodide (7.2 mg, 0.038 mmol), N,N'-dimethylcyclohexane-1,2-diamine (23.7 μl, 0.150 mmol) and 1,4-dioxane (2.0 ml) was stirred in a microwave reactor (Initiator (trade name), Biotage AB) at 120°C for 30 min. Copper iodide (72 mg, 0.38 mmol) and N,N-dimethylcyclohexyldiamine (94.8 μl, 0.600 mmol) were further added and the mixture was stirred in a microwave reactor (Initiator (trade name), Biotage AB) at 120°C for 30 min. Water was poured into the reaction solution and the mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane = 1:9) to give the title compound (59.6 mg , yield 19%) as a solid. 1H-NMR (CDCl3) δ:1.39 - 1.45 (3H, m), 4.40 (2H, q, J = 6.9 Hz), 6.67 (1H, d, J = 3.8 Hz), 7.39 - 7.53 (3H, m), 7.57 - 7.64 (2H, m), 7.68 - 7.74 (1H, m), 7.99 - 8.07 (2H, m), 8.21 - 8.27 (1H, m), 8.64 - 8.69 (1H, m).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP2298731, 2011, A1 Location in patent: Page/Page column 56-57

48
[ 1202502-98-4 ]
[ 29898-32-6 ]
[ 1202503-07-8 ]

Yield	Reaction Conditions	Operation in experiment
25%	With sodium t-butanolate In toluene at 100℃; for 24h;	40 ethyl 3-[1-(2,4-dichlorophenyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl]benzoate Reference Example 40 ethyl 3-[1-(2,4-dichlorophenyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl]benzoate A mixture of ethyl 3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)benzoate (190 mg, 0.708 mmol) obtained in Reference Example 35, 1,3-dichloro-4-iodobenzene (144 μl, 1.06 mmol), sodium tert-butoxide (102 mg, 1.06 mmol), tris(dibenzylideneacetone)dipalladium(O) (13.0 mg, 0.014 mmol), 2-(dicyclohexylphosphino)-2',4',6'-triisopropyl-1,1'-biphenyl (20.3 mg, 0.042 mmol) and toluene (3.8 ml) was stirred at 100°C for 1 day. Water was poured into the reaction solution and the mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane = 1:9) to give the title compound (72.8 mg, yield 25%) as a solid. 1H-NMR (CDCl3) δ: 1.41 (3H, t, J = 7.2 Hz), 3.17 - 3.25 (2H, m), 4.05 (2H, t, J = 8.4 Hz), 4.38 (2H, q, J = 7.2 Hz), 7.13 - 7.19 (1H, m), 7.30 (1H, dd, J = 8.7, 2.4 Hz), 7.40-7.51 (3H, m), 7.57 (1H, d, J = 8.7 Hz), 7.95 - 8.01 (1H, m), 8.06 - 8.13 (1H, m), 8.53 (1H, t, J = 1.6 Hz).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP2298731, 2011, A1 Location in patent: Page/Page column 57

49
[ 61676-62-8 ]
[ 29898-32-6 ]
1,3-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	With n-butyllithium; Triisopropyl borate In tetrahydrofuran; hexane at -60℃;

Reference： [1]Browne, Duncan L.; Baumann, Marcus; Harji, Bashir H.; Baxendale, Ian R.; Ley, Steven V. [Organic Letters, 2011, vol. 13, # 13, p. 3312 - 3315]

50
[ 1365889-00-4 ]
[ 29898-32-6 ]
[ 15164-44-0 ]
[ 1365889-17-3 ]
(Z)-4-(2-(2,4-dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75 % de	Stage #1: 5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole With bis(pinacol)diborane In 2-methyltetrahydrofuran at 83℃; for 5h; Inert atmosphere; Stage #2: p-(iodophenyl)carboxaldehyde With caesium carbonate In 2-methyltetrahydrofuran; water at 4 - 20℃; for 6h; Inert atmosphere; Stage #3: 2,4-dichloro-1-iodo-benzene With potassium hydroxide In 2-methyltetrahydrofuran; water for 4h; Inert atmosphere; Reflux;	37.1 Example 37Preparation of Compound 112: (E)-Ethyl 3-(4-((E)-2-(2,4-dichlorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenypacrylateStep 1: (E)-4-(2-(2,4-Dichlorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde A round-bottom flask equipped with a magnetic stir bar, a reflux condenser, and a N2 inlet was charged with 5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (20.0 g, 78.6 mmol; Intermediate 3), bis(pinacolato)diboron (20.17 g, 79.4 mmol), tetrakis(triphenylphosphine)platinum (0) (0.98 g, 0.8 mmol), and anhydrous 1,4-dioxane (160 mL). This mixture was degassed with three vacuum/N2 cycles and refluxed for 4 h. The solution was then allowed to cool to room temperature, and 4-iodobenzaldehyde (18.25 g, 78.6 mmol), trans-dichloro(triphenylphosphine)palladium (II) (5.52 g, 7.9 mmol), cesium carbonate (51.24 g, 157.3 mmol), and 1,4-dioxane (160 mL) were added. This mixture was degassed with three vacuum/N2 cycles, and then water (4.7 mL) was added. This mixture was stirred at room temperature for 6 h. 2,4-Dichloroiodobenzene (12.8 mL, 94.4 mmol) and 6M aqueous KOH (62.9 mL) were added, and the mixture was degassed with three vacuum/N2 cycles and refluxed for 4 h. Upon completion, the reaction mixture was filtered through a Celite/silica pad and washed with EtOAc. The filtrate was washed with water (600 mL), washed with brine (300 mL), dried over sodium sulfate, filtered, and concentrated. The crude product was purified by silica gel chromatography (0-20% ethyl acetate in hexanes) to give the title compound (27.2 g, 7:1 mixture of regioisomers) as a yellow foam. Data for major regioisomer: 1H NMR (400 MHz, DMSO-d6): δ 9.83 (s, 1H), 8.16 (s, 1H), 7.77 (d, 1H), 7.73 (s, 1H), 7.65 (d, 2H), 7.53 (d, 1H), 7.41-7.36 (m, 2H), 7.31-7.28 (m, 1H), 7.17 (d, 2H), 5.86 (dd, 1H), 3.92-3.86 (m, 1H), 3.78-3.71 (m, 1H), 2.47-2.38 (m, 3H), 2.10-1.96 (m, 2H), 1.81-1.71 (m, 1H), 1.64-1.58 (m, 2H), 0.94 (t, 3H); LCMS: 421 [(M-THP+H)+H]+.

Reference： [1]Current Patent Assignee: JOHNSON & JOHNSON INC - US2012/71535, 2012, A1 Location in patent: Page/Page column 70-71

51
[ 201230-82-2 ]
[ 29898-32-6 ]
[ 1422386-81-9 ]
[ 1422386-30-8 ]

Yield	Reaction Conditions	Operation in experiment
59%	With palladium diacetate; triethylamine In 1,4-dioxane at 80℃; for 2h;

Reference： [1]Borhade, Sanjay R.; Sandström, Anja; Arvidsson, Per I. [Organic Letters, 2013, vol. 15, # 5, p. 1056 - 1059]

52
[ 95-16-9 ]
[ 29898-32-6 ]
[ 1443352-02-0 ]

Yield	Reaction Conditions	Operation in experiment
94%	With copper(l) iodide; 1,10-Phenanthroline; oxygen; sulfur; potassium hydroxide In water; dimethyl sulfoxide at 130℃; for 7h;

Reference： [1]Wang, Xiaowei; Li, Yanjun; Yuan, Yu [Synthesis, 2013, vol. 45, # 9, p. 1247 - 1255]

53
[ 29898-32-6 ]
[ 106-53-6 ]
[ 1451093-01-8 ]

Yield	Reaction Conditions	Operation in experiment
	With 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride In 1-methyl-pyrrolidin-2-one at 130℃; for 2h; Inert atmosphere; Sealed tube;	Preparation of 1-(4-bromo-phenylsulfanyl)-2,4-dichloro-benzene N-Methyl-2-pyrrolidone (10 mL) was added to 4-bromothiophenol (0.500 g, 2.64 mmol) in a sealed tube and the mixture was purged with argon for 5 minutes. After this time, 2,4-dichloroiodobenzene (0.72 g, 2.64 mmol), CuCl (0.131 g, 1.32 mmol), tetramethyl heptanedione (0.14 mL, 0.66 mmol) and cesium carbonate (1.70 g, 5.28 mmol) were added to the reaction mixture. The reaction mixture was stirred at 130° C. under argon for 2 hours. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, and filtered through a celite bed. The filtrate was washed with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to yield the crude product. Silica gel chromatography (neat hexanes) provided impure 1-(4-bromo-phenylsulfanyl)-2,4-dichloro-benzene (0.7 g).

