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Chemical Structure| 625-38-7 Chemical Structure| 625-38-7
Chemical Structure| 625-38-7

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Synonyms: Vinylacetic acid

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of 3-Butenoic acid

CAS No. :625-38-7
Formula : C4H6O2
M.W : 86.09
SMILES Code : C=CCC(O)=O
Synonyms :
Vinylacetic acid
MDL No. :MFCD00002782
InChI Key :PVEOYINWKBTPIZ-UHFFFAOYSA-N
Pubchem ID :32743

Safety of 3-Butenoic acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H314
Precautionary Statements:P264-P270-P271-P280-P210-P304+P340-P303+P361+P353-P305+P351+P338-P310-P363-P370+P378-P330-P331-P403+P233-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of 3-Butenoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 625-38-7 ]

[ 625-38-7 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 625-38-7 ]
  • [ 2914-69-4 ]
  • [ 476468-23-2 ]
  • [ 476468-21-0 ]
  • 2
  • [ 625-38-7 ]
  • [ 22838-46-6 ]
  • methyl 3-(3-butenoyl)amino-3-phenylpropionate [ No CAS ]
YieldReaction ConditionsOperation in experiment
2.36 g (95%) With triethanolamine; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; Part B: Methyl 3-(3-Butenoyl)amino-3-phenylpropionate To a solution of vinylacetic acid (861 mg, 10.0 mmol), <strong>[22838-46-6]methyl 3-amino-3-phenylpropionate hydrochloride</strong> (2.37 g, 11.0 mmol) and TEA (1.6 mL, 12 mmol) in DCM (20 mL) at -10 C. was added DEC (2.11 g, 11.0 mmol). The resulting mixture was stirred at -10 C. for 15 hours. The mixture was then washed with water, 0.1M HCl, sat. NaHCO3, sat. NaCl and dried over anhydrous MgSO4. Concentration in vacuo followed by pumping until constant weight gave 2.36 g (95%) of the desired amide as a golden oil of suitable purity for further reaction; 1 H NMR (300 MHz, CDCl3) 87.28 (m, 5H), 6.78 (bd, J=7.7 Hz, 1H), 5.95 (m, 1H), 5.43 (dt, J=8.4, 5.9 Hz, 1H), 5.25 (m, 2H), 3.61 (s, 3H), 3.04 (d, J=7.0 Hz, 2H), 2.88 (dq, J=15.0, 5.9 Hz, 2H).
  • 3
  • [ 625-38-7 ]
  • [ 7746-27-2 ]
  • C12H12N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; at 150℃; for 0.166667h;Microwave irradiation; (1) Synthesis of methyl (E)-4-[3-methyl-1H-indazole-6-yl]-3-butenoate [133-1] (hereinafter referred to as a compound [133-1]) To a solution of <strong>[7746-27-2]6-bromo-3-methyl-1H-indazole</strong> obtained with the method described in the document () (213 mg) in N,N-dimethylformamide (2 mL) were added triethylamine (0.28 mL), palladium acetate (II) (27 mg), tris(2-methylphenyl)phosphine (62 mg) and 3-butenoic acid (0.17 mL), and the reaction mixture was subjected to microwave irradiation at 150C for 10 minutes. The reaction mixture was quenched with water, and extracted with ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. To a solution of the obtained residue in tetrahydrofuran (5 mL) was added 0.6M tetrahydrofuran solution of trimethylsilyl diazomethane (0.17 mL), and then the reaction mixture was concentrated under reduced pressure, and The obtained residue was purified by silica gel column chromatography to give the titled compound (90 mg) as a colorless oil. 1H-NMR (400 MHz, CDCl3) delta: 9.90-9.80 (1H, brs), 7.58 (1H, d, J = 8.3 Hz), 7.33 (1H, s), 7.23 (1H, d, J = 8.5 Hz), 6.58 (1H, d, J = 15.9 Hz), 6.41-6.33 (1H, m), 3.73 (3H, s), 3.28 (2H, d, J = 6.6 Hz), 2.57 (3H, s).
  • 4
  • [ 30465-68-0 ]
  • [ 625-38-7 ]
  • N-(5-methoxyquinolin-8-yl)but-3-enamide [ No CAS ]
 

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