22838-46-6|(R)-Methyl 3-amino-3-phenylpropanoate hydrochloride| Ambeed

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Quality Control of [ 22838-46-6 ] Purity: 98% SDS Specification

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Product Details of [ 22838-46-6 ]

CAS No. :	22838-46-6
Formula :	C₁₀H₁₄ClNO₂
M.W :	215.68
SMILES Code :	O=C(OC)C[C@@H](N)C1=CC=CC=C1.[H]Cl
MDL No. :	MFCD02259741

Safety of [ 22838-46-6 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301
Precautionary Statements:	P280-P305+P351+P338
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Application In Synthesis of [ 22838-46-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 22838-46-6 ]

[ 22838-46-6 ] Synthesis Path-Downstream 1~36

1
[ 75-44-5 ]
[ 22838-46-6 ]
[ 51031-37-9 ]

References: [1]Justus Liebigs Annalen der Chemie,1959,vol. 628,p. 162,170.

2
[ 3646-50-2 ]
[ 22838-46-6 ]

References: [1]Helvetica Chimica Acta,2007,vol. 90,p. 562 - 573.
[2]Justus Liebigs Annalen der Chemie,1959,vol. 628,p. 162,170.

3
[ 67-56-1 ]
[ 3646-50-2 ]
[ 22838-46-6 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; at 70℃;	The procedure for the synthesis of 3a is described as a representative one. Thionyl chloride (1.45mL, 20mmol) was dropwise added to a mixture of 3-amino-3-phenylpropanoic acid (1.65g, 10mmol) and dry methanol (15mL) in a 2-neck round bottom flask connected with a condenser. After being refluxed overnight at 70C, the mixture was cooled to ambient temperature, and methanol was removed by evaporation. The salt precipitate was washed with ethyl acetate and then dissolved in aqueous ammonium hydroxide (20mL). The resulting mixture was stirred at room temperature overnight and extracted with CH2Cl2. The organic layer was dried over Na2SO4 and evaporated under reduced pressure to obtain 3a as a white solid (1.195g, 7.28mmol, 73%): mp 99-101C (lit.20 mp 110.1C); the data of 1H and 13C NMR were in good agreement with the literature data.20 Compound 3b: mp 118-122C; 1H NMR (300MHz, CDCl3, ppm): delta 1.8 (2H, br s, NH2), 2.51-2.53 (2H, m, CH2CH), 4.36-4.40 (1H, m, CHNH2), 5.7 (1H, br s, CONH2), 6.7 (1H, br s, CONH2), 7.00-7.07 (2H, m, C6H4), 7.27-7.34 (2H, m, C6H4). 13C NMR (75MHz, CDCl3, ppm): delta 45.1, 52.2, 115.6(d), 127.5(d), 140.7(d), 160.4, 163.7, 173.5. 3c: mp 123-126C; the data of 1H and 13C NMR were in good agreement with the literature data.20 3d: mp 102-105C; the data of 1H and 13C NMR were in good agreement with the literature data.20

References: [1]Journal of Organic Chemistry,2007,vol. 72,p. 10287 - 10290.
[2]Chemistry - A European Journal,2006,vol. 12,p. 1855 - 1874.
[3]Journal of Medicinal Chemistry,2010,vol. 53,p. 1990 - 1999.
[4]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 217 - 223.
[5]Russian Journal of General Chemistry,2000,vol. 70,p. 948 - 952.
[6]Heterocycles,1989,vol. 28,p. 1015 - 1035.
[7]Journal of Organic Chemistry,1999,vol. 64,p. 8668 - 8680.
[8]Organic Letters,1999,vol. 1,p. 2153 - 2156.
[9]Tetrahedron Asymmetry,2013,vol. 24,p. 1449 - 1452.

4
[ 111-26-2 ]
[ 22838-46-6 ]
[ 127022-85-9 ]

References: [1]Pharmazie,1989,vol. 44,p. 723.

5
[ 1071-46-1 ]
[ 22838-46-6 ]
[ 124082-23-1 ]

References: [1]Heterocycles,1989,vol. 28,p. 1015 - 1035.

6
[ 22838-46-6 ]
[ 144426-20-0 ]
[ 144426-37-9 ]

References: [1]Polish Journal of Chemistry,1992,vol. 66,p. 763 - 771.