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - US2013/225588, 2013, A1 Location in patent: Paragraph 0228

54
[ 709-63-7 ]
[ 29898-32-6 ]
2-(2,4-dichloro-phenyl)-1-(4-trifluoromethyl-phenyl)-ethanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
9.1 g	With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾ In 1,4-dioxane at 150℃; for 0.5h; Inert atmosphere; Microwave irradiation;	1.i (i) 2-(2,4-Dichloro-phenyl)-1 -(4-trifluoromethyl-phenyl)-ethanone A solution of 6 g of 2,4-Dichloro-1 -iodo-benzene, 15.7 g of CS2CO3, 63 mg of Pd(dba)2 (Bis(dibenzylidenacetonpalladium), 127 mg of Xantphos (9,9-Dimethyl-4,5- bis(diphenylphosphino)xanthene) and 8.3 g of 1 -(4-Trifluoromethyl-phenyl)-ethanone in 45 ml of dioxane was heated under argon for 30 min at 150°C by microwave irradiation. After cooling to room temperature and dilution with saturated aqueous sodium hydrogen carbonate solution, the reaction mixture was filtered through a chem elut cartridge by eluting with ethyl acetate. The solvents were removed under reduced pressure and the crude product was purified by chromatography on silica gel eluting with a gradient of n-heptane/ethyl acetate. The fractions containing the product were combined and the solvent evaporated under reduced pressure. Yield: 9.1 g.

Reference： [1]Current Patent Assignee: SANOFI - WO2013/171316, 2013, A1 Location in patent: Page/Page column 46; 47

55
[ 29898-32-6 ]
[ 134469-07-1 ]
[ 1403604-85-2 ]

Yield	Reaction Conditions	Operation in experiment
69%	With copper(l) iodide; 1,10-Phenanthroline; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 30h; Inert atmosphere; Schlenk technique;	General procedure for Cu-catalyzed one-pot synthesis of benzimidazo[2,1-b]benzothiazoles General procedure: An oven-dried Schlenk tube was charged with a magneticstir bar, binucleophile 2-mercaptobenzimidazole 2 (1.0 mmol, 1.0 equiv), CuI(0.1 mmol, 10 mol %), phen (0.2 mmol, 20 mol %), and K2CO3 (2.0 mmol, 2equiv). The tube was capped and then evacuated and backfilled with nitrogen(3 times). Under a positive pressure of nitrogen, a solution of o-dihaloarene 1(1.05 mmol, 1.05 equiv) in DMF (3 mL) was added via syringe. The tube wassealed and allowed to stir at 120 C (monitored by TLC). After being cooled toroom temperature, EtOAc (40 mL) was added and the mixture was washedwith brine (20 mL 3). The organic phase was dried over Na2SO4 andconcentrated. The residue was purified by column chromatography on silicagel using petrol/EtOAc (10:1?3:1, v:v) as eluent to give product 3.

Reference： [1]Gao, Jilong; Zhu, Jiaoyan; Chen, Lubin; Shao, Yingying; Zhu, Jiaqi; Huang, Yijia; Wang, Xiaoxia; Lv, Xin [Tetrahedron Letters, 2014, vol. 55, # 22, p. 3367 - 3373]

56
[ 29898-32-6 ]
[ 292638-85-8 ]
[ 2437-79-8 ]
[ 42174-01-6 ]

Yield	Reaction Conditions	Operation in experiment
5%	With triethylamine In N,N-dimethyl-formamide at 100℃; for 2h; Inert atmosphere;	General procedure for the Heck reaction (batch mode General procedure: A mixture of 10 mg supported catalyst, 0.2 mmol (22 l)iodobenzene, 0.4 mmol (36 l) methyl acrylate, 0.68 mmol (100 l)Et3N and 1 ml DMF was stirred in an inert atmosphere at 100C for2 h. The solution was removed by a syringe and the catalyst was reused without purification. Reaction mixtures were analysed by gas chromatography(Hewlett Packard 5890) and GC-MS (Hewlett Packard 5971AGC-MSD, HP-1 column). Conversions and selectivities of the reactions were determined by GC.

Reference： [1]Urbán, Béla; Srankó, Dávid; Sáfrán, György; Ürge, László; Darvas, Ferenc; Bakos, József; Skoda-Földes, Rita [Journal of Molecular Catalysis A: Chemical, 2014, vol. 395, p. 364 - 372]

57
[ 201230-82-2 ]
[ 29898-32-6 ]
[ 62-53-3 ]
[ 6043-39-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; Schlenk technique; Inert atmosphere;	2.3.2. Catalytic reactions at atmospheric pressure General procedure: In a typical experiment a solution containing the palladiumcatalyst (with 6 mol Pd-content) was placed in a Schlenk-tube.Under argon, 0.2 mmol (22.5 l) iodobenzene (1), 0.5 mmol aminereagent, 0.7 mmol (100 l) triethylamine and 1 ml solvent wasadded and the atmosphere was changed to carbon monoxide. Thereaction mixture was heated with stirring in an oil bath at 100Cand was analysed by gas chromatography.

Reference： [1]Urbán, Béla; Papp, Máté; Srankó, Dávid; Skoda-Földes, Rita [Journal of Molecular Catalysis A: Chemical, 2015, vol. 397, p. 150 - 157]

58
[ 288-13-1 ]
[ 29898-32-6 ]
1-(2,4-dichlorophenyl)-1H-pyrazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 180℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference： [1]Fuse, Shinichiro; Morita, Taiki; Johmoto, Kohei; Uekusa, Hidehiro; Tanaka, Hiroshi [Chemistry - A European Journal, 2015, vol. 21, # 41, p. 14370 - 14375]

59
[ 120-72-9 ]
[ 29898-32-6 ]
1-(2,4-dichlorophenyl)-1H-indole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With potassium phosphate; copper In dimethyl sulfoxide at 80℃; for 5h; Inert atmosphere;	General procedure for Cu-NP catalyzed N-arylations of azoles with aryl halides General procedure: An oven dried two-necked round bottom flask was charged with aryl halide (1mmol) and K3PO4 (2mmol), evacuated and backfilled with argon. The azole compound (1mmol) and 2mL of DMSO were added under argon. After that Cu-NP (1.6mmol) was added and the flask was again backfilled with argon. The flask was then immersed in a preheated oil bath at 80°C until the conversion was completed (detected by TLC). The cooled mixture was partitioned between ethyl acetate (10mL) and saturated NH4Cl (10mL). The aqueous layer was extracted with ethyl acetate (2×10mL), the organic layer was washed with brine (20mL), dried over anhydrous Na2SO4 and concentrated in vacuum. The residue was purified by column chromatography on silica gel using ethyl acetate in hexane (1.5-10%) as eluent to afford the desired product. All the products have been characterized by 1H NMR, 13C NMR, and mass spectroscopy. For new products, FTIR data were also recorded.

Reference： [1]Pai, Gita; Chattopadhyay, Asoke P. [Tetrahedron Letters, 2016, vol. 57, # 29, p. 3140 - 3145]

60
[ 288-32-4 ]
[ 29898-32-6 ]
[ 190199-40-7 ]

Yield	Reaction Conditions	Operation in experiment
83%	With potassium phosphate; copper In dimethyl sulfoxide at 80℃; for 5h; Inert atmosphere;	General procedure for Cu-NP catalyzed N-arylations of azoles with aryl halides General procedure: An oven dried two-necked round bottom flask was charged with aryl halide (1mmol) and K3PO4 (2mmol), evacuated and backfilled with argon. The azole compound (1mmol) and 2mL of DMSO were added under argon. After that Cu-NP (1.6mmol) was added and the flask was again backfilled with argon. The flask was then immersed in a preheated oil bath at 80°C until the conversion was completed (detected by TLC). The cooled mixture was partitioned between ethyl acetate (10mL) and saturated NH4Cl (10mL). The aqueous layer was extracted with ethyl acetate (2×10mL), the organic layer was washed with brine (20mL), dried over anhydrous Na2SO4 and concentrated in vacuum. The residue was purified by column chromatography on silica gel using ethyl acetate in hexane (1.5-10%) as eluent to afford the desired product. All the products have been characterized by 1H NMR, 13C NMR, and mass spectroscopy. For new products, FTIR data were also recorded.

