Home Cart Sign in  
Chemical Structure| 16617-46-2 Chemical Structure| 16617-46-2
Chemical Structure| 16617-46-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of 3-Amino-4-pyrazolecarbonitrile

CAS No. :16617-46-2
Formula : C4H4N4
M.W : 108.10
SMILES Code : N#CC1=CNN=C1N
MDL No. :MFCD00005237
InChI Key :FFNKBQRKZRMYCL-UHFFFAOYSA-N
Pubchem ID :85515

Safety of 3-Amino-4-pyrazolecarbonitrile

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3-Amino-4-pyrazolecarbonitrile

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16617-46-2 ]

[ 16617-46-2 ] Synthesis Path-Downstream   1~5

  • 2
  • [ 1004-38-2 ]
  • [ 16617-46-2 ]
  • [ 1134190-94-5 ]
YieldReaction ConditionsOperation in experiment
94.6% Example 2) [Synthesis of Specific Compound Example (3)-4] Specific Compound Example (3)-4 is synthesized through the following route: [Show Image] - Synthesis of Intermediate Compound (6) - 1.8 parts of Compound (3) were added to 20 parts of phosphoric acid and dissolved by heating at 40C. The resulting solution was cooled on ice and kept at -3 to 0C, and 1.2 parts of sodium nitrite were added thereto and stirred for 1 hour to give a diazonium salt solution. 1.9 parts of Compound (5) were added to the above diazonium salt solution at 10C or less. Simultaneously with the completion of the addition, the ice bath was removed, and the mixture was stirred for 1 hour. The reaction solution was cooled again, then 100 parts of water were added thereto at 15 to 25C, and the mixture was stirred at 20 to 25C for additional 1 hour. Precipitated crystals were separated by filtration and sufficiently washed with water. The crystals were dried to give 3.5 parts of Intermediate Compound (6). The yield was 94.6%.
  • 3
  • [ 1001-26-9 ]
  • [ 16617-46-2 ]
  • [ 1224288-95-2 ]
  • 4
  • [ 1001-26-9 ]
  • [ 16617-46-2 ]
  • [ 1224288-95-2 ]
YieldReaction ConditionsOperation in experiment
97% Example 30; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-l-yl)pyrazolori,5-alpyrimidine-3-carboxamide; Step A: Preparation of 5-hydroxypyrazolo[l,5-alpyrimidine-3-carbonitrile.; To a mixture of 5-amino-lH-pyrazole-4-carbonitrile (2.70 g, 25.0 mmol) and CS2CO3 (16.3 g, 50.0 mmol) in dry DMF (70 mL) was added <strong>[1001-26-9]ethyl 3-ethoxyacrylate</strong> (5.41 g, 37.5 mmol) and the mixture was heated at 100 0C for 4 hours. The mixture was cooled to ambient temperature and the resultant slurry was poured into deionized H2O (150 mL). The resulting aqueous solution was cooled on an ice bath and concentrated HCl was added slowly with mixing to pH = 3.5. The resulting precipitate was collected, washed with H2O followed by Et2O. The solid was dried in vacuum to afford the product as a light beige powder (3.87 g, 97percent). MS (apci) m/z = 159.0 (M-I).
  • 5
  • [ 16617-46-2 ]
  • [ 53090-43-0 ]
  • [ 1607024-97-4 ]
YieldReaction ConditionsOperation in experiment
71% With toluene-4-sulfonic acid; In butan-1-ol; at 130℃; for 1h; A mixture of <strong>[53090-43-0]ethyl 3-(3,4-dichlorophenyl)-3-oxopropanoate</strong> (1.2 g, 4.60 mmol, 1.20 equiv), 5-amino-lH-pyrazole-4-carbonitrile (400 mg, 3.70 mmol, 1.00 equiv), butan-l-ol (1 mL), and TsOH (10 mg, 0.06 mmol, 0.05 equiv) was stirred for 1 h at 130C. The reaction progress was monitored by LCMS. The solids were collected by filtration. The solid was washed with 3x1 mL of methanol. This resulted in 0.8 g (71%) of 5-(3,4-dichlorophenyl)-7-oxo-4H,7H-pyrazolo[l,5-a]pyrimidine-3- carbonitrile as a white solid. *H NMR (300 MHz, DMSO): delta 8.44 (s, 1H), 8.17 (s, 1H), 7.85 (s, 1H), 6.37 (s, 1H)
 

Historical Records

Technical Information

Categories