7
[ 22838-46-6 ]
[ 144426-23-3 ]
[ 144426-41-5 ]

References: [1]Polish Journal of Chemistry,1992,vol. 66,p. 763 - 771.

8
[ 22838-46-6 ]
[ 144426-21-1 ]
[ 144426-40-4 ]

References: [1]Polish Journal of Chemistry,1992,vol. 66,p. 763 - 771.

9
[ 98-01-1 ]
[ 628-30-8 ]
[ 22838-46-6 ]
1-Furan-2-ylmethyl-6-phenyl-3-propyl-2-thioxo-tetrahydro-pyrimidin-4-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 9358 - 9360.

10
[ 404-72-8 ]
[ 22838-46-6 ]
[ 100-52-7 ]
1-Benzyl-3-(3-fluoro-phenyl)-6-phenyl-2-thioxo-tetrahydro-pyrimidin-4-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 9358 - 9360.

11
[ 2257-09-2 ]
[ 22838-46-6 ]
[ 100-52-7 ]
1-Benzyl-3-phenethyl-6-phenyl-2-thioxo-tetrahydro-pyrimidin-4-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 9358 - 9360.

12
[ 22838-46-6 ]
[ 1122-91-4 ]
[ 24066-82-8 ]
[3-(4-Bromo-benzyl)-6-oxo-4-phenyl-2-thioxo-tetrahydro-pyrimidin-1-yl]-acetic acid ethyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 9358 - 9360.

13
[ 404-72-8 ]
[ 22838-46-6 ]
[ 591-31-1 ]
3-(3-Fluoro-phenyl)-1-(3-methoxy-benzyl)-6-phenyl-2-thioxo-tetrahydro-pyrimidin-4-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 9358 - 9360.

14
[ 59661-86-8 ]
[ 22838-46-6 ]
[ 174635-62-2 ]

References: [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 1053 - 1065.

15
[ 22838-46-6 ]
[ 108-88-3 ]
COCl₃ [ No CAS ]
[ 51031-37-9 ]

References: [1]Justus Liebigs Annalen der Chemie,1959,vol. 628,p. 162,170.

16
[ 22838-46-6 ]
[ 98-86-2 ]
paraformaldehyde [ No CAS ]
[ 88831-32-7 ]

References: [1]Pharmazie,1983,vol. 38,p. 509 - 511.

17
[ 4530-20-5 ]
[ 22838-46-6 ]
[ 329911-77-5 ]

References: [1]Russian Journal of General Chemistry,2000,vol. 70,p. 948 - 952.
[2]Acta poloniae pharmaceutica,2000,vol. 57,p. 15 - 21.

18
[ 111-24-0 ]
[ 22838-46-6 ]
[ 7032-62-4 ]

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 217 - 223.

19
[ 53406-00-1 ]
[ 22838-46-6 ]
3-carbamoyl-1-(2-methoxycarbonyl-1-phenylethyl)pyridinium chloride [ No CAS ]
[ 97-02-9 ]

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 217 - 223.

20
[ 38330-80-2 ]
[ 22838-46-6 ]
[ 656808-19-4 ]

References: [1]Monatshefte fur Chemie,2003,vol. 134,p. 1129 - 1136.

21
[ 22838-46-6 ]
[ 365450-80-2 ]
N'-{N-[3-oxo-20⁽²⁹⁾-lupen-28-oyl]-9-aminononanoyl}-3-amino-3-phenylpropionic acid [ No CAS ]

References: [1]Chemistry of Natural Compounds,2002,vol. 38,p. 331 - 339.

22
[ 118-48-9 ]
[ 22838-46-6 ]
(rac)-methyl 3-(2-aminobenzamido)3-phenylpropanoate [ No CAS ]

References: [1]Tetrahedron Asymmetry,2005,vol. 16,p. 629 - 634.

23
[ 82911-69-1 ]
[ 22838-46-6 ]
methyl (rac)-3-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-phenylpropanoate [ No CAS ]

References: [1]Tetrahedron Asymmetry,2005,vol. 16,p. 629 - 634.

24
[ 22838-46-6 ]
[ 807627-82-3 ]
[ 807627-84-5 ]

References: [1]Russian Journal of Organic Chemistry,2006,vol. 42,p. 1174 - 1182.

25
[ 24424-99-5 ]
[ 22838-46-6 ]
[ 257861-50-0 ]