Reference： [1]Pai, Gita; Chattopadhyay, Asoke P. [Tetrahedron Letters, 2016, vol. 57, # 29, p. 3140 - 3145]

61
[ 29898-32-6 ]
N⁸-benzylthiazolo[5,4-f]quinazolin-9(8H)-one [ No CAS ]
N⁸-benzyl-2-(2,4-dichlorophenyl)thiazolo[5,4-f]quinazolin-9(8H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	Stage #1: N⁸-benzylthiazolo[5,4-f]quinazolin-9(8H)-one With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 0.166667h; Microwave irradiation; Sealed tube; High pressure; Stage #2: 2,4-dichloro-1-iodo-benzene With palladium diacetate In N,N-dimethyl-formamide at 120℃; Microwave irradiation; Sealed tube; High pressure; regioselective reaction;
62%	Stage #1: N⁸-benzylthiazolo[5,4-f]quinazolin-9(8H)-one With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 0.166667h; Microwave irradiation; Inert atmosphere; Stage #2: 2,4-dichloro-1-iodo-benzene With palladium diacetate In N,N-dimethyl-formamide at 120℃; for 5h; Inert atmosphere; Microwave irradiation; regioselective reaction;	Palladium- and Copper-Assisted C-H Arylation of Compounds 6; Typical Procedure for Products 7 (Schemes 4 and 5) General procedure: Thiazolo[5,4-f]quinazolin-9(8H)-one 6 (0.341 mmol), CuI (0.065 g, 0.341 mmol, 1 equiv), and DBU (101 μL, 0.682 mmol, 2.0 equiv) in anhyd DMF (850 μL) were added to a 2 mL glass microwave vial. The mixture was stirred under microwave irradiation at 120 °C for 10 min. Then Pd(OAc)2 (7.6 mg, 0.034 mmol, 10 mol%) and the appropriate aryl halide (0.682 mmol, 2.0 equiv) were added to the mixture. The reaction mixture was then stirred under microwave irradiation at 120 °C for 5 h. The resulting solution was diluted with CH2Cl2, filtered through a cotton plug and washed with CH2Cl2 (50 mL). The crude product obtained by concentration of CH2Cl2 was purified by flash chromatography on silica gel with EtOAc/CH2Cl2 as eluent (1:0 to 1:1, v/v, for 7ah-j; 7:3 to 1:4, v/v for 7ba-j) to afford the corresponding product 7.
62%	Stage #1: N⁸-benzylthiazolo[5,4-f]quinazolin-9(8H)-one With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 0.166667h; Sealed tube; Microwave irradiation; Stage #2: 2,4-dichloro-1-iodo-benzene With palladium diacetate at 120℃; for 5h; Microwave irradiation; regioselective reaction;

Reference： [1]Harari, Marine; Couly, Florence; Fruit, Corinne; Besson, Thierry [Organic Letters, 2016, vol. 18, # 13, p. 3282 - 3285]
[2]Couly, Florence; Dubouilh-Benard, Carole; Besson, Thierry; Fruit, Corinne [Synthesis, 2017, vol. 49, # 20, p. 4615 - 4622]
[3]Couly, Florence; Harari, Marine; Dubouilh-Benard, Carole; Bailly, Laetitia; Petit, Emilie; Diharce, Julien; Bonnet, Pascal; Meijer, Laurent; Fruit, Corinne; Besson, Thierry [Molecules, 2018, vol. 23, # 9]

62
[ 38072-88-7 ]
[ 29898-32-6 ]
N-(2,4-dichlorophenyl)-5-methoxypyrrolidin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 60℃; for 88h; Inert atmosphere;	Synthesis of N-Arylpyroglutamic Derivatives 40-44 by Cross-Coupling of DL-5-Methoxypyrrolidin-2-one (3a) or Aminopyrrolidinones 3b,c with Aromatic Halides; General Procedure General procedure: A suspension of DL-5-methoxypyrrolidin-2-one (3a) or arylaminopyrrolidinones 3b,c (1 equiv), CuI (0.5 equiv), cesium carbonate (2 equiv), and corresponding aryl iodide (1 equiv) in dioxane was placed under a nitrogen atmosphere. The coupling ligand DMEDA (1 equiv) was added dropwise by using a syringe and the mixture was then stirred at 60 °C for various periods of time (14-88 h). At the end ofthe reaction, the insoluble salts deposited after cooling at r.t. were collected by filtration then washed with dichloromethane. The resulting filtrate was concentrated in vacuo and the residue was partitioned between water and dichloromethane. The organic layer was dried on MgSO4 and evaporated to dryness. The residue was finally purified by chromatography on silica gel column (EtOAc/n-heptane) to afford pure N-arylated compound 40-44.

Reference： [1]Baudelet, Davy; Daïch, Adam; Rigo, Benoît; Lipka, Emmanuelle; Gautret, Philippe; Homerin, Germain; Claverie, Christelle; Rousseau, Jolanta; Abuhaie, Cristina-Maria; Ghinet, Alina [Synthesis, 2016, vol. 48, # 14, p. 2226 - 2244]

63
[ 29898-32-6 ]
5-[(4-methoxyphenyl)amino]pyrrolidin-2-one [ No CAS ]
1-(2,4-dichlorophenyl)-5-[(4-methoxyphenyl)amino]pyrrolidin-2-one [ No CAS ]
[ 104-94-9 ]
[ 501-58-6 ]

Yield	Reaction Conditions	Operation in experiment
1: 23% 2: 33% 3: 35%	With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 60℃; for 15h; Inert atmosphere;	Synthesis of N-Arylpyroglutamic Derivatives 40-44 by Cross-Coupling of DL-5-Methoxypyrrolidin-2-one (3a) or Aminopyrrolidinones 3b,c with Aromatic Halides; General Procedure General procedure: A suspension of DL-5-methoxypyrrolidin-2-one (3a) or arylaminopyrrolidinones 3b,c (1 equiv), CuI (0.5 equiv), cesium carbonate (2 equiv), and corresponding aryl iodide (1 equiv) in dioxane was placed under a nitrogen atmosphere. The coupling ligand DMEDA (1 equiv) was added dropwise by using a syringe and the mixture was then stirred at 60 °C for various periods of time (14-88 h). At the end ofthe reaction, the insoluble salts deposited after cooling at r.t. were collected by filtration then washed with dichloromethane. The resulting filtrate was concentrated in vacuo and the residue was partitioned between water and dichloromethane. The organic layer was dried on MgSO4 and evaporated to dryness. The residue was finally purified by chromatography on silica gel column (EtOAc/n-heptane) to afford pure N-arylated compound 40-44.

Reference： [1]Baudelet, Davy; Daïch, Adam; Rigo, Benoît; Lipka, Emmanuelle; Gautret, Philippe; Homerin, Germain; Claverie, Christelle; Rousseau, Jolanta; Abuhaie, Cristina-Maria; Ghinet, Alina [Synthesis, 2016, vol. 48, # 14, p. 2226 - 2244]

64
[ 29898-32-6 ]
[ 63190-94-3 ]
C₁₇H₁₉Cl₂N₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	Stage #1: 2,4-dichloro-1-iodo-benzene; 2,2-dimethyl-4-(1H-1,2,4-triazole-1-yl)hept-6-yn-3-one With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 60℃; Inert atmosphere; Stage #2: With methanol; sodium tetrahydroborate	21 Compound I-15 Under an argon atmosphere, the 0.82g (3mmol) 2,4-dichloro-iodobenzene, 0.02g (0.03mmol) bis(triphenylphosphine)palladium dichloride and 0.018 (0.06 mmol) CuI was dissolved in 30 ml dry triethylamine, stirrred and heated to 60 °C, was added 0.62g (3.3mmol) of 2,2-dimethyl-4-(1H-1,2,4-triazol-1-yl)hept-6-yn-3-one (II-4), mixing, TCL monitor completion of the reaction, the solvent was stripped on a rotary evaporator, the residue was poured into 50mL of water, with 10mL of ethyl acetate three times, the organic layers combined, dried over anhydrous sodium sulfate, the solvent off on a rotary evaporator, the resulting residue was dissolved in methanol, was added 0.23g (6mmol) of sodium borohydride reduction, to rotate again in the instrument after removal of the solvent was evaporated, and the residue was poured into 50mL water and extracted with 10mL of ethyl acetate three times, the organic layers combined, dried over anhydrous sodium sulfate, the solvent off on a rotary evaporator, to give a white solid in recrystallization from ethyl acetate, yield 78%

Reference： [1]Current Patent Assignee: CENTRAL CHINA NORMAL UNIVERSITY - CN105820129, 2016, A Location in patent: Paragraph 0188-0191

