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CAS No. : | 63503-60-6 |
Formula : | C6H6BClO2 |
M.W : | 156.37 |
SMILES Code : | ClC1=CC=CC(=C1)B(O)O |
MDL No. : | MFCD00161354 |
InChI Key : | SDEAGACSNFSZCU-UHFFFAOYSA-N |
Pubchem ID : | 2734323 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302+H312+H332 |
Precautionary Statements: | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium carbonate;tetrakis(triphenylphosphine)palladium (0); In ethanol; water; toluene; | Referential Example 30 To 20 mL of toluene solution containing 2.0 g of <strong>[890315-72-7]tert-butyl 4-bromo-2-nitrobenzoate</strong>, 6.0 mL of ethanol, 3.0 mL of water, 1.2 g of 3-chlorophenylboronic acid, 1.7 g of sodium carbonate and 0.23 g of tetrakis(triphenylphosphine)palladium (0) were added sequentially, and the resulting mixture was heated to reflux under nitrogen atmosphere for 3 hours. Water was added after the reaction mixture was cooled to room temperature. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain 0.70 g of tert-butyl 4-(3-chlorophenyl)-2-nitrobenzoate as white solid. 1H-NMR (DMSO-d6) delta: 1.52 (9H, s), 7.53-7.59 (2H, m), 7.77-7.82 (1H, m), 7.89-7.95 (2H, m), 8.15 (1H, dd, J = 8.1, 1.6 Hz), 8.34 (1H, d, J = 1.6 Hz). | |
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; for 3.0h;Heating / reflux; | To toluene 20mL solution of <strong>[890315-72-7]tert-butyl 4-bromo-2-nitrobenzoate</strong> 2.0g were added ethanol 6.0mL, water 3.0mL, 3-chlorophenylboronic acid 1.2g, sodium carbonate 1.7g and tetrakis(triphenylphosphine)palladium(0) 0.23g sequentially, and it was heated and refluxed under nitrogen atmosphere for 3 hours. After the reaction mixture was cooled to room temperature, water was added to it. The organic layer was separated and collected, dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [Fuji SILYSIA Chemical Ltd., PSQ100B(spherical type), eluent; hexane:ethyl acetate=10:1] to give tert-butyl 4-(3-chlorophenyl)-2-nitrobenzoate 0.70g of white solid. 1H-NMR(DMSO-d6) delta value: 1.52(9H,s),7.53-7.59(2H,m),7.77-7.82(1H,m),7.89-7.95(2H,m),8.15(1H,dd,J=8.1,1.6Hz),8.34(1H,d,J=1.6Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | General procedure: A solution of sodium carbonate (0.55mmol) in water (1.75mL) and EtOH (1.25mL) was prepared and degassed. In a 10mL vial Tetrakis (triphenylphosphine) palladium (0.055mmol) was added to a solution of 4a-e (0.275mmol) in DME (5mL) in a 10mL vial. Argon was bubbled into the DME solution with stirring for 10min. The boronic acid (1.650mmol) was added to the vial followed by the addition of the sodium carbonate mixture. The vial was sealed under argon and heated to 80C while stiring for 12h. The mixture was diluted in water and extracted with ethyl acetate. The extracts were washed with brine and dried over magnesium sulfate. The mixture was concentrated in vacuo to give the product as an oil. The product was purified in by column chromatography and characterized by 1H and 13C NMR. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With caesium carbonate;tetrakis(triphenylphosphine) palladium(0); at 150℃; for 1h;Microwave irradiation; | A suspension of 5-bromo[l,2,4]triazolo[l,5-alpha]pyridin-2-amine (5.1 g, 24 mmol, 1 equiv), 3-chlorophenylboronic acid (3.8 g, 24 mmol, 1.0 equiv), cesium carbonate (9.4 g, 29 mmol, 1.2 equiv), tetrakistriphenylphosphine palladium (2.7 g, 2.4 mmol, 0.1 equiv) was heated to 150 C for 1 h under <n="96"/>microwave irradiation. The reaction mixture was diluted with ethyl acetate and filtered through Celite. The filtrate was washed with saturated aqueous sodium chloride solution. The organic phase was dried over magnesium sulfate, filtered, and concentrated. Purification by flash column chromatography (30% ethyl acetate in petroleum ether) provided product as a solid (3.5 g, 61%). LCMS (ESI) m/z: 244.9. |
