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Chemical Structure| 19240-91-6 Chemical Structure| 19240-91-6

Structure of 19240-91-6

Chemical Structure| 19240-91-6

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Product Details of [ 19240-91-6 ]

CAS No. :19240-91-6
Formula : C7H5BrCl2O
M.W : 255.92
SMILES Code : COC1=C(Cl)C=C(Br)C=C1Cl
MDL No. :MFCD10699182
Boiling Point : No data available
InChI Key :OAYSFAKCFYRCRU-UHFFFAOYSA-N
Pubchem ID :12963416

Safety of [ 19240-91-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 19240-91-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19240-91-6 ]

[ 19240-91-6 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 19240-91-6 ]
  • 4-bromo-2,6-dichloro-3,5-dinitro-anisole [ No CAS ]
  • 3
  • [ 104-92-7 ]
  • [ 50638-47-6 ]
  • [ 19240-91-6 ]
  • [ 83801-98-3 ]
  • 4
  • [ 19240-91-6 ]
  • HNO3+H2SO4 [ No CAS ]
  • 4-bromo-2,6-dichloro-3,5-dinitro-anisole [ No CAS ]
  • 5
  • [ 63503-60-6 ]
  • [ 19240-91-6 ]
  • [ 98068-70-3 ]
  • 6
  • [ 1679-18-1 ]
  • [ 19240-91-6 ]
  • [ 74298-91-2 ]
  • 7
  • [ 3900-89-8 ]
  • [ 19240-91-6 ]
  • [ 97028-06-3 ]
  • 8
  • [ 19240-91-6 ]
  • [ 68716-47-2 ]
  • [ 74298-93-4 ]
  • 9
  • [ 3217-15-0 ]
  • [ 67-68-5 ]
  • [ 19240-91-6 ]
  • 10
  • [ 19240-91-6 ]
  • [ 98-80-6 ]
  • [ 74298-90-1 ]
  • 11
  • [ 19240-91-6 ]
  • [ 99769-19-4 ]
  • [ 92436-58-3 ]
  • 12
  • [ 19240-91-6 ]
  • [ 99768-12-4 ]
  • [ 92436-59-4 ]
  • 13
  • [ 3217-15-0 ]
  • [ 74-88-4 ]
  • [ 19240-91-6 ]
YieldReaction ConditionsOperation in experiment
84.9% With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 16h; Step 2: Preparation of 5-bromo-1,3-dichloro-2-methoxybenzene A mixture of 4-bromo-2,6-dichlorophenol (10 g, 41.67 mmol), K2CO3 (11.5 g, 83.3 mmol) and CH3I (8.88 g, 62.5 mmol) in DMF (100 mL) was stirred at rt for 16 h. TLC (EtOAc/petroleum ether=1:2) indicated complete consumption of 4-bromo-2,6-dichlorophenol. The reaction mixture was poured into water (300 mL). The aqueous phase was extracted with EtOAc (2*100 mL). The combined organic phases were dried over anhydrous Na2SO4, and concentrated in vacuo to give crude 5-bromo-1,3-dichloro-2-methoxybenzene, which was purified by column chromatography (silica gel, EtOAc/petroleum ether=1:5) to yield the ether product (9 g, yield 84.9%) as a white solid. 1H NMR (400 MHz, CDCl3): δ 7.45 (s, H), 3.91 (s, 3H) ppm.
  • 15
  • [ 124-38-9 ]
  • [ 19240-91-6 ]
  • [ 37908-97-7 ]
  • 16
  • [ 19240-91-6 ]
  • [ 97028-36-9 ]
  • 17
  • [ 19240-91-6 ]
  • 3.5-Dichlor-4-hydroxy-3'-methoxycarbonyl-biphenyl [ No CAS ]
  • 18
  • [ 19240-91-6 ]
  • 3.5-Dichlor-4-hydroxy-4'-methoxycarbonyl-biphenyl [ No CAS ]
  • 19
  • [ 19240-91-6 ]
  • 3',5'-dichloro-4'-hydroxy-biphenyl-3-carboxylic acid [ No CAS ]
  • 21
  • [ 19240-91-6 ]
  • [ 1137-59-3 ]
  • 22
  • [ 19240-91-6 ]
  • [ 4400-06-0 ]
  • 23
  • [ 19240-91-6 ]
  • [ 72490-71-2 ]
  • 24
  • [ 19240-91-6 ]
  • 3,3',5-trichloro-4-hydroxybiphenyl [ No CAS ]
  • 25
  • [ 19240-91-6 ]
  • 4-Hydroxy-2',3,4',5-tetrachlorobiphenyl [ No CAS ]
  • 26
  • [ 19240-91-6 ]
  • 4-bromo-2,6-dichloro-3,5-dinitro-phenol [ No CAS ]
  • 27
  • [ 19240-91-6 ]
  • [ 73183-34-3 ]
  • 2-(3,5-dichloro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane [ No CAS ]
YieldReaction ConditionsOperation in experiment
42.4% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 70℃; for 16h;Inert atmosphere; Step 3: Preparation of 2-(3,5-dichloro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane A mixture of 5-bromo-1,3-dichloro-2-methoxybenzene (1 g, 3.94 mmol), bis(pinacolato)diboron (1.46 g, 5.83 mmol), Pd(dppf)Cl2(0.135 g, 0.19 mmol), KOAc (1.13 g, 11.6 mmol) in 1,4-dioxane (20 mL) was degassed with N2 for 5 min. The reaction mixture was stirred at 70 C. for 16 h. TLC (EtOAc/Petroleum ether=1:5) indicated complete consumption of the bromo starting material. The reaction mixture was poured into water (40 mL) and extracted with EtOAc (3*70 mL). The combined organic phases were dried over anhydrous Na2SO4, and concentrated in vacuo to give crude product, which was purified by column chromatography (silica gel, EtOAc/petroleum ether=1:10) to get the pure boron compound (0.5 g, yield 42.4%) as a white solid. 1H NMR (400 MHz, CDCl3): δ 7.71 (s, 2H), 3.91 (s, 3H), 1.33 (s, 12H) ppm.
  • 28
  • [ 19240-91-6 ]
  • [ 1437779-43-5 ]
  • 29
  • [ 19240-91-6 ]
  • [ 1437779-85-5 ]
  • 30
  • [ 19240-91-6 ]
  • [ 71742-42-2 ]
  • 31
  • [ 19240-91-6 ]
  • C14H16Cl2O5 [ No CAS ]
  • 32
  • [ 19240-91-6 ]
  • C10H8Cl2O5 [ No CAS ]
  • 33
  • [ 19240-91-6 ]
  • C22H10Cl8O5 [ No CAS ]
  • 34
  • [ 19240-91-6 ]
  • C20H14Cl3N3O3S [ No CAS ]
  • 35
  • [ 67-56-1 ]
  • [ 17318-08-0 ]
  • [ 19240-91-6 ]
 

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Technical Information

Categories

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[ 19240-91-6 ]

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