65
[ 201230-82-2 ]
[ 29898-32-6 ]
[ 50-84-0 ]

Yield	Reaction Conditions	Operation in experiment
69%	With water; palladium diacetate; triethylamine; triphenylphosphine In 1,4-dioxane at 110℃; for 2h; Flow reactor;	Ortho-substituted carbonylation in flow using a “tube-in-tube” reactor General procedure: For a typical reaction, a Vapourtec 2R+ Series was used as the platform with a Vapourtec Gas/Liquid Membrane Reactor to load the carbon monoxide. The HPLC pump were both set at 0.125 mL/min, temperature of the reactor at 110 °C, pressure of CO at 15 bar with a back pressure regulator of 250 psi (17.24 bar). The system was left running for 2 h to reach steady state after which time the flow streams were switched to pass from the loops where the substrates and catalysts were loaded. The first loop (5 mL) was filled with a solution of palladium acetate (20 mg, 0.08 mmol), triphenylphosphine (48 mg, 0.168 mmol) in 6 mL of 1,4-dioxane while the second loop (5 mL) was filled with a solution made from the ortho-substituted iodoarene substrate (1.68 mmol), triethylamine (0.272 g, 0.374 mL, 2.69 mmol) and water (0.505 g, 28 mmol) in 5.8 mL of 1,4-dioxane. An Omnifit column filled with 1.71 cm3 (r = 0.33 cm, h = 5.00 cm) of cotton was positioned just before the back pressure regulator to trap any particulate matter formed to avoid blocking of the back pressure regulator. After the substrates were passed through the system, the outlet of the flow stream was directed into a receptacle where the excess carbon monoxide gas was vented off in the fume cupboard. The reaction mixture was then evaporated to dryness, ethyl acetate (25 mL) and sodium carbonate solution (2 M, 10 mL) were added and transferred to a separating funnel. After collecting the aqueous layer, the organic layer was extracted with sodium carbonate solution (2 M, 2 × 10 mL). The combined aqueous layers were acidified by the addition of 2 M HCl solution which was then extracted with ethyl acetate (3 x 25 mL). The organic layer was dried over sodium sulfate, and the solvent evaporated under vacuum to give the crude product as a solid. The crude product was then recrystallised from the appropriate solvent.

Reference： [1]Mallia, Carl J.; Walter, Gary C.; Baxendale, Ian R. [Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 1503 - 1511]

66
[ 29898-32-6 ]
[ 98-80-6 ]
[ 33284-50-3 ]

Yield	Reaction Conditions	Operation in experiment
62%	With C₂₀H₂₉Cl₂N₅O₂Pd; potassium carbonate In ethanol at 80℃; for 2h;	Synthesis of PCB congeners 1 and 2 and chloromethoxybiphenyl 8 by the Suzuki reaction. General procedure: A 2×10-3 solution of complex 6 [27] in 8×10-7 mol of ethanol (0.4 mL) was added with stirring to a hot (80°) mixture of 5-10 mL of ethanol, 1.0-3.0 mmol of aryliodide, 1.1 equiv of arylboronic acid, and 1.5 equiv of K2CO3. The reaction mixture was heated on an oil bath at 80° for 2 h and then cooled to room temperature and diluted with 10 mL of water. The reaction product was extracted with a hexane-dichloromethane mixture (5 : 1, 3×20 mL), the organic layer was dried over anhydrous Na2SO4, the solvent was evaporated, and the residue was weighed and analyzed by 1H NMR and GLC. When necessary, the product was additionally purified by column chromatography (eluent hexane). 2,4-Dichlorobiphenyl (1) [32] was prepared from1.0 mmol of 2,4-dichloro-1-iodobenzene. Yield138 mg (62%), light yellow oily liquid. 1 NMR spectrum, δ, ppm: 7.29-7.49 m (7H), 7.52 d (1H, 3,J = 1.2 Hz). Mass spectrum, m/z (Irel, %): 222 (100)[]+, 152 (75) [M - 2Cl]+.

Reference： [1]Khaibulova, T. Sh.; Boyarskaya; Polukeev; Boyarskii [Russian Journal of General Chemistry, 2016, vol. 86, # 10, p. 2318 - 2324][Zh. Obshch. Khim., 2016, vol. 86, # 10, p. 1670 - 1677,8]

67
[ 27329-70-0 ]
[ 29898-32-6 ]
[ 56300-69-7 ]

Yield	Reaction Conditions	Operation in experiment
53%	With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; ethanol; water at 65℃; for 1h;	Method A- Suzuki Reaction General procedure: 1.00 mmol arylhalide, 1.30 mmol furfural-boronic acid and 0.05 mmolBis(triphenylphosphine)palladium(II) dichloride were treated with 0.30 mLdimethoxyethane, 0.50 mL ethanol and 0.30 mL aqueous 2M sodium carbonate solution.The reaction was heated to 65°C for 1h or until the TLC showed no remaining startingmaterial. The mixture was evaporated and extracted three times with ethyl acetate. Thecombined organic layers were washed with brine, dried over MgSO4, filtered andconcentrated. The crude product was purified by column chromatography usinghexanes/ethyl acetate (9:1).
	With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 80℃; for 3h;

Reference： [1]Krake, Susann H.; Martinez, Pablo David G.; McLaren, Jenna; Ryan, Eileen; Chen, Gong; White, Karen; Charman, Susan A.; Campbell, Simon; Willis, Paul; Dias, Luiz Carlos [European Journal of Medicinal Chemistry, 2017, vol. 126, p. 929 - 936]
[2]Ji, Sen; Ma, Shuang; Wang, Wen-Jing; Huang, Shen-Zhen; Wang, Tian-Qi; Xiang, Rong; Hu, Yi-Guo; Chen, Qiang; Li, Lin-Li; Yang, Sheng-Yong [Chemical Biology and Drug Design, 2017, vol. 89, # 4, p. 585 - 598]

68
[ 29898-32-6 ]
C₅H₅N₅S [ No CAS ]
C₁₁H₇Cl₂N₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; 2,9-dimethyl-1,10-phenanthroline monohydrate; potassium <i>tert</i>-butylate In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	1 preparation of intermediate product Under the protection of nitrogen, general compound 14 (0.30 mmol), Compound (7) (0.90 mmol), neocuproine hydrate (2,9-dimethyl-1,10-phenanthroline hydrate, 0,03 mmol), and copper iodide (0·03 mmol) And potassium tert-butoxide (0.60 mmol) dissolved in DMF (2 mL), heated to 110 ° C in oil bath, stirring reaction 24 h, cooled to room temperature, reduced DMF, crude product. Separation of Silicone Column for Crude Product (Silicone column length 30cm, inner diameter 24Silicone type 200-300, Qingdao Ocean Chemical Co., Ltd .; 1st piece stepped decanting solution 10 volume CHC13 sum 0.5 volume NH40H 3mL / min, flow rate 3mL / min, washout time 10min; 2 nd stage decalcification solution CHC13,1 volume OH total volume 0.5 NH40H composition, flow rate 3mL / min, Advanced chemical decontamination progressive layered sedimentation, Tenacious dehydration 10 CHC13, 1 Total volume 0.5 Total NH40H composition), Proven compound 8. Compound 7 (compound 7a), compound 8a (presence, second step, overflow, washout time, 40 min., Thin layer deposition, Rf = 0.4). Compound 8a

Reference： [1]Current Patent Assignee: BEIJING ZHONGKE YONGBANG BIOTECHNOLOGY - CN103570717, 2016, B Location in patent: Paragraph 0040-0043