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; for 5h;Reflux; | Compound 14Compound 13 (750 mg, 3.5 mmol) was dissolved in toluene/ethanol (1 :1, 20 ml), to which was added 2M aqueous Na2CO3 (3.5 ml) and 3- chlorophenylboronicacid (1.1 g, 7.0 mmol). Pd (PPh3) 4 (202 mg) was added last, the mixture was flushed with nitrogen and refluxed for 5 hours in a sealed tube. The reaction mixture was allowed to cool.The reaction solvent was removed and the residue was purified on silica gel (ethylacetate : hexanes 50%) to give 514mg of compound 14 as white solid. LC-MS (ESI, positive): 247 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In methanol; water; toluene;Inert atmosphere; Reflux; | General procedure: To a solution of bromobiphenylaldehyde (6, 260 mg, 1 mmol) and various phenyl boronic acids (7a-j, 1 mmol) in 2 M aqueous sodium carbonate (2 mL) and toluene/ethanol (9:3 mL) is added a catalytic amount (0.4% mol) of tetrakis-triphenylphosphine palladium, and the mixture was reflux under argon atmosphere for 2-3 h. After completion of reaction, the suspension is cooled and extracted with ethyl acetate (3 × 30 mL) and the organic phase was washed with water and brine, dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure to get the crude product. This residue was further purified by column chromatography using ethyl acetate and hexane to afford the pure terphenylaldehydes (8). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
32% | With caesium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In N,N-dimethyl-formamide; at 80.0℃;Inert atmosphere; | Under nitrogen atmosphere, <strong>[1214328-42-3]6-bromo-5-chloro-pyridine-2-carboxylic acid</strong> (0.38 g, 1.6 mmol), 3-chlorophenylboronic acid (CAN 63503-60-6, 0.33 g, 2.1 mmol), 1,1'-bis(diphenylphosphino)-ferrocene-palladium(II) dichloride methylene chloride complex (CAN 95464-05-4, 30 mg) and cesium carbonate (CAN 534-17-8, 1.6 g, 4.8 mmol) was added into DMF (30 mL). The mixture was stirred at 80 C. overnight. After evaporation of solvents, the crude product was purified by column chromatography (silica gel, 12 g, petroleum ether/ethyl acetate 4/1 firstly, then methanol/methylene chloride 1/10) to give the title compound (0.14 g, 32%) as brown solid; MS (EI): m/e=268.0 [M+H]+. |
32% | With caesium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In N,N-dimethyl-formamide; at 80.0℃;Inert atmosphere; | Under nitrogen atmosphere, <strong>[1214328-42-3]6-bromo-5-chloro-pyridine-2-carboxylic acid</strong> (0.38 g, 1.6 mmol), 3-chlorophenylboronic acid (CAN 63503-60-6, 0.33 g, 2.1 mmol), Iota,Gamma- bis(diphenylphosphino)-ferrocene-palladium(II) dichloride methylene chloride complex (CAN 95464-05-4, 30 mg) and cesium carbonate (CAN 534-17-8, 1.6 g, 4.8 mmol) was added into DMF (30 mL). The mixture was stirred at 80C overnight. After evaporation of solvents, the crude product was purified by column chromatography (silica gel, 12 g, petroleum ether/ethyl acetate 4/1 firstly, then methanol/ methylene chloride 1/10) to give the title compound (0.14 g, 32%) as brown solid; MS (EI): m/e = 268.0 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With caesium carbonate; In dichloromethane; water; | Step 6 To a solution of ethyl (7-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)acetate (1.00 g, 2.94 mmol) in a degassed (with Ar stream) mixture of 1,4-dioxane/H2O (25/5 mL) was added 3-chloro-phenylboronic acid (898 mg, 5.74 mmol) and cesium carbonate (2.807 g, 8.61 mmol), to which was added 1,1'-bis(diphenylphosphino)ferrocenepalladium(II) dichloride, complex with dichloromethane (1:1). The reaction mixture was capped under argon atmosphere and stirred at 80° for 2 h. The solvent was evaporated under vacuum and the residue partitioned between ethyl acetate and water. The organic phase was dried on Na2SO4 and concentrated to dryness. The crude was purified by chromatography on a silica gel column (eluent: DCM I/EtOAc/EtOH:60/35/5) to afford 0.573 g (60percent yield) as a light brown solid. 1H NMR (400 MHz, DMSO-d6) delta 7.71 (d, J=1.22 Hz, 1H), 7.64 (t, J=1.83 Hz, 1H), 7.58 (d, J=1.83 Hz, 1H), 7.51-7.56 (m, 1H), 7.35 (t, J=7.93 Hz, 1H), 7.20 (ddd, J=0.98, 2.08, 7.93 Hz, 1H), 7.10 (d, J=1.83 Hz, 1H), 4.60-4.69 (m, 1H), 4.11 (dq, J=1.16, 7.10 Hz, 2H), 3.71 (ddd, J=1.89, 4.18, 13.09 Hz, 1H), 3.35-3.42 (m, 1H), 2.89 (dd, J=5.13, 6.84 Hz, 2H), 1.18 (t, J=7.08 Hz, 3H) HRMS (ESI) calcd for C17H18ClN2O3[M+H]+ 333.1001 found 333.1005. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; toluene; for 12h;Reflux; | General procedure: A mixture of 2-chloro-4-(trifluoromethyl)-benzonitrile (1.00 mmol), appropriate boronic acid (1.20 mmol)were dissolved in toluene/dioxane:2 N Na2CO3 (2:1:1) solution(6 ml). Tetrakis(triphenyl-phosphine)palladium(0) (0.10 mmol)and 1,10-Ferrocenediyl-bis(diphenylphosphine) (0.20 mmol) wasadded to the mixture and it was refluxed for 12 h. After cooleddown to ambient temperature, the reaction was filtered over celiteand extracted with EtOAc twice. The combined organic extractswere dried over MgSO4, filtered, and concentrated in vacuo. Theresidue was purified by flash column chromatography on silicagel using EtOAc/hexanes (1:10) eluant condition. (R-B(OH)2 =1-pentenyl boronic acid for 53, 1-cyclohexenylboronicacid for 54). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 12h;Inert atmosphere; Reflux; | 15 g (46.55 mmol) of <strong>[1097884-37-1]4-bromo-9-phenylcarbazole</strong> (cas: 1097884-37-1) was added to 140 mL of tetrahydrofuran and 70 mL of distilled water in a 500 mL round-bottomed flask, 1.1 equivalent of 3-chlorophenyl boronic acid, 0.03 equivalents of tetrakistriphenylphosphine palladium, and 2 equivalents of potassium carbonate were added thereto, and the mixture was heated and refluxed under a nitrogen atmosphere. After 12 hours, the reaction solution was cooled down, an organic layer was extracted to remove a solvent under a reduced pressure. A compound concentrated therefrom was treated through silica column chromatography to obtain Intermediate C-1-2 at a yield of 85%. |
85% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 12h;Reflux; Inert atmosphere; | Add 15g (46.55mmol) of <strong>[1097884-37-1]4-bromo-9-phenylcarbazole</strong> (cas: 1097884-37-1) into 140mL of tetrahydrofuran and 70mL of distilled water in a 500mL round bottom flask,1.1 equivalents of 3-chlorophenylboronic acid, 0.03 equivalents of tetrakis(triphenylphosphine)palladium, and 2 equivalents of potassium carbonate were added thereto, and the resulting mixture was heated and refluxed under a nitrogen atmosphere. After 12 hours, the reaction solution was cooled, the organic layer was extracted therefrom, and the solvent was removed under reduced pressure. The concentrated compound was processed by silica column chromatography to obtain the intermediate product C-1-2 with a yield of 85%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With palladium diacetate; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; toluene;Reflux; Inert atmosphere; | first, 50.0 g (125 mmol, 1.0 eq.) Of<strong>[57103-20-5]3,6-dibromo-9-phenyl-carbazole</strong>(CAS 57103-20-5) and 19.5 g (125 mmol, 1.0 eq.) Of 3-chlorobenzene boronic acid (CAS 6350-60-6) and together, 400 of water, Of 400 of dioxane and 400 Injecting a mixture of toluene,30 minutes Degassing. 280 (1.25 mmol, 1 mol-percent) of palladium (II) acetate and 1.14 g (3.75 mmol, 3 mol-percent)After addition of the tree -o- tolyl phosphine,When heating the batch at reflux overnight, and the reaction is complete, the addition of a small amount of water. The organic phase was separated, and extracted twice with water. After drying the organic phase over sodium sulfate, The residue was recrystallized from heptane / toluene, yielding a beige solid of 44.8 g (103 mmol, 83percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With lithium hydroxide monohydrate; C36H27N2OPPd; In methanol; water; N,N-dimethyl-formamide; at 80℃; for 24h; | General procedure: In a 10 ml round bottom flask, 3,5-dihalosalicylaldehyde(1 mmol), arylboronic acid (2.2 mmol for diiodo precursor or2.5 mmol for dibromo precursor), LiOHH2O (2 mmol) and complex2 (0.01 mol% for diiodo precursor or 0.05 mol% for dibromo precursor)in 0.1 ml dimethylformamide were taken in 2 ml of watermethanol(1:1) mixture. The reaction mixture was then heated at80 C under aerobic condition. Progress of the reaction was monitoredby TLC. On completion, the reaction mixture was cooled toroom temperature and extracted with two 10 ml portions of ethylacetate. The combined extract was washed with water (2 x 10 ml),dried over anhydrous Na2SO4 and finally the solvent was removedunder reduced pressure. The solid obtained was subjected to columnchromatography over silica gel using ethyl acetate and hexanemixture as the eluent to afford the pure product. All the functionalizedtriaryl products obtained were characterized by 1H NMRspectroscopy and high resolution mass spectrometry. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | A mixture of N-boc-2-(4-bromophenyl)ethylamine, the desiredarylboronic acid (a-m) (1.2 equiv), tetrakis(triphenylphosphine)-palladium(0) (0.04 equiv), Na2CO3 (5 equiv) in degassed toluene/H2O (5/2) was refluxed for 18 h. The reaction mixture was filteredthrough Celite and concentrated in vacuo. The resulting residuewas dissolved in in EtOAc (200 mL), washed with H2O (200 mL 2) and brine (200 mL). The organic layer was dried with anhydrousNa2SO4 and concentrated in vacuo. The residue was purified by columnchromatography on SiO2. Using Method E, 13 (1.00?g, 3.3?mmol), 3-chlorophenylboronic acid (0.63?g, 4.0?mmol), tetrakis(triphenylphosphine)palladium(0) (0.15?g, 0.1?mmol), Na2CO3 (1.77?g, 16.7?mmol) in toluene/H2O (33?ml/13.3?ml), followed by 4.0?M HCl in dioxane (2.50?ml, 10.0?mmol) gave 14g as a white solid (0.84?g, 67%): Rf?=?0.00 (EtOAc 9: acetone 1): 1H NMR (DMSO-d6, 400?MHz) delta 2.93-3.09 (m, NH3CH2CH2), 7.25-7.82 (m, 8 ArH), 8.33 (s, NH3); 13C NMR (DMSO-d6, 100?MHz) delta 33.1 (NCH2CH2), 128.0, 129.0, 129.4, 129.6, 129.7, 129.9, 130.3, 131.5, 131.7, 131.9, 137.6, 140.0 (12 ArC). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
