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Chemical Structure| 29976-56-5 Chemical Structure| 29976-56-5

Structure of 29976-56-5

Chemical Structure| 29976-56-5

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Product Details of [ 29976-56-5 ]

CAS No. :29976-56-5
Formula : C8H9Br2N
M.W : 278.97
SMILES Code : CC1=C(Br)C(C)=C(Br)C(C)=N1
MDL No. :MFCD00234421

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Application In Synthesis of [ 29976-56-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 29976-56-5 ]

[ 29976-56-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 29976-56-5 ]
  • [ 22237-13-4 ]
  • 3,5-bis(4-ethoxyphenyl)-2,4,6-trimethylpyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In toluene; at 90℃;Inert atmosphere; General procedure: A vigorously stirred mixture of 1 (150 mg, 0.53 mmol), arylboronic acid (2.8 equiv), palladium acetate (4.0 mol %), S-Phos (8.0 mol %) and K3PO4 (4.0 equiv) in 10 ml of toluene was heated at 90 C (oil bath) under inert gas atmosphere for 1-2 hours. The progress of the reaction was monitored by GC-MS. After completion of the process, the mixture was cooled and quenched with cold water (25 ml). The mixture was then extracted with ethyl acetate (3 × 10 ml). Combined organic extracts were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude mixture was purified by column chromatography on silica gel (230-400 mesh) with the appropriate solvent system. Pure 3,5-diaryl-4-alkoxy-2,4,6-trimethylpyridines P6 (4-29) were obtained in moderate to good yield.
 

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