69
[ 29898-32-6 ]
N⁸-cyclopropylthiazolo[5,4-f]quinazolin-9(8H)-one [ No CAS ]
N⁸-cyclopropyl-2-(2,4-dichlorophenyl)thiazolo[5,4-f]quinazolin-9(8H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	Stage #1: N⁸-cyclopropylthiazolo[5,4-f]quinazolin-9(8H)-one With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 0.166667h; Microwave irradiation; Inert atmosphere; Stage #2: 2,4-dichloro-1-iodo-benzene With palladium diacetate In N,N-dimethyl-formamide at 120℃; for 5h; Inert atmosphere; Microwave irradiation; regioselective reaction;	Palladium- and Copper-Assisted C-H Arylation of Compounds 6; Typical Procedure for Products 7 (Schemes 4 and 5) Thiazolo[5,4-f]quinazolin-9(8H)-one 6 (0.341 mmol), CuI (0.065 g, 0.341 mmol, 1 equiv), and DBU (101 μL, 0.682 mmol, 2.0 equiv) in anhyd DMF (850 μL) were added to a 2 mL glass microwave vial. The mixture was stirred under microwave irradiation at 120 °C for 10 min. Then Pd(OAc)2 (7.6 mg, 0.034 mmol, 10 mol%) and the appropriate aryl halide (0.682 mmol, 2.0 equiv) were added to the mixture. The reaction mixture was then stirred under microwave irradiation at 120 °C for 5 h. The resulting solution was diluted with CH2Cl2, filtered through a cotton plug and washed with CH2Cl2 (50 mL). The crude product obtained by concentration of CH2Cl2 was purified by flash chromatography on silica gel with EtOAc/CH2Cl2 as eluent (1:0 to 1:1, v/v, for 7ah-j; 7:3 to 1:4, v/v for 7ba-j) to afford the corresponding product 7.
65%	Stage #1: N⁸-cyclopropylthiazolo[5,4-f]quinazolin-9(8H)-one With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 0.166667h; Microwave irradiation; Sealed tube; Stage #2: 2,4-dichloro-1-iodo-benzene With palladium diacetate at 120℃; for 5h; Microwave irradiation; regioselective reaction;

Reference： [1]Couly, Florence; Dubouilh-Benard, Carole; Besson, Thierry; Fruit, Corinne [Synthesis, 2017, vol. 49, # 20, p. 4615 - 4622]
[2]Couly, Florence; Harari, Marine; Dubouilh-Benard, Carole; Bailly, Laetitia; Petit, Emilie; Diharce, Julien; Bonnet, Pascal; Meijer, Laurent; Fruit, Corinne; Besson, Thierry [Molecules, 2018, vol. 23, # 9]

70
[ 135-67-1 ]
[ 29898-32-6 ]
C₁₈H₁₁Cl₂NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; calcium carbonate In tetrahydrofuran; water for 1.5h;	2 Preparation of compound IM-7 SM1 (50 g, 0.27 mol) and 2,4-dichloro-1-iodobenzene (82 g, 0.3 mol) were dissolved in tetrahydrofuran (THF) , And an aqueous solution of calcium carbonate was added thereto. Tetrakis- (triphenylphosphine) palladium (0.95 g, 0.0008 mol) was added and the mixture was stirred for 1.5 hours while boiling. Thereafter, the reaction mixture was cooled to room temperature, and the organic layer was separated. The organic layer was recrystallized from chloroform and ethanol to obtain a compound IM-3 solid (62 g, yield 69%).

Reference： [1]Current Patent Assignee: LG CHEM CO.,LTD. - KR2017/139350, 2017, A Location in patent: Paragraph 0134-0136

71
[ 89-75-8 ]
[ 29898-32-6 ]

Yield	Reaction Conditions	Operation in experiment
85%	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In o-xylene at 150℃; for 12h;

Reference： [1]Lee, Yong Ho; Morandi, Bill [Nature Chemistry, 2018, vol. 10, # 10, p. 1016 - 1022]

72
[ 29898-32-6 ]
[ 19335-11-6 ]
5-amino-1-(2,4-dichlorophenyl)-1H-indazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; copper(l) iodide; trans-1,2-cyclohexanediamine In 1,4-dioxane at 100℃; for 72h;	Representative Synthetic Procedure for 5-Amino-1-Aryl-1H-Indazoles (18 g-i). General procedure: A mixture of 5-amino-1H-indazole(50 mg, 0.38 mmol), 3-chloro-1-fluoro-4-iodobenzene (100 μL, 0.376 mmol), cuprous iodide (7 mg, 0.04 mmol),trans-cyclohexane-1,2-diamine (25 μL, 0.19 mmol), andtripotassium phosphate (140 mg, 0.676 mmol) in1,4-dioxane (2 mL) was heated at 100C for 3 days. Aftercooling to room temperature, the reaction mixture was partitionedbetween dichloromethane and water, and theorganic layer was dried over magnesium sulfate. The solventwas evaporated in vacuo and the residue was separatedby chromatography on a silica gel column (n-hexane: ethylacetate = 1: 1) to give 5-amino-1-(2-chloro-4-fluorophenyl)-1H-indazole (18 g, 10 mg, 10%).

Reference： [1]Gu, Sujin; Jung, Myoung Eun; Yoon, Ji-Yong; Yoon, Sang-Eun; Lee, Jeong-Ju; Lee, Kwangho; Choi, Gildon; Kim, Nam-Soon; Jeon, Moon-Kook [Bulletin of the Korean Chemical Society, 2018, vol. 39, # 10, p. 1125 - 1138]

73
[ 29898-32-6 ]
[ 100-52-7 ]
[ 7254-06-0 ]

Yield	Reaction Conditions	Operation in experiment
65%	With palladium diacetate; potassium hydrogencarbonate; DL-Pro-NHMe In tert-Amyl alcohol at 120℃; for 24h; Inert atmosphere;	10 4.2. General procedure for the synthesis of 9-fluorenone General procedure: A mixture of arylaldehyde (0.1 g, 1 mmol), dihaloarene (0.565 g, 2 mmol), Pd(OAc)2 (0.022 g, 10.0 mol%), N-phenylpicolinamide (L7, 0.019 g, 15.0 mol%) and potassium hydrogen carbonate (0.5 g, 5 mmol) in tert-amyl alcohol (5.0 ml) was taken in 100.0 ml round bottom flask under N2 atmosphere and stirred for 120°C for 24 h. Progress of the reaction was monitored continuously by TLC with ethyl acetate: hexane (2:3) eluent system. After completion of reaction, crude was poured into crushed ice and then filter the reaction mixture. Filtrate then extracted with ethyl acetate (3 times). Organic layer was separated, dried (over anhydrous Na2SO4) and evaporated under reduced pressure and purified by column chromatography to obtain desired product. Characterization data of compounds 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3v and 3x were found exactly similar as reported in the literature (References of above compound are mentioned in Supplementary data).

Reference： [1]Patel, Anuj; Shaikh, Mahommedumar; Chikhalia, Kishor [Tetrahedron, 2019, vol. 75, # 2, p. 236 - 245]

74
[ 29898-32-6 ]
[ 15764-16-6 ]
6-chloro-1,3-dimethyl-9H-fluoren-9-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With palladium diacetate; potassium hydrogencarbonate; DL-Pro-NHMe; In tert-Amyl alcohol; at 120℃; for 24h;Inert atmosphere;	General procedure: A mixture of arylaldehyde (0.1 g, 1 mmol), dihaloarene (0.565 g, 2 mmol), Pd(OAc)2 (0.022 g, 10.0 mol%), N-phenylpicolinamide (L7, 0.019 g, 15.0 mol%) and potassium hydrogen carbonate (0.5 g, 5 mmol) in tert-amyl alcohol (5.0 ml) was taken in 100.0 ml round bottom flask under N2 atmosphere and stirred for 120C for 24 h. Progress of the reaction was monitored continuously by TLC with ethyl acetate: hexane (2:3) eluent system. After completion of reaction, crude was poured into crushed ice and then filter the reaction mixture. Filtrate then extracted with ethyl acetate (3 times). Organic layer was separated, dried (over anhydrous Na2SO4) and evaporated under reduced pressure and purified by column chromatography to obtain desired product. Characterization data of compounds 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3v and 3x were found exactly similar as reported in the literature (References of above compound are mentioned in Supplementary data).

Reference： [1]Tetrahedron,2019,vol. 75,p. 236 - 245

75
[ 29898-32-6 ]
bis(2,4-dichlorophenyl)diselenide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.55 g	Stage #1: 2,4-dichloro-1-iodo-benzene With selenium; copper(II) oxide; potassium hydroxide In dimethyl sulfoxide at 20 - 90℃; Stage #2: In water; ethyl acetate	4.3 Diselenides 2a-2c: general procedure General procedure: Iodoaryl derivative 1a-c (0.004 mol), black metallic selenium(0.632 g, 0.008 mol), and nano-cupric oxide (0.064g, 0.0008 mol) were suspended in anhydrous DMSO(8 mL) at room temperature. The reagents were heatedto a temperature of 90°C. Then, finely ground potassiumhydroxide (0.896 g, 0.016 mol) was added portionwise. Thesuspension was stirred at 90°C until the disappearance ofthe starting iodide (TLC, hexane) (1.5-3.5 h). The reactionmixture was allowed to cool to room temperature. Water(90 mL) and ethyl acetate (50 mL) were added to the reactionmixture. The resulting biphasic mixture was stirredvigorously for 5-10 min. The layers were then separated.The aqueous layer was further extracted with ethyl acetate(3 × 40 mL) controlling the content of the product (TLC).The combined organic layers were dried over magnesiumsulfate. The drying agent, the residue of copper oxide, andselenium were filtered off. Removal of the solvent underreduced pressure afforded the crude product. The crudeproduct was applied onto silica gel using ethyl acetate assolvent. The mixture of the silica and the crude productwas applied at the top of the chromatographic column. The product was eluted with hexane to give diselenides 2a-2c.

