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Chemical Structure| 118-41-2 Chemical Structure| 118-41-2
Chemical Structure| 118-41-2

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Trimethylgallic acid, a natural product isolated and purified from the branchs of Eucalyptus globulus Labill, exert hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation.

Synonyms: Eudesmic acid; Trimethylgallic Acid; TMBA

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Product Details of 3,4,5-Trimethoxybenzoic acid

CAS No. :118-41-2
Formula : C10H12O5
M.W : 212.20
SMILES Code : O=C(O)C1=CC(OC)=C(OC)C(OC)=C1
Synonyms :
Eudesmic acid; Trimethylgallic Acid; TMBA
MDL No. :MFCD00002501
InChI Key :SJSOFNCYXJUNBT-UHFFFAOYSA-N
Pubchem ID :8357

Safety of 3,4,5-Trimethoxybenzoic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3,4,5-Trimethoxybenzoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 118-41-2 ]

[ 118-41-2 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 57616-74-7 ]
  • [ 118-41-2 ]
  • [ 60439-46-5 ]
  • 2
  • [ 124012-42-6 ]
  • [ 3086-62-2 ]
  • [ 66335-38-4 ]
  • [ 118-41-2 ]
  • [ 69260-71-5 ]
  • 5
  • [ 118-41-2 ]
  • [ 2478-38-8 ]
  • 6
  • [ 118-41-2 ]
  • [ 6638-05-7 ]
  • 7
  • [ 369-26-6 ]
  • [ 118-41-2 ]
  • C18H18FNO6 [ No CAS ]
  • 8
  • [ 455-37-8 ]
  • [ 67-68-5 ]
  • [ 118-41-2 ]
  • 2-(3-fluorobenzoyl)-4,5,6-trimethoxyisoindolin-1-one [ No CAS ]
  • 9
  • [ 34837-88-2 ]
  • [ 118-41-2 ]
  • C20H21NO9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% General procedure: CDI (8.63 mmol) was added to a round-bottomed flask containing compound 8 (5.08 mmol) and anhydrous DMF, and the mixture was stirred vigorously for 30 min at room temperature. Subsequently, the flask was placed in an ice bath, and methyl phenyl acetates 7 (5.33 mmol) and NaH (17.76 mmol) were added. The reaction was stirred for 4 h, the mixture was poured into a saturated solution of NH4Cl(aq) until pH = 7 was reached, and it was extracted with AcOEt. The combined organic phases were washed with a saturated solution of NaCl(aq) and dried over anhydrous MgSO4. After filtration, the organic solvent was removed under reduced pressure. The crude residue was purified by column chromatography using petroleum ether/ethyl acetate (2:1) as the eluent to yield purified compounds 9a-9e.
  • 10
  • [ 13338-63-1 ]
  • [ 118-41-2 ]
  • 11
  • [ 19387-91-8 ]
  • [ 118-41-2 ]
  • C8H13N3O4S*C10H12O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In water; for 1.66667h; General procedure: The TN salts/molecular salts was preparedby grinding an equimolar mixture containing 200mg (1 mmol) of TN and 1mmol of correspondingcarboxylic acids/PTSA wetted with few drops of waterwas manually grounded in an agate mortar for 100minutes until a dried powder was obtained.
  • 12
  • [ 939-69-5 ]
  • [ 118-41-2 ]
  • 2-[5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-3-yl]benzo[d]thiazol-6-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With hydroxylamine hydrochloride; Acetate de N,N-dimethylamino-4 pyridinium; at 100℃; for 6h; In a 5-mL round-bottom flask, compound 3 (10 g, 56.7 mmol), hydroxylamine hydrochloride (7.8 g, 113.5 mmol) and 3,4,5-trimethoxybenzoic acid 4 (12 g, 56.7 mmol) were mixed with 4-(dimethylamino)pyridinium acetate (51.6 g, 283.5 mmol). The reaction mixture was heated to 100°C for 6 h. The mixture was cooled down to room temperature, ethanol (1 mL) was added, and stirring continued for 30 min more. Water (5 mL) was added to the reaction mixture. The solid product was filtered off, washed twice with water (2×5 mL) and purified by column chromatography with hexanes/ethyl acetate (3 : 7) to afford pure compound 5. Yield 75percent, mp 271?273°C. 1H NMR spectrum, delta, ppm: 3.88 s (3H), 3.92 s(6H), 7.28 d (1H, J = 7.56 Hz), 7.40 s (1H), 7.46 s (2H),7.82 d (1H, J = 7.56 Hz), 9.67 s (1H). MS (ESI): 386 [M]+.
 

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