22% | With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 100℃;Inert atmosphere; | General procedure: 31 (1 eq.), boronic acid (1.5 eq.) or pinacol ester [for compound14 (1.5 eq.)], Na2CO3 (9 eq.), Pd(OAc)2 (0.05 eq.) and TPPTS (0.15 eq.)were added to a 10mL round-bottom flask, equipped with a stir bar.Next, the flask was evacuated and refilled with argon. This procedure was repeated three times in total. Next, degassed MeCN(2 mL/mmol SM) and H2O (4 mL/mmol SM) were added to the solids under argon. After 5 min of stirring, the mixture was heatedto 100 C in a pre-heated oil bath. When the starting material was fully consumed (usually 1e3 h), the mixture was cooled to ambient temperature, and neutralized (pH ~ 7) with 0.5M aq. HCl. Themixture was evaporated till dryness, resuspended in MeOH and evaporated (three times). Next, the mixture was adsorbed onto Celite (fromMeOH) and eluted over a short silica pad (~5 cm) with 20% MeOH/DCM. The liquid was evaporated in vacuo and purified by column chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; oxygen; In N,N-dimethyl-formamide; for 48h; | At r.t., copper acetate (572.15 mg, 3.15 mmol) and pyridine (498.33 mg, 6.30 mmol, 508.50 muL) were added into I1 (700.00 mg, 3.15 mmol) and 3-chloro-phenylboronic acid (738.85 mg, 4.72 mmol) in N,N-dimethylformamide (20.00 mL) solution, and was stirred for 48 hours under oxygen atmosphere, EtOAc (180 mL), washed by water (120 mL×2) and saturated brine (120 mL), dried over anhydrous sodium sulfate, then filtered and concentrated to give the crude compound 11-A. MS m/z: 332.9 [M+H]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 18h;Inert atmosphere; Reflux; | 14.06 g (56.90 mmol) of <strong>[26608-06-0]3-bromo-dibenzofuran</strong>,200 ml of tetrahydrofuran and 100 ml of distilled water were placed in a 500 ml round bottom flask, and 1 equivalent of 3'-chloro-phenylboronic acid,0.03 equivalent of tetratriphenylphosphine palladium and 2 equivalents of potassium carbonate,And the mixture was heated and refluxed under a nitrogen atmosphere.After 18 hours,The reaction solution was cooled, filtered and the solid precipitated therein was washed with 500 ml of water. Recrystallize the solid with 500 ml of monochlorobenzene to obtain 12.05 g of intermediateB-71-1. (76% yield) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; for 5h;Inert atmosphere; Reflux; | General procedure: Dissolve 0.065mol of Intermediate 1-2 in 230ml of 1,4-dioxane solvent, and stir with nitrogen.Add 0.065 mol of 4-bromo-1-iodo dibenzofuran, 0.16 mol of K2CO3, and 0.65 mmol of tetrakis (triphenylphosphine) palladium in sequence, and heat to reflux for reaction.After 5h, HPLC detects that the raw material has basically reacted.The reaction solution was spin-dried under reduced pressure,The residue was passed through column chromatography to obtain Intermediate 1-3 (yield: 74%). |
Tags: 3-Chlorophenyl boronic acid | Benzene Compounds | Chlorides | Organoboron | Aryls | Boronic Acids | Organic Building Blocks | Boronic Acids/Esters | Organometallic Reagents | 63503-60-6
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P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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