Reference： [1]Zakrzewski, Jerzy; Huras, Bogumiła; Kiełczewska, Anna; Krawczyk, Maria [Zeitschrift fur Naturforschung, B: Chemical Sciences, 2018, vol. 73, # 12, p. 1005 - 1013]

76
[ 29898-32-6 ]
C₂₉H₃₄BNO₄ [ No CAS ]
C₂₉H₂₅Cl₂NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide In 2-methyltetrahydrofuran; water at 80℃; for 12h; Inert atmosphere;	37.A; 60.A Step A: Compound 12 (300.00mg, 560.05umol, 1.00eq) and 2,4-dichloro-1-iodobenzene (275.11mg, 1.01mmol,1.80eq), 2-methyltetrahydrofuran (10.00mL) and aqueous potassium hydroxide solution (4M, 784.06uL, 5.60eq) wereadded to a 100mL three-necked flask with magnetic stirring. After the reaction system was purged with nitrogen for threetimes, Pd(PPh3)2Cl2 (11.79mg, 16.80umol, 0.03eq) was added. The reaction system was purged with nitrogen for threetimes again, then the reaction solution was stirred at 80°C for 12 hours, and eventually turned from yellow to black. Aftercompletion of the reaction, water (30mL) was added to the reaction solution and the mixture was extracted with dichloromethane(30mL3). The organic phase was combined, washed with saturated brine (30mL2), dried over anhydroussodium sulfate, filtered and concentrated to give a crude product, which was purified by column chromatography(PE:EA=1:0 to 20:1) to give the compound 79 (330.00mg, crude). MS (ESI,M+1): 490.0.

Reference： [1]Current Patent Assignee: LUOXIN HEALTHCARE SCIENCE AND TECHNOLOGY DEVELOPMENT BEIJING - EP3434668, 2019, A1 Location in patent: Paragraph 0200; 0242

77
[ 29898-32-6 ]
[ 292638-85-8 ]
[ 82475-76-1 ]

Yield	Reaction Conditions	Operation in experiment
84%	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h;	2.2. General procedure for Heck reaction General procedure: A mixture of aryl halide (1 mmol), alkene (1.2 mmol), K2CO3(2 mmol) and MNPs-Mel-Pd (0.02 g) was stirred in DMF at 100° Cand the progress of the reaction was monitored by TLC. Aftercompletion of the reaction, the catalyst was separated using anexternal magnet, the mixture was cooled to room temperature andthe product was solidified by addition of water to the mixture andpure products were obtained in yields of 76-99%. The chromatographictechniques were not used to isolate the products.

Reference： [1]Bodaghifard, Mohammad Ali [Journal of Organometallic Chemistry, 2019, vol. 886, p. 57 - 64]

78
[ 480-91-1 ]
[ 29898-32-6 ]
2-(2,4-dichlorophenyl)isoindolin-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 20 - 120℃;	General Procedure A for the Synthesis of Compounds A1~A12. General procedure: Isoindolin-1-one (200 mg, 1.50mmol) was dissolved in super-dry DMSO (4 mL), and Cs2CO3 (1215 mg, 3.75 mmol), CuI (58 mg, 0.30mmol) and N1,N2-dimethylethane-1,2-diamine (27 mg, 33 μL, 0.30 mmol) were added to the solution.The resulting mixture was stirred at room temperature for 10 min, after which iodobenzene (2.25mmol) was added. Then the mixture was heated to 120 °C. When TLC showed that isoindolin-1-onehad been fully converted, the reaction was stopped. The mixture was extracted with ethyl acetate (20mL) and H2O (10 mL). The water phase was re-extracted with ethyl acetate (20 mL). The organic layerwas combined and washed with brine (10 mL). Then the solution was dried over anhydrous MgSO4,filtered and concentrated, and the crude residue was purified by flash chromatography over silica gelusing CH2Cl2/CH3OH as the gradient elution to afford the title compounds.

Reference： [1]Wang, Yixuan; Wang, Huiqiang; Jiang, Xinbei; Jiang, Zhi; Guo, Tingting; Ji, Xingyue; Li, Yanping; Li, Yuhuan; Li, Zhuorong [Molecules, 2019, vol. 24, # 5]

79
[ 124-38-9 ]
[ 29898-32-6 ]
2,6-dichloro-3-iodobenzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium; diisopropylamine In tetrahydrofuran; ethyl acetate at -78 - -50℃; Inert atmosphere; Molecular sieve;	1 Example 1 Synthesis of Compound Intermediate B (B1,B2,B3) 1. Synthetic routeamong them, the condition (a) is LiTMP, THF, -78 to -60 ° C, 2 to 3 h / CO 2 , -60 to -50 ° C, 2 to 3 h.2, the synthesis step (1) After the reaction vessel is washed and dried, High-purity ultra-dry nitrogen is used as the reaction shielding gas. Pay attention to removing the air in the reaction vessel and protect the nitrogen ball. (2) Add 60 mL of ultra-dry tetrahydrofuran (THF) containing molecular sieve under nitrogen protection, then anhydrous diisopropylamine (30 mmol, 8.41 mL) was taken under nitrogen. Magnetically stir and put in a Dewar Add 300 ± 5 mL of ethyl acetate to the Dewar, slowly add crushed dry ice to lower the reaction temperature below -20 °C. Stir at low temperature for 10 min; (3) Under the protection of nitrogen, add n-butyl lithium (2.5 M, 30 mmol, 12 mL) to the reaction vessel. Stirring at a low temperature of -20 ° C for 30 min; (4) Immediately after the addition of crushed dry ice in the ethyl acetate solvent of the Dewar, the cooling temperature is lowered to -78 to -60 ° C. Adding substituted iodobenzene A with different halogen structures (eg 2,4-dichloro-1-iodobenzene, 2-trifluoromethyliodobenzene or 4-chloroiodobenzene, added in an amount of 2.72 mL, 2.9 mL or 2.4 mL, respectively), 20 mmol, the reaction was stirred at a low temperature of -78 ° C for 2 h. Excess milled dry ice is then added to the reaction vessel under nitrogen protection. The reaction is carried out at a low temperature of -50 ° C or lower for 2 to 3 hours. Remove the Dewar bottle until the temperature of the reaction vessel rises to room temperature; The reaction endpoint was detected by TLC [developing agent: V (petroleum ether) / V (ethyl acetate) = 1 / 1]; (5) After the reaction is completed, tetrahydrofuran and other volatile solvents are removed under reduced pressure at 45 ° C. Slowly add 50mL of deionized water. Slowly add 4M HCl solution under magnetic stirring to adjust the pH of the system to 1~2. Extracted three times with ethyl acetate, drying through anhydrous MgSO4, and the mixture was filtered and evaporated to give a crude brown solid. Purified by silica gel column chromatography [eluent: V ( petroleum ether) / V (ethyl acetate) = 16 / 1] obtaining the compound intermediate B (B1,B2,B3), white or light gray solids with yields of 91%, 14% and 45%, respectively.

Reference： [1]Current Patent Assignee: GUANGDONG UNIVERSITY OF TECHNOLOGY - CN110143869, 2019, A Location in patent: Paragraph 0067-0076

80
[ 29898-32-6 ]
[ 95-92-1 ]
[ 34966-51-3 ]

Yield	Reaction Conditions	Operation in experiment
89%	Stage #1: 2,4-dichloro-1-iodo-benzene With iodine; magnesium at 20℃; for 1h; Inert atmosphere; Stage #2: oxalic acid diethyl ester at 20℃; for 4h; Inert atmosphere;	2,4-Dichloro-α-oxo-benzeneacetic ethyl ester (21) To a suspension of pre-activated magnesium turnings (0.35 g, 14.66 mmol) and a single crystal of I2 (cat.) in 10 mL ether, was added 2,4-dichloroiodobenzene (20, 2 g, 7.33 mmol) dropwise at room temperature under argon protection. After addition, the mixture was stirred at room temperature for 1 h to generate a slurry. Gently adding the fresh made Grignard reagent to a solution of diethyl oxalate (1.3 g, 8.80 mmol) in 5 mL ether dropwise. Again, keep the mixture stirring at room temperature and argon protection for 4 h. The reaction was quenched with water, then partitioned between EtOAc (150 mL) and brine (150 mL). The organic layer washed two more times with brine. The organic layers were dried, filtered, and concentrated. The crude residue was purified by column chromatography (SiO2, 10% EtOAc in hexanes) to produce 21 as a colorless oil (1.6 g, 89%). 1H NMR (500 MHz, Chloroform-d) δ 7.77 (d, J = 8.3 Hz, 1H), 7.51 (d, J = 1.9 Hz, 1H), 7.44 (dd, J = 8.4, 2.0 Hz, 1H), 4.46 (q, J = 7.1 Hz, 2H), 1.44 (t, J = 7.2 Hz, 3H); 13C NMR (126 MHz, CDCl3) δ 185.47, 162.80, 140.32, 134.80, 132.62, 131.70, 130.53, 127.83, 62.99, 13.89.

