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Chemical Structure| 619-14-7 Chemical Structure| 619-14-7
Chemical Structure| 619-14-7

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Product Details of 3-Hydroxy-4-nitrobenzoic acid

CAS No. :619-14-7
Formula : C7H5NO5
M.W : 183.12
SMILES Code : OC(=O)C1=CC=C(C(O)=C1)N(=O)=O
MDL No. :MFCD00007110
InChI Key :XLDLRRGZWIEEHT-UHFFFAOYSA-N
Pubchem ID :69265

Safety of 3-Hydroxy-4-nitrobenzoic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3-Hydroxy-4-nitrobenzoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 619-14-7 ]

[ 619-14-7 ] Synthesis Path-Downstream   1~11

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  • 5
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  • 6
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  • 7
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  • [ 885620-30-4 ]
  • 9
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  • [ 83079-77-0 ]
  • (S)-tert-butyl 2-(3-hydroxy-4-nitrobenzamido)-4-phenylbutanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
30% With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 4h; (MM- 1 -22 ) 3-Hydroxy-4-nitrobenzoic acid (272 mg, 1.49 mmol) , <strong>[83079-77-0]HoPhe-OtBu</strong> (350 mg, 1.49 mmol, 1.00 equiv) and HOAt (223 mg, 1.64 mmol, 1.10 equiv) were combined in a 25 mL round bottom flask with stir bar. Anhydrous DMF (8 mL) and 2,6-lutidine (0.87 mL, 7.44 mmol, 5.00 equiv) were added, and the mixture was stirred until dissolution of the reagents. EDCI'HCl (300 mg, 1.56 mmol, 1.05 equiv) was added, and the mixture stirred for 4 hours, then diluted with EtOAc (30 mL) . The organic phase was washed with 1 N HC1 (3 χ 15 mL) , then washed with H20 (10 mL) and sat. aqueous NaCl (20 mL) . After drying with Na2SC>4, the organic phase was decanted and concentrated. Flash chromatography (Si02, 15 → 30% EtOAc/hexanes) provided 180 mg (30%) of the coupled amide. XH NMR (300 MHz, CDC13) δ 10.55 (s, 1H) , 8.15 (dd, J = 8.8, 0.7 Hz, 1H) , 7.42 (dd, J = 1.9, 0.7 Hz, 1H) , 7.36 - 7.16 (m, 5H) , 6.70 (d, J = 7.6 Hz, 1H) , 4.82 - 4.70 (m, 1H) , 2.79 - 2.66 (m, 2H) , 2.33 (m, 1H) , 2.23 - 2.08 (m, 1H) , 1.54 (s, 9H) .
  • 10
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  • [ 870837-70-0 ]
  • 11
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  • [ 146224-62-6 ]
 

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