Reference： [1]Wen, Jiachen; Teske, Kelly A.; Kyle Hadden [Bioorganic and Medicinal Chemistry Letters, 2020, vol. 30, # 2]

81
[ 1142-19-4 ]
[ 29898-32-6 ]
3,7-dichlorophenoxathiine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	With copper(l) iodide; caesium carbonate; dimethyl sulfoxide at 120℃; for 9h; Inert atmosphere;	Synthesis of 3-chlorophenoxathiine (3a). General procedure: CuI (10 mol %) Was added at room temperature to a mixture of disulfide 1a (0.5 mmol) with o-chloro-iodobenzene 2a (0.6 mmol) and Cs2CO3 (1.8 mmol) in DMSO (5 mL). The reaction mixture was stirred at 120°C for 9 h under the atmosphere of nitrogen. Upon completion of the process, the solvent was distilled off, and the residue was purified by column chromatography on silica gel (ethyl acetate-petroleum ether = 1 : 30, v:v) to give the product 3a.

Reference： [1]Chao, Fei; Xu, Wen-Heng; Ren, Zhi-Lin; Wang, Long [Russian Journal of General Chemistry, 2019, vol. 89, # 12, p. 2558 - 2561]

82
[ 29898-32-6 ]
Methyl 6,7,8,9-tetrahydro-5-oxo-5H-benzocycloheptene-2-carboxylate [ No CAS ]
methyl 6-(2,4-dichlorophenyl)-5-oxo-6,7,8,9-tetrahydrobenzo[7]annulene-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene for 22h; Inert atmosphere; Reflux;	2.1.S1 3.2: Alternative 2 A degassed mixture containing compound (5) (0.5 g), 1 -iodo-2,4- dichlorobenzene (0.76 ml), toluene (9 ml), water (1 ml), CS2CO3 (1 .05 g), palladium acetate (50 mg) and Xantphos (250 mg) is heated to reflux during about 22 hours. After cooling to room temperature, the organic phase is diluted with dichloromethane, washed with water and purified by chromatography on silica gel to yield 730 mg (87%) of a white solid. (0173) 1H NMR (400 MHz, DMSO-d6 in ppm): 1 .78 (m, 1 H); 2.01 (m, 1 H); 2.19 (m, 2 (0174) H); 3.09 (m, 1 H); 3.21 (m, 1 H); 3.89 (s, 3 H); 4.47 (dd, J=1 1.3, 3.7 Hz, 1 H); 7.47 (m, 2 H); 7.60 (d, J=2.0 Hz, 1 H); 7.64 (d, J=8.1 Hz, 1 H); 7.92 (dd, J=7.9, 1.5 Hz, 1 H); 7.95 (s, 1 H).

Reference： [1]Current Patent Assignee: SANOFI - WO2020/49150, 2020, A1 Location in patent: Page/Page column 23

83
[ 29898-32-6 ]
3-phenyloxindole [ No CAS ]
C₂₀H₁₃Cl₂NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate In toluene at 120℃; Inert atmosphere;	1.1-5 Synthesis of Intermediate IM-5 Under an argon (Ar) atmosphere, 15.00 g (71.7 mmol) of 3-phenyl-1H-oxindole was added one by one to a 500 ml three-necked flask,1.24g (0.03 equivalent, 2.2mmol) of Pd (dba) 2, 10.22g (1.5 equivalent, 107.5mmol) of NaOtBu,358ml of toluene, 21.52g (1.1 equivalents, 78.9mmol) of 2,4-dichloro-1-iodo-benzene and 1.45g (0.1 equivalents, 7.2mmol) of tBu3P,Then heat to about 120 ° C and stir. After cooling to room temperature in the air, water was added to the reaction solution, and the organic layer was taken separately.Toluene was added to the aqueous layer, and the organic layer was extracted again. The organic layers were put together and washed with brine solution and dried over MgSO4.After filtering MgSO4, the organic layer was concentrated. The crude product thus obtained was separated by silica gel column chromatography using a mixture solvent of hexane and toluene as a developing solution to obtain intermediate IM-5 (19.55 g, yield 77%).

Reference： [1]Current Patent Assignee: SAMSUNG ELECTRONICS CO.,LTD.; Samsung Display (in: Samsung) - CN111039956, 2020, A Location in patent: Paragraph 0141; 0173-0178

84
[ 29898-32-6 ]
3-(dibenzothiophen-4-yl)oxindole [ No CAS ]
C₂₆H₁₅Cl₂NOS [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate In toluene at 120℃; Inert atmosphere;	1.1-4 Synthesis of Intermediate IM-3 Under an argon (Ar) atmosphere, to a 500ml three-necked flask was added 15.00g (47.6mmol) of3-dibenzothiophen-4-yl) -1H-oxindole, 0.82g (0.03 equivalent, 1.4mmol) of Pd (dba) 2,6.86g (1.5 equivalents, 71.3mmol) of NaOtBu, 238ml of toluene, 14.28g (1.1 equivalents,52.3 mmol) of 2,4-dichloro-1-iodobenzene and 0.96 g (0.1 equivalent, 4.8 mmol) of tBu3P, then heated to about 120 ° C and stirred.After cooling to room temperature in the air, water was added to the reaction solution, and the organic layer was taken separately. Toluene was added to the aqueous layer, and the organic layer was extracted again.The organic layers were put together and washed with brine solution and dried over MgSO4. After filtering MgSO4, the organic layer was concentrated to obtain a crude product.The crude product thus obtained was separated by silica gel column chromatography using a mixture solvent of hexane and toluene as a developing solution to obtain intermediate IM-3 (15.77 g, yield 72%).

Reference： [1]Current Patent Assignee: SAMSUNG ELECTRONICS CO.,LTD.; Samsung Display (in: Samsung) - CN111039956, 2020, A Location in patent: Paragraph 0141; 0163-0168

85
[ 201230-82-2 ]
[ 29898-32-6 ]
[ 874-42-0 ]

Yield	Reaction Conditions	Operation in experiment
78%	With rhodium(III) chloride trihydrate; hydrogen; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 90℃; for 12h; Autoclave;	General procedure for reductive carbonylation of aryl iodides with CO and H₂ General procedure: All reactions were carried out in an 80 mL Teflon-lined stainless steel reactor equipped with a magnetic stirring bar. Typically, in a glovebox, the aryl iodides (1.0 mmol), RhI3(0.025 mmol), PPh3 (0.1 mmol), Et3N (1.2 mmol), and DMA (2 mL) were loaded into the reactor. Then, the autoclave was screwed up, charged with CO and H2 to a total pressure of 10 bar (1:1) and transferred to an oil bath preheated at 90 °C, which was controlled by a Haake-D3 temperature controller. After completion of the reaction, the reactor was cooled in iced water and the gas carefully vented. The conversion and yield of the aryl iodides and arylaldehydes were determined by GC analysis using dodecane as an internal standard. For yield determination of the other products, the reaction mixture was first analyzed by GC-MS to determine the structures of the aromatic aldehyde products. Then, CH2Cl2 (5 mL) was added to the reaction mixture, after which deionized water (10 mL) was added to extract the solvent DMA for 5 times. The organic layer was dried over anhydrous Na2SO4, concentrated by rotary evaporation and finally purified by column chromatography on silica gel using n-hexane/ethyl acetate as eluent to obtain the pure products and isolated yields.

Reference： [1]Chen, Suqing; Liu, Zhenghui; Mu, Tiancheng; Wang, Peng; Yan, Zhenzhong; Yu, Dongkun; Zhao, Xinhui [Beilstein Journal of Organic Chemistry, 2020, vol. 16, p. 645 - 656]

86
[ 29898-32-6 ]
[ 34633-08-4 ]
C₂₄H₃₅B₂NO₄ [ No CAS ]
C₂₉H₂₅Cl₂NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: (E)-ethyl 3-(4-iodophenyl)prop-2-enoate; C₂₄H₃₅B₂NO₄ With bis-triphenylphosphine-palladium(II) chloride In water for 12h; Inert atmosphere; Stage #2: 2,4-dichloro-1-iodo-benzene With potassium hydroxide In water at 70℃; for 12h; Inert atmosphere;	General procedure for the preparation of target compounds (1-25) General procedure: To a solution of Compound 27 (1.00 eq) in 2-MeTHF (10 Vol) was added 4,4,5,5-tetramethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaborolane (1.00 eq) and Pt(PPh3)4 (0.05 eq). The mixture was degassed via three vacuum/nitrogen ingress cycles and stirred for 5 h at 70 °C, Compound 28 in this solution was used directly for the next step. Another 2-MeTHF (10 Vol) and H2O (1 Vol) was added, followed Cs2CO3 (2.00 eq), ethyl (E)-3-(4-iodophenyl)prop-2-enoate (0.80 eq) and Pd(PPh3)2Cl2 (0.05 eq) was added at 0 °C. The mixture was degassed via three vacuum/nitrogen ingress cycles and was stirred for 12 hours at 15°C. Corresponding substituted benzene (2.00 eq), KOH (4 M, 5.00 eq) and Pd(PPh3)2Cl2 (0.05 eq) was added to the resulted mixture. The mixture was degassed via three vacuum/nitrogen ingress cycles and was stirred for 12 hours at 70 °C , filtered via a celite. The filtrate was washed with brine, the organic layers was dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure to get the crude product, which was purified via column chromatography to give compound 29. To a solution of compound 29 (1.00 eq) in MeOH (9 Vol), THF (9 Vol) and H2O (3 Vol) was added LiOH.H2O (10.00 eq). The mixture was stirred for 1 hour at 35 °C then monitered by LCMS. Water (9 Vol) was added, the mixture was adjusted to pH= 5 with aq. HCl (1M) and extracted with EtOAc. The combined organic phase was washed with water, dried over anhydrous Na2SO4, filtered and evaporated under vacuum to get the crude product, which was purified via preparative HPLC to give Compounds (1-25).

Reference： [1]Dong, Jiaqiang; Wang, Tie-lin; Lu, Jianyu; Ding, Charles Z.; Hu, Lihong; Hu, Guoping; He, Huijun; Zeng, Xu; Li, Xiaoting; Sun, Deheng; Zhu, Yingjie; Shen, Liang; Gu, Qingyang; Chan, Chi-chung; Xia, Yuanfeng; Li, Jian; Chen, Shuhui [Bioorganic and Medicinal Chemistry Letters, 2020, vol. 30, # 22]

87
[ 64-18-6 ]
[ 29898-32-6 ]
[ 874-42-0 ]

Yield	Reaction Conditions	Operation in experiment
80%	With iodine; triethylamine; triphenylphosphine In toluene at 80℃; Inert atmosphere; Sealed tube;	Heterogeneous Palladium-Catalyzed Formylation of Aryl Iodides with HCOOH; General Procedure General procedure: A dried 10 mL reaction tube was charged with I 2 (152 mg, 1.2 mmol),PPh 3 (315 mg, 1.2 mmol), and toluene (4 mL) under argon. The mixture was stirred at r.t. for 10 min. Then aryl iodide 1 (1 mmol), 2P-Fe3O4SiO2-Pd(OAc)2 (79 mg, 3 mol%), and Et3N (606 mg, 6 mmol)were added to this solution. After the addition of HCOOH (184 mg, 4mmol), the reaction tube was immediately sealed and the reactionmixture was stirred at 80°C for 3-5 h. After cooling to r.t., the Pd catalyst was magnetically separated from the mixture, washed with toluene (2 mL), distilled H2O (2 × 2 mL) and EtOH (2 × 2 mL), dried undervacuum at 80 °C, and used directly in the next cycle. The reaction mixture was then filtered and concentrated under vacuum. The residue was purified by silica gel column chromatography (light PE/EtOAc10:1) to afford the desired product 2.

Reference： [1]You, Shengyong; Zhang, Rongli; Cai, Mingzhong [Synthesis, 2021, vol. 53, # 11, p. 1962 - 1970]

88
[ 29898-32-6 ]
O₅-benzyl O₁-ethyl 2-(2-amino-5-methylthiazol-4-yl)-2-ethylpentanedioate [ No CAS ]
O₅-benzyl O₁-ethyl 2-[2-(2,4-dichloroanilino)-5-methylthiazol-4-yl]-2-ethylpentanedioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In water; toluene at 100℃; for 24h; Inert atmosphere;	23.5 Step 5. Synthesis of O5-benzyl O1-ethyl 2-[2-(2,4-dichloroanilino)-5-methyl-thiazol-4-yl]-2- ethyl-pentanedioate To a solution of 2,4-dichloro-1-iodo-benzene (314.48 mg, 1.15 mmol, 1.5 eq) and O5-benzyl O1-ethyl 2-(2-amino-5-methylthiazol-4-yl)-2-ethyl-pentanedioate (0.3 g, 768.25 umol, 1 eq) in toluene (10 mL) /H2O (1 mL) was added K2CO3 (318.53 mg, 2.30 mmol, 3 eq), Pd2(dba)3 (70.35 mg, 76.83 umol, 0.1 eq) and Xantphos (88.91 mg, 153.65 umol, 0.2 eq). The mixture was purged with N2 several time and stirred at 100 °C for 24 h. The residue was poured into water (15 mL). The aqueous phase was extracted with ethyl acetate (20 mL3). The combined organic phase was washed with brine (15 mL2), dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by silica gel chromatography (100-200 mesh silica gel, Petroleum ether/Ethyl acetate=0/1, 5/1) to afford the title compound (0.18 g, 215.13 umol, 28.00% yield, 64% purity) as yellow oil. [0317] LCMS: (M+H+): 535.1 1.363 min (5-95% ACN in H2O, 2.0 min).

Reference： [1]Current Patent Assignee: MONTEFIORE MEDICAL CENTER - WO2021/91823, 2021, A1 Location in patent: Paragraph 0316-0317

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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CAS No. :	29898-32-6	MDL No. :	MFCD00001035
Formula :	C₆H₃Cl₂I	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ZQKJCBDCOGLKCQ-UHFFFAOYSA-N
M.W :	272.90	Pubchem ID :	96864
Synonyms :

Num. heavy atoms :	9
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	0.0
Num. H-bond donors :	0.0
Molar Refractivity :	49.18
TPSA :	0.0 Å²

GI absorption :	Low
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.75 cm/s

Log Po/w (iLOGP) :	2.38
Log Po/w (XLOGP3) :	4.53
Log Po/w (WLOGP) :	3.6
Log Po/w (MLOGP) :	4.37
Log Po/w (SILICOS-IT) :	4.11
Consensus Log Po/w :	3.8

[ CAS No. 29898-32-6 ] {[proInfo.proName]}

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[ 29898-32-6 ] Synthesis Path-Upstream 1~2

[ 29898-32-6 ] Synthesis Path-Downstream 1~88

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[ 29898-32-6 ]

Aryls

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Lipinski :	1.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Log S (ESOL) :	-4.88
Solubility :	0.0036 mg/ml ; 0.0000132 mol/l
Class :	Moderately soluble
Log S (Ali) :	-4.25
Solubility :	0.0153 mg/ml ; 0.000056 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-4.58
Solubility :	0.00719 mg/ml ; 0.0000264 mol/l
Class :	Moderately soluble

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.29

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

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P378
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
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[ CAS No. 29898-32-6 ] {[proInfo.proName]}

Quality Control of [ 29898-32-6 ]

Related Doc. of [ 29898-32-6 ]

Product Details of [ 29898-32-6 ]

Calculated chemistry of [ 29898-32-6 ]

Physicochemical Properties

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Water Solubility

Medicinal Chemistry

Safety of [ 29898-32-6 ]

Application In Synthesis of [ 29898-32-6 ]

[ 29898-32-6 ] Synthesis Path-Upstream 1~2

[ 29898-32-6 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 29898-32-6 ]

Aryls

Chlorides

Iodides

Precautionary Statements-General

Prevention

Response

Storage

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Physical hazards

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Environmental hazards

Inquiry

Related Functional Groups of
[ 29898-32-6 ]